Distal PancreatectomyNCT06814249
A Prospective Cohort Study on Ligation of Pancreatic Stump After Distal Pancreatectomy
A study testing ligation of pancreatic stump with a quantified force and Manual suturing or stapling closure. in people with Distal Pancreatectomy and Postoperative Pancreatic Fistula, run by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology at 1 site in China.
Trial summary
The goal of this clinical trial is to learn if igation of pancreatic stump with quantified force works in decrease postoperative pancreatic fistula following distal pancreatectomy. The main outcome measures are: Postoperative pancreatic fistula; Postoperative hospital stay. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Distal Pancreatectomy, Postoperative Pancreatic Fistula
- What is being tested?
- ligation of pancreatic stump with a quantified force and Manual suturing or stapling closure.
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteChina
- Study dates
- 21 Nov 2024to 31 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients fully understand this study, voluntarily participate, and sign the Informed Consent Form (ICF);
- Age between 18 and 75 years old;
- Planned for distal pancreatectomy (including body and tail of the pancreas);
- The intended pancreatic transection line is located on the left side of the portal vein.
Who cannot join
- History of previous pancreatic surgery;
- Additional surgical procedures required for the residual pancreas;
- Proximal pancreatic duct obstruction, with planned anastomosis between the residual pancreas and the digestive tract;
- Use of long-acting somatostatin analogues during the perioperative period;
- Patients who are judged by the investigator to be unsuitable for participation in this study.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Prospective Cohort Study on Ligation of Pancreatic Stump With Quantified Force During Distal Pancreatectomy
The goal of this clinical trial is to learn if igation of pancreatic stump with quantified force works in decrease postoperative pancreatic fistula following distal pancreatectomy. The main outcome measures are:
Postoperative pancreatic fistula; Postoperative hospital stay.
Researchers will compare ligation to other pancreatic stump closure techniques to see if it decrease postoperative pancreatic fistula and postoperative hospital stay following distal pancreatectomy.
Read the detailed description
Introduction The closure of pancreatic stump after distal pancreatectomy remains controversial. Currently, the main methods of pancreatic stump closure include manual suturing and stapler closure. However, both methods carry a high risk of pancreatic fistula, which may be associated with the difficulty of balancing the provision of sufficient pancreatic duct burst pressure and ensuring blood supply to the stump. Through in vitro experiments, we demonstrated that applying quantified ligation forces to pancreatic stumps can provide a pancreatic duct burst pressure of approximately 50-70 mmHg. This burst pressure is higher than the upper limit of normal pancreatic duct pressure and lower than the normal mean arterial pressure, theoretically balancing the pancreatic duct burst pressure and stump blood supply. Therefore, we designed this prospective cohort study to verify the above hypothesis.
Methods and analysis This is a prospective cohort study at single centre in China. The major eligibility criterion is the presence of lesions planned for distal pancreatectomy. The texture of the pancreas was determined by the surgeon and the first assistant during the operation as soft, medium, or hard. After severing the pancreas, the pancreas was ligated at 5 mm from the pancreatic stump with a quantified force. Postoperative regular follow-up will be performed. The primary outcomes included pancreatic fistula and postoperative hospital stay, and the secondary outcomes included intra-abdominal infection, incision infection, and postoperative treatment costs. The primary outcomes and secondary outcomes of patients in this cohort will be statistically compared with historical data using appropriate tests.
Ethics and dissemination The study has been approved by the Ethics Committee of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology(2024-0833-02). The results of the study will be published in an international peer-reviewed journal.
- Being tested
- ligation of pancreatic stump with a quantified force, Manual suturing or stapling closure.
- Keywords
- Pancreatic surgery, Distal pancreatectomy, Pancreatic texture, Pancreatic stump ligation, Postoperative pancreatic fistula
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ligation of pancreatic stump with a quantified forceOther
After severing the pancreas, the pancreas was ligated at 5 mm from the pancreatic stump with a quantified force.
