Clinical trials: Pancreatic Fistula
Neuroendocrine Carcinoma of Pancreas, Duodenum Carcinoma
Preoperative Radiotherapy in Patients at High Risk of Postoperative Pancreatic Fistula After Pancreatoduodenectomy
The FIBROPANC-1 investigates the feasibility and safety of preoperative stereotactic radiotherapy of 4cm pancreas in patients undergoing pancreatoduodenectomy at high risk (>25%) of developing post operative pancreatic fistula…
- Conditions
- Neuroendocrine Carcinoma of Pancreas, Duodenum Carcinoma, Pancreas Neoplasm, Distal Cholangiocarcinoma
- Trial name
- FIBROPANC-1 (NCT05641233)
- Testing
- Stereotactic radiotherapy
- Where
- 2 sites in Netherlands
- Volunteers
- 33 people
- Sponsor
- Erasmus Medical Center
Acute Pancreatitis, Pancreatic Fistula
Post-Operative Acute Pancreatitis After Pancreaticoduodenectomy
The occurrence of post-pancreatectomy acute pancreatitis (PPAP) can critically impact outcomes after pancreaticoduodenectomy. Although diagnosing a PPAP can be challenging, its identification appears crucial as it can trigger…
- Conditions
- Acute Pancreatitis, Pancreatic Fistula, Postoperative Complications
- Trial name
- NCT04917172
- Testing
- postoperative acute pancreatitis evaluation
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Distal Pancreatectomy, Postoperative Pancreatic Fistula
Intrapapillary Botulinum Toxin Injection for PREvention of Post-surgical PAncREactic Fistula
Surgery is required for the treatment of many pancreatic conditions, either malignant or benign. Mortality of pancreatic surgery can be up to 3% even in expert centers.
- Trial name
- PREPARE (NCT04220931)
- Testing
- botulinum toxin injection
- Where
- France
- Volunteers
- 460 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pancreatic Cancer
Predicting Pancreatic Fistula After Pancreatic Surgery Using Preoperative Immunity
The goal of this observational study is to develop and validate a preoperative immunological signature for predicting postoperative pancreatic fistula (POPF) in adult patients undergoing pancreatic surgery for pancreatic cancer.
- Trial name
- NCT07827911
- Testing
- blood sampling
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Institut Paoli-Calmettes
Pancreatic Fistula, Distal Pancreatectomy Complications
An Evaluation of a New Technique Utilizing a Biologic Glue and Tissue Patch to Seal the Cut Edge of the Pancreas Following Removal of the Tail of the Pancreas
The purpose of this trial is to determine whether the use of an autologous falciform ligament patch combined with fibrin glue will reduce the rate of pancreatic fistula in patients completing distal pancreatectomy.
- Conditions
- Pancreatic Fistula, Distal Pancreatectomy Complications, Falciform Patch Pancreatic Closure, Fibrin Glue Pancreatic Closure
- Trial name
- NCT00889213
- Testing
- Falciform patch and fibrin glue application, standard pancreatic closure
- Where
- 2 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Pancreatic Fistula
Trans-drain Occlusion for Postoperative Pancreatic Fistula- A Double Blind Randomized Clinical Trial
This is a multicenter, investigator initiated, prospective, superiority, parallel-group, randomized, double-blinded trial that aims to compare the efficacy and safety of trans-drain occlusion followed by gradual withdrawal of…
- Trial name
- NCT03800940
- Testing
- Fistulography and trans-drain occlusion, Fistulography
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Pancreatic Cancer, Pancreatic Cystic Lesions
Trial Assessing Roux-en-Y Anastomosis of the Pancreatic Stump to Prevent Pancreatic Fistula Following Distal Pancreatectomy
The objective is to clarify Roux-en-Y anastomosis of the pancreatic stump decreases pancreatic fistula following distal pancreatectomy, compared with stapling closure of the pancreatic stump.
- Conditions
- Pancreatic Cancer, Pancreatic Cystic Lesions, Chronic Pancreatitis, Pancreatic Neuroendocrine Tumors
- Trial name
- NCT01384617
- Testing
- Stapling closure of the pancreatic stump, Roux-en-Y anastomosis of the pancreatic stump
- Where
- Japan
- Volunteers
- 136 people
- Sponsor
- Wakayama Medical University
Pancreatic Fistula, Pancreaticoduodenectomy
Effect of Trans-Nasal Afferent Loop Decompression on Post-Pancreaticoduodenectomy Pancreatic Fistula
Postoperative pancreatic fistula (POPF) is a major complication and an important cause of mortality after pancreaticoduodenectomy (PD).
- Conditions
- Pancreatic Fistula, Pancreaticoduodenectomy, Complication of Surgical Procedure
- Trial name
- NCT04989868
- Testing
- Trans-Nasal Afferent Loop Decompression, Without Trans-Nasal Afferent Loop Decompression
- Where
- China
- Volunteers
- 299 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Periampullary Carcinoma, Pancreatic Fistula
Trial of Omental Roll-up Technique on Pancreato-jejunostomy Anastomosis for Reducing Perioperative Complication in Patients Undergoing Pancreatoduodenectomy
Despite the fact that pancreatoduodenectomy is the standard treatment of malignant tumor at periampullary area, the morbidity and mortality rate with intra-abdominal collection, post pancreatectomy hemorrhage, and delayed gastric…
- Trial name
- NCT03083938
- Testing
- Omental Roll-up
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Severe Sepsis, Pancreatitis
A Prospective Study of The Complement Depletion in Patients With Severe Abdominal Sepsis
The role of complement system in bridging innate and adaptive immunity has been confirmed in various invasive pathogens. The aim of this study is to investigate the alteration of complement C3 in patients with severe abdominal…
- Conditions
- Severe Sepsis, Pancreatitis, Abdominal Abscess, Appendicitis
- Trial name
- NCT01568853
- Testing
- Norepinephrine, Open abdomen, enteral nutrition
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Jinling Hospital, China
Pancreatic Cancer
Placebo Controlled Trial of SOM230 for the Reduction of Post-Pancreatectomy Fistula, Leak, and Abscess
The purpose of this study is to help us learn more about how to lower the patient's risk of the most common complications after their pancreas operation.
