Clinical trials: Palliative Radiotherapy
Cancer, Neoplasm Metastasis
ECI301 and Radiation for Advanced or Metastatic Cancer
Background: ECI301 is a drug that may help make cancer cells more visible to the immune system after radiation. The drug may also help the immune system destroy the cancer at sites that have not received radiation therapy.
- Conditions
- Cancer, Neoplasm Metastasis, Radiation Oncology, Neoplasm
- Trial name
- NCT01441115
- Testing
- Radiation Therapy, ECI301
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Cancer Institute (NCI)
Spinal Metastases
Study Comparing Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy (CRT) for Spinal Metastases
The purpose of this study is to find out if SBRT is better than CRT at controlling pain in the spine 3 months after receiving treatment.
- Trial name
- NCT02512965
- Testing
- 20 Gy in 5 fractions, Conventional SBRT: 24 Gy in 2 fractions
- Where
- 22 sites in Australia, Canada
- Volunteers
- 229 people
- Sponsor
- Canadian Cancer Trials Group
Palliative Care
Palliative Short Course Radiotherapy for Advanced Thoracic Cancer
The study wants to define the maximum tolerated dose (MTD), safety and efficacy of a short course radiation therapy in patients with symptomatic advanced thoracic cancer.
- Trial name
- NCT03465553
- Testing
- Short course radiotherapy
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Pelvic Cancer, Radiotherapy
Short Course Radiation Therapy in Palliative Treatment of Pelvic Cancer
Aim of the study is to assess efficacy of a short course radiation treatment in patients with symptomatic pelvic malignant lesions
- Conditions
- Pelvic Cancer, Radiotherapy, Palliative Care
- Trial name
- NCT03804333
- Testing
- standard treatment, short course treatment
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Oesophageal Cancer
Role of Radiotherapy Following Oesophageal Stenting in Cancer
To assess the benefits of oesophageal stenting and external beam radiotherapy over oesophageal stenting alone in patients with inoperable oesophageal cancer
- Trial name
- NCT01179074
- Testing
- oesophageal stenting with self expandable metal stent, Oesophageal stent followed by external beam radiotherapy
- Where
- India
- Volunteers
- 84 people
- Sponsor
- All India Institute of Medical Sciences
Metastatic or Recurrent Lesions in the Spine, Metastatic or Recurrent Lesions in the Pelvis
Image-Guided Navigation for High Dose Rate Temporary Interstitial Brachytherapy in the Palliative Management of Previously Treated Tumors of the Spine and Pelvis
The purpose of this study is to see if using a form of imaging during surgery helps the doctors to guide the placement of radiation catheters more accurately.
- Trial name
- NCT01757717
- Testing
- Ir-192 high dose rate (HDR)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Carcinoma, Non-Small-Cell Lung
Prospective Trial of Induction Immunotherapy in Locally Advanced or Oligometastatic NSCLC Without a Primary Curative Option
In a certified lung- cancer center, patients with NSCLC and a potentially curative stage (including patients with oligometastatic disease) are prospectively enrolled if curative treatment (either definitive radio-chemotherapy or…
- Trial name
- KOMPASSneo (NCT04926584)
- Testing
- induction therapy
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Klinikum Esslingen
Non-small Cell Lung Cancer
Phase II Trial of Erlotinib and Concurrent Palliative Thoracic Radiation Therapy for Non-small Cell Lung Cancer (PEARL)
To improve the clinical outcomes of patients with non-small cell lung cancer treated with radiation therapy.
- Trial name
- NCT00391248
- Testing
- Erlotinib
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Locally Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm
Ride to Care - Quality of Life With Transportation for RT
This trial studies how well Uber health intervention works in eliminating transportation barriers for disadvantaged patients with cancer that has spread to nearby tissue, lymph nodes, or other places in the body, undergoing…
- Trial name
- NCT03849742
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Supportive Care
- Sponsor
- University of California, San Francisco
Metastatic Spinal Cord Compression
To Determine Whether it is Feasible to Treat Patients Requiring Urgent Radiotherapy Diagnosed With Metastatic Cord Compression (MSCC) on the Magnetic Resonance Linear Accelerator (MRL) in a Single Appointment and Compare it to the Standard of Care Radiotherapy Pathway
The goal of this clinical trial is to understand whether the Magnetic Resonance Linear Accelerator (MRL) could expedite Radiotherapy treatment for Metastatic Cord Compression (MSCC) by removing the need for a planning CT (pCT)…
- Trial name
- RESONATE (NCT06965101)
- Testing
- Radiotherapy to the spine in a single appointment
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- The Christie NHS Foundation Trust
Bone Metastases
Palliation: the Effect of Education on Pain
Rationale: Although radiotherapy is an effective palliative treatment for patients with painful bone metastases with over 70% responders, pain intensity is not always sufficiently controlled.
- Trial name
- PEEP (NCT01358539)
- Testing
- Pain education
- Where
- Netherlands
- Volunteers
- 354 people
- Sponsor
- University Medical Center Groningen
Head and Neck Cancer
Photodynamic Therapy in Treating Patients With Recurrent, Refractory, or Second Primary Head and Neck Cancer That Cannot Be Treated With Surgery or Radiation Therapy
RATIONALE: Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill tumor cells. This may be an effective palliative treatment for head and neck cancer.
- Trial name
- NCT00003856
- Testing
- temoporfin
- Where
- 7 sites in United States
- Volunteers
- 75 people
- Sponsor
- Quintiles, Inc.
Breast Cancer, Metastatic Cancer
Radiation Therapy in Treating Patients With Bone Metastases From Breast or Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which radiation therapy regimen is more effective for bone metastases.
- Conditions
- Breast Cancer, Metastatic Cancer, Pain, Prostate Cancer
- Trial name
- NCT00003162
- Testing
- pain therapy, radiation therapy
- Where
- 253 sites in United States, Canada
- Volunteers
- 949 people
- Sponsor
- Radiation Therapy Oncology Group
Advanced Head and Neck Cancer
Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in Patients With Advanced Head and Neck Cancer
This study is being done to answer the following question: Does stereotactic body radiation therapy (SBRT) provide better cancer control compared to standard radiation therapy (RT) for those with advanced head and neck cancer?
- Trial name
- NCT06641791
- Testing
- Standard Radiotherapy (SRT), Stereotactic Body Radiotherapy (SBRT)
- Where
- 10 sites in Canada
- Volunteers
- 196 people
- Sponsor
- Canadian Cancer Trials Group
Breast Cancer, Kidney Cancer
Genistein in Treating Patients Undergoing External-Beam Radiation Therapy for Bone Metastases
RATIONALE: Genistein may increase the effectiveness of radiation therapy in treating pain caused by bone metastases. PURPOSE: This phase I/II trial is studying the side effects of genistein and to see how well it works in…
- Conditions
- Breast Cancer, Kidney Cancer, Lung Cancer, Melanoma
- Trial name
- NCT00769990
- Testing
- genistein, radiation therapy
- Sponsor
- Masonic Cancer Center, University of Minnesota
mCRC
Radiotherapy Combined QL1706, TAS-102 and Bevacizumab in mCRC
This single-center, single-arm, prospective study plans to enroll patients with advanced colorectal cancer who have failed first-line or higher systemic therapies.
- Trial name
- NCT07116577
- Testing
- Palliative radiotherapy, Iparomlimab and tuvonralimab, TAS-102
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Jinan Central Hospital
Kidney Cancer, Melanoma (Skin)
Cryoablation or External-Beam Radiation Therapy in Treating Patients With Painful Bone Metastases
RATIONALE: Cryoablation kills cancer cells by freezing them. Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells.
- Conditions
- Kidney Cancer, Melanoma (Skin), Metastatic Cancer, Pain
- Trial name
- NCT00540969
- Testing
- cryosurgery, radiation therapy
- Where
- 7 sites in United States
- Volunteers
- 3 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Tumor Size Greater Than or Equal to 5 cm
Efficacy and Toxicity of SCART
This study is expected to enroll patients for a period of five years, with a total of 30 participants. It is a prospective observational study involving cancer patients with tumors having a longest diameter greater than or equal…
- Trial name
- NCT06341257
- Testing
- Stereotactic Central/Core Ablative Radiation Therapy (SCART)
- Where
- Taiwan
- Sponsor
- Taichung Veterans General Hospital
Vertebral Bony Metastases
Intensity-modulated Radiotherapy With Integrated-boost in Patients With Spinal Bone Metastases
The primary goal of the study is to determine the local control-rate after radiotherapy (RT) with and without simultaneous integrated boost (SIB) concepts in patients with bone metastases of the spine.
- Trial name
- IRON-2 (NCT02832765)
- Testing
- A, B, C
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Heidelberg University
Neoplasm Metastasis
Dexamethasone for Palliation - Brain Metastases
Brain metastases occur when cancer cells from the initial tumour site (for example, lung or breast) spread to the brain. This develops in approximately 10% - 30% of adults with cancer.
- Trial name
- NCT00188864
- Testing
- dexamethasone
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto