Clinical trials: Parkinson Disease
Parkinson Disease, Neuro-Degenerative Disease
Conventional Physical Therapy Action Observation Therapy on Freezing of Gait and Functional Mobility in Parkinson's Disease
The goal of this study is to determine the effects of action observation therapy with conventional physical therapy on freezing gait and functional limitation in participants with Parkinson's disease.
- Trial name
- NCT07244900
- Testing
- Conventional Physical Therapy, Action Observation plus conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- University of Lahore
Parkinson's Disease
Attributional Style and Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disorder affecting 1-2% of the population over 65 years-old. In addition to the motor impairment characterized by resting tremor, bradykinesia, rigidity and postural…
- Trial name
- ParkAIHQ (NCT03371277)
- Testing
- Medical visit for specific questionnaires
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CHU de Reims
Autonomic Failure, Pure Autonomic Failure
CPAP for the Treatment of Supine Hypertension
This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their…
- Conditions
- Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy, Parkinson Disease
- Trial name
- NCT05489575
- Testing
- Active CPAP, Sleeping in a head-up tilt (HUT) position
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Vanderbilt University Medical Center
Parkinson's Disease
Expectation and Response to Levodopa and Acupuncture in Parkinson's Disease
To investigate how levodopa and acupuncture affect fatigue and muscle function in people who suffer from Parkinson's disease. Subjects may choose to participate in levodopa or acupuncture part, or both.
- Trial name
- NCT00692328
- Testing
- Levodopa or acupuncture
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Oregon Health and Science University
Healthy Volunteers
Sustained Release Oral Formulation for Treatment of Parkinson's Disease
Achieving sustained blood levels of carbidopa/levodopa has been a challenge in the treatment of PD and although levodopa remains the most commonly used drug, motor fluctuations remain a major disability especially in advanced…
- Trial name
- NCT05471609
- Testing
- levodopa/carbidopa oral formulation A, levodopa/carbidopa oral formulation B
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinson's Disease
Biomarkers of Neurodegeneration and Neuroplasticity in Parkinson's Disease Patients Treated by Bilateral M1-iTBS
Intermittent theta-burst stimulation (iTBS) is a promising therapeutic option for Parkinson's disease patients. A study involving 24 patients will assess its effectiveness in alleviating clinical deficits.
- Trial name
- NCT06840145
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Instituto de investigación e innovación biomédica de Cádiz
Parkinson's Disease, Mild Cognitive Impairment
Mild Cognitive Impairment in Parkinson's Disease
Mild cognitive impairment, including difficulty with solving problems, planning, attention, or recalling information, can be a significant problem for individuals with Parkinson's disease.
- Trial name
- NCT01519271
- Testing
- Exelon Patch (rivastigmine transdermal system)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Pennsylvania
Parkinson Disease
Chinese Exercise Modalities in Parkinson's Disease
This study will compare the effects of two Chinese and one Western exercise modalities on the signs and symptoms of Parkinson's disease.
- Trial name
- NCT00029809
- Testing
- Chinese exercise modalities
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Parkinson's Disease
Effect of an Apomorphine Pump on the Quality of Sleep in Parkinson's Disease Patients (POMPRENELLE).
Parkinson's disease is not only a pathology of movements. There are many non-motor symptoms that complicate and impair patients' quality of life. Among those disorders are sleep disorders. Insomnia is the most frequent symptom.
- Trial name
- POMPRENELLE (NCT02688465)
- Testing
- Apomorphine
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Parkinson Disease
Managing Fatigue in People With Parkinson's Disease
This pilot study aims to evaluate the feasibility of Managing Fatigue: The Individual Program (MFIP) in people living with Parkinson's disease.
