Clinical trials: Parathyroid Adenomas
Mediastinal Parathyroid Adenoma, Hyperparathyroidism
VATS for Resection of Mediastinal Parathyroids
Background: hyperparathyroidism (HPT) is a disease caused by hypersecretion of one or more parathyroid glands, it can be associated with ectopic mediastinal parathyroid glands (MEPA) in 2% of cases.
- Trial name
- NCT05696405
- Testing
- VATS resection of MEPA
- Volunteers
- 4 people
- Sponsor
- Hospital General Ajusco Medio
Parathyroid Adenoma
PTeye in Parathyroid Adenoma
Identifying the parathyroids is compulsory for success of parathyroidectomy for parathyroid adenoma. Near-infrared autofluorescence devices have been proposed as useful intraoperative tools for the identification of parathyroid…
- Trial name
- NCT06913296
- Testing
- parathyroidectomy
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Aristotle University Of Thessaloniki
Parathyroid Neoplasm, Parathyroid Diseases
Evaluation of MRI and SPECT Fusion Software to Localize Parathyroid Adenomas
The purpose of this study is to design a method to better localize parathyroid adenomas. This study will include approximately 6 patients who have not had surgery and another 25 patients who have already had surgery over the…
- Trial name
- NCT00639405
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- State University of New York - Upstate Medical University
Parathyroid Adenoma, Hyperparathyroidism
Trial Comparing 2 Diagnostic Strategies for Preoperative Localization of Parathyroid Adenoma in Primary Hyperparathyroidism:TEMP / CT With Tc99m-sestaMIBI or PET / CT With F18-choline in First Intention
The investigators hypothesize that positron emission tomography with fluorocholline (F18-choline PET) will reduce the proportion of unnecessary invasive surgery decisions and that the higher cost of positron emission tomography…
- Conditions
- Parathyroid Adenoma, Hyperparathyroidism, F18-choline
- Trial name
- APACH2 (NCT04040946)
- Testing
- MIBI scintigraphy, F18-choline PET
- Where
- 4 sites in France
- Volunteers
- 59 people
- Sponsor
- Centre Francois Baclesse
Parathyroid Adenoma, Thyroid Nodule
The Feasibility of Bilateral Intermediate Cervical Plexus Block for Thyroidectomy/Parathyroidectomy
The aim of this study was evaluated the feasibility of bilateral intermediate cervical plexus blockade to be anesthesia for simple thyroid/parathyroid surgery.
- Trial name
- NCT04905641
- Testing
- Bilateral intermediate cervical plexus block
- Where
- Thailand
- Volunteers
- 19 people
- Sponsor
- Mahidol University
Parathyroid Neoplasms
Using X-Ray Dye to Locate Hidden Parathyroid Tumors
Occasionally tumors of the parathyroid gland cannot be detected by standard x-ray diagnostic procedures (CT scans, MRIs, and ultrasounds). In order for the tumor to be removed surgically it must first be localized.
- Trial name
- NCT00001394
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Thryoid Cancer, parathyrıoid Adenoma
New Intraoperative Nerve Monitoring Device
This study is testing a new device developed to protect the recurrent laryngeal nerve, which is at risk of damage during thyroid and parathyroid surgeries.
- Trial name
- IONM (NCT07071571)
- Testing
- neuromonitoring
- Volunteers
- 40 people
- Sponsor
- SB Istanbul Education and Research Hospital
Solid Tumor, Lymphoma
Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma
This is a Phase I dose escalation study of PXD101 administered orally. Oral belinostat will be given once or twice daily at various dosing schedules to patients with solid tumors.
- Trial name
- NCT00413075
- Testing
- oral belinostat
- Where
- 6 sites in United States, Denmark and 1 more
- Volunteers
- 121 people
- Sponsor
- Valerio Therapeutics
18F-fluorocholine, Positron-Emission Tomography
FCH PET/MRI Parathyroid Localization
A prospective trial comparing the accuracy of [F-18]-FCH PET/MRI to US and 99mTc-MIBI SPECT/CT for pre-operative parathyroid localization in patients with primary hyperparathyroidism
- Conditions
- 18F-fluorocholine, Positron-Emission Tomography, Hyperparathyroidism, Primary
- Trial name
- NCT03324893
- Testing
- [F-18]-FCH PET/MRI
- Where
- Canada
- Volunteers
- 47 people
- Sponsor
- University Health Network, Toronto
Dementia, Movement Disorders
Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region.
The goal of this clinical study is to compare the current standard-of-care PET/CT scanner with the new NeuroEXPLORER PET/CT, with the aim of demonstrating the added diagnostic value of the new scanner.
- Conditions
- Dementia, Movement Disorders, ALS - Amyotrophic Lateral Sclerosis, Epilepsy
- Trial name
- NCT07595666
- Testing
- Standard-of-care PET/CT, NeuroEXPLORER
- Where
- Belgium
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- prof. dr. Koen Van Laere
Hyperparathyroidism, Primary
18F-Fluorocholine for the Detection of Parathyroid Adenomas
The investigators are studying the ability of F18 labeled fluorocholine PET to localize parathyroid adenomas in patients with hyperparathyroidism prior to surgery.
- Trial name
- NCT03764007
- Testing
- 18F-Fluorocholine, Positron Emission Tomography (PET)
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Thomas Hope
Hyperparathyroidism
Input of C11-Choline PET/CT in Localization of Parathyroid Adenoma
The purpose of the study is to determine a possible input of C11-Choline PET/CT in identification and localization of a parathyroid adenoma (PTA).
- Trial name
- NCT01221896
- Testing
- C11-Choline PET/CT
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Hyperparathyroidism, Parathyroid Adenoma
The Utility of 18F-fluorocholine PET/CT in the Imaging of Parathyroid Adenomas
We assessed sensitivity of 18F-FCH PET/CT in preoperative localisation of hyperfunctioning parathyroid tissue in patients with primary hyperparathyroidism (PHPT).
- Trial name
- NCT04570033
- Testing
- We assessed sensitivity of 18F-FCH PET/CT in preoperative localisation of hyperfunctioning parathyroid tissue in patients with primary hyperparathyroidism
- Volunteers
- 65 people
- Sponsor
- Military Institute od Medicine National Research Institute
Advanced Adult Primary Liver Cancer, Anaplastic Thyroid Cancer
Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu
Interleukin-12 may kill tumor cells by stopping blood flow to the tumor and by stimulating a person's white blood cells to kill cancer cells.
- Conditions
- Advanced Adult Primary Liver Cancer, Anaplastic Thyroid Cancer, Bone Metastases, Carcinoma of the Appendix
- Trial name
- NCT00004074
- Testing
- recombinant interleukin-12, ABI-007/carboplatin/trastuzumab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Cancer
MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: MS-275 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: This phase I trial is studying the side effects and best dose of MS-275 in treating patients with advanced solid…
- Trial name
- NCT00020579
- Testing
- entinostat
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Pleural Neoplasms, Mesothelioma
The ISET (Isolation by Size of Epithelial Tumor Cells) and the CellSearch Methods in Malignant Pleural Mesothelioma
Malignant pleural mesothelioma (MPM) has a growing incidence and in spite of early diagnostic, their outcome remains dismal. The evolution of MPM is often local with rare distant metastases.
- Conditions
- Pleural Neoplasms, Mesothelioma, Pneumothorax, Parathyroid Neoplasms
- Trial name
- NCT01776385
- Testing
- Blood sampling, Control Group
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Primary Hyperparathyroidism Due to Adenoma
Intraoperative Identification of Parathyroid Adenomas Using PTeye™ and FLUOBEAM® LX: a Prospective Cohort Study
The goal of this observational study is to evaluate the efficacy of PTeyeTM device to confirm a parathyroid adenoma on a visually suspected tissue in comparison with the FLUOBEAM®LX device.
- Trial name
- PTeye (NCT06788223)
- Testing
- Parathyroidectomy
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Hyperparathyroidism
F-18 PSMA for Localization of Parathyroid Adenoma
Parathyroid glands are in the neck and produce a substance called parathormone which maintains the calcium level in the blood. Sometimes one or more of the parathyroid glands become hyperactive and produce too much parathormone…
- Trial name
- NCT05299632
- Testing
- 99mTc-MIBI planar imaging and SPECT/CT., F- 18PSMA PET/CT imaging study
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Primary Hyperparathyroidism, Primary Hyperparathyroidism Due to Adenoma
A Retrospective Analysis of the Diagnostic Performance of 11C-choline PET/CT in Primary Hyperparathyroidism
The leading cause of primary hyperparathyroidism (pHPT) is a solitary adenoma (89%). The treatment of pHPT is generally surgical removal of the overactive parathyroid gland(s).
- Trial name
- NCT04608253
- Testing
- 11C-choline PET/CT
- Volunteers
- 36 people
- Sponsor
- University Medical Center Groningen
Hyperparathyroidism
Interest of the F18-choline as a Second Line of the Tracer for Detection of Parathyroid Adenomas
The rationale for the proposed pilot study is to investigate the ability of PET-CT with F18-choline to detect and locate the parathyroid adenoma in patients with primary hyperparathyroidism and negative or non-contributory MIBI…
- Trial name
- APACH1 (NCT02432599)
- Testing
- F18-choline PET examination
- Where
- 2 sites in France
- Volunteers
- 28 people
- Sponsor
- Centre Francois Baclesse