Clinical trials: Parasitic Disease
Malaria
Safety and Efficacy of Methylene Blue Combined With Amodiaquine or Artesunate for Malaria Treatment in Children of Burkina Faso
The purpose of the study is to investigate the safety and efficacy profile of a new paediatric MB formulation combined with AQ or AS and compared to AS-AQ in young African children with uncomplicated falciparum malaria.
- Trial name
- NCT00545935
- Testing
- Methylenblue-Amodiaquine (MB-AQ), Methylenblue-Artesunate (MB-AS), Artesunate-Amodiaquine (AS-AQ)
- Where
- Burkina Faso
- Volunteers
- 186 people
- Sponsor
- Heidelberg University
Malaria (Plasmodium Falciparum)
Controlled Human Malaria Infection by Mosquito Bites Using a Local Strain of Plasmodium Falciparum
The project aims to reproduce the malaria infection cycle using African mosquitoes, namely Anopheles gambiae and a local strain of Plasmodium parasites.
- Trial name
- BB-LaCHMI-01 (NCT07816497)
- Testing
- Controlled Human Malaria Infection
- Where
- Gabon
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche Médicale de Lambaréné
Intestinal Helminthiasis
Impact of Health Education on School Children
There is a sever lack in application of health education intervention for Soil Transmitted Disease (STH) in rural communities and in school children among Orang Asli in Pahang in Malaysia, and also there is a lack of information…
- Trial name
- NCT01640626
- Testing
- Health Education package
- Where
- Malaysia
- Volunteers
- 317 people
- Sponsor
- University of Malaya
Uncomplicated Plasmodium Falciparum Malaria
Efficacy, Safety and Tolerability of KAF156 in Combination With Lumefantrine Solid Dispersion Formulation (LUM-SDF) in Pediatric Population With Uncomplicated Plasmodium Falciparum Malaria
This study aimed to determine the efficacy, safety and tolerability of the investigational drug KAF156 in combination with a solid dispersion formulation of lumefantrine (LUM-SDF) in pediatric patients (6 months to < 18 years of…
- Trial name
- KALUMI (NCT04546633)
- Testing
- KAF156, LUM-SDF, Coartem
- Where
- 9 sites in Burkina Faso, Côte d’Ivoire and 3 more
- Volunteers
- 295 people
- Sponsor
- Novartis Pharmaceuticals
Malaria
Spatial Repellents for Vector Control
The primary objective of the study is to demonstrate and quantify the protective efficacy of a single Spatial Repellent (SR) product, in reducing malaria infection in a human cohort.
- Trial name
- AEGIS Mali (NCT04795648)
- Testing
- Transfluthrin
- Where
- 2 sites in Mali
- Volunteers
- 1,911 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Leishmaniasis, Cutaneous
Antimicrobial Adjuvants to Revert the Imbalance of Skin Microbiota for Improved Outcomes of Complicated Cutaneous Leishmaniasis Treatment in Ethiopia
This clinical trial aims to evaluate the effectiveness of combining the standard treatment for complicated cutaneous leishmaniasis (CL), sodium stibogluconate (SSG), with either topical fusidic acid 2% cream or a vehicle cream…
- Trial name
- AIM-CL (NCT06695143)
- Testing
- Fusidic Acid, Vehicle cream
- Where
- 2 sites in Ethiopia
- Volunteers
- 180 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Asymptomatic P.Falciparum Malaria
Artemisia Annua Infusion for the Treatment of Asymptomatic Plasmodium Falciparum Infection
The goal of this clinical trial is to determine whether Artemisia annua dried leaves, used as an infusion, can treat individuals with malaria parasites but no symptoms.
- Trial name
- ART-CT001 (NCT07819825)
- Testing
- Artemisia Annua Leaf, Centaurii herba
- Where
- Gabon
- Volunteers
- 20 people
- Sponsor
- Centre de Recherche Médicale de Lambaréné
Malaria
Dihydroartemisinin (DHA)-Piperaquine for IPT to Prevent Malaria in Children in Burkina Faso
The aim of the study is to determine whether piperaquine plus dihydroartemisinin (DHA-PQ) is as effective, and better tolerated, than sulfadoxine-pyrimethamine plus amodiaquine (SP+AQ), when used for seasonal Intermittent…
- Trial name
- NCT00941785
- Testing
- DHA-PQ, SP-AQ
- Where
- Burkina Faso
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Liver Abscess, Amoebic Liver Abscess
Efficacy of Diloxanide Furoate as Additional Luminal Agent Along With Metronidazole for the Treatment of Amoebic Liver Abscess
Liver abscess is a common cause of presentation to medical emergency. Among the various causes of liver abscess, Amoebic liver abscess (ALA) is a frequent cause that can resemble pyogenic infections in tropical regions.
- Trial name
- DFALA RCT (NCT07807150)
- Testing
- Diloxanide furoate
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Cutaneous Leishmaniases
Outcomes of Complicated CL in Ethiopia Treated With Miltefosine
Cutaneous Leishmaniasis in Ethiopia causes severe dermatological mutilations. Forms that require systemic treatment are cLCL, MCL, and DCL. National guidelines recommend equally all drugs that are also used for VL treatment.
- Trial name
- NCT04004754
- Testing
- Miltefosine (administration is not part of study procedures)
- Where
- 2 sites in Ethiopia
- Volunteers
- 94 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Anemia, Anemia, Iron-Deficiency
Lucky Iron Fish Home Fortification of Iron
The purpose of this research is to determine if cooking with an iron ingot called the Lucky Iron Fish (LIF) increases the hemoglobin status in women of childbearing age living in Preah Vihear, Cambodia.
- Conditions
- Anemia, Anemia, Iron-Deficiency, Hemoglobinopathies
- Trial name
- NCT02341586
- Testing
- Lucky Iron Fish - home fortification system, 18 mg elemental iron, Nutrition Education
- Where
- Cambodia
- Volunteers
- 340 people
- Sponsor
- University of British Columbia
Malaria, Severe Acute Malnutrition
Efficacy and Bio-availability of Artemether-Lumefantrine in Severely Malnourished Children
The general objective of the study is to answer to the question: "Is the current dose of AL less efficacious in the severely malnourished compared to the non-severely malnourished children, and is PK in cause?" We aim to assess…
- Trial name
- MAL-NUT (NCT01958905)
- Testing
- Artemether-lumefantrine fixed combination
- Where
- 2 sites in Mali, Niger
- Volunteers
- 399 people
- Sponsor
- Epicentre
Chagas' Disease (Chronic) With Other Organ Involvement
Lower Urinary Tract Dysfunction in Chronic Chagas' Disease : Clinical and Urodynamic Presentation
Chagas disease is one of the most neglected vector-borne infectious disease worldwide. The first decades following the discovery of the pathology drove an international research enthusiasm, mainly concentrated on understanding…
- Trial name
- NCT03189056
- Testing
- Chagas serology, Creatinina, Urodynamic exploration
- Where
- Bolivia
- Volunteers
- 152 people
- Sponsor
- Institut de Recherche pour le Developpement
Filarial; Infestation
Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection
Diethylcarbamazine (DEC) essentially a micro-filaricidal drug is given for 12 days as standard treatment for the clearance of W. bancrofti infection.
- Trial name
- NCT02005653
- Testing
- Diethylcarbamazine, Albendazole, Doxycycline
- Where
- India
- Volunteers
- 146 people
- Sponsor
- Indian Council of Medical Research
Malaria, Plasmodium Falciparum
A Study to Assess the Experimental Malaria Vaccines RH5.2-VLP and R21
This is a Phase Ib multi-stage Plasmodium falciparum malaria vaccine study to assess the safety and immunogenicity of the blood-stage vaccine candidate RH5.2 virus-like particle (VLP) in Matrix-MTM and the pre-erythrocytic stage…
- Trial name
- NCT05357560
- Testing
- Matrix-M with RH5.2 VLP and/or R21
- Where
- The Gambia
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Uncomplicated Plasmodium Falciparum Malaria
Test Efficacy Study on the Recommended Antimalarial Drugs in the Democratic Republic of the Congo
Malaria remains a public health concern, despite efforts that are invested in the disease control. The Democratic Republic of the Congo (DRC) is one of the most affected countries in Sub Saharan Africa.
- Trial name
- TES2022 (NCT06076213)
- Testing
- Artesunate-amodiaquine, Artemether-lumefantrine
- Where
- 7 sites in Democratic Republic of the Congo
- Volunteers
- 1,260 people
- Sponsor
- Ministry of Public Health, Democratic Republic of the Congo
Chagas Disease, Trypanosoma Cruzi Infection
Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease.
A phase 2 clinical trial to evaluate the the efficacy of different benznidazole regimens (300mg/day for 60 days, 150mg/day for 60 days, and 400mg/day for 15 days) for the treatment of chronic Chagas disease in adult patients.
- Trial name
- MULTIBENZ (NCT03191162)
- Testing
- Benznidazole
- Where
- 7 sites in Argentina, Brazil and 2 more
- Volunteers
- 238 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Neurocysticercosis, Health Literacy
The Impact of Medical TV Drama in Improving Literacy on Neurocysticercosis
This randomized controlled trial evaluates whether exposure to a medical television drama improves knowledge of neurocysticercosis (NCC) among young adults.
- Conditions
- Neurocysticercosis, Health Literacy, Epilepsy
- Trial name
- NCT07208656
- Testing
- Medical TV Drama Episode (House M.D.)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cephas Health Research Initiative Inc, Ibadan, Nigeria
Irritable Bowel Syndrome
Prevalence of Intestinal Parasitic Infections in Patients With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is common medical disorder and represent a group of diseases of the gastrointestinal tract that is characterized by chronic abdominal pain , bloating , passage of mucus or straining with bowel…
- Trial name
- NCT05830370
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Malaria, Respiratory Infections
A Trial of Seasonal Malaria Chemoprevention Plus Azithromycin in African Children
The primary objective of this study is to determine whether addition of azithromycin (AZ) to Seasonal Malaria Chemoprevention (SMC) using sulphadoxine/pyrimethamine (SP) +amodiaquine (AQ) will provide an additional reduction in…
- Trial name
- SMCAZ (NCT02211729)
- Testing
- Sulphadoxine-Pyrimethamine+ Amodiaquine+ Azithromycin
- Where
- 2 sites in Burkina Faso, Mali
- Volunteers
- 22,090 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
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