Clinical trials: Palliative Cancer, open to volunteers
Esophageal Cancer
Treatment Outcomes of Esophageal Cancer
This study will be a carried out through a prospective observational cohort design in conjunction with researchers in the African Esophageal Cancer Consortium (AfrECC).
- Trial name
- NCT05177393
- Testing
- Assessment of patient-reported outcomes (PROs)
- Where
- 6 sites in Kenya, Malawi and 1 more
- Volunteers
- 2,476 people
- Sponsor
- University of California, San Francisco
Older Patients, Colorectal Cancer
DOSAGE Study: Upfront Dose-Reduced Chemotherapy in Older Patients with Metastatic Colorectal Cancer
The goal of this phase III, open-label, non-inferiority randomized controlled clinical trial is compare upfront dose-reduced chemotherapy with the standard dose chemotherapy in older patients ( ≥70 years) with metastasized…
- Conditions
- Older Patients, Colorectal Cancer, Metastatic Cancer, Candidates for Palliative Chemotherapy
- Trial name
- DOSAGE (NCT06275958)
- Testing
- Doublet Chemotherapy, Standard Dose (100%), Doublet Chemotherapy, Dose-reduced (75%), Monotherapy, Standard Dose (100%)
- Where
- 36 sites in Netherlands
- Volunteers
- 587 people
- Sponsor
- Leiden University Medical Center
Neoplasm, Colorectal, Cognitive Impairment
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
The purpose of this research study is to see how the brain changes in patients receiving chemotherapy (cytotoxic drug) treatment for colon or rectal cancer at Parkview Cancer Institute.
- Conditions
- Neoplasm, Colorectal, Cognitive Impairment, Cognitive Dysfunction, Cognitive Change
- Trial name
- Chemo Brain (NCT05014399)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Joseph McCollom
Neoplasms, Palliative Care
Effectiveness and Implementation of 'Supportive and Palliative Care Review Kit in Locations Everywhere'
Advanced cancer patients often experience significant physical and emotional symptoms, which can lead to frequent hospital visits and reduced quality of life.
- Trial name
- SPARKLE-2 (NCT07745816)
- Testing
- SPARKLE-2
- Where
- 2 sites in Singapore
- Volunteers
- 300 people
- Sponsor
- National Cancer Centre, Singapore
Palliative Care Referral, Advanced Cancer
Electronic Patient Reporting of Symptoms and Unmet Needs to Connect Patients With Advanced Cancer to Palliative Care Services
This study is testing whether electronic surveys can help patients with advanced cancer report their symptoms and care needs so their doctors can connect them to palliative/supportive care services sooner.
- Conditions
- Palliative Care Referral, Advanced Cancer, Palliative Care, Health Services, Metastatic Cancer (Different Solid Tumour Types)
- Trial name
- PRO-CONNECT (NCT07195513)
- Testing
- ePRO-Directed Referral and Navigation to Palliative/Supportive Care, ePRO Symptom Monitoring with Usual Palliative Care Referral
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
GI Cancer
Effect of Geriatric Intervention in Frail Patients with Gastric, Biliary, and Pancreatic Cancer Receiving Palliative Chemotherapy
Gastric, biliary and pancreatic cancer are commonly malignancies from gastro- intestinal tract in Taiwan. Because lack of specific symptoms at presentation and effective screening methodology, majority of these patients are…
- Trial name
- NCT06040801
- Testing
- Frailty intervention measures
- Where
- Taiwan
- Volunteers
- 138 people
- Sponsor
- Chang Gung Memorial Hospital
Palliative Care, Cancer
Attitudes Towards Deprescribing Medications in Cancer Patients and Impact of Educational Intervention by a Clinical Pharmacist
Participation in this study consists in responding to some questions from two questionnaires in Romanian about how participants feel about deprescribing, participants' treatment and how participants understand medical…
- Trial name
- NCT06771999
- Testing
- Educational intervention by a clinical pharmacist
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Pancreas Cancer, Non-Resectable Pancreas Carcinoma
Gemcitabine Versus Reduced-dose Combination Chemotherapy in Fragile Patients with Non-resectable Pancreatic Cancer
The aim of the study is to compare the efficacy and toxicity of full-dose Gemcitabine and reduced-dose combination chemotherapy in patients with non-resectable pancreatic cancer, who are unfit for full-dose combination…
- Trial name
- NCT05841420
- Testing
- Gemcitabine, Nab paclitaxel
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- Morten Ladekarl
Vertebral Fracture, Multiple Myeloma
Examination of Vertebroplasty in Addition to Regular Treatment of Patients With Multiple Myeloma.
Patients with newly diagnosed or known multiple myeloma with newly diagnosed vertebral lesion(s) will be invited to participate in a cross-sectoral randomized controlled trial.
- Trial name
- NCT04533217
- Testing
- Vertebroplasty
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Spine Centre of Southern Denmark
Esophageal Cancer
Precision Palliative Care for Patients With Advanced Esophageal Cancer
The goal of this clinical trial is to learn if precision palliative care improves survival of patients with advanced esophageal cancer in adults.
