Clinical trials: Palliative Radiotherapy
Esophageal Cancer, Radiotherapy
Short Course Radiation Therapy in Palliative Treatment of Esophageal Cancer
Aim of the study is to assess efficacy of a short course radiation treatment in patients with symptomatic esophageal malignant lesions
- Conditions
- Esophageal Cancer, Radiotherapy, Palliative Care
- Trial name
- NCT03804203
- Testing
- standard treatment, short course treatment
- Where
- Italy
- Volunteers
- 98 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Leydig Cell Tumor, Ovarian Sarcoma
Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer
The purpose of this phase I study is to determine the highest dose of carboplatin and gemcitabine (gemcitabine hydrochloride) that can be given safely to subjects with gynecologic cancer, in combination with stereotactic body…
- Conditions
- Leydig Cell Tumor, Ovarian Sarcoma, Ovarian Stromal Cancer, Pseudomyxoma Peritonei
- Trial name
- NCT01652794
- Testing
- stereotactic body radiation therapy, carboplatin, gemcitabine hydrochloride
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Case Comprehensive Cancer Center
Head and Neck Squamous Cell Carcinoma, Cutaneous Squamous Cell Carcinoma
Thermotherapy in Addition to SOC Palliative Radiotherapy
This study aims to investigate the efficacy and safety profile of superficial hyperthermia (wIRA) in addition to standard of care (SOC) palliative radiotherapy in patients with inoperable/incurable locally advanced or…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, Breast Cancer Recurrent
- Trial name
- ThermoRad wIRA (NCT06659146)
- Testing
- Superficial hyperthermia
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College London
Solid Tumour Refractory to Conventional Treatment
Phase I Study to Assess Safety of AZD6738 Alone and in Combination With Radiotherapy in Patients With Solid Tumours
This study will investigate the use of a new drug targeting the DNA repair pathway AZD6738, an ATR inhibitor). Many tumours have lost important DNA repair functions and rely more heavily on a few remaining repair pathways to…
- Trial name
- Patriot (NCT02223923)
- Testing
- AZD6738, Palliative radiotherapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 87 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Renal Cell Carcinoma, Renal Cell Carcinoma Metastatic
Partial Volume High-Dose Irradiation in Renal Cell Carcinoma for Intra-TUmoural Control ALongside Current Management
Prospective, randomised, feasibility study of patients with localised or metastatic renal cell carcinoma (RCC) comparing standard palliative dose radiotherapy to a high-dose hypofractionated regime.
- Trial name
- VIRTUAL (NCT06995664)
- Testing
- radiotherapy
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Metastatic Cancer, Palliative
Patient Reported Outcomes/Metrics Program Trial
This is an observational study to investigate if it is feasible to recruit 100 patients receiving radiotherapy (RT) to metastatic disease to wear Hexoskin and if Hexoskin will facilitate the monitoring, detection and early…
- Trial name
- PROMPT (NCT04983199)
- Testing
- Hexoskin Medical System
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Cancer
Dexamethasone for the Prophylaxis of Pain Flare Study
Radiation treatment is often recommended as a safe and quick treatment that gives most people good relief from bone pain within a couple of weeks.
- Trial name
- NCT00438828
- Testing
- dexamethasone
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cancer
Default Options to Reduce Unnecessary Daily Imaging During Palliative Radiation
The goal of this study is to reduce preference sensitive, unnecessary daily imaging during radiation treatment in which a pre-planned quality improvement default option for radiation treatment prescriptions will be introduced…
- Trial name
- NCT03110692
- Testing
- Default initiation
- Where
- United States
- Volunteers
- 1,188 people
- Sponsor
- University of Pennsylvania
Non-small Cell Lung Cancer
CT-Based Versus Conventional Simulation for Palliative Radiotherapy of Non-Small Cell Lung Cancer
Radiotherapy (RT) treatment to the chest is a standard way of trying to decrease symptoms like cough or shortness of breath. Before any RT can be delivered, it must be planned, either using conventional x-rays ("fluoroscopy") or…
- Trial name
- NCT00862030
- Testing
- CT- simulation scan
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Alberta Health services
Lung Cancer
Palliative 3-Dimensional Conformal Radiation Therapy in Reducing Radiation Side Effects in Patients With Lung Cancer. ICORG 06-34
RATIONALE: 3-dimensional conformal radiation therapy may lessen side effects caused by palliative radiation therapy and improve the quality of life of patients with lung cancer.
