Clinical trials: Pancreatic Solid Lesions
Pancreatic Solid Lesions
Artificial Intelligence (AI) Cytopathology Trial
Purpose The primary objective of the study is to compare interpretation of EUS FNA/FNB samples for adequacy between ROSE and AI at bedside.
- Trial name
- NCT05018663
- Testing
- Artificial Intelligence software ROSE
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center, Houston
Biopsy, Fine-needle, Pancreatic Neoplasm
EUS-FNB With ROSE Vs. EUS-FNB Without ROSE
Rationale: Rapid on-Site Evaluation (ROSE) of cytologic specimens acquired with EUS-guided fine needle aspiration (EUS-FNA) represents the most accurate available technique to reach a definitive diagnosis in patients with…
- Trial name
- FROSENOR (NCT03322592)
- Testing
- Rapid on-site evaluation (ROSE), Histologic evaluation
- Where
- 13 sites in United States, Australia and 6 more
- Volunteers
- 800 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pancreatic Cancer
Trial Comparing 19 and 25G Needles for Fine Needle Aspiration (FNA) of Solid Pancreatic Mass Lesions Greater Than 35mm
This study will test two different needles for performing a biopsy of the pancreas during endoscopic ultrasound (EUS) procedures.
- Trial name
- NCT01815606
- Testing
- biopsy with 19 gauge needle, biopsy with 25 gauge needle
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- AdventHealth
Pancreatic Carcinoma, Pancreatic Neuroendocrine Tumor
Study on Microflora Characteristics of Pancreatic Solid Lesions Via Endoscopic Ultrasound-guided Fine Needle Aspiration/Biopsy
Study objective: To describe the microflora characteristics of the pancreatic solid lesions via the tissue acquired via the endoscopic ultrasound-guided fine needle aspiration/biopsy (EUS-FNA/B).
- Conditions
- Pancreatic Carcinoma, Pancreatic Neuroendocrine Tumor, Autoimmune Pancreatitis, Microflora
- Trial name
- NCT05171517
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Pancreas Cyst, Pancreas Mass
RNA Sequencing of Solid and Cystic Lesions of the Pancreas
The nature of cysts and solid masses in the pancreas can be difficult to diagnose. They may be benign, precancerous, or cancer. Current tests such as cytology (looking under a microscope) and tumor markers do not always give us…
- Trial name
- NCT01807325
- Testing
- pancreas biopsy
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Oregon Health and Science University
Pancreatic Cancer, Pancreatitis
Validation of Joint-AI in Diagnosing Pancreatic Solid Lesions
This clinical trial aims to learn if a multimodal artificial intelligence (AI) model can enhance the diagnosis of pancreatic solid lesions. The main questions it aims to answer are: 1.
- Conditions
- Pancreatic Cancer, Pancreatitis, Pancreatic Neuroendocine Neoplasms (pNETs), Autoimmune Pancreatitis
- Trial name
- NCT06753318
- Testing
- The assistance of the Joint-AI model, The assistance of the interpretable Joint-AI model
- Where
- China
- Volunteers
- 716 people
- Sponsor
- Huazhong University of Science and Technology
Pancreatic Neoplasms
Rapid On-Site Evaluation (ROSE) by Endosonographer: for Whom, When and by Whom?
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a highly sensitive and specific method in diagnosing solid pancreatic lesions.
- Trial name
- NCT04002778
- Testing
- Fine needle aspiration, Rapid on-site evaluation
- Volunteers
- 66 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Pancreas Adenocarcinoma (MSI-H), Pancreatic Neuroendocrine Tumors (pNET)
Superb Microvascular Imaging (SMI) and Two-Dimensional Endoscopic Ultrasound Guided Shear Wave Elastography (2D-SWE-EUS) in Differential Diagnosis of Pancreatic Adenocarcinoma (PA) From Other Pancreatic Solid Lesions (PSLs) and Pancreatic neuroendocrinE Tumors (pNETs) Malignancy
Pancreatic adenocarcinoma (PA) is the most common tumor of the pancreas. Given its poor prognosis and the major therapeutic consequences, the discrimination between PA and other pancreatic solid lesions is mandatory.
- Trial name
- SMILE (NCT07274657)
- Testing
- SMI and 2D-SWE modes
- Where
- France
- Volunteers
- 150 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Pancreas Cancer
Conventional Versus Elastography Targeted Endoscopic Ultrasound Fine Needle Aspiration of Solid Pancreatic Lesions
Diagnostic assessment of solid pancreatic lesions may represent a real challenge in the clinical practice, even with the aid of tissue sampling by means of endoscopic ultrasound (EUS) fine needle aspiration (FNA).
- Trial name
- NCT03210948
- Testing
- RTE-guided EUS-FNA, Conventional EUS-FNA
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- Ospedali Riuniti di Foggia
Pancreatic Neoplasms
Comparison of Two Types of Biopsy Needles for EUS-FNB in Solid Pancreatobiliary Mass Lesions
EUS-guided tissue acquisition is an established modality to diagnose malignancies of the pancreas and extrahepatic bile ducts. In the recent years fine needle biopsy (FNB) needles have largely replaced fine needle aspiration…
- Trial name
- NCT04975620
- Testing
- Fine needle biopsy
- Where
- Iran
- Volunteers
- 114 people
- Sponsor
- University of Tehran
Pancreatic Neoplasms, Mediastinal Neoplasms
22G-Adapt Needle Biopsy Versus Fine-needle Aspiration in Endoscopic Ultrasound-guided Sampling of Solid Lesions
The investigators conduct a multicenter randomized controlled study to evaluate the diagnostic value and safety of 22G Adapt Aspiration puncture needle for histopathology of solid lesions.
- Conditions
- Pancreatic Neoplasms, Mediastinal Neoplasms, Abdominal Neoplasm, Excluding Pancreas Neoplasm
- Trial name
- NCT06563232
- Testing
- FNA group, Adapt FNB group
- Where
- China
- Volunteers
- 656 people
- Sponsor
- Huazhong University of Science and Technology
Pancreatic Cyst, Pancreatic Neuroendocrine Carcinoma
Diagnosis of PCL With EUS-FNA and Cross-sectional Imaging - A Report of Accuracy
Pancreatic cystic lesions (PCLs) comprise of a heterogeneous group of entities that are benign, premalignant or malignant. With increased use of modern imaging techniques in recent years, incidentally discovered PCL have become…
- Conditions
- Pancreatic Cyst, Pancreatic Neuroendocrine Carcinoma, Pancreatic Pseudocyst, Pancreatic Serous Cystadenoma
- Trial name
- NCT03884179
- Volunteers
- 58 people
- Sponsor
- Sahlgrenska University Hospital
Pancreatic Neoplasms, Pancreatic Solid Lesions
EUS-DFI in Solid Pancreatic Lesions
This prospective, international, multicenter observational study aims to evaluate the role of Endoscopic Ultrasound-guided Detective Flow Imaging (EUS-DFI) in the characterization of solid pancreatic lesions.
- Trial name
- DFI (NCT07763561)
- Volunteers
- 48 people
- Sponsor
- Julio Iglesias García
Pancreatic Cancer, Neuroendocrine Tumors
A Clinical Trial With a New Needle Device Comparing Two Needles for EUS_FNA of Solid Lesions.
Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA) is a reliable, safe, and effective technique for obtaining samples from the GI wall lesions and from organs adjacent to the GI tract (pancreas…
- Conditions
- Pancreatic Cancer, Neuroendocrine Tumors, Lymphadenopathies, GIST
- Trial name
- EUS-FNA (NCT02246322)
- Testing
- 25G needle, 22G needle
- Where
- Italy
- Volunteers
- 144 people
- Sponsor
- Istituto Clinico Humanitas
Pancreas Neoplasms
Comparing of a 22G EUS Procore Fine Needle Biopsy Device and a 20G EUS Procore Fine Needle Biopsy Device
The purpose of this study is to compare the diagnosis accuracy of 22G EUS Procore fine needle biopsy （FNB）device and 20G EUS Procore fine needle biopsy device for solid pancreatic lesions.
- Trial name
- NCT03803930
- Testing
- Using 22G FNB, the first pass is SP, Using 22G FNB, the first pass is MWST, Using 20G FNB, the first pass is SP
- Where
- China
- Volunteers
- 1,224 people
- Sponsor
- Huazhong University of Science and Technology
Cancer of Pancreas, Pancreatic Neoplasm
Trial Comparing 19 and 25-gauge EUS-FNA Needles
This study compares the 19G and 25G needles for procuring tissue samples from the pancreas during Endoscopic Ultrasound (EUS) procedures.
- Trial name
- EUS-FNA (NCT01677312)
- Testing
- Pancreatic Biopsy, Histological Samples
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- AdventHealth
Pancreatic Cancer, Pancreatic Neoplasms
Intermittent Suction Technique in the Diagnosis of Pancreatic Solid Lesions
The aim of this study is to compare the diagnostic yield of intermittent versus continuous suction in the diagnosis of pancreatic solid lesions.
- Trial name
- NCT03829748
- Testing
- Intermittent aspiration
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Solid Pancreatic Mass Lesions
EUS-FNA With and Without Suction
To compare the number of passes required for cellblock acquisition with and without suction using the 25g needle.
- Trial name
- NCT02072915
- Testing
- Suction
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Alabama at Birmingham
Pancreatic Neoplasms
Diagnostic Yield of 20-gauge Procore Needle for EUS-guided FNA Biopsy in Solid Pancreatic Lesions
This study aims to examine technical feasibility and diagnostic yield of new 20-gauge Procore needle for EUS-guided fine needle biopsy in solid lesions by comparing with 22-gauge Procore needle.
- Trial name
- NCT02920944
- Testing
- EUS-FNB with 20 gauge ProCore needle, EUS-FNB with 22 gauge ProCore needle
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seung Bae Yoon
Pancreatic Disease
Endoscopic Ultrasound-guided Fine-needle Aspiration of Solid Pancreatic Lesions With Rapid Staining of Cytological Smears Followed by Whole Slide Scanning and Artificial Intelligence Diagnosis: A Prospective, Multicenter Study.
The objective of this observational study is to investigate whether the self-developed whole slide scanning and artificial intelligence diagnostic system for pancreatic solid lesion puncture cytopathology (hereinafter referred to…
- Trial name
- NCT06824909
- Testing
- ROSE-AI diagnostic system
- Where
- 2 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Ruijin Hospital