Clinical trials: Palliative Medicine
Irritable Bowel Syndrome
Acupuncture/Moxibustion for Irritable Bowel Syndrome (IBS)
The objective of this study is to test the efficacy of a symptom management treatment strategy, namely, Acupuncture/Moxibustion (Acu/Moxa) to improve the symptoms associated with Irritable Bowel Syndrome (IBS) in persons between…
- Trial name
- Acu/MoxaIBS (NCT00945074)
- Testing
- Standard Acupuncture/Moxibustion (fixed protocol), Individualized Acupuncture/Moxibustion
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- New York University
Palliative Medicine, Palliative Care
Palliative Care Needs Among Elderly People at Emergency Department
Aim: To assess what proportion of all patients over the age of 75 who seek care at the emergency department have palliative care needs and whether these are documented in the patient's medical record.
- Conditions
- Palliative Medicine, Palliative Care, Elderly Person
- Trial name
- NCT05883696
- Testing
- Swedish Palliative Care Guide (S-PCG)
- Where
- 2 sites in Sweden
- Volunteers
- 204 people
- Sponsor
- Region Skane
Terminal Cancer
Nasal Fentanyl and Buccal Midazolam for Dying Patients
When patients are dying they become unable to take oral medication and if they develop symptoms (e.g. pain or agitation) they need to be given a subcutaneous injection of medication.
- Trial name
- NCT02009306
- Testing
- PecFent and Epistatus, Standard subcutaneous medication, Epistatus Alone
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Incurable Cancer Diseases, Other Incurable Diseases
Incurable Ill Patients Attitudes Towards Euthanasia and Assisted Suicide
Euthanasia and assisted dying are of growing interest for patients with incurable diseases. The possible methods are widely discussed by patient-societies, physicians, lawyers, theologians and philosophers.
- Trial name
- ESPIL (NCT00495482)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Klinikum St. Georg gGmbH
Cancer Pain, Cancer Palliative Care
Efficacy of Non-opioid Drugs in Addition to Opioid Therapy for Cancer Pain Management
The investigators investigate the efficacy of non-opioid analgesics compared to placebo together with opioid therapy for cancer pain management.
- Trial name
- NoDoubt (NCT07682558)
- Testing
- Metamizole, Ibuprofen
- Where
- Switzerland
- Volunteers
- 318 people
- Sponsor
- University Hospital, Basel, Switzerland
Breast Cancer Early Stage Breast Cancer (Stage 1-3), Endocrine Therapy
Symptom Monitoring Using Patient-Report to Improve Medication Use
This is an intervention targeting patients at risk for non-adherence to endocrine therapy after primary treatments for hormone-positive breast cancer.
- Trial name
- SyMPTOM (NCT06765707)
- Testing
- Pharmacist delivered symptom monitoring and management
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- Medical College of Wisconsin
Cancer, Neuralgia
Amitriptyline or Pregabalin to Treat Neuropathic Pain in Incurable Cancer
Rationale: Often, incurable cancer patients suffer from severe symptoms as (neuropathic) pain and fatigue with polypharmaceutic interventions as a consequence.
- Trial name
- Off-label (NCT00740571)
- Testing
- amitriptyline, pregabalin
- Where
- 2 sites in Netherlands
- Volunteers
- 130 people
- Sponsor
- Radboud University Medical Center
Lennox Gastaut Syndrome
Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome
Lennox-Gastaut syndrome is a serious and rare form of epilepsy that begins in infancy and early childhood. Seizures and their consequences need medical attention, emergency encounters, and hospitalizations.
- Trial name
- SOM-L (NCT05374824)
- Where
- 4 sites in United States
- Volunteers
- 4,680 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Cancer, Quality of Life
Integrative Care Training Program for Nurses on Supportive Cancer Care
The integration of complementary medicine in supportive and palliative cancer care (i.e., Integrative Oncology) is becoming more prevalent in many of the leading oncology centers in Israel and worldwide.
- Conditions
- Cancer, Quality of Life, Nurse's Role
- Trial name
- NCT03676153
- Testing
- Nurse-provided guidance, Integrative medicine treatment program
- Where
- Israel
- Volunteers
- 363 people
- Sponsor
- Carmel Medical Center
Palliative Care, Primary Care
Introducing the Palliative Care Comprehensive Tool in Family Medicine
The purpose of this study is to pilot the introduction of a newly developed palliative care tool to clinicians in a family health team.
