Clinical trials: Pancreatectomy
Pancreatic Neoplasm
Endocrine-exocrine Functions and Prognosis After Pancreatectomy
Pancreatic diseases often require surgery or invasive procedures to provide a chance for a cure. However, due to the pancreas's unique anatomical structure, its relative position to adjacent organs, and its dual endocrine and…
- Trial name
- NCT07396662
- Testing
- pancreatectomy
- Where
- Taiwan
- Volunteers
- 3,500 people
- Sponsor
- National Taiwan University Hospital
Exocrine Pancreatic Insufficiency
Registry of Pancreatic Exocrine Insufficiency: Enzyme Dose Requirements and Outcomes in Pancreatic Exocrine Insufficiency Across Aetiologies
EURO-PEI is a multicentre, observational registry conducted at eight specialist pancreatic centres in Spain, Hungary, France, Italy, and the United Kingdom.
- Trial name
- EURO-PEI regis (NCT05450627)
- Testing
- Pancreatic Enzyme
- Where
- Spain
- Volunteers
- 1,015 people
- Sponsor
- Hospital Clinico Universitario de Santiago
Pancreatitis, Chronic; Diabetes; Transplant
Anti-inflammatory Therapy to Improve Outcomes After TPIAT
Patients with severe chronic pancreatitis may be candidates to have their pancreas removed and their islets transplanted into the liver to reduce the risk of diabetes mellitus, a procedure called total pancreatectomy with islet…
- Trial name
- NCT02713997
- Testing
- etanercept, Alpha 1-Antitrypsin
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Minnesota
Distal Pancreatectomy
Textbook Outcome in Distal Pancreatectomy
The auditing of results and improving the quality of care are key aspects of surgical activity. Patients, hospitals and health institutions need information on the results obtained with specific procedures.
- Trial name
- TO-ERPANDIS (NCT05423288)
- Testing
- Distal pancreatectomy (DP)
- Volunteers
- 450 people
- Sponsor
- Universidad de Extremadura
Distal Pancreatectomy
TissueLink Versus SEAMGUARD After Distal Pancreatectomy
The purpose of this research study is to find a lowest leak rate following a distal pancreatectomy (removal of the left side of the pancreas).
- Trial name
- PLATS (NCT01051856)
- Testing
- SEAMGUARD with bioabsorbable staple, TissueLink with radiofrequency ablation
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- Mayo Clinic
Pancreatectomy, Fluid Therapy
Comparison of Fluid Requirements in Pancreatectomy: Laparotomy vs. Laparoscopy
In this retrospective cohort study, the investigators reviewed and analyzed the electronic medical records of consecutive patients who underwent distal pancreatectomy either via laparotomy or laparoscopy.
- Conditions
- Pancreatectomy, Fluid Therapy, Laparoscopy
- Trial name
- NCT03060408
- Volunteers
- 304 people
- Sponsor
- Seoul National University Bundang Hospital
Pancreatic Leak, Pancreatic Fistula
A Phase II Trial of Lanreotide for the Prevention of Postoperative Pancreatic Fistula
This is a single arm investigator-initiated study designed to test the feasibility and potential efficacy of preoperative lanreotide to reduce the risk of postoperative abscess or pancreatic leak and fistula.
- Conditions
- Pancreatic Leak, Pancreatic Fistula, Pancreaticoduodenal; Fistula, Pancreatectomy; Hyperglycemia
- Trial name
- NCT03174353
- Testing
- Lanreotide Prefilled Syringe
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- University of Washington
Pancreatoduodenectomy, Periampullary Carcinoma
Application of "Heidelberg Triangle" Dissection in Pancreatoduodenectomy and Distal Pancreatectomy
Aim of the study : To evaluate the effect and safety of "Heidelberg Triangle" dissection (TRIANGLE operation) combined with Pancreatoduodenectomy or Distal Pancreatectomy on the prognosis of pancreatic cancer and periampullary…
- Conditions
- Pancreatoduodenectomy, Periampullary Carcinoma, Pancreatic Cancer
- Trial name
- NCT05703581
- Testing
- TRIANGLE operation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Type 1 Diabetes, Pancreatectomy; Hyperglycemia
Collection of Human Liver Biopsy and Whole Blood Samples From T1DM, TP or PP Patients for Potential Use for Insulin Producing Cells in Future Clinical Studies
In this study, liver samples will be collected, processed and stored in a specialized, clinical grade, cell bank for potential future clinical use.
- Trial name
- NCT04038931
- Testing
- Liver biopsy collection
- Volunteers
- 20 people
- Sponsor
- Orgenesis Ltd.
Pancreatic Cancer, Surgery
Laparoscopic vs Open Pancreatectomy for Body and Tail Pancreatic Cancer
Open distal pancreatectomy (ODP) has been commonly employed for the treatment of a variety of cancers in body and tail of pancreas.
