Clinical trials: Parkinson Disease-tremor
Tremor, Essential, Parkinson's Disease
Mapping the Target for the MRgFUS Treatment of Tremor
The purpose of this investigation is to determine the optimal DRT/VIM target location and its safety margins based on MR-SISET imaging features by comparing with postoperative lesions and clinical outcomes in patients with tremor…
- Trial name
- NCT04661241
- Testing
- Automatic DRT/VIM target-recognition method using MR-SISET and ML approaches, Routine clinical MRI protocol
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- NYU Langone Health
Transcutaneous Vagal Nerve Stimulation (tVNS), Parkinson Disease (PD)
Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s Disease
This study aims to determine whether electrical stimulation of the ear, when combined with physical and speech therapy, can improve symptoms in subjects diagnosed with Parkinson´s disease, by comparing two different application…
- Trial name
- tVNS_PD (NCT07588191)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve, Conventional Physical therapy, Conventional Speech Therapy
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Universidade da Coruña
Essential Tremor, Parkinson's Disease (PD)
Attention and Eye Movement in Parkinson's Disease
The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and non-PD movement…
- Conditions
- Essential Tremor, Parkinson's Disease (PD), Dystonias
- Trial name
- NCT06899022
- Testing
- Normal therapeutic DBS, Reduced current DBS, Reduced frequency DBS
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Dystonia, Parkinson Disease
Lesioning Procedures for Movement Disorders
Dystonia is a rare syndrome with varying etiologies. Similarly, tremor conditions refractory to medical management and disabling that they need surgical interventions are rare in our setting.
- Conditions
- Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT06352268
- Testing
- Pallidal, subthalamic or thalamic lesioning
- Where
- India
- Volunteers
- 250 people
- Sponsor
- All India Institute of Medical Sciences
Essential Tremor, Parkinsons Disease (PD)
Effects of Microelectrode-based Brain Stimulation in Humans
The currently available treatments of Parkinson's disease (PD) and Essential Tremor (ET) are inadequate and accompanied by adverse side effects making the treatment much less effective.
- Trial name
- HDBS (NCT07820189)
- Testing
- High Definition Brain Stimulation (HDBS)
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Lund University
Parkinson Disease
Strategy for Daily Activity Improvement in Patients With Parkinson's Disease
The symptoms and signs of patients with Parkinson's disease (PD) include bradykinesia, rigidity, tremor and poor sensory integration, which result in mobility disability.
- Trial name
- Parkinson (NCT03972241)
- Testing
- foot insole
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kwan-Hwa Lin
Parkinson's Disease
Cannabis and Parkinson's Disease Tremor: A Natural History Study
This is a prospective, observational study designed to describe the effects of Cannabis on Parkinson's Disease tremor.
- Trial name
- NCT02028858
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Bastyr University
Essential Tremor, Parkinson Disease
Environmental Epidemiology of Essential Tremor
This study's research is devoted to studying the causes of tremor, and especially essential tremor (ET), which is the most common type of tremor.
- Trial name
- RULET (NCT04576676)
- Where
- United States
- Volunteers
- 1,497 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Parkinson Disease, Essential Tremor
JAME, a Wearable Device to Control Tremor
The study is a pilot feasibility study aimed at verifying that (1) tremor can be recognized using an accelerometer placed on the hand area and a data mining algorithm properly trained and (2) TENS applied in the hand area is able…
- Trial name
- NCT06847581
- Testing
- JAME
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Parkinson's Disease
Phase II Subthalamic Nucleus (STN) vs. Globus Pallidus (GPi) Trial
The goal of the second phase of the study is to determine if simultaneous bilateral subthalamic nucleus stimulation or simultaneous bilateral globus pallidus stimulation is more effective in reducing symptoms of Parkinson's…
- Trial name
- NCT01076452
- Testing
- Bilateral Deep Brain Stimulation
- Where
- 14 sites in United States
- Volunteers
- 299 people
- Sponsor
- US Department of Veterans Affairs
Parkinson&Amp;#39;s Disease, Action Tremor
Effectiveness of STIL Orthosis in PD
Parkinson's disease is a neurodegenerative condition that leads to uncontrollable shaking (tremor), which can substantially impair everyday activities.
