Clinical trials: Pancreas Tumor
Pancreas Cancer
Bazedoxifene as a Concomitant Treatment of Patients With Metastatic Pancreatic Adenocarcinoma
Bazedoxifene, a selective estrogen receptor modulator is thought to have effective anti-tumoral properties for pancreatic cancer via IL-6 pathway (GP130/STAT3) inhibition.
- Trial name
- BAZE (NCT04812808)
- Testing
- Bazedoxifene 20 mg
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Hôpital Fribourgeois
Pancreatic Neuroendocrine Tumor
Neoadjuvant PRRT With Y-90-DOTATOC in pNET
Neuroendocrine tumors (NETs) are relatively rare tumors, mainly originating from the digestive system, that tend to be slow growing and are often diagnosed when metastatic.
- Trial name
- NeoNet (NCT05568017)
- Testing
- peptide receptor radionuclide therapy with Y-90-DOTATOC
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- European Institute of Oncology
Pancreatic Cancer
Gemcitabine With Abraxane and Other Investigational Therapies in Neoadjuvant Treatment of Pancreatic Adenocarcinoma
This study will evaluate the role of Gemcitabine and Abraxane in the treatment of resectable and borderline-resectable pancreatic cancer by giving the chemotherapy before surgery.
- Trial name
- GAIN-1 (NCT01470417)
- Testing
- Chemotherapy, Chemotherapy + ChemoRadiotherapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Refractory Pancreatic Ductal Adenocarcinoma, Refractory Pancreatic Adenocarcinoma
JDB153 Combined With Serplulimab for Pancreatic Cancer After Standard Treatment Failure
The goal of this clinical trial is to evaluate the safety and efficacy of JDB153 combined with Serplulimab in patients with pancreatic cancer after standard treatment failure.
- Trial name
- NCT07175389
- Testing
- JDB153, Serplulimab
- Where
- China
- Volunteers
- 10 people
- Sponsor
- West China Hospital
Insulinoma
Clinical Evaluation of 68Ga-NOTA-MAL-Cys39-exendin-4 Positron Emission Tomography in the Detection of Insulinoma
Glucagon-like peptide-1 receptor (GLP-1R) is a kind of G protein coupled receptor which regulate the insulin secretion and serves as potential target in the diagnosis of functional pancreas neuroendocrine tumor.
- Trial name
- NCT04185350
- Testing
- 68Ga-NOTA-MAL-Cys39-exendin-4
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Pancreatic Cancer
Analyzing Childhood Recall Antigens in Patients With Pancreatic Cancer
The investigator is developing an immune therapy against pancreatic cancer. Immune cells, known as "T cells with tumor killing capacity", are involved in this immune therapy.
- Trial name
- NCT03848182
- Testing
- Gemcitabine, TT vaccine booster
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Locally Advanced Pancreatic Cancer
Pancreatic Locally Advanced Irresectable Cancer Ablation
The aim of the PELICAN trial is to investigate the survival benefit of RFA plus standard palliative chemotherapy as compared to palliative chemotherapy alone in patients with LAPC after 2 months of induction chemotherapy.
- Trial name
- PELICAN (NCT03690323)
- Testing
- Radiofrequency ablation (RFA), FOLFIRINOX, Nab-paclitaxel plus Gemcitabine
- Where
- 2 sites in Netherlands
- Volunteers
- 228 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pancreatic Cancer, Gut Microbiota
The Mechanism of Enhancing the Anti-tumor Effects of CAR-T on PC by Gut Microbiota Regulation
Pancreatic cancer (PC) is one of the deadliest diseases of human digestive malignancies. Despite the recent advances in surgery and chemotherapy, the 5-year survival rate of PC continues to be less than 10%.
- Conditions
- Pancreatic Cancer, Gut Microbiota, CAR-T
- Trial name
- NCT04203459
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Pancreatic Cancer, Adenocarcinoma of the Pancreas
Switch Maintenance in Pancreatic
This study is being done to test the safety and effectiveness of combining domvanalimab (AB154), zimberelimab (AB122), and APX005M with pancreatic cancer that has spread to other parts of body.
- Conditions
- Pancreatic Cancer, Adenocarcinoma of the Pancreas, Squamous Cell Carcinoma of Pancreas, Adenosquamous Carcinoma of the Pancreas
- Trial name
- NCT05419479
- Testing
- ZIMBERELIMAB, DOMVANALIMAB, APX005M
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- James Cleary, MD, PhD
Pancreatic Cancer
Mitomycin C and Ifosfamide in Treating Patients With Metastatic Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy, such as mitomycin C and ifosfamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- PACT-11 (NCT00967291)
- Testing
- ifosfamide, mitomycin C
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Cancer
An Observational Study of Erlotinib Plus Gemcitabine in Patients With Metastatic Pancreatic Cancer
This observational study will evaluate the impact of rash on survival of patients with metastatic pancreatic cancer treated with erlotinib plus gemcitabine. Further, clinical effectiveness, efficacy and safety will be assessed.
