Clinical trials: Pancreatic Cancers
Pancreatic Cancer
Endoscopic Ultrasound (EUS) Guided Fine Needle Aspiration (FNA) EUS-FNA of Solid Pancreatic Mass Lesions Using a Novel Corkscrew Technique: a Pilot Study
This research is being done to investigate if a new technique to biopsy the pancreas will lead to a larger amount tissue material that can be analyzed.
- Trial name
- NCT02116322
- Testing
- EUS-FNA with Corkscrew technique, Expect 19 G Flex needle
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Johns Hopkins University
Resected Pancreatic Adenocarcinoma
Hyperthermia European Adjuvant Trial
Improvement of the clinical outcome in patients with resectable pancreatic carcinoma through an intensified adjuvant treatment with gemcitabine, cisplatin and regional deep hyperthermia as compared to standard chemotherapy.
- Trial name
- HEAT (NCT01077427)
- Testing
- Gemcitabine + Cisplatin + regional hyperthermia, Gemcitabine + Capecitabine
- Where
- Germany
- Volunteers
- 336 people
- Sponsor
- Klinikum der Universitaet Muenchen, Grosshadern
Chemotherapy-induced Peripheral Neuropathy, Colorectal Cancer Stage II
Effect of Hemp-CBD on Patients With CIPN
The purpose of this study is to assess the effect of a hemp-based cannabidiol (CBD) product, Ananda Hemp Spectrum Gelcaps, on the severity and duration of chemotherapy-induced neuropathy (CIPN) among non-metastatic breast…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Colorectal Cancer Stage II, Colorectal Cancer Stage III, Breast Cancer
- Trial name
- Coala-T-CBD (NCT04398446)
- Testing
- Hemp-based CBD
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Main Line Health
Colorectal Cancer, Pancreatic Cancer
KRAS Neoantigen Nanovaccine as Adjuvant Therapy for Colorectal Cancer/Pancreatic Cancer
This clinical trial will utilize a neoantigen nanovaccine constructed from the bacterial membranes of an engineered Lactococcus lactis strain (FOLactis).
- Trial name
- NCT07353645
- Testing
- KRAS Neoantigen Nanovaccine
- Where
- China
- Volunteers
- 49 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Pancreas Cancer, Relapse
Autologous CAR-T Cells Targeting B7-H3 in PDAC
The purpose of this gene therapy research study is to test the safety and tolerability of using a new treatment called autologous T lymphocyte chimeric antigen receptor cells against the B7-H3 antigen (iC9.CAR.B7-H3 T cells) in…
- Conditions
- Pancreas Cancer, Relapse, Resistant Cancer
- Trial name
- NCT06158139
- Testing
- iC9-CAR.B7-H3 T cell infusion
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Pancreatic Cancer
Preoperative Rehabilitation During Neoadjuvant Therapy for Pancreatic Cancer
The goal of this research study is to learn if it is possible to start a home-based exercise and nutrition program for patients with pancreatic cancer or who may have pancreatic cancer before surgery (pre-operative…
- Trial name
- NCT02295956
- Testing
- Questionnaires, Exercise, Nutrition Counseling
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- M.D. Anderson Cancer Center
Advanced Solid Tumor, Non Small Cell Lung Cancer
A Study of CLSP 5282 in HLA-A*03:01 Positive Adult Patients With Solid Tumors (SENTINEL-101)
Phase 1, open-label, multicenter study to evaluate the safety, tolerability, PK, PD, and preliminary clinical activity of CLSP 5282 when administered to HLA A*03:01-positive adult patients with advanced solid tumors that harbor…
- Conditions
- Advanced Solid Tumor, Non Small Cell Lung Cancer, Pancreatic Carcinoma, Colorectal Cancer
- Trial name
- NCT07650357
- Testing
- CLSP-5282
- Where
- 4 sites in United States
- Volunteers
- 140 people
- Sponsor
- Clasp Therapeutics, Inc.
Advanced Pancreatic Carcinoma
A Phase II Clinical Trial of Fruquintinib as Third Line Treatment in Advanced Pancreatic Cancer
A Phase II Clinical Trial of the Safety and Efficacy of Fruquintinib in Advanced Pancreatic Cancer Patients Who Failed Second-line Gemcitabine or 5-FU Based Chemotherapy
- Trial name
- NCT05257122
- Testing
- Fruquintinib
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Fudan University
Pancreatic Cancer, Pancreatic Cancer Metastatic
Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
The purpose of this study is to evaluate the safety and efficacy of an investigational RAS(ON) inhibitor administered as monotherapy or in combination with chemotherapy, compared with standard of care (SOC) chemotherapy alone.
- Conditions
- Pancreatic Cancer, Pancreatic Cancer Metastatic, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma
- Trial name
- RASolute 303 (NCT07491445)
- Testing
- daraxonrasib, gemcitabine, nab-paclitaxel
- Where
- 82 sites in United States, Australia and 14 more
- Volunteers
- 900 people
- Sponsor
- Revolution Medicines, Inc.
Malignancy, Digestive Cancer
Target-specific immunoPET Imaging of Digestive System Carcinoma
The aim of this study is to establish and optimize the target-specific PET/CT imaging method, and its physiological and pathological distribution characteristics, on the basis of which the diagnostic efficacy of the above imaging…
- Conditions
- Malignancy, Digestive Cancer, Digestive System Neoplasm, Digestive System Carcinoma
- Trial name
- NCT06715839
- Testing
- [68Ga]Ga-DOTA-H2D3, [18F]F-RESCA-RB14, [68Ga]Ga-NOTA-T4
- Where
- China
- Volunteers
- 400 people
- Sponsor
- RenJi Hospital
Liver Cancer, Pancreatic Cancer
Phase II Trial Evaluating OS With Therasphere® + 2nd-Line FOLFOX in Pancreatic Liver Mets
The purpose of this study is to evaluate the safety and impact on survival with treatment with 90-Y glass microspheres in conjunction with leucovorin, 5-fluorouracil (5-FU) and oxaliplatin (FOLFOX) as second-line treatment with…
- Trial name
- NCT01581307
- Testing
- FOLFOX7 (Folinic acid, 5-Fluorouracil, and Oxaliplatin), TheraSpheres
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Pancreatic Pseudocysts
Evaluation of Pancreatic Pseudocyst Drainage With a Metal Stent
The purpose of this study is to study the evaluation of the effectiveness of endoscopic Pancreatic Pseudocyst drainage using a metal stent.
- Trial name
- NCT01239056
- Testing
- Endoscopy
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Florida
Pancreatic Cancer
Irinotecan and Docetaxel With or Without Cetuximab in Treating Patients With Metastatic Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as cetuximab can locate tumor cells and either kill them or deliver tumor-killing…
- Trial name
- NCT00042939
- Testing
- cetuximab, docetaxel, irinotecan hydrochloride
- Volunteers
- 94 people
- Sponsor
- Eastern Cooperative Oncology Group
Pancreatic Cancer
CPI-613 in Combination With Modified FOLFIRINOX in Locally Advanced Pancreatic Cancer
The purpose of this study is to treat participants with the combination of CPI-613 (the study drug) with FOLFIRINOX (the standard combination of drugs) to determine if it is safe and effective for participants with localized and…
- Trial name
- NCT03699319
- Testing
- CPI 613, Oxaliplatin, Irinotecan
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- David Bajor, MD
Pancreatic Cancer, Pancratic Ductal Adenocarcinoma
A Study of GC203 TIL in PDCA (RJ)
This study is to investigate the safety and efficacy of gene-edited tumor infiltrating lymphocyte (GC203 TIL) therapy in patients with pancreatic ductal adenocarcinoma.
- Conditions
- Pancreatic Cancer, Pancratic Ductal Adenocarcinoma, Treatment Side Effects, Tumor Infiltrating Lymphocytes
- Trial name
- NCT06828328
- Testing
- GC203 TIL
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai Juncell Therapeutics
Pancreatic Adenocarcinoma
Portal Vein Thrombosis Associated With Unresectable Pancreatic Cancers : a Prospective Multicentric Cohort Study
Little is known concerning the management of portal vein thrombosis (PVT) in digestive cancers other than hepato-cellular carcinoma (HCC).
- Trial name
- THROMPAN (NCT04814251)
- Testing
- Observationnal cohort
- Volunteers
- 200 people
- Sponsor
- Poitiers University Hospital
Pancreatitis, Pancreatic Carcinoma
Endoscopic Ultrasound (EUS) Processor Comparison
The primary objective for this study is to compare the image quality of two endoscopic ultrasound (EUS) processors used for imaging of the pancreas.
- Trial name
- NCT01814631
- Testing
- image quality and resolution
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- AdventHealth
Pancreas Cancer
Evaluation and Comparison of the Growth Rate of Pancreatic Cancer Patient-derived Organoids
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive forms of cancer. Despite advances in the understanding of the mechanisms underlying PDAC pathogenesis, the impact on patient benefit is lagging.
- Trial name
- NCT03990675
- Testing
- FNA, FNB
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Locally Advanced Solid Tumor, Metastatic Cancer
ACE1702 in Subjects With Advanced or Metastatic HER2-expressing Solid Tumors
ACE1702 (anti-HER2 oNK cells) is an off-the-shelf Natural Killer (NK) cell product that targets human HER2-expressing solid tumors.
- Conditions
- Locally Advanced Solid Tumor, Metastatic Cancer, Solid Tumor, HER2-positive Gastric Cancer
- Trial name
- NCT04319757
- Testing
- ACE1702, Cyclophosphamide, Fludarabine
- Where
- 3 sites in United States, Taiwan
- Volunteers
- 12 people
- Sponsor
- Acepodia Biotech, Inc.
Pancreatic Cancer
PD-1 Combined With Chemotherapy and PULSAR in LAPC and Local Recurrence Patients
This trial is a phase II clinical trial of the safety and efficacy of PD-1 antibody (Toripalimab) in combination with paclitaxel (albumin-bound type) and gemcitabine and PULSAR radiotherapy in patients with locally advanced…
- Trial name
- NCT06359275
- Testing
- PD-1, Nab-paclitaxel, Gemcitabine
- Where
- China
- Volunteers
- 81 people
- Sponsor
- Fudan University
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