Clinical trials: Pancreatic Cancer, Resected
Pancreatic Cancer
Vaccine Therapy With or Without Cyclophosphamide in Treating Patients Undergoing Chemotherapy and Radiation Therapy for Stage I or Stage II Pancreatic Cancer That Can Be Removed by Surgery
RATIONALE: Vaccines made from gene-modified tumor cells may help the body build an effective immune response to kill pancreatic cancer cells.
- Trial name
- NCT00727441
- Testing
- GVAX pancreatic cancer vaccine, cyclophosphamide
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pancreatic Cancer, Multivisceral Pancreatic Resections
Multivisceral Oncological Resections Involving the Pancreas - An International Multicenter Study
Background: Complete resection is the primary curative option for most non-metastatic solid malignancies. Locally advanced stages, involving adjacent organs or structures, may require multivisceral resection.
- Trial name
- MORIP-AIMS (NCT07091097)
- Where
- Germany
- Volunteers
- 1,283 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Pancreatic Cancer
Combination Chemotherapy Followed by Chemotherapy and Radiation Therapy and/or Surgery in Treating Patients Who Have Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug with radiation therapy and/or surgery may kill more tumor cells.
- Trial name
- NCT00003332
- Testing
- cisplatin, gemcitabine hydrochloride, surgical procedure
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- NYU Langone Health
Pancreatic Cancer
A Study of Gemcitabine/Nab-paclitaxel and Radiation Therapy Followed by Surgery in Patients With Advanced Pancreatic Cancer
This is a phase 1 (the first phase in testing a new drug, to see how safe a new drug or new indication/population ) and phase 2 (the second phase in testing a new drug or new indication/population to see how effective the drug…
- Trial name
- NCT02481635
- Testing
- Gemcitabine, Nab-paclitaxel, Radiation Therapy
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University Health Network, Toronto
Pancreatic Malignant Neoplasm Primary
Failure to Adjuvant Therapy After Pancreatic Resection for Pancreatic Cancer
This study aims to evaluate the rate of patients submitted to pancreatic resection for pancreatic cancer, who fail to access to adjuvant therapy or do not complete adjuvant therapy.
- Trial name
- FOUNTAIN (NCT03788382)
- Where
- Italy
- Volunteers
- 317 people
- Sponsor
- Universita di Verona
Pancreatic Cyst, Pancreatic Mucinous Cystic Neoplasm
Chemoprevention With Tamoxifen in Pre-Invasive Pancreas Mucinous Cystic Neoplasms Not Undergoing Immediate Resection
Pancreatic mucinous cystic neoplasm (MCN) is a precursor to invasive pancreatic adenocarcinoma which occurs almost exclusively in females in their 5th-7th decade.
- Trial name
- MCN_Tam (NCT06320990)
- Testing
- Tamoxifen 20mg
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Nebraska
PDAC, Pancreatoduodenectomy
Mesopancreas Study in Pancreatic Cancer
After the Introduction of the pathological circumferential resection margin (CRM status by LEEPP Protocol), residual cancer (R1 resection) was most often found in the dorsal and medial resection margins.
- Conditions
- PDAC, Pancreatoduodenectomy, Margin, Resection, Surgery
- Trial name
- MESOPANC-01 (NCT05895214)
- Testing
- oncological relevance of the mesopancreas
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Pancreatic Cancer
Study of Personalized Tumor Vaccines (PCVs) and a PD-L1 Blocker in Patients With Pancreatic Cancer That Can be Treated With Surgery
The purpose of this study is to evaluate the safety or treating pancreatic cancer with surgery to remove cancerour tissue, followed by atezolizumab, followed by a personalized cancer vaccine (PCV), and then with chemotherapy.
- Trial name
- NCT04161755
- Testing
- Atezolizumab, RO7198457, mFOLFIRINOX
- Where
- 7 sites in United States
- Volunteers
- 29 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Venous Thromboembolism, Pancreatic Cancer
Venous Thromboembolism in Primary Pancreatic Tumour Resection
This study will evaluate the development of venous thromboembolism (VTE) and possible determinants in patients with primary pancreatic cancer undergoing pancreatic cancer resection.
- Conditions
- Venous Thromboembolism, Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma
- Trial name
- PaTR-VTE (NCT05964621)
- Where
- Greece
- Volunteers
- 64 people
- Sponsor
- University of Thessaly
Pancreas Cancer
Molecular Profile-related Individualized Targeted Therapy in Resected Pancreatic Cancer With High-Risk of Cancer Recurrence
This is a prospective, open-label therapeutic interventional investigation designed to interrogate the efficacy and safety of individualized matched therapies in patients with pancreatic cancer at high risk of disease recurrence…
- Trial name
- PROTECT-PANC (NCT06228599)
- Testing
- Treatment Plan
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
Colorectal Neoplasms, Gastric Neoplasms
Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer
Background: Recent advances in cancer research have led to new therapies to treat the disease. It is important to continue these advances and discover new ones. To do that, researchers need tissue samples from solid tumors.
- Conditions
- Colorectal Neoplasms, Gastric Neoplasms, Cholangiocarcinoma, Bile Duct Cancer
- Trial name
- NCT01915225
- Where
- United States
- Volunteers
- 1,800 people
- Sponsor
- National Cancer Institute (NCI)
Pancreas Cancer
Electrochemotherapy of Posterior Resection Surface for Lowering Disease Recurrence Rate in Pancreatic Cancer (PanECT Study)
The aim of the study is to evaluate toxicity and effectiveness of electrochemotherapy (ECT) with bleomycin in pancreatic cancer in clinical study phase I and II.
- Trial name
- PanECT (NCT04281290)
- Testing
- Electrochemotherapy - electroporation with Cliniporator Vitae® and chemotherapy drug Bleomycin PHC 15 e. (United States Pharmacopeia - USP)
- Where
- Slovenia
- Volunteers
- 10 people
- Sponsor
- University Medical Centre Ljubljana
Pancreatic Cancer, Pancreatitis, Chronic
Enhancing Fitness Before Pancreatic Surgery
This is a pilot study to investigate the effect of prehabilitation on patients undergoing elective surgery for pancreatic disease.
- Trial name
- MedEx (NCT02940067)
- Testing
- MedEx
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Pancreatic Cyst
Study Using Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging in Patients With Pancreatic Cysts Undergoing Surgical Resection
To learn if Hyperpolarized C-Pyruvate Magnetic Resonance (HP-MR) Spectroscopic Imaging can help doctors detect low-risk (benign) and high-risk (malignant) cysts.
- Trial name
- NCT05873699
- Testing
- Hyperpolarized 13-C-pyruvate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Pancreatic Tumor, Benign, Solid Pseudopapillary Tumor of the Pancreas
Oncologic Safety and Lymphadenectomy in Parenchyma-Sparing Resection for SPN
Solid pseudopapillary neoplasm (SPN) of the pancreas is a low-grade malignant tumor primarily treated with surgical resection. However, the oncologic safety of parenchyma-sparing resection (PSR) and the necessity of…
- Trial name
- PSR for SPN (NCT07592663)
- Testing
- Parenchyma-sparing resection
- Where
- China
- Volunteers
- 708 people
- Sponsor
- Fudan University
Surgery, Liver Tumor
Evaluation of Resection Techniques for Pancreatic Tumors
The objective of this study is to compare open and minimally invasive pancreatic and liver resection techniques and analyze the different outcome variables from the clinical standpoint.
- Conditions
- Surgery, Liver Tumor, Pancreas Tumor
- Trial name
- NCT05128890
- Testing
- Resection techniques for pancreatic and liver tumors
- Where
- United States
- Volunteers
- 431 people
- Sponsor
- Methodist Health System
Pancreatic Cancer
Signature for Precise Chemosensitivity Prediction in PDAC
Pancreatic ductal adenocarcinoma (PDAC) is largely heterogeneous. We sought to develop and validate a signature to precisely predict chemotherapy sensitivity in PDAC.
- Trial name
- NCT06461598
- Testing
- Chemotherapy
- Where
- China
- Volunteers
- 365 people
- Sponsor
- Ruijin Hospital
Pancreatic Neoplasms, Pancreaticoduodenectomy
Benchmarking Outcomes in Pancreatic Surgery - WhippleBenchmarks.Org
The WhippleBenchmark 2 Collaborative study aims at defining benchmark criteria for best achievable outcomes after pancreaticoduodenectomy with portal vein resection.
- Trial name
- NCT04053998
- Testing
- Pancreaticoduodenectomy with portal vein resection
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 1,462 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Pancreatic Cancer
Study of Intratumoral Hypoxia Using Pre-operative Administration of Pimonidazole
This study involves the administration of a hypoxia marker, pimonidazole hydrochloride, taken orally approximately 24 hours before surgical resection of a pancreatic tumor in order to identify areas of lower oxygen content on…
- Trial name
- NCT01248637
- Testing
- Pimonidazole hydrochloride
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Pancreatic Cancer
Preoperative Chemotherapy (Gemcitabine and Erlotinib) With or Without Radiation Therapy
Primary Objective: To assess margin positive resection rate (R1 resection rate; defined as "tumor within 2 mm of surgical margin on final pathology report") in patients treated with preoperative chemotherapy (gemcitabine and…
- Trial name
- NCT00766636
- Testing
- Gemcitabine, Radiation Therapy, Erlotinib
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- M.D. Anderson Cancer Center