Clinical trials: Pancreatic Diseases
Pancreatic Ductal Adenocarcinoma (PDAC), Squamous Cell Carcinoma of Head and Neck
A Study of [225Ac]-FPI-2059 in Adult Participants With Solid Tumours
This is a first-in-human Phase 1 clinical trial designed to investigate the safety, tolerability, pharmacokinetics, and biodistribution of [225Ac]-FPI-2059 and [111In]-FPI-2058 in participants with neurotensin receptor 1…
- Conditions
- Pancreatic Ductal Adenocarcinoma (PDAC), Squamous Cell Carcinoma of Head and Neck, Colorectal Cancer, Gastric Cancer
- Trial name
- NCT05605522
- Testing
- [225]-FPI-2059, [111In]-FPI-2058
- Where
- 8 sites in United States, Australia
- Volunteers
- 19 people
- Sponsor
- 3B Pharmaceuticals GmbH
Short Bowel Syndrome
Use of Pancreatic Enzymes in Short Bowel Syndrome
Patients with short bowel syndrome have a high mortality rate that is mainly attributed to complications from central lines and long-term intravenous (IV) nutrition.
- Trial name
- SBS (NCT03097029)
- Testing
- Pancreatic Enzyme
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospital of Philadelphia
Solid Tumor, Pancreatic Ductal Adenocarcinoma (PDAC)
Study of JYP0015 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
Evaluate the safety and antitumor activity of JYP0015 in adults with specific RAS mutant advanced solid tumors.
- Conditions
- Solid Tumor, Pancreatic Ductal Adenocarcinoma (PDAC), Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC)
- Trial name
- STAR (NCT06895031)
- Testing
- JYP0015
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Guangzhou JOYO Pharma Co., Ltd
Pancreatic Diseases
Validation of an AI-Assisted Pancreatic EUS System for Training Improvement: a Prospective, Multi-Center, Randomized Trial
The goal of this clinical trial is to verify the auxiliary role of the artificial intelligence (AI) system in pancreatic endoscopic ultrasound (EUS) scans. The main questions it aims to answer are as follows: 1.
- Trial name
- NCT06790134
- Testing
- Artificial intelligence device
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Unresectable Locally Advanced Cancer, Metastatic Pancreatic Cancer
Evaluation of an Adapted Physical Activity Program in Patients With Unresectable Pancreatic Cancer
Adapted Physical Activity (APA) program may provide an opportunity to improve symptoms for patients with unresectable pancreatic cancer.
- Trial name
- NCT02184663
- Testing
- without APA program, APA program
- Where
- 17 sites in France
- Volunteers
- 313 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Ovarian Cancer
A Study of DMOT4039A in Participants With Unresectable Pancreatic or Platinum-Resistant Ovarian Cancer
This multicenter, open-label, dose-escalating study will assess the safety, tolerability, and pharmacokinetics of DMOT4039A in participants with unresectable pancreatic or platinum-resistant ovarian cancer.
- Trial name
- NCT01469793
- Testing
- DMOT4039A
- Where
- 6 sites in United States, Netherlands
- Volunteers
- 71 people
- Sponsor
- Genentech, Inc.
Pancreatitis, Acute
Resolution of Organ Injury in Acute Pancreatitis - RESORP
Acute pancreatitis (AP) is inflammation of the pancreas usually triggered by gallstones or drinking excessive alcohol. 80% of people who have an episode of AP will recover without complications.
- Trial name
- RESORP (NCT03342716)
- Where
- United Kingdom
- Volunteers
- 229 people
- Sponsor
- University of Edinburgh
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer
This phase I trial is studying the side effects and best dose of erlotinib hydrochloride when given together with cetuximab and to see how well they work in treating patients with advanced gastrointestinal cancer, head and neck…
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Advanced Adult Primary Liver Cancer, Carcinoma of the Appendix
- Trial name
- NCT00397384
- Testing
- cetuximab, erlotinib hydrochloride, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Cancer Institute (NCI)
Pancreas Neoplasm
Usefulness of 3D Digital Reconstruction in the Imaging Diagnosis of Pancreatic Tumors
Reconstruction using 3D virtual models has brought about a revolution in diagnostic imaging and its use is increasingly widespread.
- Trial name
- NCT04783844
- Testing
- Virtual modelization.
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Locally Advanced Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8
Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer
This phase I/II trial studies the safety, side effects and best dose of M3814 and to see how well it works when given together with radiation therapy in treating patients with pancreatic cancer that has spread to nearby tissue or…
- Trial name
- NCT04172532
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- 44 sites in United States
- Volunteers
- 92 people
- Sponsor
- National Cancer Institute (NCI)
Cancer Diagnosis, LungCancer
Prospective Screening and Differentiating Common Cancers Using Peripheral Blood Cell-Free DNA Sequencing
The goal of this observational study is to screen and differentiate common cancers in participants with or without suspicious lesions.
