Clinical trials: Pancreatic Surgery
Whipple Procedures, Pancreatic Cancer
Energy Expenditure and Nutrition After Pancreatic Surgery
This prospective observational cohort study examines the energy requirements and nutritional care of patients undergoing total or partial pancreatectomy for pancreatic tumors.
- Conditions
- Whipple Procedures, Pancreatic Cancer, Pancreaticoduodenectomy, Pancreatic Neoplasms
- Trial name
- NUTRI-PD (NCT07703813)
- Testing
- Pancreatectomy, Indirect calorimetry
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Evangelismos Hospital
Acute Appendicitis, Acute Cholecystitis
Web-based International Register of Emergency Surgery and Trauma
The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a…
- Conditions
- Acute Appendicitis, Acute Cholecystitis, Acute Diverticulitis, Post-operative Complications
- Trial name
- WIRES-T (NCT03643718)
- Testing
- Emergency General Surgery
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Pancreatoduodenectomy, Clinically Relevant Postoperative Pancreatic Fistula
Internal Biodegradable Stent Versus Non-Stent in Patients at High-Risk of Developing Fistula After Pancreatoduodenectomy
The aim of this randomized controlled study is to compare the efficacy of biodegradable internal pancreatic stenting versus no stenting in patients undergoing pancreatoduodenectomy (PD), focusing on a possible superiority…
- Conditions
- Pancreatoduodenectomy, Clinically Relevant Postoperative Pancreatic Fistula, Internal Biodegradable Pancreatic Stent
- Trial name
- BioSteP (NCT05668260)
- Testing
- Biodegradable Stent
- Where
- Italy
- Volunteers
- 122 people
- Sponsor
- Ospedale San Raffaele
Gastric Adenocarcinoma, Pancreatic Adenocarcinoma
An Exercise and Nutrition Monitoring Intervention (Pt Pal) for the Improvement of Strength in Patients With Pancreatic or Stomach Cancer Receiving Chemoradiation Therapy Before Surgery, SurgeryStrong Study
This clinical trial studies the effectiveness of a home-based exercise and nutrition monitoring program called Pt Pal in improving strength in patients with pancreatic or stomach cancer receiving chemoradiation therapy before…
- Trial name
- NCT05056805
- Testing
- Aerobic Exercise, Dietary Intervention, Nutritional Intervention
- Sponsor
- M.D. Anderson Cancer Center
Chronic Pancreatitis, Surgery
Robot-assisted Versus Open Lateral Pancreaticojejunostomy for the Treatment of Symptomatic Chronic Pancreatitis (PANACOTTA)
PANACOTTA is a multicenter randomized controlled trial including patients with symptomatic chronic pancreatitis and a dilated main pancreatic duct to either robot-assisted or open lateral pancreaticojejunostomy.
- Conditions
- Chronic Pancreatitis, Surgery, Minimally Invasive Surgical Technique, Robot Surgica
- Trial name
- PANACOTTA (NCT07109180)
- Testing
- Robot-assisted lateral pancreaticojejunostomy, Open lateral pancreaticojejunostomy
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pancreas Cancer, Periampullary Cancer
Neoadjuvant vs Upfront Surgery for Resectable Pancreatic Cancer and Periampullary Cancer
Adjuvant chemotherapy after surgery significantly improved the survival of pancreatic cancer (PC) patients, but there is a problem that only about 50% of patients start adjuvant chemotherapy after pancreatectomy.
- Conditions
- Pancreas Cancer, Periampullary Cancer, Periampullary Carcinoma Resectable, Pancreatic Cancer Resectable
- Trial name
- NCT07081360
- Testing
- Neoadjuvant chemotherapy, Upfront Surgery Group
- Where
- Egypt
- Volunteers
- 262 people
- Sponsor
- Minia University
Pancreatic Adenocarcinoma
Pancreatic Adenocarcinoma Neoadjuvant Chemotherapy Before Surgery
This is a single-arm, single-center feasibility trial of patients with borderline resectable pancreatic adenocarcinoma receiving chemotherapy with mFOLFIRINOX or gemcitabine / nab-paclitaxel followed by pancreatectomy.
- Trial name
- PANCREAS (NCT04452461)
- Testing
- mFOLFIRINOX, Gemcitabine / Nab-paclitaxel
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Hamilton Health Sciences Corporation
Insulinoma
Laparoscopy to Remove Pancreatic Tumors (Insulinomas)
This study will determine if laparoscopy can be used successfully to find and remove insulinomas (insulin-secreting tumors of the pancreas).
- Trial name
- NCT00005910
- Testing
- Intraoperative ultrasound
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pancreatic Neoplasms, Hypotension
Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia
This randomized clinical trial compares the hemodynamic effects of general anesthesia versus combined general anesthesia (thoracic epidural) in patients undergoing pancreatoduodenectomy.
- Conditions
- Pancreatic Neoplasms, Hypotension, Pancreatoduodenectomy
- Trial name
- NCT06953193
- Testing
- General Anesthesia, Combined General Anesthesia (Thoracic Epidural)
- Where
- Mexico
- Volunteers
- 206 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Insulin Resistance, Proteomics
Proteomics in Morbid Obesity After Bariatric Surgery
Glycemic control is rapidly restored in patients with insulin resistance after bariatric surgery, in particular after the mal-absorptive one (i.e. Bilio-pancreatic diversion, BPD).
- Conditions
- Insulin Resistance, Proteomics, Morbid Obesity
- Trial name
- PROTOBESE (NCT01151917)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Catholic University of the Sacred Heart
Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm
Secretin-enhanced Magnetic Resonance Imaging (S-MRI) for Pancreatic Cancer Detection
The aim of the study is to evaluate the utility of secretin-enhanced MRI (S-MRI) in detecting and measuring pancreatic lesions in patients with known adenocarcinoma or Intraductal papillary mucinous neoplasm (IPMN) lesions.
- Trial name
- NCT01094626
- Testing
- Secretin
- Sponsor
- Elizabeth Hecht
Surgery
Improving Surgeon Performance Measures for Robot-Assisted Surgery
The purpose of this study is to develop new tools to understand surgeon performance to improve surgical training and participant outcomes after surgery.
- Trial name
- NCT06037837
- Testing
- Robotic Surgery
- Where
- 7 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pancreatic Cancer
Chemotherapy, Interferon Alfa, and Radiation Therapy in Treating Patients Who Have Undergone Surgery For Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin and fluorouracil, use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00068575
- Testing
- Recombinant Interferon Alfa, Cisplatin, Fluorouracil
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- M.D. Anderson Cancer Center
Pancreatic Cancer
Gemcitabine, Capecitabine, and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot Be Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as gemcitabine and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- SCALOP (NCT01032057)
- Testing
- capecitabine, gemcitabine hydrochloride, quality-of-life assessment
- Where
- 26 sites in United Kingdom
- Volunteers
- 114 people
- Sponsor
- Lisette Nixon
Pancreatic Cancer
Utilizing Standard of Care Induction Chemotherapy Followed by MR-LINAC Radiotherapy and Surgical Exploration to Improve Resectability Rates in Potentially Resectable Locally Advanced Pancreatic Cancer
Locally advanced pancreatic cancer (LAPC) is a high-mortality condition. This single-institution, Phase II, single-arm investigator-initiated trial at Allegheny Health Network investigates the optimal timing and integration of…
- Trial name
- NCT07871461
- Testing
- Induction Chemotherapy - FOLFIRINOX, Induction Chemotherapy - Gemcitabine and Nab-Paclitaxel, MR-LINAC Guided Radiotherapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Pancreatic Cancer, Ampullary Cancer
Recurrence After Whipple's (RAW) Study
Pancreatic head malignancies are aggressive cancers that are often inoperable when they are diagnosed. In the ~20% of patients who are diagnosed when the disease is still operable, surgery is the only treatment that can provide a…
- Conditions
- Pancreatic Cancer, Ampullary Cancer, Bile Duct Cancer, Cholangiocarcinoma, Extrahepatic
- Trial name
- NCT04596865
- Testing
- Pancreaticoduodenectomy
- Where
- 29 sites in Australia, Austria and 6 more
- Volunteers
- 1,484 people
- Sponsor
- University Hospital Plymouth NHS Trust
Pancreatic Resection, Preoperative Frailty
Prehabilitation in Pancreatic Surgery
The purpose of this study is to use functional studies to study the effectiveness of prehabilitation prior to surgery. The investigators know that stronger patients have better outcomes after surgery compared to weaker patients.
- Trial name
- NCT03688867
- Testing
- Prehabilitation regimen
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Case Comprehensive Cancer Center
Pancreatic Cancer
Biological Therapy in Stage I, Stage II, or Stage III Surgically Resected Pancreatic Cancer
Rational: White blood cells that have been treated with carcinoembryonic antigen peptide-1 may help the body build an immune response to and kill tumor cells that express CEA.
- Trial name
- NCT00003434
- Testing
- carcinoembryonic antigen peptide 1, hepatitis B antigen peptide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Duke University
Pancreatic Insulinoma
EUS-RFA Versus Surgery for Pancreatic Insulinoma (ERASIN-RCT)
The goal of this muticentre randomized controlled trial is to compare endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) with surgery for treatment of pancreatic insulinoma.
- Trial name
- ERASIN-RCT (NCT05735912)
- Testing
- Endoscopic ultrasound-guided radio frequency ablation, Surgery
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Intra Abdominal Pressure, Abdominal Compartment Syndrome
Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients After Pancreatic Procedures.
This study investigates the development of intra-abdominal hypertension and compartment syndrome in patients undergoing elective pancreatic procedures.
- Conditions
- Intra Abdominal Pressure, Abdominal Compartment Syndrome, Pancreatic Surgery, Pancreatic Fistula After Pancreaticoduodenectomy
- Trial name
- HYPA (NCT06672601)
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Charles University, Czech Republic