Clinical trials: Palliative Medicine
Neoplasms Pancreatic, Cachexia; Cancer
The Effect of Cannabis in Pancreatic Cancer
Cannabinoids are known to increase appetite, but THC components have psychogenic properties too. CBD is the main component in the plant, and have only minimal psychogenic effects.
- Conditions
- Neoplasms Pancreatic, Cachexia; Cancer, Cannabis, Appetite Loss
- Trial name
- NCT03245658
- Testing
- THC and CBD Mixture
- Where
- Denmark
- Sponsor
- Jens Rikardt Andersen
Depression in Adolescence
Evaluation of MoodRing on Improving the Quality of Depression Management in Adolescents
The MoodRing intervention is a mobile application for adolescents, parents, and an accompanying web-based clinician portal which enables adolescents to monitor their mood through the use of passively collected smartphone data.
- Trial name
- TECH-E (NCT05376358)
- Testing
- MoodRing App, Usual Care
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Ana Radovic
Nausea, Vomiting
Treatment Algorithm for Nausea and Vomiting in the Palliative Phase
Nausea and vomiting are frequently occurring problems in the palliative phase of patients with cancer. Between 20-50% of them regularly suffer from nausea, retching or vomiting.
- Conditions
- Nausea, Vomiting, Cancer
- Trial name
- NCT03017391
- Testing
- metoclopramide, granisetron, Dexamethasone
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Terminal Cancer
Towards Cancer Patient Empowerment for Optimal Use of Antithrombotic Therapy at the End of Life
Despite the fact that antithrombotic therapy (ATT) has little or even negative effects on the well-being of cancer patients during their last year of life, stopping ATT is rare in clinical practice.
- Trial name
- SERENITY (NCT05706740)
- Testing
- Physician survey on antithrombotic medication during end-of-life care in cancer patients
- Where
- 12 sites in Denmark, France and 6 more
- Volunteers
- 467 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Patients With Advanced Cancer Receiving Specialized Palliative Care
Empower the Heart of Patients With Terminal Cancer Using Cardiac Medicines Trial
The pathophysiological implications of various cancer diseases and anti-cancer therapies is the occurrence of a cardiac disease-like phenotype with cardiac dysfunction, cardiac wasting, and cardiac homeostasis changes (incl.
- Trial name
- EMPATICC (NCT05636774)
- Testing
- Heart failure medication
- Where
- Germany
- Volunteers
- 97 people
- Sponsor
- University Hospital, Essen
Prostatic Neoplasms
Vitamin C as an Anti-cancer Drug
Can high dose, intravenous Vitamin C prolong life for patients with metastatic prostate cancer? Prostate cancer is the most common cancer (excluding skin cancer) in men in Denmark and the Unites States.
- Trial name
- NCT01080352
- Testing
- Ascorbic Acid (Vitamin C)
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Copenhagen University Hospital at Herlev
Lung Neoplasms, Symptom Management
Construction and Feasibility Study of a Home-Based Intelligent Symptom Management Program for Lung Cancer Patients Receiving Combined Drug Therapy Based on Symptom Journey Profiling
The goal of this clinical trial is to develop and evaluate a home-based intelligent symptom management program based on symptom journey profiles for patients with lung cancer receiving combination drug therapy.
- Conditions
- Lung Neoplasms, Symptom Management, mHealth Intervention
- Trial name
- NCT07632703
- Testing
- Home-Based Intelligent Symptom Management Program for Lung Cancer Patients During Intermittent Periods of Combined Drug Therapy, routine care
- Volunteers
- 60 people
- Sponsor
- Feifei Huang
Heart Failure
Palliative Care for Heart Failure Patients
The purpose of this study is to assess the impact of palliative care consultation on quality of life and symptom management for patients hospitalized with acute heart failure with a randomized control trial at Abbott Northwestern…
- Trial name
- NCT01519479
- Testing
- Palliative Care Consultation, Control
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- Allina Health System
Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia
A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication.
The goal of this clinical trial is to learn if an educational website can help patients make an informed decision and engage in shared decision-making with their healthcare provider regarding cholesterol lowering medication use…
- Conditions
- Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Cardiovascular Diseases, Pharmacists
- Trial name
- 1821534-10 (NCT06423365)
- Testing
- Virtual Statin Management (VSM)
- Where
- United States
- Volunteers
- 898 people, healthy volunteers welcome
- Sponsor
- University of Utah
Palliative Care, Pain
A Study of Sativex® for Pain Relief in Patients With Advanced Malignancy
The purpose of this study is to determine whether Sativex® and GW-2000-02 are effective in the management of subjects with intractable cancer-related pain.
