Clinical trials: Paralysis
Stroke, Hemiparesis
Trans Auricular Vagus Nerve Stimulation (taVNS) and Robotic Training for Paralyzed Arm After Stroke
To determine whether treatment with transauricular vagus nerve stimulation (taVNS) during the training of an affected upper limb of a patient with chronic stroke on a robotic motor task alters the motor impairment.
- Trial name
- VaNSaRTS (NCT05339893)
- Testing
- In Motion Rehabilitation Robot
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Cerebral Palsy
Effects of UP-CAT With and Without Visual Feedback in Children With CP
Cerebral palsy (CP) is the most common neurological disorder of movement and/or posture and of motor function, which are due to a non-progressive interference or abnormality of the developing brain.
- Trial name
- NCT06198179
- Testing
- upper limb children action-observation training (UPCAT), upper limb children action-observation training (UP-CAT) with visual feedback
- Where
- Pakistan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Gait, Spastic
Walking Ability and Limit of Stability in Children With Spastic Cerebral Palsy
Trunk control in children with spastic Cerebral Palsy (CP) is impaired. They have weaker trunk muscle strenght, and insufficient sitting/standing balance according to their developing peers.
- Trial name
- NCT05583929
- Testing
- GAITRite gaitway system, Bertec Balance System
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Gastroparesis, Functional Dyspepsia
Transauricular Vagal Nerve Stimulation; Functional Dyspepsia and Gastroparesis
The goal of this study is to establish parameters of gastric myoelectrical activity and heart rate variability in healthy human subjects and compare and contrast them to those with gastroparesis and functional dyspepsia, at…
- Conditions
- Gastroparesis, Functional Dyspepsia, Healthy, Digestive System Disease
- Trial name
- AVNS (NCT05405842)
- Testing
- Transauricular Vagal Nerve Stimulation
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Parkinson Disease, Progressive Supranuclear Palsy
Cholinergic Mechanisms of Attentional-motor Integration and Gait Dysfunction in Parkinson Disease (UDALL)
To perform a prospective cohort study with [(18)F]fluoroethoxybenzovesamicol (FEOBV) brain PET at baseline and 2-year follow-up in PD subjects at risk of conversion to non-episodic and episodic (falls and FoG) PIGD motor features…
- Trial name
- NCT05459753
- Testing
- (18)F]fluoroethoxybenzovesamicol ([(18)F (FEOBV) PET, Dihydrotetrabenazine (DTBZ) PET
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cerebral Palsy, Periventricular White Matter Abnormalities
Predicting Cerebral Palsy in Infants With White Matter Injury Using MRI
The goal of this study is to determin the MRI features associated with cerebral palsy and to develop prediction models of pediatric disorders by combining MRI with artificial intelligence.
- Trial name
- NCT06575283
- Testing
- No intervention will be performed in this cohort study
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Diabetes Mellitus, Gastroparesis
Drug Trial of Lixisenatide on Gastric Emptying and Blood Pressure Drops in Type 2 Diabetics and Healthy People
The purpose of this study is to determine the effects of the drug lixisenatide on blood sugar levels, stomach emptying, blood pressure and heart rate, release of gut hormones and blood flow in the gut after a glucose drink in…
- Trial name
- Lixi (NCT02308254)
- Testing
- Lixisenatide
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Royal Adelaide Hospital
Cerebral Palsy (CP), Spasticity
Predictors of Motor İmagery Performance in Cerebral Palsy
There are very few studies in the literature examining the effect of age on motor imagery ability in children with cerebral palsy. To our knowledge, no studies have investigated the impact of other related factors.