- Trial name
- NCT00994110
- Testing
- Pasireotide (SOM230)
- Where
- United States
- Volunteers
- 439 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pancreaticoduodenectomy, Distal Pancreatectomy
Randomized Controlled Trial Comparing Closed-suction Drain Versus Passive Gravity Drain Following Pancreatic Resection
Pancreatic resection is the only potentially curative modality of treatment for pancreatic neoplasm. The mortality associated with this procedure decreased rapidly in the past decades.
- Trial name
- DRAPA (NCT01988519)
- Testing
- Closed gravity drain, closed suction drain
- Where
- 2 sites in Czechia
- Volunteers
- 223 people
- Sponsor
- University Hospital Hradec Kralove
Pancreatic Fistula
External Pancreatic Stent in Pancreaticojejunostomy
Pancreatic fistula is one of the most serious complication after pancreatoduodenectomy. To reduce pancreatic fistula, many authors recommend pancreatic stent in pancreatojejunostomy.
- Trial name
- NCT06743516
- Testing
- Pancreaticojejunostomy with external stent, Pancreaticojejunostomy without external stent
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Pancreatoduodenectomy, Whipple Procedure
Antiseptic-Coated Sutures and Pancreatic Fistula Risk After Pancreatoduodenectomy
The purpose of this study is to determine if the use of antiseptic-coated sutures is better than the use of the standard sutures in preventing postoperative fistulas within 90 days after pancreatoduodenectomy.
- Trial name
- Triclosan (NCT07318493)
- Testing
- Standard (non-antiseptic coated) suture will be used., Triclosan/antiseptic -coated suture
- Where
- 3 sites in United States
- Volunteers
- 436 people
- Sponsor
- The Cleveland Clinic
Pancreatic Fistula After Pancreaticoduodenectomy
Isolated Roux Loop Pancreaticojejunostomy Versus Pancreaticogastrostomy After Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD)is the treatment of choice for patients with periampullary tumour (benign or malignant). In the recent years, the mortality rate of PD has decreased to 5% in many centers.
- Trial name
- PD (NCT01859806)
- Testing
- Pancreaticogastrostomy group, Isolated Roux PJ group
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Pancreatic Fistula, Pancreaticoduodenectomy
Prevention of Postoperative Pancreatic Fistula Following Pancreaticoduodenectomy by Preoperative Radiotherapy : a Phase 2 Trial
Design of the study Prospective, single arm, multicentric, phase II open trial Number of participating sites 14 French centers of HPB Surgery departments associated with 14 Radiation Oncology Departments.
- Trial name
- PreFiR (NCT07370987)
- Testing
- Stereotactic radiotherapy / pancreaticoduodenectomy
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fistula Pancreatic
Intraoperative Biodegradable Stent Placement to Reduce Complications After Pancreatoduodenectomy
The aim of this prospective, randomized, blinded clinical superiority trial is to establish intraoperative placement of biodegradable stents in the pancreatojejunostomy as a safe, effective, and feasible preventive measure…
- Trial name
- NCT06205693
- Testing
- Fast Degradable, Biodegradable ARCHEMEDES stent
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Laparoscopic Pancreatic Surgery, Pancreatic Fistula
Application and Optimization of the International Study Group of Pancreatic Surgery (ISGPS) Definition and Grading Criteria for Postoperative Complications of Pancreatic Surgery in Laparoscopic Pancreatic Surgery
In recent years, with the continuous development of minimally invasive techniques, laparoscopic pancreatic surgery has also been widely used.
- Conditions
- Laparoscopic Pancreatic Surgery, Pancreatic Fistula, Postoperative Bleeding, Delayed Gastric Emptying
- Trial name
- NCT05657327
- Volunteers
- 1,000 people
- Sponsor
- West China Hospital
Healing Time of Post Operative Pancreatic Fistulas
Does Post Operative Pancreatic Fistula, After Left Sided Resections, Heal Faster After the Introduction of a Pancreatic Stent?
Dividing pancreas when performing left-sided resections opens the risk for leakage from the divided end of the pancreas. Pancreatic juices could have a severe effect on surrounding abdominal tissues with abscess formation…
- Trial name
- NCT02220010
- Testing
- Pancreatic stent
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska University Hospital
Cancer of Pancreas
Pancreatico Enteric Anastomosis Post Pancreaticoduodenectomy
The aim of this study is to make a step for evaluation and presentation of a safe technique for pancreatico-jejunostomy that help in minimizing post-operative morbidity and mortality in pancreatic cancer patient by comparing…
- Trial name
- PEAPP (NCT05163977)
- Testing
- Blumgart Anastomosis, Cattell Warren Anastomosis
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University