Clinical trials: Pancreatectomy
Pancreatic Neoplasms, Distal Pancreatectomy (DP)
Feasibility and Effectiveness of Three-day Discharge After Distal Pancreatectomy
Background: Enhanced recovery after surgery (ERAS) programs and the minimally invasive approach have significantly improved recovery outcomes following distal pancreatectomy (DP).
- Trial name
- 3DD (NCT07095621)
- Testing
- 3 days discharge
- Volunteers
- 35 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Fistula, Pancreatectomy
Distal Pancreatectomy Pancreatic Fistula Risk Prediction Model Validation Study
Distal pancreas resection is a relatively rare procedure with a known risk of postoperative pancreatic fistula. Until quite recently, no valid risk prediction models for this have been available.
- Trial name
- DPFValid (NCT05737875)
- Where
- United Kingdom
- Volunteers
- 2,284 people
- Sponsor
- University of Edinburgh
Pancreaticoduodenectomy, Distal Pancreatectomy
The Novel Modified Cattell-Warren Duct-To-Mucosa Pancreaticojejunostomy Technique Significantly Reduces POPF.
Pancreatic surgeries, such as pancreaticoduodenectomy and distal pancreatectomy, are associated with high morbidity and mortality. The most common cause of this morbidity is postoperative pancreatic fistula(POPF).
- Conditions
- Pancreaticoduodenectomy, Distal Pancreatectomy, Postoperative Pancreatic Fistula
- Trial name
- POPF (NCT07038161)
- Testing
- Modified Cattell-Warren duct-to-mucosa pancreaticojejunostomy, Institutional Prehabilitation Protocol
- Where
- Nepal
- Volunteers
- 27 people
- Sponsor
- Nepal Medical College and Teaching Hospital
Pancreatectomy
Tomoelastography in Predicting Postoperative Pancreatic Fistula
Postoperative pancreatic fistula (POPF) is a prevalent and severe complication of pancreaticoenteric anastomosis; however, its accurate preoperative prediction is challenging.
- Trial name
- POPF (NCT07014800)
- Where
- China
- Volunteers
- 157 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Pancreas Neoplasms, Liver Metastasis
Surgical Approach for Adenocarcinoma of the Pancreas With Synchronous Liver Metastases
The study focuses on patients with synchronous liver metastasis from pancreatic adenocarcinoma that underwent both pancreatic and liver resection.
- Conditions
- Pancreas Neoplasms, Liver Metastasis, Pancreas Ductal Adenocarcinoma, Surgery of the Pancreatic Head
- Trial name
- NCT06980792
- Testing
- Pancreatectomy and liver resection, Chemotherapy
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Locally Advanced Pancreatic Cancer, Borderline Resectable Pancreatic Cancer
A New Clinical Pathway for Personalized Management of Borderline Resectable and Locally Advanced Pancreatic Cancer
NORPACT-3 is a nationwide, Norwegian single arm prospective study that evaluates the resectability rates and survival in patients with borderline resectable and locally advanced pancreatic cancer who received primary…
- Conditions
- Locally Advanced Pancreatic Cancer, Borderline Resectable Pancreatic Cancer, Pancreatectomy, Chemotherapy Effect
- Trial name
- NORPACT-3 (NCT06944587)
- Testing
- Chemotherapy, Radiology, Pancreatectomy
- Where
- 5 sites in Norway
- Volunteers
- 400 people
- Sponsor
- Oslo University Hospital
Pancreatic Cancer, Neoadjuvant Chemotherapy
Multimodal Therapy Impact on Pancreatic Cancer Survival
The goal of this retrospective cohort study is to analyze change of treatment strategies affect the survival outcomes in patients of pancreatic cancer who received curative-intent treatment.
- Conditions
- Pancreatic Cancer, Neoadjuvant Chemotherapy, Pancreatectomy
- Trial name
- MMTIPS (NCT06938906)
- Where
- Taiwan
- Volunteers
- 405 people
- Sponsor
- National Cheng Kung University
Pancreatectomy, Enhanced Recovery After Surgery
Effect of an Enhanced Recovery After Surgery Program on Outcomes After Pancreatoduodenectomy
This study assesses whether patients with pancreatic cancer who undergo surgery experience improved outcomes following the implementation of a multidisciplinary care pathway, specifically an enhanced recovery after surgery (ERAS)…
- Conditions
- Pancreatectomy, Enhanced Recovery After Surgery, Pancreatic Cancer Resectable
- Trial name
- NCT06935448
- Testing
- enhanced recovery after surgery
- Where
- Greece
- Volunteers
- 170 people
- Sponsor
- University of Thessaly
Whipple Procedure, Distal Pancreatectomy
Music Therapy in Patients Undergoing Pancreatic Surgery (MUSIC PUPS)
Pilot single arm non-randomized trial to determine the feasibility and acceptability of: 1) a tailored music-assisted relaxation and imagery intervention; 2) biological sample collection; and 3) mobile device patient-reported…
- Conditions
- Whipple Procedure, Distal Pancreatectomy, Acute Pain
- Trial name
- MUSIC PUPS (NCT06123013)
- Testing
- Music Assisted Relation Intervention (MARI)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University Hospitals Cleveland Medical Center
Pancreatectomy, Augmented Reality
Feasibility and Effectiveness of Augmented Reality Assistance System for Pancreatic Surgery
Pancreatic cancer necessitates surgical resection for complete tumor eradication, serving as the primary curative approach. However, pancreatic surgery is still challenging due to the organ's retroperitoneal anatomy and proximity…
- Trial name
- ARAS-P (NCT06208579)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Klinikum Saarbrücken, Klinik für Allgemein-, Viszeral- und Thoraxchirurgie, Chirurgische Onkologie
Distal Pancreatectomy, Postoperative Pancreatic Fistula
A Prospective Cohort Study on Ligation of Pancreatic Stump After Distal Pancreatectomy
The goal of this clinical trial is to learn if igation of pancreatic stump with quantified force works in decrease postoperative pancreatic fistula following distal pancreatectomy.
