Clinical trials: Pancreas Transplantation
Diabetes Mellitus, Type 1
Safety of ENC-201-CED ENCRT
The purpose of the study is to evaluate the safety and tolerability of ENC-201-CED in a subcutaneous space in patients with Type I diabetes.
- Trial name
- NCT06408311
- Testing
- ENC-201-CED hPI
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Encellin
Chronic Pancreatitis
Analysis of Graft Function Following Autologous Islet Transplantation
Analyze inflammatory markers and islet graft function through blood samples collected from subjects with chronic pancreatitis who undergo total pancreatectomy with auto islet transplantation.
- Trial name
- NCT03097185
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
Chronic Pancreatitis
Carbon Monoxide-Saturated Medium for Islet Isolation
The goal of this study is to determine whether harvesting islets using carbon monoxide (CO)-saturated mediums can protect islet cell from death after autologous islet transplantation in patients with chronic pancreatitis.
- Trial name
- NCT02567240
- Testing
- Carbon monoxide-bubbled mediums
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical University of South Carolina
End Stage Liver DIsease
Comparison of Hypothermic Versus Normothermic Ex-vivo Preservation.
Study groups: The study is a multicenter (Pisa and Milan), prospective, randomized study comparing D-HOPE (HMP) vs NMP in DCD and ECD-DBD (extended criteria brain-dead donors).
- Trial name
- DCDNet (NCT04744389)
- Testing
- Hypothermic Machine Perfusion, Normothermic Machine Perfusion
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Diabetes
Pancreatic Islet Transplantation Into the Anterior Chamber of the Eye
The intervention in this trial is intraocular islet transplantation. A single dose of 1000 - 3000 Islet Equivalents (IEQ)/kg recipient body weight (BW) will be infused into the anterior chamber of the eye through a self-sealing…
- Trial name
- NCT02846571
- Testing
- Human Pancreatic Islet Transplantation
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Midhat H. Abdulreda
Progressive Fibrosing Interstitial Lung Disease, Lung Transplant
Integrating Electronic Patient Reported Biometric Measures (ePReBMs) From Wearable Devices in Respiratory Diseases
Lung diseases are one of the most common causes of emergency room visits. There are very few tools that are able to predict which patients will have a worsening or increasing severity of their condition.
- Conditions
- Progressive Fibrosing Interstitial Lung Disease, Lung Transplant, Cystic Fibrosis, Bronchiectasis
- Trial name
- NCT04857814
- Testing
- ADAMM- RSM Device
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Alberta
Kidney Transplant Rejection, Positive FCXM (T or B Cell Positive)
Spleen Transplant in Solid Organ Transplantation
Although the notions that kidney transplantation is the treatment of choice for patients with end-stage renal disease and that simultaneous kidney and pancreas transplant is the only treatment able to restore euglycemia in…
- Conditions
- Kidney Transplant Rejection, Positive FCXM (T or B Cell Positive), Positive CDC Cross-Match (B Cell Positive), Kidney/Pancreas Transplant Rejection
- Trial name
- NCT04827186
- Testing
- Spleen Transplantation/Removal
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Pancreatitis, Diabetes
Sitagliptin Therapy to Improve Outcomes After Islet Autotransplant
The purpose of the study is to test the effects of sitagliptin on the need for insulin (the hormone that lowers blood sugars) by patients who receive a pancreatectomy and islet autotransplant for chronic pancreatitis.
- Trial name
- NCT01186562
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Minnesota
Cystic Fibrosis, Diabetes Related Cystic Fibrosis
Metabolic Efficiency of Combined Pancreatic Islet and Lung Transplant for the Treatment of End-Stage Cystic Fibrosis
Patients with end-stage cystic fibrosis (CF) and severe CF-related diabetes (CFRD) may benefit from combined lung-pancreatic islet transplantation.
- Conditions
- Cystic Fibrosis, Diabetes Related Cystic Fibrosis, Insulin-dependent Diabetes
- Trial name
- PIM (NCT01548729)
- Testing
- Combined pancreatic islet and lung transplantation
- Where
- 28 sites in France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Strasbourg, France
Kidney Transplant, Pancreatic Transplat
SARS-CoV2 (COVID-19) Seroepidemiological Transplanted Subjects (Kidney, Kidney-pancreas, Pancreas, Langerhans Islets)
Evaluate SARS-CoV2 infection and the degree of immunity possibly developed in transplanted population using the Luciferase Immuno Precipitation System (LIPS) test.
