Clinical trials: Palliative Cancer
Cancer, Surgery
Study of PG2 Injection for Improving Fatigue in Patients After Palliative Abdominal Surgery for Cancer
PG2 has been approved in Taiwan to treat cancer-related fatigue for advanced cancer patients. The primary objective of this study is to evaluate the efficacy of PG2 on fatigue relief in patients undergoing palliative abdominal…
- Conditions
- Cancer, Surgery, Fatigue
- Trial name
- NCT02077621
- Testing
- PG2
- Where
- Taiwan
- Sponsor
- PhytoHealth Corporation
Advanced Malignant Neoplasm, Locally Advanced Malignant Neoplasm
Caregiver Burden, Quality of Life, and Symptom Distress at Different Palliative Cancer Care Settings
This trial studies caregiver burden, quality of life, and symptom distress of patients and their informal (unpaid) caregivers at different palliative care settings.
- Conditions
- Advanced Malignant Neoplasm, Locally Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm, Recurrent Malignant Neoplasm
- Trial name
- NCT04186884
- Testing
- Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cancer
The Role of Oxygen in the Management of Dyspnoea in Advanced Cancer
The purpose of this study is to determine the effect that oxygen has when administered to patients complaining of shortness of breath, where the underlying cause of this symptom is advanced cancer.
- Trial name
- NCT00206609
- Testing
- Oxygen and air administration
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Bayside Health
Head and Neck Neoplasms, Squamous Cell Carcinoma of Head and Neck
Quad Shot Versus Split Course Radiotherapy in Incurable Head and Neck Cancer
Head and neck cancer in its advanced, incurable stage causes severe symptoms such as pain, trouble swallowing, and bleeding. Palliative radiation therapy is frequently used to relieve these symptoms and improve the patient's…
- Trial name
- QSSC-HN (NCT07823309)
- Testing
- Quad Shot Radiotherapy, Split Course Radiotherapy
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Cancerologia, Columbia
Advanced Cancer
Adjunctive Effect of Acupuncture for Advanced Cancer Patients With Palliative Care: a Three-arm Randomized Trial
The proposed study aims to evaluate the adjunctive effect of MA with standard care (ASC) for relieving cancer-related symptoms in a collaborative model of palliative care compared to sham MA plus standard care (SSC) or standard…
- Trial name
- NCT04398875
- Testing
- Acupuncture and standard care (ASC), Standard care (SC)
- Volunteers
- 120 people
- Sponsor
- The University of Hong Kong
Breast Cancer Survivors, Symptom Management
Effects of an e-Home Based Symptom Management and Mindfulness Training Programme on QoL in Breast Cancer Survivors
Breast cancer is the most common cancer in women in Singapore. Breast cancer survivors usually experience side effects/symptoms after surgery and/or adjuvant chemotherapy and/or radiotherapy such as fatigue, lymphedema, problems…
- Conditions
- Breast Cancer Survivors, Symptom Management, Mindfulness Based Cognitive Therapy, Quality of Life
- Trial name
- NCT02931864
- Testing
- Online mindfulness training, Online symptom management
- Where
- 2 sites in Singapore
- Volunteers
- 172 people
- Sponsor
- National University of Singapore
Breast Cancer Patients Receiving Chemotherapy
Awareness Based Stress Reduction Program Applied to Breast Cancer Patients Receiving Chemotherapy
Implementation of awareness-based stress reduction program in breast cancer patients receiving chemotherapy and examining its effects on psychological resilience, symptom management and quality of life.
- Trial name
- Mindfulness (NCT06183164)
- Testing
- Mindfulness: Awareness-Based Stress Reduction Program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Firat University
Esophageal Cancer (EsC)
Patient-Reported Symptom Care Versus Usual Care After Esophageal Cancer Surgery: A Single-Center Phase 3 Randomized Trial
Symptom management is fundamental to clinical care, and symptom monitoring is an effective means to detect potential adverse events early and prevent serious complications.
- Trial name
- NCT07211009
- Testing
- Patient-Reported Outcome (PRO)-Based Symptom Management, Conventional Management
- Volunteers
- 240 people
- Sponsor
- Sichuan University
Cancer, Heart Failure
Goal Concordant Care Learning Laboratory
The goal-concordant care lab will develop and test strategies to optimize communication in advanced serious illness.
- Conditions
- Cancer, Heart Failure, Copd, Dementia
- Trial name
- NCT05879211
- Testing
- Feedback
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Duke University
Male Breast Cancer
Tamoxifen +/- GnRH Analogue vs Aromatase Inhibitor + GnRH Analogue in Male Breast Cancer Patients
A prospective, randomised multi-centre phase II study evaluating the adjuvant, neoadjuvant or palliative treatment with tamoxifen +/- GnRH analogue versus aromatase inhibitor + GnRH analogue in male breast cancer patients (MALE).