- Conditions
- Palliative Care, Pain, Cancer
- Trial name
- SPRAY (NCT00674609)
- Testing
- Sativex®, THC Alone
- Where
- United Kingdom
- Volunteers
- 177 people
- Sponsor
- Jazz Pharmaceuticals
Pain, Fever
Evaluation of Efficacy and Safety of Subcutaneous Acetaminophen
Subcutaneous perfusion is an underused technique, the effectiveness of which has been demonstrated. A number of drugs of different therapeutic classes, including morphine, have a good level of scientific evidence for use by this…
- Conditions
- Pain, Fever, Drug Effect, Drug Reaction
- Trial name
- APAPSubQ (NCT03635684)
- Testing
- Acetaminophen
- Where
- Lebanon
- Volunteers
- 31 people
- Sponsor
- Saint-Joseph University
Pediatric Palliative Care, Life Limiting Conditions
Experiential and Relaxation Virtual Reality as a Tool for Easing Anxiety in Seriously Ill Children
The goal of this clinical trial is to assess the use of experiential and relaxation virtual reality (VR) interventions in easing anxiety and other distress symptoms in children with life-limiting and/or life-threatening…
- Conditions
- Pediatric Palliative Care, Life Limiting Conditions, Life Threatening Diseases
- Trial name
- NCT06915883
- Testing
- Relaxation virtual reality (VR), Experiential virtual reality (VR)
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- National Institute of Mental Health, Czech Republic
Cancer, Terminal Cancer
The Use of Alternative Medicine by Palliative Care Patients
Palliative care centres in Lyon, France as well as the disclosure of Complementary and Alternative Medicine and conventional healthcare use to conventional and Complementary and Alternative Medicine practitioners respectively.
- Trial name
- NCT03260946
- Testing
- Complementary medicine use
- Where
- 3 sites in France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Palliative Care, Terminal Care
Appropriate Medication Use in Dutch Terminal Care
The AMUSE trial is a multicentre stepped-wedge cluster randomized controlled trial where medication optimization of patients with a life expectancy of less than three months is investigated by using CDSS-OPTIMED (a personalized…
- Conditions
- Palliative Care, Terminal Care, Medication Therapy Management, Clinical Decision Support System (CDSS)
- Trial name
- AMUSE (NCT05351281)
- Testing
- CDSS-OPTIMED
- Where
- 7 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Prof.dr Carin (C.C.D.) van der Rijt
Cancer, Overall Survival
Study of the Safety, Tolerability and Efficacy of Metabolic Combination Treatments on Cancer
The purpose of this study is to determine the effectiveness of a regimen of selected metabolic treatments for patients with cancer in a real world setting and to conduct exploratory analysis on the relationship between the degree…
- Trial name
- METRICS (NCT02201381)
- Testing
- Metabolic treatment
- Where
- United Kingdom
- Sponsor
- Health Clinics Limited
Complementary Alternative Medicine, Complementary Alternative Therapy
Use of CAM by Hospice Oncology Patients During Ambulatory Palliative Care
The aim of the study is to assess Prevalence of complementary and alternative therapy use by adult patients from the area of Silesian agglomeration (Poland) with advanced, metastatic cancer disease who were admitted to "Pro…
- Conditions
- Complementary Alternative Medicine, Complementary Alternative Therapy, Hospice Care
- Trial name
- CAM (NCT03747172)
- Testing
- complementary and alternative therapy
- Where
- Poland
- Volunteers
- 1,004 people
- Sponsor
- Silesian University of Medicine
Palliative Medicine, Pediatric ALL
Paediatric Palliative Care Pain Management in the Community
To describe the the barriers and facilitators experienced by carers and healthcare professionals when managing medicines for pain relief for infants, children, and young people approaching the end of life in out of hospital…
- Trial name
- PARAMOUNT (NCT04519632)
- Testing
- Qualitative study
- Where
- United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Southampton
End-Of-Life, Inappropriate Prescribing
Effectiveness of a Person-centred Prescription Model at the End of Life
This study's main objective is to investigate whether the application of an adapted person-centred prescription model during a hospital stay would reduce the use of inappropriate or futile regular medications in older people at…
- Conditions
- End-Of-Life, Inappropriate Prescribing, Deprescriptions, Palliative Medicine
- Trial name
- NCT05454644
- Testing
- Person-Centred Prescription Model
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Matia Foundation
Metastatic Cancer
N-of-1 Trial: Actionable Target Identification in Metastatic Cancer for Palliative Systemic Therapy
The metastatic lesions may be very different from the primary tumor because of intrinsic tumor heterogenity, clonal selection through metastatic process and following previous cytotoxic treatments.
- Trial name
- MetAction (NCT02142036)
- Testing
- EMA-approved ATI based targeted therapy
- Where
- 2 sites in Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Breast Cancer, Drug/Agent Toxicity by Tissue/Organ
Combination Chemotherapy After Surgery With or Without Chinese Herbal Therapy to Treat Symptoms in Women With Breast Cancer
RATIONALE: Herbs used in traditional Chinese medicine may decrease the side effects of chemotherapy. PURPOSE: Randomized phase I/II trial to study the effectiveness of herbs used in traditional Chinese medicine in decreasing the…
- Trial name
- NCT00028964
- Testing
- Chinese herbs, cyclophosphamide, doxorubicin hydrochloride
- Where
- United States
- Sponsor
- University of California, San Francisco