Clinical trials: Paratonia
Dementia, Paratonia
Safety and Effectiveness of Botulinum Toxin in Elderly Patients With Dementia and Muscle Stiffness
Aim of the study is to perform a pilot study to assess the impact of Botulinum toxin on muscle tone, and caregiver burden in individuals who are cognitively impaired and who are fully dependent.
- Trial name
- NCT02212119
- Testing
- Botulinum Toxin, Saline
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Assistive Technology Clinic, Canada
Dementia, Paratonia
Short-term Effect of Positioning Cushions and Harmonic Techniques on Paratonia in Persons With Dementia
This study investigated the short-term effect of both harmonic techniques and supporting cushions on muscle tone, range of motion, pain and daily care activities in 22 patients with moderate to severe paratonia.
- Trial name
- NCT03538405
- Testing
- Supporting cushions, Harmonic techniques
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- University Ghent
Women and Men Over 18 Years Old, AF Ablation (ECS recommendation2020&ACS2014) Either for Paroxysmal AF Unresponsive to Anti-arrhythmic Treatment Either for Persisting Symptomatic AF
Predictive Properties of Myocardial Fibrosis Biomarkers on the Outcome of Atrial Fibrillation Ablation
Atrial fibrillation (AF) is the most common cardiac arrhythmia. As an independent predictor of cardiovascular mortality, particularly for stroke, its management is a real public health issue.
- Conditions
- Women and Men Over 18 Years Old, AF Ablation (ECS recommendation2020&ACS2014) Either for Paroxysmal AF Unresponsive to Anti-arrhythmic Treatment Either for Persisting Symptomatic AF, Able to Give His Non Opposition to Participate to the Study
- Trial name
- PROFIB-AF (NCT05179902)
- Where
- France
- Volunteers
- 190 people
- Sponsor
- University Hospital, Clermont-Ferrand
Aging, Refusal, Treatment
Opposition to Diagnostic or Therapeutic Procedures by Aged Hospitalized Patient
The main object is to identify and understand why some hospitalized aged patients oppose himself to treatment or diagnosis procedure. This mixed study will used a census in a geriatrics department and a qualitative research.
- Conditions
- Aging, Refusal, Treatment, Qualitative Research, Epidemiology
- Trial name
- OPTAH (NCT03373838)
- Testing
- Census
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Healthy
EMG-Assessed Paratonia: A New Approach to Response Inhibition
Paratonia is the inability to relax muscles during the assessment of muscle tone in the absence of spasticity and parkinsonian rigidity.
- Trial name
- NCT06573918
- Testing
- EMG-based assessment of paratonia
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universita degli Studi di Genova
Stress Disorders, Post-Traumatic, Tissue Donors
Evaluation of Post-traumatic Stress Among the Nearest Relatives of Brain-dead Organ Donors
The goal is to compare post tramautic stress between the nearest relatives of brain-dead patients who are organ donor to those of brain-dead patients who are not organ donors for medical, legal or opposition reasons.
- Conditions
- Stress Disorders, Post-Traumatic, Tissue Donors, Tissue and Organ Procurement
- Trial name
- NCT01214018
- Testing
- Questionnaires and interview
- Where
- 4 sites in France
- Volunteers
- 91 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Dementia Alzheimers
Surface EMG to Measure Paratonia in Dementia
Rationale: A prominent and degenerative motor symptom of dementia is paratonia that heavily affects quality of life. However, paratonia is poorly recognized and the diagnosis yet relies on subjective evaluation by caregivers.
- Trial name
- NCT05606445
- Testing
- Elbow movement
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Organ Donation
Characterization of Opposition to Organ Donation at Strasbourg University Hospital in 2024-2025
In 2024, 29,000 people are waiting for organ transplants in France, and only 6,034 transplants were performed during the year. 852 people died while waiting for a transplant.
- Trial name
- OPPO-PMO (NCT07345975)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Dementia, Gait
Fine and Gross Motor Function and Relationship With Muscle Tone in Older Adults With and Without Dementia
The purpose of this study was (1) to investigate changes in gait, balance, fine motor function, and muscle tone, and (2) to find out if there is a correlation between muscle tone/presence of paratonia and motor function (gross…
- Conditions
- Dementia, Gait, Balance, Muscle Tone
- Trial name
- NCT03479567
- Testing
- Gait accelerometry, balance accelerometry, Fine motor skill test
- Where
- Belgium
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University Ghent