- Trial name
- MALE (NCT01638247)
- Testing
- Tamoxifen, Tamoxifen and GnRH analogue, Exemestane and GnRH analogue
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- GBG Forschungs GmbH
Cancer, Chronic Pain
Prospective Multicentre Study of the Use of Ketamine in the Treatment of Refractory Chronic Pain in the French CLCC
The primary objective of this study is to describe the administration practices of the antalgic Ketamine in French CLCC (Centre de Lutte Contre le Cancer) in terms of indication (neuropathic sequelae pains, morphine additional…
- Conditions
- Cancer, Chronic Pain, Neuropathic Pain, Opioid Use
- Trial name
- KETACANCER (NCT04459234)
- Testing
- Ketamine use in CLCC sites (indication and administration protocol)
- Where
- 12 sites in France
- Volunteers
- 81 people
- Sponsor
- Centre Leon Berard
Dementia, Chronic Disease
Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1)
The objective of this protocol is to test the effectiveness of a Jumpstart intervention on patient-centered outcomes for patients with chronic illness by ensuring that they receive care that is concordant with their goals over…
- Conditions
- Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasm
- Trial name
- PICSI-H (NCT04281784)
- Testing
- EHR-based Clinician Jumpstart
- Where
- 3 sites in United States
- Volunteers
- 2,512 people
- Sponsor
- University of Washington
Hormone Receptor Positive HER-2 Negative Breast Cancer, Advanced or Metastatic Breast Cancer
Evaluating the Addition of Elacestrant (Oral SERD) to Olaparib (PARP-inhibitor) in Patients With Advanced/Metastatic HR+/HER2- Breast Cancer
Trial design: Phase II, prospective, multi-center, randomized, open label, parallel group study in patients with HR-positive, HER2-negative locally advanced or metastatic breast cancer with gBRCA1/2 mutation, with 2:1…
- Conditions
- Hormone Receptor Positive HER-2 Negative Breast Cancer, Advanced or Metastatic Breast Cancer, BRCA1 Mutation, BRCA2 Mutation
- Trial name
- ELEMENT (NCT06201234)
- Testing
- Olaparib + Elacestrant, Olaparib
- Where
- 36 sites in Germany
- Volunteers
- 176 people
- Sponsor
- GBG Forschungs GmbH
Abdomen Tumors, Radiotherapy
Short Course Radiation Therapy in Palliative Treatment of Abdominal Cancer
Aim of the study is to assess efficacy of a short course radiation treatment in patients with symptomatic abdominal malignant lesions
- Conditions
- Abdomen Tumors, Radiotherapy, Palliative Care
- Trial name
- NCT03775005
- Testing
- standard treatment, short course treatment
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cancer
Post-chemotherapy Symptom Management SMART
Survivors of solid tumors (N=451) who completed curative intent chemotherapy for a solid tumor within the past 2 years were interviewed at baseline and stratified as high or low need for symptom management based on comorbidity…
- Trial name
- NCT03494166
- Testing
- Start with SMSH+TIPC, Start with SMSH alone
- Where
- 2 sites in United States
- Volunteers
- 498 people
- Sponsor
- University of Arizona
Cancer
The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study
The purpose of this feasibility study is to inform a larger randomized, placebo-controlled, double blind, parallel-group, single-centre trial of an oral, daily administered single dose of melatonin to prevent delirium in patients…
- Trial name
- NCT02200172
- Testing
- Melatonin
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Bruyère Health Research Institute.
Metastatic Melanoma
Standard Palliative Care Versus Standard Palliative Care Plus Polychemotherapy in Metastasized Malignant Melanoma
The purpose of this multicenter study is to examine whether the proposed randomized treatment regime results in a significantly longer survival time and higher quality of life than any additionally applied multiple chemotherapy…
- Trial name
- NCT00226473
- Testing
- Cisplatin, Vindesine, Dacarbazine (drugs)
- Where
- 13 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Dermatologic Cooperative Oncology Group
Stricture, Obstruction
Patency of a Prototype Large Plastic Biliary Stent in the Palliation of Malignant Distal Biliary Strictures.
Plastic biliary stents which are a new larger size will remain free of obstructions for a longer period of time than currently used 10 French stents in cancer in the common bile duct.
- Conditions
- Stricture, Obstruction, Cancer
- Trial name
- NCT01590394
- Testing
- Large plastic biliary stent
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Colorectal Cancer, Surgery
Survival Analysis of Frail Patients With Localised Colorectal Cancer
The purpose of this study is to analyse the survival of frail patients with localized colorectal cancer who undergo surgical treatment in comparison with those with palliative treatment
- Conditions
- Colorectal Cancer, Surgery, Frailty
- Trial name
- NCT04422002
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Corporacion Parc Tauli
Advanced Malignant Neoplasm, Delirium
Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent Cancer
This randomized phase II/III trial studies how well haloperidol with or without chlorpromazine works in treating delirium in patients with cancer that has spread to other parts of the body or has come back.
- Conditions
- Advanced Malignant Neoplasm, Delirium, Locally Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm
- Trial name
- NCT03021486
- Testing
- Chlorpromazine, Haloperidol, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- M.D. Anderson Cancer Center
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