- Conditions
- Pancreatic Cancer, Surgery, Laparoscopy
- Trial name
- NCT03792932
- Testing
- Laparoscopic distal pancreatectomy, Open distal pancreatectomy
- Where
- 11 sites in China
- Volunteers
- 306 people
- Sponsor
- Fudan University
Distal Pancreatectomy (DP)
REinforcement of the Pancreas in distaL pAncreatectomY (REPLAY)
Despite an improvement regarding morbidity and mortality since 30 years, especially in expert centers, pancreatic surgery remains currently associated to a significant postoperative morbidity reaching more than 60%.
- Trial name
- REPLAY (NCT03030170)
- Testing
- ENDO GIA X-tra Thick reload with Tri Staple Technology, ENDO GIA Articulating Reinforced Reload with Tri-Staple Technology
- Where
- 7 sites in France
- Volunteers
- 207 people
- Sponsor
- Rennes University Hospital
Distal Pancreatectomy, Postoperative Pancreatic Fistula
A Prospective Cohort Study on Ligation of Pancreatic Stump After Distal Pancreatectomy
The goal of this clinical trial is to learn if igation of pancreatic stump with quantified force works in decrease postoperative pancreatic fistula following distal pancreatectomy.
- Trial name
- NCT06814249
- Testing
- ligation of pancreatic stump with a quantified force, Manual suturing or stapling closure.
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Pancreatectomy, Pancreatoduodenectomy
Twenty Years of Pancreatic Surgery in Iceland
A retrospective analysis of patients undergoing pancreatic operations in Landspitali University Hospital, Reykjavik, Iceland, between 2003 and 2022.
- Conditions
- Pancreatectomy, Pancreatoduodenectomy, Distal Pancreatectomy (DP)
- Trial name
- NCT06738914
- Volunteers
- 244 people
- Sponsor
- Linkoeping University
Pancreas Disease
Minimally Invasive Robot-assisted and Laparoscopic Distal Pancreatectomy in a Pan-European Registry
A planned analysis of outcomes among consecutive patients after MIDP from centers participating in the E-MIPS registry (2019-2021).
- Trial name
- NCT06160154
- Testing
- no intervention
- Where
- Netherlands
- Volunteers
- 1,672 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pancreaticoduodenectomy, Distal Pancreatectomy
The Novel Modified Cattell-Warren Duct-To-Mucosa Pancreaticojejunostomy Technique Significantly Reduces POPF.
Pancreatic surgeries, such as pancreaticoduodenectomy and distal pancreatectomy, are associated with high morbidity and mortality. The most common cause of this morbidity is postoperative pancreatic fistula(POPF).
- Conditions
- Pancreaticoduodenectomy, Distal Pancreatectomy, Postoperative Pancreatic Fistula
- Trial name
- POPF (NCT07038161)
- Testing
- Modified Cattell-Warren duct-to-mucosa pancreaticojejunostomy, Institutional Prehabilitation Protocol
- Where
- Nepal
- Volunteers
- 27 people
- Sponsor
- Nepal Medical College and Teaching Hospital
Hepatocellular Carcinoma, Pancreas Cancer
Scheduled Meditation for Improving Postoperative Outcomes in Patients Undergoing Pancreatectomy
This clinical trial tests the feasibility and how well a scheduled meditation intervention works to improve postoperative outcomes such as pain, anxiety, insomnia, stress and mobility for patients undergoing pancreatectomy.
- Conditions
- Hepatocellular Carcinoma, Pancreas Cancer, Biliary Tract Neoplasms
- Trial name
- NCT07608458
- Testing
- Actigraphy, Online Mindfulness Meditation, Smartphone Application-based Intervention
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- City of Hope Medical Center
Pancreatic Neoplasms
Reinforced Staple Line on Leak Rate in Distal Pancreatectomy
The investigators propose a randomized, controlled trial of stapled pancreatic transection versus mesh reinforced stapled pancreatic transection.
- Trial name
- NCT01359410
- Testing
- Mesh reinforced staple line (SEAMGUARD), Stapled without mesh reinforcement (PER-STRIPS DRY)
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Washington University School of Medicine
Islets of Langerhans Transplantation, Pancreatitis, Chronic
Clinical Outcome After Total Pancreatectomy With Islet Autotransplantation
A total pancreatectomy with islet autotransplantation (TPIAT) can be performed for a number of benign indications, such as chronic pancreatitis.
- Conditions
- Islets of Langerhans Transplantation, Pancreatitis, Chronic, Diabetes Mellitus
- Trial name
- TOPPER (NCT05287737)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Leiden University Medical Center
Colectomy, Pancreatectomy
Implementation of a GDT Algorithm for Major Surgery Patients
This study examines the effect of an algorithm for GDT for patients undergoing major surgery under routine conditions.
- Conditions
- Colectomy, Pancreatectomy, Fluid Therapy
- Trial name
- NCT02509910
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Philipps University Marburg
PDAC of the Body and the Tail of the Pancreas, CR- POPF
Oncologic Impact of Pancreatic Fistula
Clinically-relevant post-operative fistula is a major complication after DP, but it did not affect post-operative therapeutic path nor oncologic long-term outcomes.
- Trial name
- POPF-DSS (NCT04348084)
- Where
- France
- Volunteers
- 382 people
- Sponsor
- University Hospital, Montpellier