- Conditions
- Cancer Diagnosis, LungCancer, Gastric Cancer, Liver Cancer
- Trial name
- NCT06036563
- Where
- 8 sites in China
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Eating Disorder, Bulimia Nervosa
Co-Feedback Action of Growth Hormone, PP and PYY on Ghrelin in Bulimia
This study evaluates the addition of Acipimox or placebo to exercise on growth hormone release and ghrelin secretion in bulimic patients and in healthy women.
- Trial name
- NCT03338387
- Testing
- Acipimox
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Pancreatitis, Chronic
Phone-based Smoking Cessation Intervention for Patients With Chronic Pancreatitis.(START)
This study aims to explore whether regular telephone intervention in patients with chronic pancreatitis can improve their smoking cessation rate.
- Trial name
- NCT05940987
- Testing
- Phone-based smoking cessation intervention
- Where
- China
- Volunteers
- 382 people
- Sponsor
- Changhai Hospital
Pancreatic Neoplasms, Biliary Tract Neoplasms
Nonstented Stump-closed vs Duct-to-Mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy
Pancreaticojejunostomy is the key procedure of pancreaticoduodenectomy. The aim of our study is to investigate a new pancreaticojejunal (PJ) anastomosis procedure named "nonstented stump-closed pancreaticojejunostomy" in…
- Conditions
- Pancreatic Neoplasms, Biliary Tract Neoplasms, Pancreatitis, Chronic, Duodenal Neoplasms
- Trial name
- NCT01731821
- Testing
- pancreaticojejunostomy
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Fudan University
Chronic Pancreatitis
Fat Malabsorption in Chronic Pancreatitis
The objective of this study is to evaluate the malabsorption blood test (MBT), stool coefficient of fat absorption (CFA) and stool bomb calorimetry (BC) methods as potential screening or diagnostic tests for reduced exocrine…
- Trial name
- NCT02849704
- Testing
- Creon36™
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Pancreatic Cancer
Abraxane Therapy in Patients With Pancreatic Cancer Who Failed First-Line Gemcitabine Therapy
RATIONALE: Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00691054
- Testing
- Abraxane
- Where
- 2 sites in United States, Singapore
- Volunteers
- 20 people
- Sponsor
- University of Miami
Cancer of Pancreas
Pancreatico Enteric Anastomosis Post Pancreaticoduodenectomy
The aim of this study is to make a step for evaluation and presentation of a safe technique for pancreatico-jejunostomy that help in minimizing post-operative morbidity and mortality in pancreatic cancer patient by comparing…
- Trial name
- PEAPP (NCT05163977)
- Testing
- Blumgart Anastomosis, Cattell Warren Anastomosis
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Pancreatic Neoplasms, Solid Tumors
Brightline-2: A Study to Test Whether Brigimadlin (BI 907828) Helps People With Cancer in the Biliary Tract, Pancreas, Lung or Bladder
This study is open to adults with advanced cancer in the biliary tract, pancreas, lung, or bladder. This is a study for people for whom previous treatment was not successful or no treatment exists.
- Conditions
- Pancreatic Neoplasms, Solid Tumors, Biliary Tract Cancer, Lung Neoplasms
- Trial name
- NCT05512377
- Testing
- Brigimadlin
- Where
- 60 sites in United States, Australia and 14 more
- Volunteers
- 99 people
- Sponsor
- Boehringer Ingelheim
Pancreatic Cancer
PD-1 Combined With Chemotherapy and PULSAR in LAPC and Local Recurrence Patients
This trial is a phase II clinical trial of the safety and efficacy of PD-1 antibody (Toripalimab) in combination with paclitaxel (albumin-bound type) and gemcitabine and PULSAR radiotherapy in patients with locally advanced…
- Trial name
- NCT06359275
- Testing
- PD-1, Nab-paclitaxel, Gemcitabine
- Where
- China
- Volunteers
- 81 people
- Sponsor
- Fudan University
Pancreatic Cancer
Chemotherapy for Patients With Locally Advanced Pancreatic Cancer (LAPC) With Additional Chemo-radiotherapy (CRT) for Patients With Borderline Resectable Tumours
Treating patients with initial local non-resectable pancreatic cancer with a combination of oxaliplatin, irinotecan \& 5-FU(FOLFIRINOX), consolidated with chemoradiotherapy in potentially resectable patients, will result in a…
- Trial name
- NCT01397019
- Testing
- Oxaliplatin, irinotecan, 5-FU & leucovorin
- Where
- 3 sites in Denmark
- Volunteers
- 56 people
- Sponsor
- Per Pfeiffer
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