Clinical trials: Pandemic, COVID-19
COVID-19 Pandemic
Motivation, Syringe Exchange, and COVID-19
People who inject drugs (PWIDs) are highly vulnerable to SARS-CoV-2 infection and to the disease caused by SARS-CoV-2, coronavirus disease 2019 (COVID-19), however, rates of SARS-CoV-2 testing and vaccination uptake -vital to…
- Trial name
- NCT05534061
- Testing
- Connect2Test
- Where
- United States
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- University of Oregon
COVID-19
Losmapimod Safety and Efficacy in COVID-19
The therapeutic hypothesis for the use of losmapimod in COVID-19 disease is that increased mortality and severe disease is caused by p38 mitogen-activated protein kinase (MAPK)-mediated exaggerated acute inflammatory response…
- Trial name
- LOSVID (NCT04511819)
- Testing
- Losmapimod oral tablet
- Where
- 16 sites in United States, Brazil and 2 more
- Volunteers
- 52 people
- Sponsor
- Fulcrum Therapeutics
COVID-19, Post Acute Sequelae of SARS-CoV-2
Mindfulness Intervention for Post-Covid Symptoms
The purpose of this study is to assess the feasibility of using a wearable brain-sensing wellness device (Muse-S) to potentially reduce stress and anxiety during Post-Covid, which is characterized by increased stress and anxiety.
- Trial name
- NCT05199233
- Testing
- Muse S™ Headband system
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic
Anxiety, Depressive Symptoms
StriveWeekly Online Mental Health Trial Post-pandemic
With the COVID-19 pandemic completely altering the landscape of higher education, students have been experiencing more stress than ever.
- Conditions
- Anxiety, Depressive Symptoms, Stress, Emotional
- Trial name
- NCT04927845
- Testing
- StriveWeekly
- Where
- United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- Harvard University
Covid19, Intellectual Disability
Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic
The primary goal of this project is to identify the best messaging and implementation strategies to maximize SARS-CoV-2 testing for children with intellectual and developmental disabilities (IDD) and their teachers to help ensure…
- Conditions
- Covid19, Intellectual Disability, Developmental Disability, Child Development Disorder
- Trial name
- NCT04565509
- Testing
- Standard Messaging, Enhanced Messaging, COVID-19 Testing
- Where
- 3 sites in United States
- Volunteers
- 1,143 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
2019 Novel Coronavirus Disease, 2019 Novel Coronavirus Infection
Leidos-Enabled Adaptive Protocol (LEAP-CT) for Evaluation of Post-exposure Prophylaxis for Newly-infected COVID-19 Patients
This study is designed to test the efficacy and safety of combinations of two well-understood agents - famotidine and celecoxib.
- Conditions
- 2019 Novel Coronavirus Disease, 2019 Novel Coronavirus Infection, 2019-nCoV Disease, 2019-nCoV Infection
- Trial name
- NCT05077969
- Testing
- Famotidine, Celecoxib
- Where
- 15 sites in United States
- Volunteers
- 4 people
- Sponsor
- Leidos Life Sciences
Health Personnel Attitude, Health Knowledge, Attitudes, Practice
Healthcare Provider Human Papillomavirus Education and Professional Skills Intervention
Healthcare providers (HCP) serving the El Paso U.S.-Mexico Border Region will be recruited to compare educational and professional skills interventions focused on the human papillomavirus (HPV).
- Trial name
- NCT05120869
- Testing
- Tailored HPV Education and Professional Skills Intervention Group, General HPV Education and Communication Skills Control Group
- Where
- 2 sites in United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Bereavement, Severe Grief Reaction
Supporting Family Members With Severe Grief Reaction During the COVID-19 Pandemic
This is a feasibility study taking place at The Ottawa Hospital (TOH), Hôpital Montfort, and Queensway Carleton Hospital that seeks to evaluate the impact of the COVID-19 pandemic on family member bereavement and study the effect…
- Trial name
- NCT04588415
- Testing
- Bereavement Virtual Support Group
- Where
- Canada
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Gastrointestinal Disease, Infectious Disease
Feasibility of Non-contact Magnetically-controlled Capsule Endoscopy During COVID-19 Pandemic
In December 2019, an outbreak of pneumonia associated with a novel coronavirus named as severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) was reported in Wuhan city, China, and spread exponentially throughout China and…
- Conditions
- Gastrointestinal Disease, Infectious Disease, Capsule Endoscopy
- Trial name
- NCT04389333
- Testing
- non-contact magnetically-controlled capsule endoscopy
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Resilience, Stress
First Responder Resiliency Program During COVID-19
Evaluating a wellness program developed to provide effective sustainable solutions for medical professionals providing care to COVID-19 pandemic patients.
- Conditions
- Resilience, Stress, Sleep
- Trial name
- NCT04536376
- Testing
- Resilience Program
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
COVID-19
Patients and Health Staff of Cancer Centres During the Covid-19 Pandemic
The Covid-19 has, in a few weeks, made the world tremble: the number of deaths (mainly elderly and / or co-morbid) continues to increase, the confinement causes the collapsing of the economy and the decline of relationships…
- Trial name
- PAPESCO-19 (NCT04421625)
- Testing
- Diagnostic test for SARS-Cov2 for patients and health staff
- Where
- 3 sites in France
- Volunteers
- 1,102 people, healthy volunteers welcome
- Sponsor
- Institut Cancerologie de l'Ouest
COVID-19
Safety and Efficacy of Thymic Peptides in the Treatment of Hospitalized COVID-19 Patients in Honduras
This is a single-arm, open-label, phase II clinical study to evaluate the safety and efficacy of thymic peptides in the treatment of hospitalized COVID-19 patients in Honduras.
- Trial name
- NCT04771013
- Testing
- Thymic peptides
- Where
- Honduras
- Volunteers
- 22 people
- Sponsor
- Universidad Católica de Honduras
COVID-19
Study to Monitor the Occurrence of Viral Variants in Patients With Compromised Immune Systems Being Treated for COVID-19
Sotrovimab binds to a conserved epitope on the severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 spike protein outside the receptor-binding motif and has been shown to reduce the risk of hospitalization…
- Trial name
- LUNAR (NCT05305651)
- Testing
- Sotrovimab
- Where
- 8 sites in United Kingdom
- Volunteers
- 217 people
- Sponsor
- GlaxoSmithKline
Healthy
A Study of Adolescents Undergoing a Mindfulness Training During COVID-19
The COVID-19 pandemic has been significantly affecting people's lives around the globe. Social distancing, self-quarantine, shelter-in-place measures, economic challenges, and COVID-19-cased illness and deaths have the potential…
- Trial name
- NCT04548544
- Testing
- Training for Awareness, Resilience, and Action (TARA)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Major Depressive Disorder
A Novel Cognitive Remediation Intervention Targeting Poor Decision-making and Depression in Veterans at High Risk for Suicide: A Safe, Telehealth Approach During the COVID-19 Pandemic
Despite large-scale, nationwide efforts to better address suicidal behavior in Veterans at high risk, the development of interventions that target some of the key risk factors associated with suicide remains limited.
- Trial name
- CogRemVet (NCT04952532)
- Testing
- Neuropsychological Educational Approach to Cognitive Remediation (NEAR, termed Cognitive Remediation plus Bridging)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
COVID-19, SARS-CoV-2
Safety, Reactogenicity, and Immunogenicity Trial of CV2CoV mRNA Vaccine Against SARS-CoV-2 in Seropositive Adult Participants
Prevention of COVID-19 caused by SARS-CoV-2.
- Trial name
- NCT05260437
- Testing
- CV2CoV (2 µg), CV2CoV (4 µg), CV2CoV (8 µg)
- Where
- 24 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COVID-19, Severe Acute Respiratory Syndrome (SARS)
ANTIBODY-LEVEL BASED ANALYSIS OF COVID-19 CONVALESCENT SERUM (ABACCuS)
The goal of this study is to evaluate the safety and effectiveness of Coronavirus-90 (COVID-19) convalescent plasma for the treatment of COVID-19.
- Conditions
- COVID-19, Severe Acute Respiratory Syndrome (SARS), Coronavirus Infections
- Trial name
- ABACCuS (NCT04432272)
- Testing
- COVID-19 convalescent plasma
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Corewell Health East
Intrusive Memories of Traumatic Event(s)
A Brief GAmeplay Intervention for NHS ICU Staff Affected by COVID-19 Trauma (GAINS Study)
Intensive care unit (ICU) staff are frequently exposed to traumatic events at work (e.g., witnessing patients die), amplified by the COVID-19 pandemic.
- Trial name
- GAINS (NCT04992390)
- Testing
- Brief digital imagery-competing task intervention
- Where
- United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- P1vital Products Limited
Covid19, Mental Health
Mental Health Among Patients, Providers, and Staff During the COVID-19 Era
The Mental Health Among Patients, Providers, and Staff (MHAPPS) Study is designed to study how the COVID-19 pandemic has affected mental health and wellbeing, and how to support mental health while minimizing the burden on the…
- Trial name
- MHAPPS (NCT04700137)
- Testing
- Caring Contacts Plus Introductory Phone Call (CC+), Caring Contacts without an introductory phone call (CC)
- Where
- United States
- Volunteers
- 666 people
- Sponsor
- St. Luke's Health System, Boise, Idaho
Sars-CoV2, Serum; Disease
Serological Response to SARS-Cov-2 Virus in Personnel of the Institut Bergonié in the Context of the COVID-19 Pandemic
The question of the immune response of the population, particularly of professional populations in contact with vulnerable populations (such as those with chronic conditions such as cancer), is an important issue.
- Trial name
- PRO-SERO-COV (NCT04426006)
- Testing
- PRO-SERO-COV
- Where
- France
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Institut Bergonié