- Trial name
- MFIP (NCT04267107)
- Testing
- Individual Managing Fatigue Program
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Dalhousie University
Parkinson Disease, Mild Cognitive Impairment
Adaptango Performance PRocess for Older Adults Community reHabilitation
This study is being done to answer the question: How do people with Parkinson's disease, people with Mild Cognitive Impairment, and younger people process difficult topics in conversation? It will also explore themes related to…
- Conditions
- Parkinson Disease, Mild Cognitive Impairment, Old Age; Dementia
- Trial name
- APPROACH (NCT07824128)
- Testing
- Adaptango Performance Process (APP) program
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Emory University
Parkinson's Disease, Essential Tremor
Evaluation of Directional Recording and Stimulation Using spiderSTN
The purpose of this study is to provide proof-of-concept that directional stimulation and directional recording, in an intraoperative setting, is perceivable in a subject.
- Trial name
- NCT02894567
- Testing
- Intraoperative test during a deep brain stimulation surgery
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- Aleva Neurotherapeutics SA
Parkinson's Disease
Efficacy of Ethnodyne Visio in Parkinson's Disease
ETHNODYNE VISIO is a food supplement composed of an innovative plant-based active ingredient acting alongside vitamin B2. It is proposed in patients with visual problems.
- Trial name
- ETHNOPARK (NCT02815800)
- Testing
- ETHNODYNE VISIO
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Strasbourg, France
Deep Brain Stimulation, PARKINSON DISEASE (Disorder)
Cortical Network Modulation by Subthalamic Nucleus DBS
Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) can provide substantial motor benefit yet can also produce unwanted mood and cognitive side effects.
- Trial name
- NCT04922411
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Bladder Outlet Obstruction, Multiple Sclerosis
GentleCath™ for Men Intermittent Catheter With FeelClean™ Technology
Male self catherterisng observational study.
- Conditions
- Bladder Outlet Obstruction, Multiple Sclerosis, Cauda Equina Syndrome, Enlarged Prostate With Lower Urinary Tract Symptoms
- Trial name
- NCT05470751
- Testing
- Intermittent self-catheterisation
- Where
- 16 sites in United States, France and 1 more
- Volunteers
- 72 people
- Sponsor
- ConvaTec Inc.
Parkinson's, Parkinson Disease
Longitudinal Investigation of I2BS in PD
In this study, the researchers aim to find a biomarker of PD. Using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI).
- Conditions
- Parkinson's, Parkinson Disease, Parkinson's Disease, Neurodegenerative Diseases
- Trial name
- FOX_2 (NCT05516719)
- Testing
- Positron Emission Tomography (PET) scan using BU99008 tracer, FP-CIT Single-photon Emission Computed Tomography (SPECT) scan, Magnetic Resonance Imaging (MRI) Scan
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Parkinson Disease
The Outcome of Subthalamic Deep Brain Stimulation in Advanced Parkinson's Disease and Morphometry
The research will evaluate possible clinical and individual brain topographic features affecting the outcome in subthalamic deep brain stimulation (DBS) with patients with Parkinson's disease (PD).
- Trial name
- NCT06095245
- Where
- Finland
- Volunteers
- 35 people
- Sponsor
- Hospital District of Helsinki and Uusimaa
Parkinson Disease, Stroke
Smart Wearable Device (gaitQ): Walk Better Project
This study will be underpinned by the new MRC guidelines for developing a complex intervention with a participatory design methodology that uses evidence-based research and behaviour change models alongside COSMIN methodology for…
- Conditions
- Parkinson Disease, Stroke, Multiple Sclerosis, Osteoporosis
- Trial name
- NCT05913219
- Where
- United Kingdom
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Parkinson Disease, PD
Genetic Characterization of Parkinson's Disease
This study will explore the risks and causes of Parkinson's disease, a chronic progressive nervous system disorder. Patients typically have tremors, muscle weakness and a shuffling gait.
- Conditions
- Parkinson Disease, PD, Movement Disorder, Healthy Volunteer
- Trial name
- NCT00105131
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Acupuncture
Acupuncture for Management of Balance Impairment in Patients With Parkinson's Disease
This plan is to evaluate the effectiveness of scalp acupuncture, a modern acupuncture technique specialized to neurological disorders, in managing motor function and body balance for PD patients.
- Trial name
- NCT03178175
- Testing
- Acupuncture, Needle Insertion
- Where
- Taiwan
- Volunteers
- 4 people
- Sponsor
- Chang Bing Show Chwan Memorial Hospital
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