Clinical trials: Palpable Breast Cancer
Breast Cancer
Avidination for RadionuclideTHerapy in Nonpalpable Breast Cancer
This is an interventional, open-label, non comparative phase 2 trial enrolling patients with nonpalpable breast cancer
- Trial name
- ARTHE (NCT06390241)
- Testing
- Avidin-biotin-Dota-90Y
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Breast Cancer
Survival of BCS vs Mx in Asymptomatic Screen-detected NPBC
We performed this study on a consecutive cohort of women with asymptomatic screen-detected NPBC. The clinicopathological characteristics, 10-year relapse-free survival (RFS) and overall survival (OS) were compared between BCS and…
- Trial name
- NCT06103032
- Testing
- Breast Conserving Surgery, Mastectomy
- Where
- China
- Volunteers
- 1,020 people
- Sponsor
- Peking Union Medical College Hospital
Breast Cancer
Neoadjuvant Chemotherapy Using Doxorubicin and Paclitaxel in Treating Women With Large Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as doxorubicin and paclitaxel, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00096291
- Testing
- Doxorubicin followed by Paclitaxel, Paclitaxel followed by Doxorubicin
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer
Use of Sentinel Lymph Node Biopsy in Patients With Early-Stage, Palpable Node-Positive HR+/HER2- Breast Cancer Having Upfront Surgery and Adjuvant Radiation
The purpose of this study is to find out how often the researchers can avoid an ALND in patients with early-stage, node-positive HR+/HER2- breast cancer who are having upfront surgery.
- Trial name
- NCT04854005
- Testing
- Breast surgery
- Where
- 10 sites in United States
- Volunteers
- 78 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
A Study to Evaluate the Accuracy of a Breast Cancer Locator (BCL) in Patients With Palpable Cancers
In this study, the investigators will enroll women with palpable cancers to assess the accuracy of the Breast Cancer Locator (BCL) and the concomitant procedure as a vehicle to optimize and validate the approach in such surgical…
- Trial name
- NCT02550210
- Testing
- Breast Cancer Locator (BCL)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Cancer, Breast-conserving Surgery
Efficacy and Accuracy of Combined Localization Versus Single Localization in Non-palpable Breast Cancer
The standard method for localizing non-palpable breast cancer is currently preoperative wire-guided localization, its positive margin rate still remains around 20-50%.
- Trial name
- NCT05797454
- Testing
- Wire-guided localization and marker clip localization, Wire-guided localization
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer, Breast-Conserving Surgery
IntraOperative UltraSound Guided vs Wire Guided vs Magnetic Seed Guided Breast-Conserving Surgery for Non-palpable Tumors
This is a multi-center, randomized, open-label clinical trial that will enroll 1302 adult patients with non-palpable breast lesions.
- Trial name
- MANOLA (NCT07185568)
- Testing
- IOUS HydroMark™, Magnetic Sirius Pintuition Seed®, Wire localization (WL)
- Where
- 5 sites in Italy
- Volunteers
- 1,302 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors
This phase I trial evaluates the safety and effectiveness of in situ immunomodulation with CDX-301, radiotherapy, CDX-1140 and Poly-ICLC (Cohort A) and these with intravenous (IV) pembrolizumab and subcutaneous (SC) tocilizumab…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Prognostic Stage IV Breast Cancer AJCC v8, Unresectable Breast Carcinoma
- Trial name
- NCT04616248
- Testing
- Anti-CD40 Agonist Monoclonal Antibody CDX-1140, Poly ICLC, Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Southern California
Breast Cancer
Comparison Between ROLL Versus Magnetic Seed for Preoperative Localization of Non-palpable Breast Lesion by Randomized Clinical Study.
Several localization techniques are now in use for localization of non-palpable breast lesions. Several studies have compared wire guided localization (WGL), which has been for years the gold standard for non-palpable breast…
- Trial name
- SEED02 (NCT05942118)
- Testing
- Breast conservative surgery
- Where
- Italy
- Volunteers
- 262 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Sentinel Lymph Node Biopsy
Oncologic Safety of Sentinel Lymph Node Biopsy in Clinically Palpable Axillary Lymph Node in Breast Cancer Patients
Evaluation patients with palpable lymph node with breast cancer by sentinel lymph node biopsy and how to affect on the management of breast cancer.
- Trial name
- NCT05703295
- Testing
- Biopsy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Breast Cancer
Combining CEM and Magnetic Seed Localization of Non-Palpable Breast Tumors
Rationale: Breast cancer patients are increasingly treated with neoadjuvant chemotherapy for various reasons. These women receive chemotherapy before any surgery is performed.
- Trial name
- CEMMAG (NCT06049446)
- Testing
- Pintuition
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Zuyderland Medisch Centrum
Breast Tumor
Radiofrequency Chip for Localization of Non-Palpable Breast Lesions
The purpose of the project is to compare Radiofrequency identification device (RFID) localization technique with the current clinical standard wire localization technique.
- Trial name
- NCT03684408
- Testing
- RFID Localization, Wire Localization, RFID and Wire Localization
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Missouri-Columbia
Palpable Breast Cancer
A Pilot Multi-Institutional Study to Evaluate the Accuracy of a Breast Cancer Locator in Patients With Palpable Cancers
The project objective is to determine whether the Breast Cancer Locator (BCL) can safely and effectively localize breast cancers in patients treated at locations distant from the site of BCL manufacture.
- Trial name
- BCL (NCT03573661)
- Testing
- Breast Cancer Locator (BCL)
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Neoplasm
SAVI SCOUT Clinical Evaluation Study
The purpose of this study is to evaluate the performance of the SAVI SCOUT® Surgical Guidance System (SAVI SCOUT). The SAVI SCOUT is a medical device, used to provide real-time guidance during localized excisional biopsy or…
- Trial name
- NCT02370082
- Testing
- Localization of breast lesion
- Volunteers
- 150 people
- Sponsor
- Cianna Medical, Inc.
Breast Neoplasms
Magnetic Occult Lesion Localization and Imaging (MOLLI)
The proposed trial is a non-randomized, single-arm study examining the technical feasibility and safety of magnetic occult lesion localization and imaging (MOLLI) for Breast Conserving Surgery (BCS), in patients with non-palpable…
- Trial name
- MOLLI (NCT03660137)
- Testing
- MOLLI Localization
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Breast Cancer Female
Radioguided Occult Lesion Localisation by Indocyanine Green
Breast cancer is the most common cancer in women. It is the main cause of cancer deaths among women. The incidence of non-palpable tumors is estimated at 60%.
- Trial name
- ROLL-1 (NCT03313908)
- Testing
- detection of the tumor lesion
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Breast Neoplasm, Lesion
Radiofrequency Identification Technology in Locating Non-palpable Breast Lesions in Patients Undergoing Surgery
This pilot clinical trial studies radiofrequency technology in locating non-palpable breast lesions in patients undergoing surgery.
- Trial name
- NCT03202472
- Testing
- Implanted Medical Device, Mammography, Questionnaire Administration
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Breast Cancer
MEthods for LOcalization of Different Types of Breast Lesions
In the last decades, the proportion of breast cancer (BC) patients receiving breast-conserving surgery has increased steadily, reaching 70-80% in developed countries.
- Trial name
- MELODY (NCT05559411)
- Where
- Germany
- Volunteers
- 7,416 people
- Sponsor
- European Breast Cancer Research Association of Surgical Trialists
Breast Neoplasm
Magnetic Occult Lesion Localization Instrument (MOLLI) Guidance System for Breast Lesion Localization
The proposed trial is a non-randomized, multi-center, sequential arm registry evaluating clinical, and health economic outcomes following treatment with the Magnetic Occult Lesion Localization Instrument (MOLLI), an approved…
- Trial name
- MOLLI (NCT04893421)
- Testing
- MOLLI Localization
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Sunnybrook Health Sciences Centre
Breast Tumour
Fluorescence-guided Resection in Breast Cancer
This is an explorative phase II study to investigate the suitability of PD L 506 in the specific intra-operative detection of breast tumour tissue.
- Trial name
- NCT01110954
- Testing
- PD L 506
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- photonamic GmbH & Co. KG