- Trial name
- NCT01782690
- Testing
- erlotinib, gemcitabine
- Where
- Germany
- Volunteers
- 338 people
- Sponsor
- Hoffmann-La Roche
Pancreatic Cancer, Metastatic Pancreatic Cancer
Nivolumab + Ipilimumab + Radiation in MSS Pancreatic Cancer
This research is being done to study the effects of the combination of ipilimumab, nivolumab, and radiation therapy in people with microsatellite stable pancreatic cancer.
- Trial name
- NCT04361162
- Testing
- Nivolumab, Ipilimumab, Radiation
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Pancreatic Cyst
Accuracy of Dilution of EUS-FNA Pancreatic Cyst Fluid for Carcinoembryonic Antigen (CEA) Measurement
The purpose of this research project is to determine if pancreatic cyst fluid can be diluted and provide an accurate Carcinoembryonic Antigen (CEA) level.
- Trial name
- NCT01494077
- Testing
- Laboratory processing for results
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, Irvine
Pancreatic Adenocarcinoma, Pancreatic Cysts
Robotic Versus Open Pancreaticoduodenectomy for Pancreatic and Periampullary Tumors
This multicenter randomized trial aims to primarily assess and compare the functional recovery of patients who undergo open versus robotic pancreaticoduodenectomy for benign and malignant lesions of the head of the pancreas.
- Conditions
- Pancreatic Adenocarcinoma, Pancreatic Cysts, Pancreatic Endocrine Tumors, Chronic Pancreatitis
- Trial name
- PORTAL (NCT04400357)
- Testing
- Robotic pancreaticoduodenectomy, Open pancreaticoduodenectomy
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Ruijin Hospital
Pancreatic Cancer
Contrast-enhanced Ultrasound and Pancreatic Lesions
The characterization of pancreatic lesions is one of the fundamental steps in the management of pancreatic neoplastic diseases. In terms of a subjective assessment of vascular enhancement in the various examination stages, the…
- Trial name
- NCT05977777
- Testing
- Contrast- enhanced ultrasound
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Non-small Cell Lung Cancer, Pancreatic Cancer
EGF Ointment for Erlotinib Skin Lesion
Epidermal growth factor receptor-tyrosin kinase inhibitor (EGFR-TKI, Erlotinib) has demonstrated its efficacy in patients with non-small cell lung cancer and pancreatic cancer.
- Trial name
- NCT01593995
- Testing
- Epidermal growth factor (EGF) ointment
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Dong-A University Hospital
Pancreatic Cancer
Gemcitabine With or Without Capecitabine in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if gemcitabine is more effective with or without capecitabine in treating pancreatic…
- Trial name
- NCT00032175
- Testing
- capecitabine, gemcitabine hydrochloride
- Where
- 30 sites in United Kingdom
- Volunteers
- 508 people
- Sponsor
- Cancer Research UK
Pancreatic Cancer, Colorectal Cancer
IX001 TCR-T In the Treatment of Advanced Pancreatic Cancer and Colorectal Cancer Induced by KRAS Mutations
This is a single-arm, single-center, open-label clinical study aimed at evaluating the safety and efficacy of IX001 TCR-T (T cell receptor-engineered T-Cell) injection in patients with advanced pancreatic cancer and colorectal…
- Trial name
- NCT06487377
- Testing
- IX001 TCR-T cells
- Where
- China
- Sponsor
- Shanghai Pudong Hospital
Colorectal Cancer, Cholangiocarcinoma
A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors
This is an open-label, Phase 1/2 study to determine the safety, tolerability, and efficacy of APL-5125 for the treatment of selected locally advanced or metastatic solid tumors with particular focus on Colorectal carcinoma (CRC).
- Conditions
- Colorectal Cancer, Cholangiocarcinoma, Appendiceal Adenocarcinoma, Pancreatic Adenocarcinoma
- Trial name
- NCT06399757
- Testing
- APL-5125
- Where
- 9 sites in United States
- Volunteers
- 27 people
- Sponsor
- Apollo Therapeutics Ltd
Pancreatic Cancer, Psychological Distress
The Emotional Impact of Surveillance for Pancreatic Cancer
Due to its rarity a population screening program for pancreatic cancer is not possible. For this reason, considering background data on genetic predisposition and familiarity for this lethal tumor, efforts have been pushed to…
- Trial name
- NCT04024345
- Testing
- Barratt Simplified Measure of Social Status (BSMSS), Global Assessment of Functioning scale (GAF), General Self-Efficacy Scale (GSES)
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
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