Clinical trials: Paralysis
Blepharoptosis, Synkinesis
Oxymetazoline Drops for Acquired Blepharoptosis From Synkinesis
After an episode of facial paralysis, as nerves recover, they aberrantly regenerate and send additional branches to the incorrect muscles in addition to the intended muscle.
- Conditions
- Blepharoptosis, Synkinesis, Hyperkinesis, Facial Paralysis
- Trial name
- NCT05945615
- Testing
- Oxymetazoline 0.1% (Pf) Oph Soln Ud, Preservative free lubricating drops
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
EEG Sleep Spindles, Motor Outcome
Sleep Spindles Organization as an Early Neural Marker of Neuromotor Outcome
The goal of this observational study is to test the effectiveness of quantitative early biomarkers in the sleep electroencephalogram (EEG), namely sleep spindles, as predictors of early sensorimotor maturation and long-term motor…
- Conditions
- EEG Sleep Spindles, Motor Outcome, Cerebral Palsy, SMA1
- Trial name
- SONNO (NCT06256887)
- Where
- 3 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Cerebral Palsy
Wavelet Analysis of Electromyography (EMG) in Cerebral Palsy
Several methods exist to evaluate motor function in the child with cerebral palsy and are used to assess the outcome of a clinical intervention.
- Trial name
- NCT00504049
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Cerebral Palsy
Evaluating Wearable Robotic Assistance on Gait
The overarching goal of this study is to improve mobility in individuals with movement disorders through advances in wearable assistance (i.e. powered orthoses).
- Trial name
- NCT04119063
- Testing
- powered orthosis
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Brain Injury, Cerebral Palsy
The Connection Between Gait Variability Parameters and Balance Performance in Children With Physical Disability
The purpose of this study is to explore the connection between gait variability parameters and balance performance in children with physical disability
- Trial name
- NCT00338858
- Testing
- walking and balance performance evaluation, muscle strength, walking and balance performance
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alyn Pediatric & Adolescent Rehabilitation Hospital
Parkinson Disease, Multiple System Atrophy
Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging
The goals of this study are: 1) to identify biomarkers using neuroimaging that are associated with progression rate using statistical methods, and 2) to identify biomarkers that are associated with the differential diagnosis of…
- Conditions
- Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- NCT03872102
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Parkinson's Disease, Parkinsonian Disorders
Gait Analysis in Neurological Disease
The purpose of this study is to investigate whether speed-dependent measures of gait (so called gait signatures) can be identified in patients with neurological conditions that affect gait, particularly in subjects with…
- Conditions
- Parkinson's Disease, Parkinsonian Disorders, Atypical Parkinson Disease, Progressive Supranuclear Palsy
- Trial name
- NCT02994719
- Testing
- Anti-Parkinson medication, Deep Brain Stimulation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Cerebral Palsy, Functioning
Effects of Action Observation Therapy and Mirror Therapy in Children With Unilateral Cerebral Palsy
The aim of this study was to examine the effects of action observation therapy and mirror therapy on upper extremity functions in children with unilateral cerebral palsy.
- Conditions
- Cerebral Palsy, Functioning, Upper Extremity Problem
- Trial name
- NCT05951829
- Testing
- Action Observation Therapy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Gastroparesis
Evaluation of the Safety, Tolerability and Pharmacokinetics of Repeat Oral Doses of GSK962040 Administered to Healthy Adult Subjects.
This study will evaluate the safety, tolerability and exposure of repeat escalating oral doses of GSK962040.
- Trial name
- NCT00733551
- Testing
- GSK962040
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gastroparesis, Dyspepsia
Magnetically Controlled Capsule Endoscopy Feasibility Study in Gastric Motility
This is a feasibility study to assess the utility of magnetically controlled capsule endoscopy in the evaluation of gastroparesis and functional dyspepsia
- Trial name
- NCT05004012
- Testing
- Magnetically Controlled Capsule Endoscopy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cerebral Palsy, Crouch Gait
Alterations of Functional Activities and Leg Stiffness After Hamstring Lengthening in Cerebral Palsy Children
Cerebral palsy (CP) is the most prevalent physical disabilities originating in childhood. Crouch gait is a common gait abnormality in patients with cerebral palsy, which is common treated with hamstring lengthening.
