Clinical trials: Palliative Care
Carers, Palliative Care
A Pilot Effectiveness and Implementation Trial of CSNAT-I in Hong Kong
In this hybrid Type 1 effectiveness-implementation pilot randomized controlled trial, 60 caregivers will be randomized into either the CSNAT-I group or usual care.
- Conditions
- Carers, Palliative Care, Needs Assessment, Supportive Care
- Trial name
- NCT07193433
- Testing
- CSNAT-I
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Perinatal Palliative Care, Life-limiting Fetal Diagnosis
Pilot-testing a Perinatal Palliative Care Intervention Program
The objective of this pilot trial is to implement a new perinatal palliative care intervention program tailored to the Flemish context, which aims to provide care to parents who receive a severe foetal/neonatal diagnosis for…
- Conditions
- Perinatal Palliative Care, Life-limiting Fetal Diagnosis, Life-limiting Neonatal Diagnosis
- Trial name
- PPC-pilot (NCT06456034)
- Testing
- Perinatal palliative care
- Where
- 2 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- Vrije Universiteit Brussel
Anxiety, Acute Anxiety
Administration of Intranasal Midazolam for Anxiety in Palliative Care
The goal of this double-blind, randomized, placebo-controlled parallel-group multicenter exploratory pilot study (three study arms) is to describe effects and safety of different doses of intranasal midazolam to treat acute…
- Conditions
- Anxiety, Acute Anxiety, Palliative Care
- Trial name
- AIM Care (NCT06330584)
- Testing
- Midazolam Nasal Spray 0.45 mg/spray, Midazolam Nasal Spray 0.9 mg/spray
- Where
- 5 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Patients With Advanced Cancer Receiving Specialized Palliative Care
Empower the Heart of Patients With Terminal Cancer Using Cardiac Medicines Trial
The pathophysiological implications of various cancer diseases and anti-cancer therapies is the occurrence of a cardiac disease-like phenotype with cardiac dysfunction, cardiac wasting, and cardiac homeostasis changes (incl.
- Trial name
- EMPATICC (NCT05636774)
- Testing
- Heart failure medication
- Where
- Germany
- Volunteers
- 97 people
- Sponsor
- University Hospital, Essen
Fever, Palliative Care
Fever In Palliative Care
The goal of this observational study is to evaluate the frequency and characteristics of fever in terminally ill adult patients admitted to the Infectious Diseases Hospice at Luigi Sacco Hospital in Milan.
- Conditions
- Fever, Palliative Care, Terminal Illness
- Trial name
- NCT07106073
- Testing
- Collection of demographic, anthropometric and clinical data.
- Where
- Italy
- Volunteers
- 145 people
- Sponsor
- Stefania Cheli
Palliative Care, Critical Illness
A Needs-focused Palliative Care Intervention for Older Adults in ICUs
The quality of intensive care unit (ICU)-based palliative care is highly variable, particularly for the 2 million older adults admitted annually to ICUs.
- Conditions
- Palliative Care, Critical Illness, Aging, Care Delivery Model
- Trial name
- PCplanner (NCT04414787)
- Testing
- PCplanner
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Duke University
Palliative Care, Supportive Care
Pharmacogenomics to Improve Supportive Care Symptoms.
To understand the clinical utility of multi-gene pharmacogenetic testing in patients receiving palliative and supportive care across palliative care settings (inpatient hospital, outpatient), specifically to calculate a drug-gene…
- Trial name
- PISCES (NCT06856122)
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Palliative Care, Tube Feeding
Evaluation of the Nutritional Status of Palliative Care Patients
This study evaluates the nutritional status of palliative care patients receiving enteral tube feeding. It aims to assess their condition using nutritional screening tools, anthropometric measurements and biochemical data to…
- Trial name
- NCT06753708
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Marmara University
Cancer Pain, Palliative Care
e-Natureza Blue Care: Nature-based Virtual Reality and Pain Perception
This randomized clinical trial aims to evaluate the effectiveness of immersive nature-based virtual reality in managing chronic pain among oncology patients.
- Trial name
- e-NatBlue (NCT07053228)
- Testing
- Nature-based virtual reality, Standard Pain Management
- Where
- Brazil
- Volunteers
- 130 people
- Sponsor
- Hospital Israelita Albert Einstein
Care Giving Burden, Dementia
E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app
The goal of this clinical trial is to test whether a web-based application called the Pain Control Enhancement App (PACE-app) can support family caregivers in managing pain for their care recipients with dementia.
- Conditions
- Care Giving Burden, Dementia, Chronic Pain, Pain Management
- Trial name
- PACE-app (NCT07032350)
- Testing
- Web-based pain management support tool, Usual Pain Management Care
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Palliative Care, Vital Signs
Remote Assessment of Signs and Symptoms in Palliative Care
Digital health interventions, including remote monitoring of patients, have been identified as a possible way to address current problems within the health service, including insufficient numbers of staff, and an increasing…
- Conditions
- Palliative Care, Vital Signs, Remote Monitoring
- Trial name
- ReASSure-PC (NCT06587321)
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- Our Lady's Hospice and Care Services
Artificial Intelligence (AI), Dementia
AI-Driven Personalization of End-of-Life Care for the Elderly
This study aims to evaluate the effectiveness of an artificial intelligence (AI)-based software in personalizing high-quality end-of-life care for elderly patients.