- Conditions
- Cerebral Palsy (CP), Spasticity, Motor Learning
- Trial name
- NCT07002567
- Testing
- Implicit motor imagery, Explicit motor imagery
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Quadriplegia/Tetraplegia
Theta Burst Stimulation to Promote Motor Re-education in Tetraplegia
A repetitive, non-invasive brain stimulation technique referred to as theta burst stimulation can modulate corticomotor excitability and therefore has great rehabilitative potential for individuals with neurologic deficits…
- Trial name
- NCT03277521
- Testing
- Intermittent theta burst stimulation
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Chronic Stroke, Cerebral Palsy
Gondola Mechanism of Action
This study will investigate the clinical, functional and neurophysiological effects of automated mechanical peripheral stimulation (AMPS) via the Gondola device administered to patients with chronic stroke, cerebral palsy and…
- Conditions
- Chronic Stroke, Cerebral Palsy, Parkinson's Disease
- Trial name
- NCT05146648
- Testing
- Gondola AMPS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gastroparesis
GI-Challenge Study for Gastroparesis Patients and Healthy Controls
Gastroparesis Patients and Healthy Controls ages 20-49 will be asked to participate in an observational study measuring vagal activity following food ingestion in order to establish parameters of autonomic nerve/vagal function in…
- Trial name
- NCT03896126
- Testing
- Observational
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cerebral Palsy
Protocol Validation of Dynamometric Measurement of Passive Inter-segmental Stiffness and Spasticity in Children With Cerebral Palsy
Cerebral palsy (CP) refers to a group of movement and posture disorders responsible for activity limitation due to brain damage that occurs during fetal development or during the first year of a child's life.
- Trial name
- NCT04596852
- Testing
- Assessment of the reliability of a protocol characterizing intersegmental hyper-resistance to passive stretch
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Fondation Ellen Poidatz
Healthy Volunteer, Stroke
Motivation While Doing Physical Exercise in a Social Dual-task Virtual Environment
The goal of this interventional study is to assess the difference in participants' motivation while performing a virtual reality-based dual-task exercise in a single-player vs. multi-player modality.
- Conditions
- Healthy Volunteer, Stroke, COPD, Cerebral Palsy
- Trial name
- ActivE3 (NCT07050654)
- Testing
- Dual-task cycling
- Where
- 4 sites in Italy
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Istituto di Sistemi e Tecnologie Industriali Intelligenti per il Manifatturiero Avanzato
Cerebral Palsy
Investigating New Methods to Study Movement in Children and Young Adults With Movement Disorders.
Background: Cerebral palsy (CP) is the most common motor disorder that affects children. People with CP have weak muscles; they may have trouble controlling the movements of their arms and legs.
- Trial name
- NCT06498596
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Stroke Sequelae, Gait, Hemiplegic
Proof of Concept of Hybrid Robotics for Gait Rehabilitation of Persons Post-stroke
Persons post-stroke suffer from hemiparesis affecting the functional abilities of the controlesional lower limb. Improving walking is therefore a primary rehabilitation goal for such patients.
- Trial name
- PoCH-Rehab (NCT06436898)
- Testing
- Combined overground gait exoskeleton and FES applied to lower limb, Overground gait exoskeleton
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Cerebral Palsy
the Use of Smart Mobile Application in Mothers With Cerebral Palsy Children
There are studies in the literature aimed at supporting parents who care for children who have Cerebral Palsy. Among these, the study conducted on the use of mobile applications in supporting parents has attracted attention in…
- Trial name
- NCT06102317
- Testing
- nursing consultancy with smartphone support
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr. Behcet Uz Children's Hospital
Diplegia, Spastic
Eye-Hand Coordination in Children With Spastic Diplegia
This study will examine how the brain controls eye-hand coordination (visuomotor skills) in children with spastic diplegia and will determine whether impairment of this skill is related to the learning difficulties in school that…
- Trial name
- NCT00024791
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Bell Palsy
Mirror Therapy on PC in Acute Bell's Palsy.
The objective of this study is to compare the effects of mime therapy using mirror therapy application of tablet PC vs mime therapy on acute bell's palsy. Study Design was Randomized control trial with Sample Size was 22.
- Trial name
- NCT04936152
- Testing
- mime therapy using tablet PC mirror application, the control intervention including the mime therapy
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Spinal Cord Injuries, Paraplegia, Spinal
Modeling, Optimization, and Control Methods for a Personalized Hybrid Walking Exoskeleton
The central objective of this study is to validate new algorithms that coordinate between functional electrical stimulation (FES) and the exoskeleton during sitting-to-standing, walking, and standing-to-sitting movements.
- Conditions
- Spinal Cord Injuries, Paraplegia, Spinal, Paraplegia, Incomplete
- Trial name
- NCT04453943
- Testing
- Exoskeleton Walking - with or without FES, Exoskeleton Sitting to Standing - with or without FES
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
Sensory Integration Disorder
Sensory Integration for Infants With Cortical Visual Impairment
Our study examines the effect of sensory integration training on sensory, motor and oculomotor skills in infants with cortical vision impairment .
- Trial name
- NCT05431647
- Testing
- Sensory integration therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hacettepe University