Manual suturing or stapling closure.Other
Handle the pancreatic stump according to conventional methods (manual suturing or stapling closure).
| Study group | Role | What they receive |
|---|---|---|
| Experimental group | Experimental | After severing the pancreas, the pancreas was ligated at 5 mm from the pancreatic stump with a quantified force. Receives: Other: ligation of pancreatic stump with a quantified force |
| Control group | Active comparator | Handle the pancreatic stump according to conventional methods (manual suturing or stapling closure). Receives: Other: Manual suturing or stapling closure. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pancreatic fistula
Postoperative pancreatic fistula adopts the definition proposed by the International Study Group of Pancreatic Surgery.
Measured: Up to half a year from enrollment
Postoperative hospital stay
Stay from operation to discharge.
Measured: Up to half a year from enrollment
Secondary outcomes (3)
Intra-abdominal infection
Intra-abdominal infection is evaluated based on Common Terminology Criteria for Adverse Event (CTCAE) V.5.0.
Measured: Up to half a year from enrollment
Incision infection
Incision infection is evaluated based on Common Terminology Criteria for Adverse Event (CTCAE) V.5.0.
Measured: Up to half a year from enrollment
Postoperative treatment costs
Treatment costs of postoperative period.
Measured: Up to half a year from enrollment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Feb 2025
- Study start21 Nov 2024
- Primary completion30 Sep 2025 (estimated)
- Study completion31 Oct 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (23)Papers the sponsor has linked to this study.
- Other trials for Distal PancreatectomyStudies of the same condition, open and under way.
- More trials run by Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Shanmiao Gou, MD, Ph.D, Principal investigator, Union Hospital, HUST, Wuhan, China
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06814249
- Sponsor's protocol ID
- PS-PF
- Status last verified
- Oct 2024
- First submitted
- 20 Dec 2024
- Last updated
- 26 Feb 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Kaneda Y, Kimura Y, Saito A, Ae R, Kawahira H, Sata N. Pancreas Ligation Device for Distal Pancreatectomy: An Ex Vivo Follow-Up Porcine Study. Cureus. 2023 Sep 6;15(9):e44771. doi: 10.7759/cureus.44771. eCollection 2023 Sep.
PubMed 37692176Funamizu N, Sogabe K, Shine M, Honjo M, Sakamoto A, Nishi Y, Matsui T, Uraoka M, Nagaoka T, Iwata M, Ito C, Tamura K, Sakamoto K, Ogawa K, Takada Y. Association between the Preoperative C-Reactive Protein-to-Albumin Ratio and the Risk for Postoperative Pancreatic Fistula following Distal Pancreatectomy for Pancreatic Cancer. Nutrients. 2022 Dec 10;14(24):5277. doi: 10.3390/nu14245277.
PubMed 36558435Mungroop TH, van der Heijde N, Busch OR, de Hingh IH, Scheepers JJ, Dijkgraaf MG, Groot Koerkamp B, Besselink MG, van Eijck CH. Randomized clinical trial and meta-analysis of the impact of a fibrin sealant patch on pancreatic fistula after distal pancreatectomy: CPR trial. BJS Open. 2021 May 7;5(3):zrab001. doi: 10.1093/bjsopen/zrab001.
PubMed 34137446Matsuda T, Kawai C, Sakurai T. [NMR blood flow measurement and NMR angiography]. Nihon Rinsho. 1987 Jan;45(1):60-6. No abstract available. Japanese.
PubMed 3820687Abe K, Kitago M, Shinoda M, Yagi H, Abe Y, Oshima G, Hori S, Yokose T, Endo Y, Kitagawa Y. High risk pathogens and risk factors for postoperative pancreatic fistula after pancreatectomy; a retrospective case-controlled study. Int J Surg. 2020 Oct;82:136-142. doi: 10.1016/j.ijsu.2020.08.035. Epub 2020 Aug 27.
PubMed 32861892Miao Y, Lu Z, Yeo CJ, Vollmer CM Jr, Fernandez-Del Castillo C, Ghaneh P, Halloran CM, Kleeff J, de Rooij T, Werner J, Falconi M, Friess H, Zeh HJ, Izbicki JR, He J, Laukkarinen J, Dejong CH, Lillemoe KD, Conlon K, Takaori K, Gianotti L, Besselink MG, Del Chiaro M, Montorsi M, Tanaka M, Bockhorn M, Adham M, Olah A, Salvia R, Shrikhande SV, Hackert T, Shimosegawa T, Zureikat AH, Ceyhan GO, Peng Y, Wang G, Huang X, Dervenis C, Bassi C, Neoptolemos JP, Buchler MW; International Study Group of Pancreatic Surgery (ISGPS). Management of the pancreatic transection plane after left (distal) pancreatectomy: Expert consensus guidelines by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2020 Jul;168(1):72-84. doi: 10.1016/j.surg.2020.02.018. Epub 2020 Apr 2.
PubMed 32249092Rozich NS, Morris KT, Garwe T, Sarwar Z, Landmann A, Siems CB, Jones A, Butler CS, McGaha PK, Axtman BC, Edil BH, Lees JS. Blame it on the injury: Trauma is a risk factor for pancreatic fistula following distal pancreatectomy compared with elective resection. J Trauma Acute Care Surg. 2019 Dec;87(6):1289-1300. doi: 10.1097/TA.0000000000002495.
PubMed 31765347Ratnayake CBB, Wells C, Hammond J, French JJ, Windsor JA, Pandanaboyana S. Network meta-analysis comparing techniques and outcomes of stump closure after distal pancreatectomy. Br J Surg. 2019 Nov;106(12):1580-1589. doi: 10.1002/bjs.11291. Epub 2019 Oct 18.
PubMed 31626341Nagakawa Y, Hijikata Y, Osakabe H, Matsudo T, Soya R, Sahara Y, Takishita C, Shirota T, Kobayashi N, Nakajima T, Hosokawa Y, Ishizaki T, Katsumata K, Tsuchida A. Why Does Postoperative Pancreatic Fistula Occur After Hand-sewn Parenchymal Closure and Staple Closure in Distal Pancreatectomy? Surg Laparosc Endosc Percutan Tech. 2019 Apr;29(2):e15-e19. doi: 10.1097/SLE.0000000000000604.
PubMed 30520812de Rooij T, van Hilst J, van Santvoort H, Boerma D, van den Boezem P, Daams F, van Dam R, Dejong C, van Duyn E, Dijkgraaf M, van Eijck C, Festen S, Gerhards M, Groot Koerkamp B, de Hingh I, Kazemier G, Klaase J, de Kleine R, van Laarhoven C, Luyer M, Patijn G, Steenvoorde P, Suker M, Abu Hilal M, Busch O, Besselink M; Dutch Pancreatic Cancer Group. Minimally Invasive Versus Open Distal Pancreatectomy (LEOPARD): A Multicenter Patient-blinded Randomized Controlled Trial. Ann Surg. 2019 Jan;269(1):2-9. doi: 10.1097/SLA.0000000000002979.
PubMed 30080726Ecker BL, McMillan MT, Allegrini V, Bassi C, Beane JD, Beckman RM, Behrman SW, Dickson EJ, Callery MP, Christein JD, Drebin JA, Hollis RH, House MG, Jamieson NB, Javed AA, Kent TS, Kluger MD, Kowalsky SJ, Maggino L, Malleo G, Valero V 3rd, Velu LKP, Watkins AA, Wolfgang CL, Zureikat AH, Vollmer CM Jr. Risk Factors and Mitigation Strategies for Pancreatic Fistula After Distal Pancreatectomy: Analysis of 2026 Resections From the International, Multi-institutional Distal Pancreatectomy Study Group. Ann Surg. 2019 Jan;269(1):143-149. doi: 10.1097/SLA.0000000000002491.
PubMed 28857813Chang YR, Kang JS, Jang JY, Jung WH, Kang MJ, Lee KB, Kim SW. Prediction of Pancreatic Fistula After Distal Pancreatectomy Based on Cross-Sectional Images. World J Surg. 2017 Jun;41(6):1610-1617. doi: 10.1007/s00268-017-3872-3.
PubMed 28091744Jang JY, Shin YC, Han Y, Park JS, Han HS, Hwang HK, Yoon DS, Kim JK, Yoon YS, Hwang DW, Kang CM, Lee WJ, Heo JS, Kang MJ, Chang YR, Chang J, Jung W, Kim SW. Effect of Polyglycolic Acid Mesh for Prevention of Pancreatic Fistula Following Distal Pancreatectomy: A Randomized Clinical Trial. JAMA Surg. 2017 Feb 1;152(2):150-155. doi: 10.1001/jamasurg.2016.3644.
PubMed 27784046Noorani A, Rangelova E, Del Chiaro M, Lundell LR, Ansorge C. Delayed Gastric Emptying after Pancreatic Surgery: Analysis of Factors Determinant for the Short-term Outcome. Front Surg. 2016 Apr 25;3:25. doi: 10.3389/fsurg.2016.00025. eCollection 2016.
PubMed 27200357Mendoza AS 3rd, Han HS, Ahn S, Yoon YS, Cho JY, Choi Y. Predictive factors associated with postoperative pancreatic fistula after laparoscopic distal pancreatectomy: a 10-year single-institution experience. Surg Endosc. 2016 Feb;30(2):649-656. doi: 10.1007/s00464-015-4255-1. Epub 2015 Jun 20.
PubMed 26091993
Study at a glance
From the registry record, last updated by the sponsor on 26 Feb 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Prospective Cohort Study on Ligation of Pancreatic Stump With Quantified Force During Distal Pancreatectomy
- ClinicalTrials.gov ID
- NCT06814249
- Acronym / sponsor ID
- PS-PF
- Keywords
- Pancreatic surgery, Distal pancreatectomy, Pancreatic texture, Pancreatic stump ligation, Postoperative pancreatic fistula
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyUniversity, hospital or other
- Study start
- 21 Nov 2024 (actual)
- Primary completion
- 30 Sep 2025 (estimated)
- Study completion
- 31 Oct 2025 (estimated)
- First posted
- 7 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn if igation of pancreatic stump with quantified force works in decrease postoperative pancreatic fistula following distal pancreatectomy. The main outcome measures are:
Postoperative pancreatic fistula; Postoperative hospital stay.
Researchers will compare ligation to other pancreatic stump closure techniques to see if it decrease postoperative pancreatic fistula and postoperative hospital stay following distal pancreatectomy.
Detailed description
Introduction The closure of pancreatic stump after distal pancreatectomy remains controversial. Currently, the main methods of pancreatic stump closure include manual suturing and stapler closure. However, both methods carry a high risk of pancreatic fistula, which may be associated with the difficulty of balancing the provision of sufficient pancreatic duct burst pressure and ensuring blood supply to the stump. Through in vitro experiments, we demonstrated that applying quantified ligation forces to pancreatic stumps can provide a pancreatic duct burst pressure of approximately 50-70 mmHg. This burst pressure is higher than the upper limit of normal pancreatic duct pressure and lower than the normal mean arterial pressure, theoretically balancing the pancreatic duct burst pressure and stump blood supply. Therefore, we designed this prospective cohort study to verify the above hypothesis.
Methods and analysis This is a prospective cohort study at single centre in China. The major eligibility criterion is the presence of lesions planned for distal pancreatectomy. The texture of the pancreas was determined by the surgeon and the first assistant during the operation as soft, medium, or hard. After severing the pancreas, the pancreas was ligated at 5 mm from the pancreatic stump with a quantified force. Postoperative regular follow-up will be performed. The primary outcomes included pancreatic fistula and postoperative hospital stay, and the secondary outcomes included intra-abdominal infection, incision infection, and postoperative treatment costs. The primary outcomes and secondary outcomes of patients in this cohort will be statistically compared with historical data using appropriate tests.
Ethics and dissemination The study has been approved by the Ethics Committee of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology(2024-0833-02). The results of the study will be published in an international peer-reviewed journal.
Study design
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Experimental group | Experimental | Other: ligation of pancreatic stump with a quantified forceAfter severing the pancreas, the pancreas was ligated at 5 mm from the pancreatic stump with a quantified force. |
| Control group | Active comparator | Other: Manual suturing or stapling closure.Handle the pancreatic stump according to conventional methods (manual suturing or stapling closure). |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Patients fully understand this study, voluntarily participate, and sign the Informed Consent Form (ICF);
- Age between 18 and 75 years old;
- Planned for distal pancreatectomy (including body and tail of the pancreas);
- The intended pancreatic transection line is located on the left side of the portal vein.
