Clinical trials: Pancreas Diseases
Pancreatitis, Pancreatitis, Acute
Corticosteroids to Treat Pancreatitis
This research is being done to determine if the administration of a short course of intravenous hydrocortisone, an anti-inflammatory medication, to patients with severe acute pancreatitis will improve their clinical outcomes and…
- Conditions
- Pancreatitis, Pancreatitis, Acute, Corticosteroid, Hydrocortisone
- Trial name
- CRISP (NCT05160506)
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Beth Israel Deaconess Medical Center
Pancreatic Neoplasms
LYNPARZA Pancreas Cancer Japan Post-Marketing Surveillance (PMS)
To collect and characterise the incidence of adverse events related to the safety specifications of the maintenance treatment after platinum-based chemotherapy in patients with BRCA mutated pancreatic cancer under the actual…
- Trial name
- NCT04889404
- Where
- 60 sites in Japan
- Volunteers
- 130 people
- Sponsor
- AstraZeneca
Pancreatic Cancer, Stage IV Pancreatic Cancer
Dose Escalation Study of OMP-54F28 in Combination With Nab-Paclitaxel and Gemcitabine in Patients With Previously Untreated Stage IV Pancreatic Cancer
This is an open-label Phase 1b dose-escalation study to assess the safety, tolerability, and PK of OMP-54F28 when combined with nab-paclitaxel and gemcitabine.
- Trial name
- NCT02050178
- Testing
- OMP-54F28, Nab-Paclitaxel and Gemcitabine
- Where
- 5 sites in United States
- Volunteers
- 26 people
- Sponsor
- OncoMed Pharmaceuticals, Inc.
Locally Advanced Solid Tumor
Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors
This is a first in human study in patients with advanced or metastatic solid tumors known to have an MTAP deletion. The first part of the study is an open-label, dose escalation and the second part is an open label dose expansion…
- Trial name
- NCT05275478
- Testing
- TNG908
- Where
- 20 sites in United States, France
- Volunteers
- 110 people
- Sponsor
- Tango Therapeutics, Inc.
Acute Pancreatitis
Randomised Treatment of Acute Pancreatitis With Infliximab: Double-blind, Placebo-controlled, Multi-centre Trial (RAPID-I)
This study evaluates the effectiveness and safety of infliximab in the treatment of acute pancreatitis in adults. A third of participants will receive one single dose of infliximab via infusion, another third will receive a…
- Trial name
- RAPID-I (NCT03684278)
- Testing
- Infusion of 5 mg/kg Infliximab, Infusion of 10 mg/kg Infliximab
- Where
- 14 sites in United Kingdom
- Volunteers
- 240 people
- Sponsor
- University of Liverpool
Chronic Pancreatitis, Osteopenia
Bone Disease in Chronic Pancreatitis: A Complex Phenomenon
The purpose of this study is to define the prevalence of low bone density (osteopenia/osteoporosis) in patients with chronic pancreatitis.
- Conditions
- Chronic Pancreatitis, Osteopenia, Osteoporosis
- Trial name
- NCT02108509
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Nebraska
Pancreatic Cancer, Radiotherapy
mFOLFIRINOX Plus Radiotherapy to Patients With CA19-9-normal Advanced Pancreatic Cancer Refractory to Chemotherapy
The purpose of this study is to evaluate the efficacy of mFOLFIRINOX plus radiotherapy to Patients with CA19-9-normal Advanced Pancreatic Cancer refractory to chemotherapy.
- Trial name
- PTCA199-10 (NCT06249321)
- Testing
- mFOLFIRINOX plus IMRT
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fudan University
Bladder Cancer, Brain and Central Nervous System Tumors
Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Conditions
- Bladder Cancer, Brain and Central Nervous System Tumors, Esophageal Cancer, Intraocular Melanoma
- Trial name
- NCT00757614
- Testing
- DNA analysis, polymorphism analysis, laboratory biomarker analysis
- Where
- United Kingdom
- Volunteers
- 14,000 people
- Sponsor
- Cancer Research UK
Neuroendocrine, Neuroendocrine Tumor
68Ga-DOTATATE PET Scan Imaging in Patients With Neuroendocrine Tumors
Neuroendocrine cancer is an unusual disease and often goes undetected by routine imaging. The 68Ga-DOTATATE PET Scan is a novel scanning method that may have improved sensitivity and resolution specifically for neuroendocrine…
- Conditions
- Neuroendocrine, Neuroendocrine Tumor, Neuroendocrine Cancer, Neuroendocrine Carcinoma
- Trial name
- NCT02038738
- Testing
- 68Ga-DOTATATE will be given in tracer doses and injected intravenously to image tumors by Positron Emission Tomography.
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Ochsner Health System
Pancreas Cancer, Pancreatic Adenocarcinoma
Safety and Tolerance of Epigenetic and Immunomodulating Drugs Combined With Chemotherapeutics in Patients Suffering From Advanced Pancreatic Cancer
A multi-center, open-label phase I/II study to to determine the safety and tolerability of Azacitidine and/or Romidepsin in combination with nab-Paclitaxel/Gemcitabine in patients with advanced pancreatic ductal adenocarcinoma…
- Conditions
- Pancreas Cancer, Pancreatic Adenocarcinoma, Pancreatic Ductal Adenocarcinoma
- Trial name
- SEPION (NCT04257448)
- Testing
- Romidepsin, Azacitidine, nab-Paclitaxel
- Where
- 9 sites in Germany
- Volunteers
- 75 people
- Sponsor
- GWT-TUD GmbH
Cystic Fibrosis
Hyperpolarized Xenon MRI in Cystic Fibrosis Pulmonary Exacerbations
The investigators aim to assess whether pulmonary MRI (hyperpolarised 129Xe ventilation imaging [Xe-MRI]) can detect changes in ventilation defects in patients with CF before and after treatment for a pulmonary exacerbation.
- Trial name
- NCT02606487
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis, MRSA
Epidemiology and Treatment of Small-colony Variant Staphylococcus Aureus in Cystic Fibrosis
Methicillin-susceptible (MSSA) and Methicillin-resistant (MRSA) Staphylococcus aureus (SA) are two of the most important infectious pathogens in CF, with 69% of CF patients having lung infection with MSSA or MRSA in the last…
- Trial name
- NCT02547116
- Testing
- Rifampin
- Where
- United States
- Sponsor
- Johns Hopkins University
Acute Pancreatitis (AP)
Neutrophil-Creatinine Index in Patients with Acute Pancreatitis: Assessment of Severity and Outcome
Acute pancreatitis is a disease that usually has a mild disease course. However, around 20-30% of the patients develop severe complications.
- Trial name
- NCT06828965
- Testing
- Neutrophil creatinine index
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Gastrointestinal Tumors, Pancreatic Tumors
Study of Everolimus Treatment in Newly-diagnosed Patients With Advanced Gastrointestinal Neuroendocrine Tumors
The purpose of this study is to explore the efficacy and safety of everolimus administered as a first-line treatment in newly-diagnosed patients with advanced or inoperable Gastrointestinal (GI) or pancreatic neuroendocrine…
- Conditions
- Gastrointestinal Tumors, Pancreatic Tumors, Gastrointestinal Neuroendocrine Tumors, Pancreatic Neuroendocrine Tumors
- Trial name
- NCT01648465
- Testing
- Everolimus
- Where
- 12 sites in Greece
- Volunteers
- 25 people
- Sponsor
- Hellenic Cooperative Oncology Group
Pancreatogenic Diabetes Mellitus, Type 2 Diabetes Mellitus (T2DM)
Assessment of Pancreatic Dysfunction in Patients With Type 2 Diabetes
The goal of this observational study is to better understand how the pancreas works in adults with type 2 diabetes. The study focuses on both hormone production (endocrine function) and digestive function (exocrine function) of…
- Conditions
- Pancreatogenic Diabetes Mellitus, Type 2 Diabetes Mellitus (T2DM), Exocrine Pancreatic Insufficiency (EPI)
- Trial name
- T3cDM-AKT (NCT07512934)
- Where
- Kazakhstan
- Volunteers
- 310 people
- Sponsor
- West Kazakhstan Marat Ospanov Medical University
Colorectal Cancer, Pancreatic Cancer
Bemalenograstim Alfa for the Prevention in Patients With Colorectal Cancer/Pancreatic Cancer
A multi-cohort, open-label, multicenter exploratory clinical study of Bemalenograstim alfa for the prevention of reduced absolute neutrophil count(ANC) in patients with colorectal cancer/pancreatic cancer following a bi-weekly…
- Trial name
- NCT06134765
- Testing
- Bemalenograstim alfa
- Where
- China
- Volunteers
- 89 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pancreatic Cancer
Capecitabine/Erlotinib Followed of Gemcitabine Versus Gemcitabine/Erlotinib Followed of Capecitabine
This crossover trial is performed in advanced and metastatic pancreatic cancer not previously exposed to chemotherapy. The study compares a standard arm with gemcitabine plus erlotinib to an experimental arm with capecitabine…
- Trial name
- NCT00440167
- Testing
- Gemcitabine, Capecitabine, Erlotinib
- Volunteers
- 280 people
- Sponsor
- PD Dr. med. Volker Heinemann
Pancreatic Cancer, EUS-FNB
Profiling the Intratumoral Microbiome of Pancreatic Ductal Adenocarcinoma Based on EUS-FNB Tissue Samples and Exploring Its Impact on Tumor Diagnosis and Prognosis.
The goal of this observational study is to use endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) to investigate the intratumoral microbiome profile in patients with pancreatic ductal adenocarcinoma (PDAC) and to evaluate…
- Conditions
- Pancreatic Cancer, EUS-FNB, Intratumoral Microbiota, Diagnosis
- Trial name
- NCT06655233
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Pancreas Cancer, Chemotherapy
The Survival Outcome of Adjuvant Chemotherapy for Stage I Pancreatic Cancer
This study aimed to evaluate the impact of adjuvant chemotherapy on survival in patients with Stage I pancreatic cancer stratified by pathologic risk factors.
- Trial name
- NCT06208436
- Testing
- Adjuvant chemotherapy
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Pancreatic Cancer, Surgery
Reconstruction Method and Delayed Gastric Emptying After Pancreatic Surgery
Pancreaticoduodenectomy (whipple procedure) is the standard operation for tumors of the pancreatic head, uncinate process, distal common bile duct as well as the papilla of vater.
- Conditions
- Pancreatic Cancer, Surgery, Improvement of Perioperative Outcome
- Trial name
- NCT01248663
- Testing
- antecolic reconstruction, retrocolic reconstruction
- Where
- Austria
- Volunteers
- 64 people
- Sponsor
- Medical University of Vienna
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