Clinical trials: Paraplegia, Complete
Perfusion; Complications
Safety and Tolerance of Local Heat Application in the Paralyzed Area of Patients With Complete Paraplegia
Preconditioning of regional skin is known to reduce post surgery complications due to increased perfusion and better skin condition.
- Trial name
- DecuHeat (NCT03001531)
- Testing
- HydroSun, Hilotherm
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Spinal Cord Injuries
Extracorporeal Shockwave Therapy (ESWT) to Improve Function in Chronic ASIA-A Patients
The global prevalence of spinal cord injury is estimated between 236 to 4187/Million. A spontaneous recovery of the sense-motoric function is decreasing with the time after injury and is only seen sporadically after 1 to 2 years.
- Trial name
- NCT03399968
- Testing
- ESWT
- Where
- 2 sites in Austria
- Volunteers
- 25 people
- Sponsor
- AUVA Trauma Center Meidling
Stroke, Spinal Cord Injuries (Complete and Incomplete)
Exoskeleton-assisted Neurorehabilitation
Objective assesment of the feasibility of integrating the Ekso Bionics - Ekso NR device into outpatient care Objective assesment of quality of life, functionality and clinical symptomps of patients with stroke, cerebellar ataxia…
- Conditions
- Stroke, Spinal Cord Injuries (Complete and Incomplete), Cerebellar Ataxia, Spastic Paraplegia
- Trial name
- NCT07352085
- Testing
- Gait training with exoskeleton
- Where
- Hungary
- Volunteers
- 5 people
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Paraplegia, Spinal, Paraplegia, Complete
Transcutaneous and Epidural Stimulation in SCI
The study seeks to improve the scientific understanding of how two electrical stimulation techniques, one which delivers electricity to the skin surface over the spine (transcutaneous electrical spinal stimulation [TESS]) and…
- Conditions
- Paraplegia, Spinal, Paraplegia, Complete, Paraplegia; Traumatic
- Trial name
- Service-Line (NCT04627441)
- Testing
- Transcutaneous spinal cord stimulator, Epidural spinal cord stimulator system
- Sponsor
- Kristin Zhao, PhD
Complete Motor Paraplegia
Assessment of the Interest of the Atalante Device for Patients With Manual Wheelchairs
The loss of standing and walking capabilities in a paraplegic person is most often the result of damage to the spinal cord, either traumatic (accidental) or pathological and has both a somatic and a psychological impact on the…
- Trial name
- M1-M2 (NCT05909774)
- Testing
- Test with Atalante exoskeleton in "continuous walk" type
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Wandercraft
Spinal Cord Injuries, Chronic
High Doses of 4-aminopyridine in Clinically Complete Chronic Spinal Cord Injury Patients.
150 patients with clinically complete chronic spinal cord Injury will be included in a randomized, parallel, placebo controlled, multi-centric, phase III trial.
- Trial name
- NCT03899584
- Testing
- 4-Aminopyridine
- Where
- Mexico
- Volunteers
- 150 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Motor Complete Spinal Cord Injury
The Effects of Passive Gait Training in Complete Motor Spinal Cord Injury (SCI)
The purpose of this study is to determine whether a three times per week, 2 month robotic assisted treadmill gait training program, will beneficially affect the fitness, physical and psychological well-being, and the vascular and…
- Trial name
- NCT01349478
- Testing
- LOKOMAT
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Dr. Gabriel Zeilig
Spinal Cord Injury
Autologous Incubated Macrophages for Patients With Complete Spinal Cord Injuries
Autologous Incubated Macrophages (ProCord) is being developed as a therapy for acute, complete spinal cord injury (SCI). The therapy is intended to reverse the loss of motor and sensory function.
- Trial name
- NCT00073853
- Testing
- Autologous Incubated Macrophages (cell therapy)
- Where
- 7 sites in United States, Israel
- Volunteers
- 61 people
- Sponsor
- Proneuron Biotechnologies
Spinal Cord Injury
Autologous Mesenchymal Stem Cells Transplantation in Thoracolumbar Chronic and Complete Spinal Cord Injury Spinal Cord Injury
The purpose of this study is to analyze the safety and efficacy of autologous bone marrow mesenchymal stem cell transplantation in patients with thoracolumbar chronic and complete spinal cord injury.
- Trial name
- NCT02574585
- Testing
- Autologous mesenchymal cells transplantation
- Volunteers
- 40 people
- Sponsor
- Hospital Sao Rafael
Paraplegia, Spinal, Paraplegia, Complete
Transcutaneous and Epidural Spinal Stimulation for Enabling Motor Function in Humans With Motor Complete Paraplegia
The purpose of this study is to compare transcutaneous electrical spinal stimulation (TESS) and epidural electrical stimulation (EES); in particular, the motor activity enabled by each method and the potential health benefits of…
- Conditions
- Paraplegia, Spinal, Paraplegia, Complete, Paraplegia; Traumatic
- Trial name
- TransEpi (NCT03945331)
- Testing
- Transcutaneous spinal cord stimulator, Epidural spinal cord stimulation system
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Spinal Cord Injuries, Paraplegia, Complete
Epidural Stimulation After Neurologic Damage
This study will evaluate a method to optimize parameter settings in epidural spinal cord stimulation used to recover lower extremity volitional movement.
- Trial name
- E-STAND (NCT03026816)
- Testing
- Epidural Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Spinal Cord Injury, Tetraplegia/Tetraparesis
Evaluation of Usability and Safety of the System Atalante in Patients With High Paraplegia and Tetraplegia
The objective of this clinical trial is to determine whether the Atalante X exoskeleton can be safely utilized by patients with tetraplegia and high paraplegia (at or above T4).
- Conditions
- Spinal Cord Injury, Tetraplegia/Tetraparesis, Paraplegia, Complete, Paraplegia, Incomplete
- Trial name
- QUATRO (NCT06939634)
- Testing
- Hands-free exoskeleton
- Where
- 3 sites in France
- Volunteers
- 35 people
- Sponsor
- Wandercraft
Spinal Cord Injury
Study to Assess Safety, Tolerability and MTD of a Central Pattern Generator-activating Tritherapy (SPINALON) in Patients With Chronic Spinal Cord Injury
As a first-in-class (Central Pattern Generator or CPG activator) approach, this tritherapy candidate called SPINALON has been identified and is currently under development for its capacity to temporarily induce episodes of…
- Trial name
- NCT01484184
- Testing
- SPINALON (buspirone + levodopa + cardidopa)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Nordic Life Science Pipeline Inc.
Myelitis, Transverse, Flaccid Paraplegia, Complete, Acute
Collaborative Assessment of Pediatric Transverse Myelitis: Understand, Reveal, Educate or CAPTURE Study
Patients and families are invited to participate in an online registry and data repository specifically for patients with transverse myelitis (TM) or acute flaccid myelitis (AFM).
- Conditions
- Myelitis, Transverse, Flaccid Paraplegia, Complete, Acute, Flaccid Paraplegia, Incomplete, Acute
- Trial name
- TMCAPTURE (NCT02144935)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Paraplegia
Training With Brain-machine Interfaces, Visuo-tactile Feedback and Assisted Locomotion for Patients With Chronic Complete Paraplegia
The purpose of this research is to compare the effectiveness of a training protocol integrating Brain-machine Interfaces, Visuo-tactile feedback and Assisted Locomotion (referred to as the Walk Again Neurorehabilitation protocol…
- Trial name
- NCT03992690
- Testing
- Brain-machine Interfaces, Visuo-tactile Feedback and Assisted Locomotion, or the WANR protocol, Training with traditional physiotherapy protocol
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
Paraplegia, Complete
Effect of the Atalante Exoskeleton on Standing and Walking in Individuals With Paraplegia: A Prospective Controlled-Environment Study in a Rehabilitation Context
This clinical study aims to evaluate the feasibility, safety, and acceptability of the Atalante robotic exoskeleton, developed by Wandercraft, within a functional rehabilitation protocol for individuals with complete paraplegia.
- Trial name
- APPEX (NCT06941896)
- Testing
- Use of the Atalante Exoskeleton
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury
Research on Wireless Brain Implant System for General Control of External Devices
The clinical trial aims to evaluate the safety and efficacy of the minimally invasive, wireless brain-machine interface system (WRS) in enabling general brain control of external devices, such as a cursor and other assistive…
- Conditions
- Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury, Brainstem Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- RISE (NCT06829212)
- Testing
- WRS
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Shanghai StairMed Technology Co., Ltd.