Clinical trials: Pancreatic Disorders
Pancreatic Adenocarcinoma, Cholangiocarcinoma
Clinical Efficacy and Safety of Paclitaxel Polymeric Micelles for Injection in the Treatment of Patients With Taxans-resistant Pancreatic Adenocarcinoma, Cholangiocarcinoma, Lung Cancer, Gastric Cancer, Esophageal Carcinoma, or Breast Cancer
This study is a single-center, single-arm, open-label, phase II clinical trial designed to evaluate the efficacy and safety of Paclitaxel Polymeric Micelles for Injection for the treatment of patients with advanced pancreatic…
- Conditions
- Pancreatic Adenocarcinoma, Cholangiocarcinoma, Lung Cancer, Stomach Cancer
- Trial name
- NCT06199895
- Testing
- Paclitaxel Polymeric Micelles for Injection
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Liu Huang
Cystic Fibrosis
Needs in Education for Pulmonary or Cardiopulmonary Transplanted Cystic Fibrosis Patients
Main objective : This project aims to assess the educational needs of patients who received a lung transplantation or a simultaneous heart-lung transplantation for mucoviscidosis.
- Trial name
- NCT01285895
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Solid Tumor, Adult, Epithelial Ovarian Cancer
Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors
This is a first-in-human, Phase 1/2 open-label, multicenter, dose-escalation, safety, pharmacokinetics (PK), and biomarker study of CBX-12 in subjects with advanced or metastatic refractory solid tumors.
- Conditions
- Solid Tumor, Adult, Epithelial Ovarian Cancer, Small Cell Lung Carcinoma, Breast Cancer
- Trial name
- NCT04902872
- Testing
- CBX-12
- Where
- 4 sites in United States
- Volunteers
- 69 people
- Sponsor
- Cybrexa Therapeutics
ERCP, Pancreatitis
Indomethacin vs Diclofenac for Preventing PEP
Pancreatitis is the most common and serious complication following post-endoscopic retrograde cholangiopancreatography (ERCP) and is associated with occasional mortality, extended hospital stays, and increased healthcare…
- Conditions
- ERCP, Pancreatitis, Non-steroidal Anti-inflammatory (NSAID), Indomethacin
- Trial name
- NCT07071441
- Testing
- Indomethacin 100 MG, Diclofenac 100mg
- Where
- 20 sites in China
- Volunteers
- 4,050 people
- Sponsor
- Air Force Military Medical University, China
Type 1 Diabetes, Nutrition
Oat Flakes β-glucan on Glycemic Variability, Pancreatic Reserve, and Dyslipidemia Among Adolescents With Type 1 Diabetes
Chronic iron overload represents a significant morbidity in Transfusion dependent β-thalassemia (TDT) leading to various endocrine complications including diabetes.
- Trial name
- NCT07593105
- Testing
- Oat Flour
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Pancreatic Cancer Stage IV
SHR- 1210 Combined With Paclitaxel (Albumin Bound) and Gemcitabine as First-line Therapy in Patients With Metastatic Pancreatic Cancer
This is an open-label, single center, non-randomized, phase I trial to evaluate safety and efficacy of using the combination treatment of SHR-1210 with Paclitaxel-albumin and gemcitabine of metastatic PDAC.
- Trial name
- NCT04181645
- Testing
- Biological: SHR-1210 Drug: Gemcitabine Drug:Paclitaxel-albumin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Resectable Pancreatic Cancer
Efficacy of Doxycycline on Metakaryote Cell Death in Patients With Resectable Pancreatic Cancer
This is a window-of-opportunity study that examines the efficacy of doxycycline, and FDA-approved oral antibiotic, on metakaryotic (cancer stem cells) in resectable pancreatic cancer following eight weeks of treatment.
- Trial name
- NCT02775695
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Medical College of Wisconsin
Advanced Cancer, Metastatic Cancer
Adagrasib in Combination With BI 1701963 in Patients With Cancer (KRYSTAL 14)
This study will evaluate safety, tolerability, drug levels, molecular effects and clinical activity of MRTX849 (adagrasib) in combination with BI 1701963 in patients with advanced solid tumors that have a KRAS G12C mutation.
- Conditions
- Advanced Cancer, Metastatic Cancer, Malignant Neoplasm of Colon, Malignant Neoplasm of Lung
- Trial name
- NCT04975256
- Testing
- MRTX849, BI 1701963
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- Mirati Therapeutics Inc.
Cystic Fibrosis
COVID-19 Antibody Responses In Cystic Fibrosis
Coronavirus disease 2019 (COVID-19) which is caused by the virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has resulted in an ongoing global pandemic.
- Trial name
- CAR-CF (NCT05158829)
- Where
- 6 sites in Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Liver Metastases
CAR-T Hepatic Artery Infusions and Sir-Spheres for Liver Metastases
This is an open label fixed dose phase Ib of anti-CEA CAR-T cells hepatic artery infusions and yttrium-90 SIR-Spheres in patients with CEA-expressing liver metastases.
- Trial name
- HITM-SIR (NCT02416466)
- Testing
- anti-CEA CAR-T cells, Sir-Spheres
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Roger Williams Medical Center
Pancreatitis, Acute Necrotizing
Effect of Traditional Chinese Medicine on GI Function Recovery and Nutrition Support in SAP
With multicenter randomized control clinical evaluation investigations, the effect of traditional Chinese medicine on gastrointestinal function recovery and nutrition support in early stage of severe acute pancreatitis (SAP) was…
- Trial name
- NCT00508729
- Testing
- Qingyi granules
- Where
- 10 sites in China
- Volunteers
- 300 people
- Sponsor
- Tianjin Nankai Hospital
Cystic Fibrosis
Early Intervention in Cystic Fibrosis Exacerbation
Individuals with cystic fibrosis (CF) develop chronic lung infections and suffer intermittent acute exacerbations of their lung disease.
- Trial name
- eICE (NCT01104402)
- Testing
- Home lung function and symptom monitoring
- Where
- 3 sites in United States
- Volunteers
- 267 people
- Sponsor
- Johns Hopkins University
Gastric Cancer, Colon Cancer
Safety and Efficacy of CEA-targeted CAR-T for CEA-positive Advanced Malignant Solid Tumors
This study is a single-arm, open-label, dose-escalating + dose-expansion clinical study, aiming to evaluate the safety and efficacy of CEA-targeted CAR-T cell preparations, and to preliminarily observe the study drug in…
- Conditions
- Gastric Cancer, Colon Cancer, Rectal Cancer, Esophageal Cancer
- Trial name
- NCT05538195
- Testing
- CEA-targeted CAR-T cells
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Pancreatic Cancer
Initial Feasibility Study to Treat Borderline Resectable Pancreatic Cancer With a Planar LDR Source
Initial study to evaluate local control and the preferred method of attachment of the CivaSheet in the setting of suspected close or positive margins at the time of surgical tumor removal.
- Trial name
- NCT02843945
- Testing
- Directional Brachytherapy Source Implant
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- CivaTech Oncology
Cervical Cancer, Colorectal Cancer
89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors
A prospective, open-label, phase 2 study to explore CAIX expression through 89Zirconium-labelled girentuximab deferoxamine (89Zr-girentuximab) PET/CT imaging in patients with solid tumors.
- Conditions
- Cervical Cancer, Colorectal Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- STARBURST (NCT05563272)
- Testing
- 89Zr-girentuximab for PET/CT imaging of CAIX positive tumors
- Where
- 10 sites in United States
- Volunteers
- 11 people
- Sponsor
- Telix Pharmaceuticals (Innovations) Pty Ltd
Cancer Pancreas
Concurrent Hyperthermia and Chemoradiotherapy in LAPC: Phase II Study
This is a phase II randomized study of concurrent chemoradiotherapy and local hyperthermia (study group) versus chemoradiotherapy alone (control group) following neoadjuvant chemotherapy in locally advanced pancreatic cancer.
- Trial name
- HEATPAC (NCT02439593)
- Testing
- Chemoradiotherapy (CTRT), Thermochemoradiotherapy (CTRTHT)
- Where
- Switzerland
- Volunteers
- 78 people
- Sponsor
- Kantonsspital Aarau
Cirrhosis, Liver Fibrosis
Non Invasive Study of the Hepatic Fibrosis in Paediatrics by the Method of Study of Pediatric Hepatic Fibrosis
Early diagnosis of liver fibrosis is useful for the follow-up and treatment of chronic liver disease. At present, the unique validated method to evaluate the liver fibrosis in children, is the liver biopsy which is an invasive…
- Conditions
- Cirrhosis, Liver Fibrosis, Portal Hypertension, Cystic Fibrosis
- Trial name
- PEDISCAN (NCT01072721)
- Testing
- Elastometry
- Where
- France
- Volunteers
- 264 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cystic Fibrosis Pulmonary Exacerbation
Markers of Pulmonary Dysbiosis Associated With Exacerbation in Patients Followed for Cystic Fibrosis
The aim objective is to identify markers of bacterial, viral and fungal pulmonary dysbiosis, associated with the occurrence of exacerbation in patients followed for cystic fibrosis.
- Trial name
- DYSBIOSE-CF (NCT03569904)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Pancreatic Cancer, Chemotherapy Effect
Efficacy and Safety of LM-302 Combined With Gemcitabine CLDN 18.2 Positive Unresectable Locally Advanced or Metastatic Pancreatic Cancer
The goal of this clinical trial is to evaluate the efficacy and safety of LM-302 combined with gemcitabine as a second-line treatment for CLDN 18.2-positive unresectable locally advanced or metastatic pancreatic cancer.
- Trial name
- NCT07108504
- Testing
- Gemcitabine, LM-302
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Pancreatic Cyst, EUS-FNA
CHARM II: Chemotherapy for Ablation and Resolution of Mucinous Pancreatic Cysts
The purpose of this study is to evaluate the efficacy and safety of chemotherapeutic pancreatic cyst ablation using ethanol lavage followed by the infusion of a dual-agent chemotherapeutic cocktail (paclitaxel + gemcitabine)…
- Trial name
- CHARM (NCT03085004)
- Testing
- Ethanol, Normal saline, Paclitaxel + Gemcitabine admixture
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Milton S. Hershey Medical Center
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