- Trial name
- NCT01176487
- Testing
- questionnaire administration, quality-of-life assessment, 3-dimensional conformal radiation therapy
- Where
- 2 sites in Ireland
- Volunteers
- 40 people
- Sponsor
- Cancer Trials Ireland
Bone Pain Flare, Bone Metastasis
Non Steroidal Anti-inflammatory Drugs in the Prevention of Bone Pain Flares After Palliative Radiotherapy
Solid tumors have the tendency to spread to other organs in around 26% of cases, with many cases involving the bone causing severe bone destruction and pain that reduces patients' quality of life.
- Trial name
- NCT06903585
- Testing
- Naproxen (Proxen S), Esomeprazole 20mg once daily
- Where
- Lebanon
- Volunteers
- 385 people
- Sponsor
- American University of Beirut Medical Center
Breakthrough Pain
Quality of Life Study Breakthrough Cancer Pain Treated in Radiation Oncology Services With Palliative Intent
In the context of radiotherapy, control of breakthrough pain represents a special challenge. Patients undergoing radiotherapy may experience different situations of pain that may be due to the need to remain immobilized during…
- Trial name
- CAVIDIOR (NCT02836379)
- Testing
- No intervention
- Where
- 11 sites in Spain
- Volunteers
- 79 people
- Sponsor
- Angelini Farmacéutica
Cancer
Is Radiation-before-pathology a Feasible Approach in the Palliative Oncology Setting? A Pragmatic Clinical Trial
When a doctor suspects cancer, often a biopsy is taken for testing to confirm if cancer is present. Usually, doctors would wait for the results of a biopsy before delivering radiation, but this may lead to a patient having to…
- Trial name
- RT-NOW (NCT06156800)
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- David Palma
Neurocognitive Deficit, Quality of Life
WHOle Brain Irradiation or STEreotactic Radiosurgery for Five or More Brain Metastases (WHOBI-STER)
This work aims to evaluate neurocognitive performance, daily activity and quality of life and local control among patients with brain metastasis (MBM) ≥ 5 due to solid tumors treated with Stereotactic RadioSurgery (SRS) or Whole…
- Conditions
- Neurocognitive Deficit, Quality of Life, Activities of Daily Living
- Trial name
- WHOBI-STER (NCT04891471)
- Testing
- Stereotactic RadioTherapy, Whole Brain Irradiation
- Where
- 4 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Mediterranean Institute of Oncology
Spine Metastases
Prophylactic Radiotherapy of MInimally Symptomatic Spinal Disease
Early palliative care has been shown to improve the quality of life and even survival for patients with metastatic cancer. More and more supportive oncology teams in cancer centers now advocate for early integration of radiation…
- Trial name
- PROMISSeD (NCT05534321)
- Testing
- Prophylactic Radiotherapy, Standard of care systemic therapy
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Baptist Health South Florida
Metastasis
Evaluation of Fast, Same-day Delivery of Palliative Radiotherapy Without a Planning CT (FAST-METS)
Palliative radiotherapy is an effective treatment for patients with painful bone metastases. Standard workflows often involve long waiting times or multiple visits.
- Trial name
- FAST-METS (NCT05288608)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Amsterdam UMC, location VUmc
Cervical Cancer
Concomitant Curcumin Palliative Radiotherapy in Advanced Cervical Cancer Trial
The goal of this clinical trial is to test curcumin as an adjunct treatment in patients with cervical cancer receiving standard-of-care palliative radiation. The main questions it aims to answer are: 1.
- Trial name
- CuPRAC (NCT05947513)
- Testing
- Curcumin, Palliative radiotherapy
- Where
- Ethiopia
- Volunteers
- 27 people
- Sponsor
- Addis Ababa University
Bone Metastases, Pain
Palliative Radiotherapy for Bone Metastases: Single Versus Multiple Fractions.
The aim of the investigators study was to determine whether 8 Gy in a single fraction provides equivalent pain and narcotic relief compared to 30 Gy in 10 fractions for patients with painful bone metastases.
- Trial name
- NCT00858741
- Testing
- single fraction, multiple fractions
- Where
- Brazil
- Volunteers
- 148 people
- Sponsor
- Marilia Medicine School
Chemotherapy-Induced Peripheral Neuropathy, Radiation Toxicity
Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2026 and 2029.
The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms who have been referred to the Dr.
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Radiation Toxicity, Chronic Pain, Delayed Wound Healing
- Trial name
- EPOOzo-2 (NCT07325851)
- Testing
- Ozone Therapy
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Bernardino Clavo, MD, PhD
Spinal Metastases
Comparing SBRT to CRT in Patients With Spinal Metastases
This is a single institutional registry-based, prospective, observational study to describe radiation oncologists' decision making during evaluation of patients and to compare real-world outcomes of SBRT vs CRT.
- Trial name
- COMBAT (NCT05589701)
- Testing
- Radiotherapy
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto