Clinical trials: Paracetamol
Healthy
A Comparative Bioavailability/Food Effect Study of Immediate-Release and Extended-Release Tramadol HCl/Acetaminophen Combination Products Following Single-Dose and Multiple-Dose Administration in Healthy Adult Volunteers
The objectives of this two-part study were to compare the single-dose and multiple-dose pharmacokinetics of extended release and immediate-release fixed combination formulations containing tramadol-HCl/acetaminophen and to…
- Trial name
- NCT00973232
- Testing
- DDS-06C (650 mg acetaminophen and 75 mg tramadol HCl), DDS-06C (650 mg acetaminophen and 75 mg tramadol), Zaldiar®
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Labopharm Inc.
Pain
A Study to Evaluate Ibuprofen (IBU) 62.5 mg and Acetaminophen (APAP) 125 mg/5 ml in an Oral Liquid Suspension Fixed-Dose Combination Product in Children Aged 6 to 11 Years
The purpose of this study will be to characterize the pharmacokinetic (PK) profile of the Fixed-Dose Combination (FDC) IBU 62.5 milligram (mg)/APAP 125 mg per 5 milliliter (mL) suspension in children 6 to 11 years of age…
- Trial name
- NCT07632274
- Testing
- Test Product
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- HALEON
Pain, Cesarean Section
Analgesia and Antihyperalgesia of Tramadol and Acetaminophen Per Oral After Caesarean Section
The aim of this study is to evaluate quality of patient-controlled peroral analgesia after cesarian section using the combination of tramadol and acetaminophen.
- Trial name
- NCT00873743
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy Subjects
A Pharmacokinetic Study Investigating the Rate and Extent of Paracetamol Absorption of Three Experimental Sustained Release Pediatric Suspensions
This proof of principle PK study will allow GSKCH to select the most favorable sustained release formulation among 3 prototypes to move to the next stage of drug development.
- Trial name
- NCT01476215
- Testing
- Paracetamol fast dissolution suspension, Paracetamol medium dissolution suspension, Paracetamol slow dissolution suspension
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Drug Induced Liver Injury
Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days
Acetaminophen is commonly used to treat fever or pain. Your body clears acetaminophen by processing it in the liver. During the processing, some of the acetaminophen may bind to proteins in the liver.
- Trial name
- Non-Drinker (NCT00616018)
- Testing
- acetaminophen
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Kennon Heard
Healthy Subjects
A Study to Compare Two Paracetamol Tablets
This is a single dose pharmacoscintigraphic study investigating the differences in paracetamol absorption between two formulations.
- Trial name
- NCT01381640
- Testing
- Marketed paracetamol, Experimental paracetamol formulation
- Where
- 2 sites in United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pain, Fever
Effect of Race/Ethnicity and Genes on Acetaminophen Pharmacokinetics
Although acetaminophen is the most commonly used nonprescription drug in the USA, little is known regarding the influence of genes and race/ethnicity on acetaminophen disposition.
- Conditions
- Pain, Fever, Hepatotoxicity
- Trial name
- NCT00768716
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Tufts University
Pharmacokinetics, Magnetic Resonance Imaging
Oral Pharmacokinetics of Sulfasalazine, Paracetamol, Fexofenadine and Valsartan Using Different Administration Mediums
The purpose of this study is to determine pharmacokinetics of the probe-drugs sulfasalazine, given in 240 ml non-caloric water and paracetamol, fexofenadine and valsartan after oral administration, given in 240 ml non-caloric…
- Conditions
- Pharmacokinetics, Magnetic Resonance Imaging, Administration, Oral
- Trial name
- NCT03012763
- Testing
- Paracetamol, Sulfasalazine, Fexofenadine
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Pain
A Pharmacokinetic Study to Compare Sustained Release and Standard Paracetamol Formulations.
This proof of principle study will evaluate an experimental formulation of paracetamol that is being developed for eventual long lasting use. This study is also used for drug safety evaluation.
- Trial name
- NCT01551797
- Testing
- Paracetamol 500 mg, Paracetamol 1000 mg, Paracetamol 750 mg
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
Pharmacokinetics and Bioequivalence of Vycavert (10 mg Hydrocodone Bitartrate/325 mg Acetaminophen) Compared to the Reference Drug Norco
This study aims to determine whether the hydrocodone and acetaminophen exposures following oral dosing of Vycavert are comparable to those following oral dosing of Norco.
- Trial name
- NCT01456520
- Testing
- Vycavert, Norco
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Pfizer
Analgesia
Preemptive Dexamethasone , Paracetamol on Postoperative Period Following Adeno-tonsillectomy in Pediatric .
Tonsillectomy is one of the most common surgical operations performed on children, and it is frequently linked with an increased risk of complications such as acute discomfort when swallowing and postoperative nausea and vomiting…
- Trial name
- NCT05143762
- Testing
- paracetamol, Dexamethasone, normal Saline
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Benha University
Alcohol Related Disorders
Hepatic Function in Alcoholics Following 5 Days of Acetaminophen Dosing
The study objective was to determine if liver injury develops in alcoholic patients during or following 5 days of therapeutic acetaminophen dosing.
- Trial name
- NCT00427206
- Testing
- acetaminophen (4g/day)
- Where
- 2 sites in United States, Canada
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Pain
Assessment of the Pharmacokinetics of a Sustained Release Formulation of a Tramadol/Acetaminophen Combination
1. Objective: To evaluate the pharmacokinetic profiles of an SR 75 mg tramadol/650 mg acetaminophen formulation compared with an immediate release (IR) 37.5 mg tramadol/325 mg acetaminophen formulation after a single dose and at…
- Trial name
- NCT01880125
- Testing
- Tramadol HCI/Acetaminophen
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yungjin Pharm. Co., Ltd.
Headache, Tension-Type
A Pharmacokinetic Study of an Experimental Paracetamol Formulation
This PK study is designed to show bioequivalence between the study treatments.
- Trial name
- NCT01476176
- Testing
- Experimental paracetamol, Paracetamol marketed formulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pharmacokinetics
A Randomized Crossover Study to Determine the Pharmacokinetics of Intranasally Administered Acetaminophen in Healthy Adults
This study is being done to determine the systemic absorption of nasally inhaled acetaminophen (Tylenol®) versus orally ingested acetaminophen by comparing the serum drug concentrations of the two groups obtained at various times…
- Trial name
- NCT00855049
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Alcohol Related Disorders
Hepatic Function During and Following Three Days of Acetaminophen Dosing in Alcoholics
The study objective was to determine whether liver injury develops in alcoholic patients who ingest therapeutic doses of APAP for three consecutive days.
- Trial name
- NCT00402571
- Testing
- acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Parkinson's Disease
Effect of Paracetamol on Opicapone Pharmacokinetics in Healthy Volunteers
Single-centre, open-label, randomised, two-way cross-over study consisting of 2 periods separated by a washout period of 14 days or more.
- Trial name
- NCT02305017
- Testing
- BIA 9-1067, Paracetamol
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Drug Toxicity, Healthy
Aminotransferase Trends During Prolonged Acetaminophen Dosing
The objective of this study is to monitor liver function tests (blood levels of an indicator of liver function) of healthy people taking the maximum labeled daily dose of acetaminophen compared to people taking placebo for 16 to…
- Trial name
- NCT00743093
- Testing
- acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Healthy
To Evaluate the Relative Abuse Potential of Hydrocodone Bitartrate and Acetaminophen
Evaluation of abuse potential in recreational abusers of Hydrocodone Bitartrate and Acetaminophen versus NORCO®.
- Trial name
- NCT03567941
- Testing
- Hydrocodon bitartrate-acetaminophen arm 1, Hydrocodon bitartrate-acetaminophen arm 2, Reference
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sun Pharma Advanced Research Company Limited
Acute Mountain Sickness, Blood Oxygen Saturation, Headache
Ibuprofen vs Acetaminophen for AMS Prevention
AMS (acute mountain sickness) affects those who ascend too high (>2000m) too fast. Acetazolamide is an effective drug for the prevention of AMS where proper acclimatization with gradual ascent may not be an option.
- Trial name
- NCT02244437
- Testing
- Ibuprofen, Acetaminophen
- Where
- Nepal
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Mountain Medicine Society of Nepal