- Conditions
- Artificial Intelligence (AI), Dementia, Palliative Care
- Trial name
- PEACE-AI (NCT07027618)
- Testing
- AI-based Software for Personalized End-of-Life Care
- Volunteers
- 140 people
- Sponsor
- Baqiyatallah Medical Sciences University
Hospice and Palliative Care Nursing, Terminally Ill Patients
The Short-Term and Long-Term Effects of Providing Mechanical Bath in Terminally Ill Patients
Providing mechanical bathing (MB) is a commonly used strategy to maintain cleanness and comfort in patients with terminally illness. However, extra devices, costs, and human resources are required for such service.
- Trial name
- NCT06620146
- Testing
- mechanical bathing
- Where
- Taiwan
- Volunteers
- 245 people
- Sponsor
- National Taiwan University Hospital
Hospices, Poly Pharmacy
Standardized Patient-Centered Medication Review in Home Hospice
This is a pilot cluster randomized trial that tests the effect of a novel intervention that trains hospice staff to 1. regularly review, simplify, and align patients' prescribed medications with their goals of care as their…
- Conditions
- Hospices, Poly Pharmacy, Deprescriptions, Caregivers
- Trial name
- SPECTORx (NCT03972163)
- Testing
- NIA Medication Management - Active Comparator, STOPPFrail (Screening Tool of Older Persons Prescriptions), "Discontinuing Medication Appropriately" and "Understanding the Art of Communication about Deprescribing"
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Massachusetts, Worcester
Palliative Care, End Stage Liver DIsease
MELD ESAS Evolution: Assessment of the Symptomatic Burden of Patients With Advanced Chronic Liver Disease
The goal of this observational study is to understand if there is a correlation between the evolution of MELD-Na and symptomatic burden of patients with advanced chronic liver disease.
- Trial name
- MELDESAS (NCT06181474)
- Testing
- ESAS
- Where
- Portugal
- Volunteers
- 44 people
- Sponsor
- Unidade Local de Saúde de Matosinhos, EPE
Palliative Care, Relaxation Therapy
The Effect of Virtual Reality-Based Video and Benson Relaxation Exercise Applied to Palliative Care Providers on Sleep Quality, Fitness and General Well-Being
The research will be conducted to evaluate the effects of Virtual Reality-Based Video and Benson Relaxation Exercise Applied to Palliative Care Providers on Sleep Quality, Fitness and General Well-Being.
- Conditions
- Palliative Care, Relaxation Therapy, Caregiver
- Trial name
- NCT06941207
- Testing
- virtual reality video viewing group, benson relaxation exercise group
- Volunteers
- 90 people
- Sponsor
- Ataturk University
Cancer Pain, Opioid Use
Epidural Association of Morphine and Ropivacaine for Cancer Pain Treatment
In 2012, more than 14 million cases of cancer were diagnosed worldwide, with the forecast for 2025 exceeding 20 million. Pain is the most critical symptom that accompanies cancer.
- Conditions
- Cancer Pain, Opioid Use, Cost Analysis, Palliative Care
- Trial name
- NCT05558397
- Testing
- Interventional Group (Epidural morphine), Control Group (Oral morphine)
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Federal de Alfenas
Geriatric, Palliative Care
PALLIATIVE ASSESSMENT COHORT IN THE GERIATRIC EMERGENCY SETTING
The PALMA project is part of a larger palliative research program COPAL in Capital Region of Denmark led by Professor Tom Møller.
- Conditions
- Geriatric, Palliative Care, Socio-demographic Risk, Frailty at Older Adults
- Trial name
- PALMA cohort (NCT06911411)
- Testing
- Prospective observational cohort study., A prospective observational cohort study
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Neoplasms Malignant, Carcinoma
Existential Distress in Patients with Advanced Cancer and Their Caregivers
Despite the potential for alleviation of existential distress through psychosocial interventions, existential concerns and their impact on health care outcomes of patients and caregivers have not yet been systematically studied.
- Conditions
- Neoplasms Malignant, Carcinoma, Palliative Care
- Trial name
- NCT04600206
- Testing
- Self-report questionnaires
- Where
- 5 sites in Germany
- Volunteers
- 800 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Palliative Care, Terminal Care
Appropriate Medication Use in Dutch Terminal Care
The AMUSE trial is a multicentre stepped-wedge cluster randomized controlled trial where medication optimization of patients with a life expectancy of less than three months is investigated by using CDSS-OPTIMED (a personalized…
- Conditions
- Palliative Care, Terminal Care, Medication Therapy Management, Clinical Decision Support System (CDSS)
- Trial name
- AMUSE (NCT05351281)
- Testing
- CDSS-OPTIMED
- Where
- 7 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Prof.dr Carin (C.C.D.) van der Rijt