- Trial name
- NCT06787313
- Testing
- precision palliative care
- Where
- China
- Volunteers
- 624 people
- Sponsor
- Fudan University
Breast Carcinoma, Colorectal Carcinoma
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
This is a multi-site clinical study enrolling 2000 newly diagnosed patients with breast, colorectal, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer, who are planning to receive one or more systemic cancer directed…
- Conditions
- Breast Carcinoma, Colorectal Carcinoma, Lung Non-Small Cell Carcinoma, Melanoma
- Trial name
- COSMIC (NCT06418204)
- Testing
- Non-interventional Study
- Where
- 491 sites in United States, Puerto Rico
- Volunteers
- 2,000 people
- Sponsor
- Wake Forest University Health Sciences
Cancer, Palliative Care
Music Therapy Program for Patients in Palliative Care (MUSPAL360)
Hospitalized patients with advanced cancer often experience a heavy burden of physical, emotional, and spiritual symptoms that affect their quality of life.
- Trial name
- NCT07831148
- Testing
- Music Therapy with Virtual Reality (Session 1), Significant Song Choice (Session 2), Biographical Musical Legacy (Session 3)
- Volunteers
- 40 people
- Sponsor
- Austral University, Argentina
Multiple Myeloma in Relapse, Multiple Myeloma, Refractory
Early Palliative Care for Patients With Multiple Myeloma and Aggressive Lymphoma
Patients with multiple myeloma experience a wide range of physical and psychological symptoms from the time of their diagnosis. Meanwhile, patients with aggressive lymphomas undergo unpredictable illness courses, resulting in…
- Conditions
- Multiple Myeloma in Relapse, Multiple Myeloma, Refractory, Multiple Myeloma Stage III, Multiple Myeloma Progression
- Trial name
- EPC-MM+L (NCT06485076)
- Testing
- Early Palliative Care
- Where
- Canada
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Breast Cancer (Locally Advanced or Metastatic), Lymphoma
Remote Monitoring and Symptom Management Digital Application
The goal of this clinical trial is to learn if an artificial intelligence phone application called ASSIST can help patients receiving cancer treatment.
- Conditions
- Breast Cancer (Locally Advanced or Metastatic), Lymphoma, Colorectal Cancer
- Trial name
- ASSIST (NCT07553572)
- Testing
- ASSIST phone application
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Patrick C. Johnson, MD
Palliative Care, Acute Myeloid Leukaemia
Effectiveness of Early Intervention in Palliative Care for Acute Myeloid Leukemia Patients Comparing to Standard of Care
Hemato-oncology patients undergoing intensive chemotherapy treatments experience different types of symptoms during and after treatments, which are often refractory to the established therapy.
- Trial name
- NCT06848270
- Testing
- Early palliative care integration
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Universidade do Porto
Breast Cancer, Chemotherapy Side Effects
Artificial Intelligence-supported Mobile Application for Patients With Breast Cancer
This randomized controlled clinical trial aims to evaluate the effects of an artificial intelligence-supported mobile application on symptom management, self-efficacy, and quality of life in breast cancer patients receiving…
- Trial name
- NCT07826338
- Testing
- AI-Supported Mobile Application
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ege University
Head and Neck Neoplasms, Xerostomia
Foot Reflexology and Ta-VNS for Symptom Management in Head and Neck Cancer During CCRT
Head and neck cancer (HNC) patients undergoing concurrent chemoradiotherapy (CCRT) frequently experience pain, xerostomia, fatigue, sleep disturbance, and other treatment-related toxicities that impair quality of life and…
- Conditions
- Head and Neck Neoplasms, Xerostomia, Cancer-related Fatigue, Pain
- Trial name
- NCT07711626
- Testing
- True Foot Reflexology, True ta-VNS, True Auricular Acupressure
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Tzu Chi University
Palliative Care, Advanced Cancer
Coaching in Palliative Surgical Oncology
This study aims to evaluate the effectiveness of a serious illness coaching intervention (CONCORD) in improving quality of serious illness conversation (SIC), treatment decision-making, goal-concordant care delivery and quality…
- Trial name
- NCT07789093
- Testing
- CONCORD coaching intervention
- Where
- Singapore
- Volunteers
- 220 people
- Sponsor
- Singapore General Hospital
Cancer
STATIC - Statin Termination in Cancer
There are many guidelines on when to start drug treatment, but surprisingly few guidelines on how and when to stop drugs. For example, there are currently no clear guidelines on when to stop preventive medications such as statins…
- Trial name
- STATIC (NCT07543432)
- Testing
- Deprescribing statins
- Where
- 2 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Stiftelsen Stockholms Sjukhem
Cancer, Heart Failure
Goal Concordant Care Learning Laboratory
The goal-concordant care lab will develop and test strategies to optimize communication in advanced serious illness.
- Conditions
- Cancer, Heart Failure, Copd, Dementia
- Trial name
- NCT05879211
- Testing
- Feedback
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Duke University