Clinical trials: Palliative Care
Dementia, Chronic Disease
Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2)
The objective of this protocol is to test the effectiveness of a Jumpstart intervention on patient-centered outcomes for patients with chronic illness by ensuring that they receive care that is concordant with their goals over…
- Conditions
- Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasms
- Trial name
- PICSI-H (NCT04283994)
- Testing
- Survey-based Patient/Clinician Jumpstart, EHR-based Clinician Jumpstart
- Where
- 3 sites in United States
- Volunteers
- 756 people
- Sponsor
- University of Washington
Dementia, Dementia, Vascular
Palliative Care for Persons With Late-stage Alzheimer's and Related Dementias and Their Caregivers
Millions of Americans have late-stage Alzheimer's and related dementias (ADRD), causing suffering due to loss of awareness of self and family, progressive dependency, physical and neuropsychiatric symptoms, and physical…
- Conditions
- Dementia, Dementia, Vascular, Dementia With Lewy Bodies, Dementia Frontal
- Trial name
- ADRD-PC (NCT04948866)
- Testing
- ADRD-PC Program
- Where
- 5 sites in United States
- Volunteers
- 884 people
- Sponsor
- University of North Carolina, Chapel Hill
Palliative Care
A Psychological Intervention for Family Caregivers of Palliative Care Patients
This work aims to study the benefits a psychological intervention in family caregivers of palliative care patients can have for reducing anxiety, depression and overburden.
- Trial name
- NCT04076670
- Testing
- Psychological intervention for family caregivers of patients at the end of life
- Where
- Spain
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Cancer, Malignancies Multiple
Remote Vital Sign Monitoring in Palliative Care Patients Using a Wearable ECG Monitor
The goal of this study is the assess the use of remote monitoring of vital signs using commercially available medical devices in patients with advanced cancer admitted to a hospice inpatient unit for end-of-life care.
- Conditions
- Cancer, Malignancies Multiple, Terminal Care, Hospice
- Trial name
- VITAL-PC (NCT07512505)
- Where
- Ireland
- Volunteers
- 120 people
- Sponsor
- Our Lady's Hospice and Care Services
Malignant Intestinal Obstruction
Efficacy and Safety of Lanreotide 120 Milligram (mg) as a Palliative Treatment of Clinical Symptoms Associated With Malignant Intestinal Obstruction in Inoperable Patients
The primary objective of this study is to assess the efficacy of Lanreotide 120 mg for the relief of clinical symptoms due to malignant bowel obstruction in inoperable patients.
- Trial name
- NCT01076803
- Testing
- Lanreotide (acetate)
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Heart Failure, Symptoms and Signs
Symptom Care at Home-Heart Failure
This project aims to adapt a computer-interface telephonic interactive voice response system that monitors symptoms and provides real-time, self-management coaching messages based on heart failure patient-reported outcomes.
- Trial name
- SCH-HF (NCT04347759)
- Testing
- Coaching Messages, Automated Daily Monitoring
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Hospice, End of Life
Tandem VR: Synchronized Nature-Based Experiences in Virtual Reality for Hospice Patients and Their Caregivers
Background: Nature-based virtual reality (VR) and other outdoor experiences in head-mounted displays (HMDs) offer powerful, non-pharmacological tools for hospice teams to help patients undergoing end-of-life (EOL) transitions.
- Conditions
- Hospice, End of Life, Palliative Care, Pain
- Trial name
- NCT06186960
- Testing
- Tandem Virtual Reality
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Cancer
Implementation and Evaluation of Dignity Therapy in Denmark
The purpose of the study is to investigate whether Danish patients with incurable cancer have a need of, interest in and benefit from Dignity Therapy.
- Trial name
- DignityDK (NCT01507571)
- Testing
- Dignity Therapy
- Where
- 2 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Bispebjerg Hospital
Breast Cancer
Arsenous Acid for Refractory Triple-Negative Breast Cancer
The primary objective of this study is to assess the progression-free survival (PFS) and safety of arsenous acid in combination with palliative chemotherapy for refractory triple-negative breast cancer following multiple lines of…
- Trial name
- NCT06678048
- Testing
- Arsenous Acid plus Chemotherapy
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Sun Yat-sen University
Palliative Medicine
The MuSt-PC: a Feasibility Study on Intent to Use a Tool With Regard to Symptom Management
A study on the intent to use a tool (MuSt-PC) to manage symptoms of patients in a palliative care trajectory.