- Conditions
- Kidney Transplant, Pancreatic Transplat, Pancreatic Islets Langerhans
- Trial name
- NCT04487197
- Testing
- blood sample for seroepidemiological investigation
- Where
- Italy
- Volunteers
- 282 people
- Sponsor
- Antonio Secchi
Type 1 Diabetes
Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Type 1 Diabetes
The primary objective is to test the hypothesis that co-transplantation of allogeneic PTG with adult pancreatic islets (derived from same deceased donor) in the IM site in people with Type 1 diabetes with functioning kidney…
- Trial name
- PARADIGM (NCT03977662)
- Testing
- Co-transplantation of PTG with pancreatic islets
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Peter Stock
Islets of Langerhans Transplantation, Diabetes Mellitus
Arginine-stimulated Indication of Early Outcome After Islet Transplantation
Through islet transplantation, functional β-cell mass can be restored. Allogeneic islet transplantation is a treatment modality for a select group of patients with complicated type 1 diabetes mellitus.
- Conditions
- Islets of Langerhans Transplantation, Diabetes Mellitus, Chronic Pancreatitis
- Trial name
- ALADDIN (NCT05540197)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Kidney Transplant; Complications, Pancreas Disease
Study of OmniGraft in Simultaneous Pancreas Kidney Recipients
The purpose of this research is learn about how OmniGraf works in kidney pancreas transplant patients. Also, to analyze the performance characteristics of OmniGrafTM (TruGraf Gene Expression Profiling (GEP) and T Cell Receptor…
- Trial name
- NCT06463873
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability
The purpose of this research study is to perfect the technique of EVLP and learn about the safety of transplanting lungs that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and perfused…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01241942
- Testing
- Steen Solution™, Conventional Lung Transplant
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of North Carolina, Chapel Hill
Pancreatitis, Chronic, Pancreatectomy; Hyperglycemia
A Prospective Observational Study of TPIAT
Multi-center, prospective, observational cohort study of patients undergoing total pancreatectomy with islet autotransplantation (TPIAT)
- Conditions
- Pancreatitis, Chronic, Pancreatectomy; Hyperglycemia, Pancreatitis
- Trial name
- POST (NCT03260387)
- Testing
- TPIAT
- Where
- 12 sites in United States
- Volunteers
- 433 people
- Sponsor
- University of Minnesota
Adenocarcinoma of the Pancreas, Adenocarcinoma of the Duodenum
Efficacy and Safety of TPIAT for Resectable Adenocarcinoma of the Pancreas Region at High Risk of Postoperative Fistula
Curative management of locally resectable invasive adenocarcinomas located in the cephalic region of the pancreas (pancreas, duodenum and ampulla of Vater) requires a pancreaticoduodenectomy followed by adjuvant chemotherapy.
- Conditions
- Adenocarcinoma of the Pancreas, Adenocarcinoma of the Duodenum, Ampullary Adenocarcinoma
- Trial name
- TPIAT-01 (NCT05116072)
- Testing
- total pancreatectomy, intraportal islet autotransplantation
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Lille
Transplant;Failure,Kidney, Transplant; Failure, Heart
EASE-SOT Pilot Study
Many transplant recipients may experience physical and emotional symptoms, such as anxiety, fatigue, sleep problems, pain, etc. Often, these symptoms are not reported or managed well, and can affect a patient's quality-of-life.
- Conditions
- Transplant;Failure,Kidney, Transplant; Failure, Heart, Transplant; Failure, Liver, Transplant; Failure, Pancreas
- Trial name
- NCT06396702
- Testing
- EASE-SOT
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
CKD (Chronic Kidney Disease) Stage 5T, Diabetes Mellitus
Observational Study to Evaluate the Safety and Efficacy of Polyclonal Antibodies in Simultaneous Pancreas Kidney Transplant Recipients
A single-centre, prospective, observational study to evaluate the safety and efficacy of Polyclonal Antibodies in simultaneous Pancreas Kidney Transplant recipients.
- Conditions
- CKD (Chronic Kidney Disease) Stage 5T, Diabetes Mellitus, Simultaneous Pancreas Kidney Transplantation
- Trial name
- PAISPK (NCT03470961)
- Testing
- Anti-Tlymphocyte Globulins, Anti-Thymocyte Globulins
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Tianjin First Central Hospital
Diabetes Mellitus, Type 1
Safety and Efficacy of PEG-Encapsulated Islet Allografts Implanted in Type I Diabetic Recipients
Insulin dependent Type I diabetics require daily insulin therapy to normalize blood glucose but may have difficulty with significant glycemic excursions and hypoglycemic episodes and crises.
- Trial name
- NCT00260234
- Testing
- Allogeneic Cultured Islet Cells (human); Encapsulated
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Novocell
Pancreas Transplant, Type 1 Diabetes Mellitus
Pancreas Transplant Alone in Uremia and Non-uremia Patients
Theoretically, pancreas transplant alone in uremia (PTAu) or pancreas before kidney transplant (PBK) may be considered for patients awaiting both pancreas and kidney grafts, alongside options like simultaneous pancreas-kidney…
- Conditions
- Pancreas Transplant, Type 1 Diabetes Mellitus, Uremia
- Trial name
- PTAu (NCT07872800)
- Testing
- pancreas transplant
- Where
- Taiwan
- Volunteers
- 184 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan