Clinical trials: Parkinson
PARKINSON DISEASE (Disorder), Multiple Sclerosis
Cognitive Recovery Via Sensor-based Robotic Upper Limb Rehabilitation in Neurological Disorders
The goal of this clinical trial is to learn if sensor-based robotic upper limb rehabilitation can improve cognitive and motor functions in adults with neurological and neurodegenerative disorders, including Parkinson's disease…
- Conditions
- PARKINSON DISEASE (Disorder), Multiple Sclerosis, Stroke, Neurological Disorders
- Trial name
- CROSS-ND (NCT07384143)
- Testing
- Sensor-Based Robotic Rehabilitation with Cognitive Tasks (SBRR), Standard Conventional Therapy
- Where
- Italy
- Volunteers
- 189 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Parkinson Disease
50 Hz Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Parkinson's Disease
Background: In transcranial magnetic stimulation (TMS), a device creates a short-lasting magnetic field which induces an electric current in the brain leading to a change in the activity of brain cells.
- Trial name
- NCT00977184
- Testing
- 50 HZ Repetitive TMS
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Parkinsonism
Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD
Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies.
- Trial name
- NCT07674264
- Testing
- Acute intermittent hypercapnic hypoxia (AIHH), Acute intermittent hypercapnic normoxia (AIHN)
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Florida
Parkinson Disease
Accuracy of Markerless Motion Capture Evaluation in Parkinson's Disease After DBS
Body motion evaluation (BME) by markerless systems is increasingly being considered as an alternative to traditional marker-based technology because they are faster, simpler, and less expensive.
- Trial name
- NCT03607721
- Testing
- Body Motion Evaluation DARI
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Hospital Zambrano Hellion
Parkinson's Disease
Apomorphine Pump in Early Stage of Parkinson's Disease (EARLY-PUMP)
The aim of the study is to assess the use of the apomorphine pump in earlier stages of Parkinson' Disease (PD), when motor complications have just developed and before patients are significantly affected in their social and…
- Trial name
- EARLY-PUMP (NCT02864004)
- Testing
- Apomorphine, Best Medical Treatment
- Where
- 20 sites in France
- Volunteers
- 134 people
- Sponsor
- Rennes University Hospital
Parkinson Disease
Neural Control of Breathing in Parkinson's Disease
Breathing is a complex process, which can be controlled through voluntary command or neural control. Parkinson's disease (PD) is a progressive neurological disorder.
- Trial name
- NEURON-PD (NCT06074614)
- Testing
- Hypercapnic ventilatory response, Respiratory related evoked potential, Transcranial magnetic stimulation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
PARKINSON DISEASE (Disorder)
SwallowFIT Study in Parkinson's Disease
The goal of this clinical trial is to learn if a proactive swallow exercise will help to improve swallow fitness in patients with Parkinson's disease.
- Trial name
- NCT07356414
- Testing
- SwallowFit
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Parkinson Disease, Mild Cognitive Impairment
Parkinson's Disease With Mild Cognitive Impairment Treated With Nicotinic Agonist Drug
To test for the first time the potential of a nicotinic agonist on cognitive symptoms in people with mild cognitive impairment (MCI) in Parkinson's disease (PD), referred to as PD-MCI.
- Trial name
- PD-MIND (NCT04810104)
- Testing
- AZD0328
- Sponsor
- King's College London
Parkinson Disease
The Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation for Anxiety in PD
This study is a double blind comparative study examining the effectiveness of the transcutaneous auricular vagus nerve stimulation treatment on Parkinson's disease patients with anxiety.
- Trial name
- NCT05950347
- Testing
- Active Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Parkinson's Disease, Chronic Appendicitis
A Study Assessing the Effects of Acupuncture in Parkinson's Disease Patients With Chronic Appendicitis
The incidence of PD is high, and when the disease is serious to a certain extent, the effect of drugs to control symptoms decreases, resulting in a significant reduction in the quality of life of patients.
- Conditions
- Parkinson's Disease, Chronic Appendicitis, Acupuncture
- Trial name
- NCT06304285
- Testing
- Acupuncture treatment
- Where
- China
- Volunteers
- 84 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Parkinson's Disease
ADAGIO Follow Up Study: Evaluation of the Long-Term Effects of Rasagiline in Parkinson's Disease Subjects
Eligible participants, who participated in the ADAGIO trial and who sign an approved informed consent form, will be enrolled into the study at their original study locations.
- Trial name
- NCT00936676
- Testing
- rasagiline mesylate
- Where
- 102 sites in United States, Argentina and 11 more
- Volunteers
- 684 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Carcinoma, Non-Small-Cell Lung, Melanoma
Study to Evaluate the Safety of Pembrolizumab in Participants With Unresectable or Metastatic Melanoma or Non-small Cell Lung Cancer in India (MK-3475-593/KEYNOTE-593)
This study has been designed to evaluate the safety of pembrolizumab in participants in India with unresectable or metastatic melanoma and participants with non-small cell lung cancer (NSCLC) who are either untreated (programmed…
- Trial name
- NCT03715205
- Testing
- Pembrolizumab
- Where
- 8 sites in India
- Volunteers
- 150 people
- Sponsor
- Merck Sharp & Dohme LLC
Parkinson Disease
Cortical Electrophysiology of Response Inhibition in Parkinson's Disease
Patients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus…
- Trial name
- NCT06234995
- Testing
- Levodopa, Clinical DBS Setting, DBS Setting Maximizing Prefrontal Activation
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Parkinson's Disease
A Long-Term, Safety Study With a Flexible Dose Range of KW-6002 in Patients With Motor Response Complications on Levodopa/Carbidopa Therapy
The primary objective of this study was to establish the long-term tolerability and safety of istradefylline treatment in subjects with Parkinson's disease treated with levodopa/carbidopa.
- Trial name
- NCT00955045
- Testing
- istradefylline
- Where
- United States
- Sponsor
- Kyowa Kirin, Inc.
Parkinson Disease
OpicApone Sleep dISorder
The aim of this study is to To investigate in an exploratory manner the efficacy of 50 mg opicapone when administered with the existing treatment of levodopa (L-dopa) plus a dopa decarboxylase inhibitor (DDCI), in Parkinson's…
- Trial name
- OASIS (NCT04986995)
- Testing
- Opicapone
- Where
- Portugal
- Volunteers
- 22 people
- Sponsor
- Bial - Portela C S.A.
Huntington's Disease, Parkinson's Disease
Treating Sleep/Wake Cycle Disturbances in Basal Ganglia Disorders With Ramelteon
The proposed study is a double-blind, placebo controlled pilot study of HD, PD, and DLB subjects with sleep disturbances. This study is designed to determine the effects of 4 weeks Ramelteon treatment on the sleep patterns of…
- Conditions
- Huntington's Disease, Parkinson's Disease, Dementia With Lewy Bodies, Sleep Disorders
- Trial name
- NCT00907595
- Testing
- Ramelteon
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Parkinson's Disease, Healthy Controls Group - Age and Sex-matched
Innovative Biomarkers in de Novo Parkinson's Disease
This study aims at identifying potential new and innovative biomarkers in de novo Parkinson's disease patients. New finding will help phenotyping patients since the diagnosis of the disease and potentially also in the preclinical…
- Trial name
- INNOBIOPARK (NCT03940677)
- Testing
- Brain MRI, TMS-EEG, Behavioral and cognitive battery
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Parkinson's Disease, Gait Impairment
Methylphenidate for the Treatment of Gait Impairment in Parkinson's Disease
The purpose of this research study is to examine whether Methylphenidate (MPD) can result in improvement of gait (walking) in a population of Parkinson's Disease (PD) patients whose main disability is freezing of gait.
- Trial name
- NCT00526630
- Testing
- Methylphenidate (MPD)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Cincinnati
Parkinson's Disease
Gastric Retentive Carbidopa/ Levodopa in Parkinson's Patients; a One Year, Open Label, Safety Extension Study
An extension of study IN 09 004 testing the long term safety of the Accordion Pill Carbidopa/Levodopa (AP-CD/LD)
- Trial name
- NCT00947037
- Testing
- AP-CD/LD
- Where
- 5 sites in Israel
- Sponsor
- Intec Pharma Ltd.
Parkinson Disease
Investigation of Dual-Task Exercise's Effect in Parkinson's Disease
This study was conducted to investigate the effects of dual-task training on upper extremity motor functions in patients with Parkinson's disease. A total of 32 patients participated in the study.
- Trial name
- NCT06803212
- Testing
- Conventional Physiotherapy Program, Dual-Task Interference
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Emre Şenocak