- Trial name
- NCT06110624
- Testing
- Survey
- Where
- 2 sites in Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Acute Leukemia
Emotion And Symptom-focused Engagement (EASE): An Intervention for Individuals With Acute Leukemia
The purpose of this study is to test the feasibility of an individual psychological and physical symptom intervention, called Emotion And Symptom-focused Engagement (EASE), to reduce traumatic stress and physical symptom burden…
- Trial name
- EASE (NCT02353559)
- Testing
- EASE
- Where
- Canada
- Volunteers
- 47 people
- Sponsor
- University Health Network, Toronto
Hematologic Malignancy
Symptom Identification and Management in Patients With Hematological Malignancy During Follow-up Care
The aim is to study the effect of a systematic approach to symptom identification and management with disease specific and clinically developed PRO (HM-PRO) with a 12 month follow up in outpatient care in patients with chronic…
- Trial name
- SIMPly-CARE (NCT04757545)
- Testing
- HM-PRO
- Where
- Denmark
- Volunteers
- 94 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Carcinoma
Pain and Fatigue Study
Patients with advanced cancer who are undergoing chemotherapy and who report pain and fatigue at intake in the past 24 hours or at a level 2 or higher of pain or fatigue at a 3 or higher on a 10-point scale will be assigned…
- Trial name
- NCT00006253
- Testing
- Nurse, Non-nurse coach
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Michigan State University
Metastatic Breast Cancer
A Multicentre Phase I-II Study to Investigate the Combination of Bendamustine With Weekly Paclitaxel as First or Second Line Therapy in Patients With Metastatic Breast Cancer
The aim of the study is to establish a feasible combination of bendamustine and paclitaxel in a weekly schedule. The two agents have different toxicity profiles and are well tolerated when given in a weekly fashion.
- Trial name
- RiTa (NCT00661739)
- Testing
- Bendamustine
- Volunteers
- 38 people
- Sponsor
- GBG Forschungs GmbH
Hypnosis, Perioperative Care
Hypnosis for Symptom Management in Elective Orthopedic Surgery
The purpose of the study is to determine if teaching self-hypnosis techniques to patients prior to knee replacement surgery will decrease their pain medication requirements, pain medication side-effects, length of stay in the…
- Conditions
- Hypnosis, Perioperative Care, Knee Arthroplasty, Total, Postoperative Pain
- Trial name
- NCT03308071
- Testing
- Hypnosis
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Stanford University
Advanced Pancreatic Cancer
Supportive Care Intervention-Pancreas
This is a pilot, randomized controlled trial of an embedded collaborative model of supportive care designed to improve quality of life and decrease use of unwanted healthcare services at the end of life for patients with advanced…
- Trial name
- SCI-P (NCT01885884)
- Testing
- Embedded Supportive Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Palliative Care
Intervention in Spirituality at the End of Life. The Kibo Protocol
This work aims to study the benefits that the therapeutic interview Kibo in palliative care patients can have for spirituality. A parallel randomized controlled trial of two groups was performed.
- Trial name
- NCT03995095
- Testing
- Therapeutic interview: kibo protocol
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Valencia
Cancer, End Stage Cancer
Community Health Worker Based Intervention to Improve Palliative Care
The study aims to find out if community health worker (CHW) support will improve palliative care outcomes in African American patients with advanced cancer, by comparing the quality of life of patients who are receiving standard…
- Conditions
- Cancer, End Stage Cancer, Malignancy, Advanced Cancer
- Trial name
- DeCIDE PC (NCT05407844)
- Testing
- Community Health Worker (CHW) based palliative care
- Where
- 4 sites in United States
- Volunteers
- 160 people
- Sponsor
- Wake Forest University Health Sciences
Heart Defects, Congenital, Hypoplastic Left Heart Syndrome
Impact of Early Intervention on Maternal Stress in Mothers of Fetuses Diagnosed With Single Ventricle Physiology
This study evaluates maternal psychological distress and the impact of early palliative care team consultation on maternal anxiety and depression symptoms, coping, and quality of life/family functioning in the care of neonates…
- Conditions
- Heart Defects, Congenital, Hypoplastic Left Heart Syndrome, Single Ventricle Defect, Stress, Psychological
- Trial name
- NCT02462434
- Testing
- Early palliative care team consultation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Hepatectomy, Hepatocellular Carcinoma
Palliative Treatments for Patients With Advanced Hepatocellular Carcinoma (HCC)
The standard treatment choice for advanced hepatocellular carcinoma (HCC) is sorafenib, and its efficacy is limited. More active treatments were performed in patients with advanced HCC in China, which include radical hepatectomy…
- Conditions
- Hepatectomy, Hepatocellular Carcinoma, Sorafenib
- Trial name
- 2011PTAHCC (NCT01409499)
- Testing
- hepatic resection, transcatheter hepatic arterial chemoembolization, sorafenib
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Sun Yat-sen University