- Conditions
- Palliative Care, Primary Care, Satisfaction
- Trial name
- NCT03267706
- Testing
- Palliative Care Comprehensive Tool
- Where
- Canada
- Volunteers
- 149 people
- Sponsor
- McMaster University
Palliative Care, Primary Palliative Care
Primary Palliative Care - a Feasibility Cluster Trial
This feasibility cluster-controlled randomized trial (RCT) evaluates a complex intervention for the delivery of primary palliative care in Family Health Units (FHUs).
- Conditions
- Palliative Care, Primary Palliative Care, Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- PrimPal (NCT07737899)
- Testing
- Primary Palliative Care Complex Intervention (PrimPal)
- Where
- 2 sites in Portugal
- Volunteers
- 30 people
- Sponsor
- University of Coimbra
Cancer, Neoplasms
Mirtazapine in Cancer-related Poly-symptomatology
Multicenter, prospective, randomized, controlled trial based on a mixed-method methodology using parallel groups, of oral mirtazapine (intervention) compared with oral escitalopram (control), with a 56 days follow-up.
- Conditions
- Cancer, Neoplasms, Neoplasm Metastasis
- Trial name
- MIR-P (NCT04763135)
- Testing
- Mirtazapine, Escitalopram
- Where
- 11 sites in France
- Volunteers
- 1 people
- Sponsor
- Hospices Civils de Lyon
Palliative Medicine
The MuSt-PC: a Feasibility Study on Intent to Use a Tool With Regard to Symptom Management
A study on the intent to use a tool (MuSt-PC) to manage symptoms of patients in a palliative care trajectory.
- Trial name
- NCT06110624
- Testing
- Survey
- Where
- 2 sites in Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Carcinoma
Pain and Fatigue Study
Patients with advanced cancer who are undergoing chemotherapy and who report pain and fatigue at intake in the past 24 hours or at a level 2 or higher of pain or fatigue at a 3 or higher on a 10-point scale will be assigned…
- Trial name
- NCT00006253
- Testing
- Nurse, Non-nurse coach
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Michigan State University
Dyspnea, Respiratory Insufficiency
Cognitive and Behavioral Intervention for the Management of Episodic Breathlessness in Patients With Advanced Disease
Episodic breathlessness is a common and distressing symptom in patients with advanced disease such as cancer, chronic obstructive pulmonary disease (COPD) and chronic heart failure.
- Conditions
- Dyspnea, Respiratory Insufficiency, Neoplasms, Pulmonary Disease, Chronic Obstructive
- Trial name
- CoBeMEB (NCT04630743)
- Testing
- Cognitive and Behavioral intervention for the Management of Episodic Breathlessness
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- University of Cologne
Palliative Medicine, Cardiovascular Disease
Statin Discontinuation in Advanced Illness
The purpose of this study is to determine if there is a difference in survival rate at 60 days after enrollment between patients with advanced life-limiting illness for whom statins are discontinued vs.
- Trial name
- NCT01415934
- Testing
- discontinue statins
- Where
- 15 sites in United States
- Volunteers
- 381 people
- Sponsor
- University of Colorado, Denver
Breast Cancer
Tumour Registry Breast Cancer
The registry aims to collect and analyse information on the antineoplastic treatment of breast cancer in daily routine practice of office-based and clinic-based medical oncologists in Germany.
- Trial name
- TMK (NCT01351584)
- Volunteers
- 4,500 people
- Sponsor
- iOMEDICO AG
Schizophrenia, Quality of Life
Milestones of Adjustment Post-Psychosis
This nested design clinical outcome study of psychiatric case manager education on disease state, psychopharmacology of schizophrenia, relapse, motivational interviewing, and the process of psychological adjustment post-psychosis…
- Conditions
- Schizophrenia, Quality of Life, Adjustment, Psychological, Medication Adherence
- Trial name
- MAPP (NCT01192594)
- Testing
- Training in all modules including MAPP Recovery Model, Training in all modules except MAPP Recovery Model
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Yale University
Neoplasm, Colorectal, Cognitive Impairment
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
The purpose of this research study is to see how the brain changes in patients receiving chemotherapy (cytotoxic drug) treatment for colon or rectal cancer at Parkview Cancer Institute.
- Conditions
- Neoplasm, Colorectal, Cognitive Impairment, Cognitive Dysfunction, Cognitive Change
- Trial name
- Chemo Brain (NCT05014399)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Joseph McCollom
Cancer, Chronic Heart Failure
Open Video System in Medicine (oVID)
Currently, there are no telemedical visits between patients and/or their relatives and a palliative physician for the evaluation of symptom and progress monitoring.
- Conditions
- Cancer, Chronic Heart Failure, Chronic Obstructive Pulmonary Disease, Palliative Care
- Trial name
- oVID (NCT06054048)
- Testing
- Telemedicine
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- University Hospital Muenster