- Trial name
- STIL-PD (NCT06886178)
- Testing
- STIL Orthosis
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease, Essential Tremor
Deep Brain Stimulation (DBS) Retrospective Outcomes Study
The primary objective of this study is to characterize real-world clinical outcomes of Deep Brain Stimulation (DBS) using retrospective review of de-identified patient records.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT03664609
- Testing
- Deep Brain Stimulation
- Where
- 20 sites in United States, Belgium and 4 more
- Volunteers
- 5,000 people
- Sponsor
- Boston Scientific Corporation
Parkinsons Disease, Essential Tremor
Battery-preserving Stimulation Patterns for Deep Brain Stimulation
The purpose of this research study is to test effectiveness of different deep brain stimulation (DBS) stimulation patterns on symptoms that may also improve the life of the battery.
- Trial name
- NCT02569021
- Testing
- Biphasic DBS stimulation, Unified Parkinson's Disease Rating Scale, Tremor Rating Scale
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Essential Tremor, Parkinson's Disease
Neurotransmitter Measurements Using (WINCS) During Deep Brain Stimulation Neurosurgery
In this study, the investigators will monitor extracellular neurotransmitter levels using a probe that is able to perform real time electrochemical detection during deep brain stimulation surgery.
- Conditions
- Essential Tremor, Parkinson's Disease, Dystonia
- Trial name
- NCT01705301
- Testing
- WINCS
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Mayo Clinic
Parkinson Disease, Essential Tremor
Investigating LFP Correlates of TUS in Patients With Movement Disorders
Transcranial Ultrasound Stimulation (TUS) is an emerging non-invasive brain stimulation(NIBS) technique that can be used on both superficial and deep brain targets with a high spatial resolution as small as a few cubic…
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- TUS-LFP (NCT05965960)
- Testing
- TUS Active
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University Health Network, Toronto
Parkinson Disease, Rest Tremor
Mindfulness-based Intervention for People With Parkinsonian Tremor
Mindfulness meditation is an approach that has shown interest in treatment of anxiety in Parkinson's disease. This pilot study aims to assess a more specific effect on tremor using Essential Tremor Embarrassment Assessment and…
- Trial name
- MEDITAPARK (NCT05168046)
- Testing
- Mindfulness based stress reduction
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Essential Tremor, Parkinson's Disease
Home Use Study of Targeted Mechanical Stimulation for Tremor Relief
Subjects will receive prototype devices to be used for participation. The study comprises three phases: 1. Alpha phase: Two remote study visits and an in-home period to gather device usability data on the alpha system.
- Trial name
- NCT07078422
- Testing
- Encora Pulse
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Encora, Inc.
Parkinson Disease, Essential Tremor
Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders
Parkinson's disease and essential tremor are chronic movement disorders for which there is no cure. When medication is no longer effective, deep brain stimulation (DBS) is recommended.
- Trial name
- INSHAPE_DBS (NCT04725045)
- Testing
- Boston Scientific: Study tool computer
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- KU Leuven
Parkinson Disease, Essential Tremor
New Stereotactic Frame System for Neurosurgery
This study is designed to demonstrate an in-house developed re-attachable stereotactic system that can markedly reduce the overall deep brain stimulation (DBS) procedure time to greatly facilitate subject access to neurosurgical…
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia, Tourette Syndrome
- Trial name
- NCT04283812
- Testing
- DBS Electrode Implantation using D1 Sterotactic System
- Sponsor
- Mayo Clinic
Tremor
Investigating Cerebellar Inhibition and Its Clinical Significance in Parkinsonian Tremor and Intention Tremor
Cerebellocerebral connection plays an important function in motor control. Nowadays it can be investigated with neuroimaging and physiological methods in humans.
- Trial name
- NCT05512299
- Testing
- Transcranial Magnetic Stimulation
- Where
- Taiwan
- Volunteers
- 84 people
- Sponsor
- China Medical University Hospital