- Trial name
- NCT00154830
- Testing
- cerebral palsy, crouch gait
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Stroke, Paralysis Arm
PNS Motor Stimulation Study
Paralysis is one of the most disabling features of Spinal cord injury and stroke. In select cases, where the nerve is intact, stimulation can achieve meaningful muscle contraction e.g. to restore grip and release function.
- Conditions
- Stroke, Paralysis Arm, Spinal Cord Injury
- Trial name
- NCT07810712
- Testing
- Stimulation of the motor unit
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Walton Centre NHS Foundation Trust
Cerebral Palsy
Independent Walking Onset of Children With Cerebral Palsy
This study will focus the gait analysis, using an optoelectronic system, of children with unilateral cerebral palsy compared to typically developed children in the first 6 months of independent walking.
- Trial name
- BB-AQM (NCT03902886)
- Testing
- gait analysis
- Where
- 2 sites in France, Romania
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Eye-tracking, Facial Palsy
Eye-Tracking FP "A Pilot Study of the Quantitative Evaluation of the Attention Paid to Faces With Facial Palsy by the Eye-tracking Technology.
The facial palsy concerns between 15 and 40 people per 100000 inhabitants. They are of various etiologies such as infectious, tumoral, traumatic or idiopathic.
- Trial name
- EyeTrackingFP (NCT04886245)
- Testing
- Video sequences
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Assessment, Self, Cerebral Palsy
Assessment by Surface Electromyography in Cerebral Palsy Footballers
Adapted sport is constantly evolving thanks to the technological and scientific advances in the field of sports that are being developed in our era.
- Conditions
- Assessment, Self, Cerebral Palsy, Technology Addiction
- Trial name
- NCT06151873
- Testing
- Adapted sport
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
Hemiplegia; Congenital
The Efficacy of Two Models of Intensive Upper Limb Training on Quality of Life in Children With Congenital Hemiplegia
This study compared the effectiveness of two-mode of activity-based upper limb rehabilitation (Modified Constraint-Induced Movement Therapy and Bimanual training) on health-related quality of life outcomes in school-aged children…
- Trial name
- NCT04425980
- Testing
- Modified Constraint-Induced Movement Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Stroke
Moving a Paralyzed Hand Through Use of a Brain-Computer Interface
This study will gain information on methods of control of a prosthetic arm in stroke patients or traumatic brain inury patients through a technique called "brain-computer interface" (BCI).
- Trial name
- NCT00242242
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Thyroidectomy
Intraoperative Neuromonitoring of the Recurrent Laryngeal Nerve Versus Neurostimulation
The purpose of this study is to evaluate if intraoperative neuromonitoring associated to neurostimulation of recurrent laryngeal nerve reduce the rate of recurrent laryngeal palsy respect to neurostimulation alone.
- Trial name
- NCT01163045
- Testing
- thyroidectomy
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Fasting, Gastric Stasis
Residual Gastric Volume After the Ingestion of Supplements Containing Carbohydrates and Whey Protein
Oral supplements (OS) containing carbohydrates are being used 2h before anesthesia. The addition of a nitrogen source would improve these drinks designed for the abbreviation of preoperative fasting.
- Conditions
- Fasting, Gastric Stasis, Perioperative Complication, Safety Issues
- Trial name
- NCT05573854
- Testing
- Gastric emptying after an oral supplement containing carbohydrates and whey protein, Overnight Fast
- Where
- Brazil
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Federal University of Mato Grosso
Gastroparesis
A Study to Evaluate the Pharmacokinetics and Absolute Bioavailability of GSK962040 Given as an Oral Dose Simultaneously With an Intravenous Microtracer Dose of [14C]-GSK962040 in Healthy Volunteers
The purpose of this study is to determine the absolute oral bioavailability and intravenous pharmacokinetics of GSK962040. The oral dose of 50 mg has been selected because it was well tolerated following single oral…
- Trial name
- NCT01267071
- Testing
- A, B
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline