Clinical trials: Pancreatitis, Acute
Acute Pancreatitis
Study of CM4620 to Reduce the Severity of Pancreatitis Due to Asparaginase
This is a phase I/II clinical trial assessing the tolerability and efficacy of CM4620 in children and young adults with acute pancreatitis caused by asparaginase.
- Trial name
- NCT04195347
- Testing
- CM4620
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- St. Jude Children's Research Hospital
Acute Pancreatitis, Fecal Microbiota Transplantation
Fecal Microbiota Transplantation for Pancreatitis With Infectious Complications(FMTPIC)
Infectious complications are responsible for most of deaths in acute pancreatitis.Intestinal barrier dysfunction and increased intestinal permeability was associated with bacterial translocation which is believed to prompted…
- Conditions
- Acute Pancreatitis, Fecal Microbiota Transplantation, Bacterial Translocation, Infectious Complications
- Trial name
- NCT02318147
- Testing
- Fecal Microbiota Transplantation, The traditional treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Acute Pancreatitis
MIld to MOderate Acute Pancreatitis: Early naSogastric Tube Feeding Compared With pAncreas Rest (MIMOSA)
Pain relapse during oral refeeding occurs in at least one-fifth of patients with acute pancreatitis. The study hypothesis is that early administered enteral tube feeding might reduce a risk of pain relapse and shorten the length…
- Trial name
- MIMOSA (NCT01128478)
- Testing
- Enteral tube feeding
- Where
- New Zealand
- Volunteers
- 35 people
- Sponsor
- University of Auckland, New Zealand
Acute Necrotizing Pancreatitis
CMV Reactivation in Acute Necrotizing Pancreatitis
Patients with the diagnosis of acute necrotizing pancreatitis (ANP) present with a wide spectrum of severity. These patients frequently require intensive care management.
- Trial name
- NCT05898048
- Where
- India
- Volunteers
- 41 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Acute Biliary Pancreatitis
Acute Biliary Pancreatitis - Optimal Time for Cholecystectomy
In patients with mild gallstone pancreatitis, early cholecystectomy within 48 hours might reduce the risk of recurrent gallstone-related complications, compared with the more commonly used strategy in our locality of conservative…
- Trial name
- NCT03085407
- Testing
- early cholecystectomy, delayed cholecystectomy
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- South Valley University
Pancreatitis
Decrease of Recurrent Pancreatitis
Retrospective studies have shown, that about half of the patients will have a recurrent episode after the first acute alcoholic pancreatitis.
- Trial name
- NCT00534534
- Testing
- Repeated behavioural intervention without any drugs
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- Tampere University
Pancreatitis, Acute
Safety and Tolerability of Pirfenidone in Acute Pancreatitis
The goal of the current pilot clinical trial is to evaluate the safety and tolerability of pirfenidone in patients with predicted moderately severe and severe acute pancreatitis.
- Trial name
- NCT05350371
- Testing
- Pirfenidone Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of Alabama at Birmingham
Acute Pancreatitis, Acute Pancreatitis With Infected Necrosis
Pancreatitis - Microbiome as Predictor of Severity II
The goal of this observational study is to evaluate the orointestinal microbiome and microbial derived metabolome in patients suffering from acute pancreatitis as a biomarker for severity.
- Trial name
- P-MAPS II (NCT06508502)
- Where
- Germany
- Volunteers
- 700 people
- Sponsor
- University Medical Center Goettingen
Acute Pancreatitis, Organ Failure, Multiple
Elevated Stearoyl-CoA Desaturase-1 Expression Predicts the Disease Severity of Severe Acute Pancreatitis
In this study, the investgatiors aimed to investigate the associations between serum levels of stearoyl-CoA desaturase-1（SCD-1） and the disease severity as well as the presence of adverse clinical events, such as local…
- Trial name
- NCT03282253
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Nanjing University School of Medicine
Pancreatitis
Acute Pancreatitis Patient Registry To Examine Novel Therapies In Clinical Experiences 2
This study is an ancillary of APPRENTICE. This will be the international based study.
- Trial name
- APPRENTICE2 (NCT03075631)
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 1,183 people
- Sponsor
- University of Pittsburgh
Pancreatitis, Chronic
Radiomic fEatures of Pancreas From Contrast Enhanced CT Image Predict One-Year RecUrrence Risk of Acute PancReatitis
One-year recurrence rate of acute pancreatitis at about 20%. 36% of the patients with recurrent acute pancreatitis will develop into chronic pancreatitis.
- Trial name
- RECUR (NCT05778929)
- Testing
- Radiomics Model
- Volunteers
- 694 people
- Sponsor
- Peking University People's Hospital
Acute Pancreatitis
Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics
The DREAM-ON study will investigate whether continuous glucose monitoring (CGM) is useful to predict risk for developing diabetes mellitus (DM) and pre-diabetes mellitus (PDM), the need for insulin therapy among those who develop…
- Trial name
- DREAM-ON (NCT06401577)
- Testing
- Dexcom Continuous Glucose Monitor (CGM)
- Where
- 13 sites in United States
- Volunteers
- 800 people
- Sponsor
- Milton S. Hershey Medical Center
Neurological Diseases, Pneumopathy
Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients
Comparison of metabolic and nutritional effects of an enteral immune enhancing diet with those of a standard polymeric one, in ICU patients
- Conditions
- Neurological Diseases, Pneumopathy, Major Abdominal Surgery, Acute Pancreatitis
- Trial name
- NCT00560157
- Testing
- Crucial (enteral tube feeding)
- Where
- 2 sites in France
- Volunteers
- 22 people
- Sponsor
- Société des Produits Nestlé (SPN)
Acute Necrotizing Pancreatitis
Effectiveness of Endorotor PED® System Versus Conventional Endoscopic Techniques for the Management of Walled-off Pancreatic Necrosis in Acute Necrotizing Pancreatitis: Randomized Single-blinded Controlled Superiority Trial and Cost-utility Analysis
This is a national single-blinded prospective multicenter randomized (1:1) controlled trial, with two parallel arms, using a PROBE methodology, including patients with complicated acute necrotizing pancreatitis who require DEN of…
- Trial name
- ROTONEC (NCT07253350)
- Testing
- Endorotor Group, Conventional group
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Pancreatitis
Searching the Best Prognostic Factor in Out Come Evaluation in Patients With Acute Pancreatitis Admitted at Assiut University Hospitals
Acute pancreatitis (AP) is rapid-onset inflammation of the pancreas that varies in severity from a self-limiting mild illness to rapidly progressive multiple organ failure.
- Trial name
- NCT03259880
- Volunteers
- 100 people
- Sponsor
- Fady Refaat Edwar Nasrallah
Choledocholithiasis With Acute Cholangitis (Diagnosis), Acute Pancreatitis Due to Gallstones
Complications After Endoscopic Retrograde Cholangiopancreatography
Retrospective study to analyze benign complications and malignancy risks after ERCP with sphincterotomy. All patients who received a ERCP with sphincterotomy for a benign disease will be included.
- Trial name
- ERCP (NCT04735224)
- Volunteers
- 500 people
- Sponsor
- Juan Carlos Martín del Olmo
Acute Pancreatitis
Evaluation of Prognosis and Prognostic Scores in Geriatric Patients With Acute Pancreatitis
To compare the prognosis of acute pancreatitis between geriatric and other adult patients To evaluate the efficacy of various prognostic scores in geriatric patients with acute pancreatitis
- Trial name
- NCT02223325
- Volunteers
- 150 people
- Sponsor
- Gazi University
Pancreatitis, Acute Necrotizing
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Investigation of GSK3335065 Intravenous (IV) Infusion in Healthy Adults
GSK3335065 is being developed as a treatment for acute pancreatitis with the intent of reducing 3-hydroxykynurenine (3HK) levels to the normal range (or lower) and maintaining them at this level throughout the treatment period.
- Trial name
- NCT03245619
- Testing
- GSK3335065
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Pancreatitis, Chronic Pain
Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis
Abdominal pain in chronic pancreatitis (CP) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable.
- Trial name
- P-QST (NCT04996628)
- Testing
- Quantitative Sensory Test 1, Quantitative Sensory Test 2, Quantitative Sensory Test 3
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Pittsburgh
Severe Acute Pancreatitis Patients, Duodenal Fistula
Effects of Delayed Enteral Nutrition on Inflammatory Responses and Immune Function Competence in Critically Ill Patients With Prolonged Fasting
Different studies suggest that early enteral nutrition (EEN) has benefits in reducing infectious complications, there is no data that addresses whether delayed enteral nutrition (EN) is detrimental and if it may have effects on…
- Conditions
- Severe Acute Pancreatitis Patients, Duodenal Fistula, Inflammatory Intestinal Obstruction
- Trial name
- NCT01834430
- Testing
- enteral nutrition
- Volunteers
- 45 people
- Sponsor
- Nanjing PLA General Hospital