Key exclusion criteria (5 listed)
- History of previous pancreatic surgery;
- Additional surgical procedures required for the residual pancreas;
- Proximal pancreatic duct obstruction, with planned anastomosis between the residual pancreas and the digestive tract;
- Use of long-acting somatostatin analogues during the perioperative period;
- Patients who are judged by the investigator to be unsuitable for participation in this study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ligation of pancreatic stump with a quantified forceAfter severing the pancreas, the pancreas was ligated at 5 mm from the pancreatic stump with a quantified force. | Other | Experimental group |
| Manual suturing or stapling closure.Handle the pancreatic stump according to conventional methods (manual suturing or stapling closure). | Other | Control group |
Primary outcome
Pancreatic fistula
Time frame: Up to half a year from enrollment
Postoperative pancreatic fistula adopts the definition proposed by the International Study Group of Pancreatic Surgery.
Postoperative hospital stay
Time frame: Up to half a year from enrollment
Stay from operation to discharge.
3 secondary outcomes
Intra-abdominal infection
Time frame: Up to half a year from enrollment
Incision infection
Time frame: Up to half a year from enrollment
Postoperative treatment costs
Time frame: Up to half a year from enrollment
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Feb 2025.
- Background: PubMed 37692176Kaneda Y, Kimura Y, Saito A, Ae R, Kawahira H, Sata N. Pancreas Ligation Device for Distal Pancreatectomy: An Ex Vivo Follow-Up Porcine Study. Cureus. 2023 Sep 6;15(9):e44771. doi: 10.7759/cureus.44771. eCollection 2023 Sep.
- Background: PubMed 36558435Funamizu N, Sogabe K, Shine M, Honjo M, Sakamoto A, Nishi Y, Matsui T, Uraoka M, Nagaoka T, Iwata M, Ito C, Tamura K, Sakamoto K, Ogawa K, Takada Y. Association between the Preoperative C-Reactive Protein-to-Albumin Ratio and the Risk for Postoperative Pancreatic Fistula following Distal Pancreatectomy for Pancreatic Cancer. Nutrients. 2022 Dec 10;14(24):5277. doi: 10.3390/nu14245277.
- Background: PubMed 34137446Mungroop TH, van der Heijde N, Busch OR, de Hingh IH, Scheepers JJ, Dijkgraaf MG, Groot Koerkamp B, Besselink MG, van Eijck CH. Randomized clinical trial and meta-analysis of the impact of a fibrin sealant patch on pancreatic fistula after distal pancreatectomy: CPR trial. BJS Open. 2021 May 7;5(3):zrab001. doi: 10.1093/bjsopen/zrab001.
- Background: PubMed 3820687Matsuda T, Kawai C, Sakurai T. [NMR blood flow measurement and NMR angiography]. Nihon Rinsho. 1987 Jan;45(1):60-6. No abstract available. Japanese.
- Background: PubMed 32861892Abe K, Kitago M, Shinoda M, Yagi H, Abe Y, Oshima G, Hori S, Yokose T, Endo Y, Kitagawa Y. High risk pathogens and risk factors for postoperative pancreatic fistula after pancreatectomy; a retrospective case-controlled study. Int J Surg. 2020 Oct;82:136-142. doi: 10.1016/j.ijsu.2020.08.035. Epub 2020 Aug 27.
- Background: PubMed 32249092Miao Y, Lu Z, Yeo CJ, Vollmer CM Jr, Fernandez-Del Castillo C, Ghaneh P, Halloran CM, Kleeff J, de Rooij T, Werner J, Falconi M, Friess H, Zeh HJ, Izbicki JR, He J, Laukkarinen J, Dejong CH, Lillemoe KD, Conlon K, Takaori K, Gianotti L, Besselink MG, Del Chiaro M, Montorsi M, Tanaka M, Bockhorn M, Adham M, Olah A, Salvia R, Shrikhande SV, Hackert T, Shimosegawa T, Zureikat AH, Ceyhan GO, Peng Y, Wang G, Huang X, Dervenis C, Bassi C, Neoptolemos JP, Buchler MW; International Study Group of Pancreatic Surgery (ISGPS). Management of the pancreatic transection plane after left (distal) pancreatectomy: Expert consensus guidelines by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2020 Jul;168(1):72-84. doi: 10.1016/j.surg.2020.02.018. Epub 2020 Apr 2.
- Background: PubMed 31765347Rozich NS, Morris KT, Garwe T, Sarwar Z, Landmann A, Siems CB, Jones A, Butler CS, McGaha PK, Axtman BC, Edil BH, Lees JS. Blame it on the injury: Trauma is a risk factor for pancreatic fistula following distal pancreatectomy compared with elective resection. J Trauma Acute Care Surg. 2019 Dec;87(6):1289-1300. doi: 10.1097/TA.0000000000002495.
- Background: PubMed 31626341Ratnayake CBB, Wells C, Hammond J, French JJ, Windsor JA, Pandanaboyana S. Network meta-analysis comparing techniques and outcomes of stump closure after distal pancreatectomy. Br J Surg. 2019 Nov;106(12):1580-1589. doi: 10.1002/bjs.11291. Epub 2019 Oct 18.
- Background: PubMed 30520812Nagakawa Y, Hijikata Y, Osakabe H, Matsudo T, Soya R, Sahara Y, Takishita C, Shirota T, Kobayashi N, Nakajima T, Hosokawa Y, Ishizaki T, Katsumata K, Tsuchida A. Why Does Postoperative Pancreatic Fistula Occur After Hand-sewn Parenchymal Closure and Staple Closure in Distal Pancreatectomy? Surg Laparosc Endosc Percutan Tech. 2019 Apr;29(2):e15-e19. doi: 10.1097/SLE.0000000000000604.
- Background: PubMed 30080726de Rooij T, van Hilst J, van Santvoort H, Boerma D, van den Boezem P, Daams F, van Dam R, Dejong C, van Duyn E, Dijkgraaf M, van Eijck C, Festen S, Gerhards M, Groot Koerkamp B, de Hingh I, Kazemier G, Klaase J, de Kleine R, van Laarhoven C, Luyer M, Patijn G, Steenvoorde P, Suker M, Abu Hilal M, Busch O, Besselink M; Dutch Pancreatic Cancer Group. Minimally Invasive Versus Open Distal Pancreatectomy (LEOPARD): A Multicenter Patient-blinded Randomized Controlled Trial. Ann Surg. 2019 Jan;269(1):2-9. doi: 10.1097/SLA.0000000000002979.
- Background: PubMed 28857813Ecker BL, McMillan MT, Allegrini V, Bassi C, Beane JD, Beckman RM, Behrman SW, Dickson EJ, Callery MP, Christein JD, Drebin JA, Hollis RH, House MG, Jamieson NB, Javed AA, Kent TS, Kluger MD, Kowalsky SJ, Maggino L, Malleo G, Valero V 3rd, Velu LKP, Watkins AA, Wolfgang CL, Zureikat AH, Vollmer CM Jr. Risk Factors and Mitigation Strategies for Pancreatic Fistula After Distal Pancreatectomy: Analysis of 2026 Resections From the International, Multi-institutional Distal Pancreatectomy Study Group. Ann Surg. 2019 Jan;269(1):143-149. doi: 10.1097/SLA.0000000000002491.
- Background: PubMed 28091744Chang YR, Kang JS, Jang JY, Jung WH, Kang MJ, Lee KB, Kim SW. Prediction of Pancreatic Fistula After Distal Pancreatectomy Based on Cross-Sectional Images. World J Surg. 2017 Jun;41(6):1610-1617. doi: 10.1007/s00268-017-3872-3.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Shanmiao Gou, MD, Ph.D principal investigator
Union Hospital, HUST, Wuhan, China
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ligation of pancreatic stump with a quantified force and Manual suturing or stapling closure. in people with Distal Pancreatectomy and Postoperative Pancreatic Fistula, run by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 26 Feb 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pancreatic fistula (time frame: Up to half a year from enrollment). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06814249, which also lists 23 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Feb 2025.