- Trial name
- NCT06814249
- Testing
- ligation of pancreatic stump with a quantified force, Manual suturing or stapling closure.
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Pancreatectomy, Pancreatoduodenectomy
Twenty Years of Pancreatic Surgery in Iceland
A retrospective analysis of patients undergoing pancreatic operations in Landspitali University Hospital, Reykjavik, Iceland, between 2003 and 2022.
- Conditions
- Pancreatectomy, Pancreatoduodenectomy, Distal Pancreatectomy (DP)
- Trial name
- NCT06738914
- Volunteers
- 244 people
- Sponsor
- Linkoeping University
Locally Advanced Pancreatic Adenocarcinoma, Borderline Resectable Pancreatic Carcinoma
Standard or Prolonged Neoadjuvant Chemotherapy Before Surgery for BR/LAPC
The goal of this multicenter randomized controlled phase III trial is to compare two durations of neoadjuvant chemotherapy (NAT) with mFOLFIRINOX or gemcitabine-nab-paclitaxel (GnP) before attempt for surgical resection in…
- Conditions
- Locally Advanced Pancreatic Adenocarcinoma, Borderline Resectable Pancreatic Carcinoma, Pancreas Cancer, Neoadjuvant Chemotherapy
- Trial name
- ADVANTAGE (NCT06714604)
- Testing
- FOLFIRINOX or gemcitabine-nab-paclitaxel
- Where
- Sweden
- Volunteers
- 432 people
- Sponsor
- Sahlgrenska University Hospital
Locally Advanced Pancreatic Adenocarcinoma, Chemotherapy Effect
Neoadjuvant Chemotherapy in Borderline Resectable and Locally Advanced Pancreatic Cancer (NORPACT-2)
This is a Norwegian prospective observational study that evaluates the resectability rate in patients with borderline resectable and locally advanced pancreatic cancer who received neoadjuvant chemotherapy in a population based…
- Conditions
- Locally Advanced Pancreatic Adenocarcinoma, Chemotherapy Effect, Borderline Resectable Pancreatic Adenocarcinoma, Pancreatectomy
- Trial name
- NCT04423731
- Testing
- Folfirinox
- Where
- Norway
- Volunteers
- 251 people
- Sponsor
- Oslo University Hospital
Pancreatectomy
Methods of Pancreatic Stump Closure for Distal Pancreatectomy
The aim of this study is to conduct a retrospective analysis of patients who underwent distal pancreatectomy in our hospital, aiming to evaluate the safety and feasibility of two methods for closure of the pancreatic remnant…
- Trial name
- NCT06424431
- Testing
- stapler combined with electrocautery, simple closure with a closure device
- Where
- China
- Volunteers
- 487 people
- Sponsor
- Changhai Hospital
Pancreatic Neoplasms, Type 3c Diabetes
Glucose Control Through a Bihormonal Artificial Pancreas in Patients After Total Pancreatectomy
In recent years total pancreatectomy is increasingly performed in selected patients due to the increasing use of preoperative chemotherapy, making more patients operable.
- Conditions
- Pancreatic Neoplasms, Type 3c Diabetes, Total Pancreatectomy
- Trial name
- PANORAMA (NCT06346366)
- Testing
- Bihormonal artificial pancreas (BIHAP) / closed loop
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pancreatic Cancer, Diagnosis
The Application of Probe Confocal Laser Endomicroscopy in Pancreatic Tumor Surgery
Aim of the study: To evaluate the value of Probe Confocal Laser Endomicroscopy (PCLE) in surgery for pancreatic tumor. Methods: Patients who are diagnosed with pancreatic tumor based on preoperative radiographic findings and will…
- Conditions
- Pancreatic Cancer, Diagnosis, Pancreatoduodenectomy, Distal Pancreatectomy
- Trial name
- NCT06289803
- Testing
- probe confocal laser endomicroscopy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Pancreatic Cancer, Patient Reported Outcome Measures
Patient Reported Outcomes Measures to Predict Pancreatic Surgery Outcomes
This is a prospective single-center observational study with the mail objective to identify specific subgroups of patients planned for pancreatic resection, at high risk for postoperative morbidity and impaired recovery through…
- Conditions
- Pancreatic Cancer, Patient Reported Outcome Measures, Quality of Life, Pancreatectomy
- Trial name
- PRO-PANC1 (NCT04431076)
- Where
- Italy
- Volunteers
- 560 people
- Sponsor
- Massimo Falconi
Pancreas Cancer, Pancreatectomy
Gastric Venous Reconstruction After Total Pancreatectomy
Total pancreatoduodenectomy (TP) is the standard surgical approach for treatment of extended pancreas tumors. If the gastric coronary vein has to be sacrificed for oncologic or for technical reasons in total pancreatectomy with…
- Trial name
- GENDER (NCT04850430)
- Testing
- Gastric venous reconstruction
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Postoperative Pancreatic Fistula, Distal Pancreatectomy
Prophylactic Abdominal Drainage vs no Drainage After Distal Pancreatectomy
Postoperative pancreatic fistula (POPF) is a major source of morbidity and mortality after pancreatic resection, especially after distal pancreatectomy (PD).
- Conditions
- Postoperative Pancreatic Fistula, Distal Pancreatectomy, Drainage
- Trial name
- PANDREAS (NCT06141044)
- Testing
- Avoid surgical drainage
- Volunteers
- 104 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra