Clinical trials: Parkinson Disease-tremor
Parkinson's Disease, Essential Tremor
Dexmedetomidine Effects on Microelectrode Recording in Deep Brain Stimulation
To test the hypothesis that sedation induced by Dexmedetomidine at levels appropriate for awake, DBS surgery has no significant effect on electrophysiological parameters of DBS micro-electrode recordings
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- NCT00608231
- Testing
- Dexmedetomidine Hydrochloride Infusion, Normal Saline
- Where
- United States
- Sponsor
- Vanderbilt University
Tremor, Limb
Deep Brain Frameless Radiosurgery for Drug Resistant Invalidating Tremor. Dose Escalation Pilot Study
The gamma knife radiosurgical thalamotomy to treat many movement disorders is recently becoming a new and well defined treatment paradigm.
- Trial name
- PRDBRS2 (NCT02585583)
- Testing
- Thalamotomy
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Parkinson Disease
Detection of Internal Tremors by Oscillometry in Parkinson's Patient
The goal of the present study is to objectively access the presence of an Internal Tremor in Parkinson's disease. Inertial sensors will be used to detect the presence of a rhythmic oscillation of 3-4 Hz.
- Trial name
- TREMOS-PD (NCT06885541)
- Testing
- Detection of objective internal tremors
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Parkinson Disease, Upper Extremity Dysfunction
Effectiveness of Noninvasive Vagus Stimulation for Upper Extremity in Parkinson's Disease
Vagus nerve stimulation in the treatment of PD is a non-pharmacological intervention with the potential to improve gait, cognition, fatigue, and autonomic functions, but more evidence is needed for VSS in the treatment of PD.
- Conditions
- Parkinson Disease, Upper Extremity Dysfunction, Tremor
- Trial name
- NCT05456451
- Testing
- noninvasive vagus nerve srimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 5 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
White Matter Lesions, Postural Instability Gait Disorders
White Matter Pathology in Parkinson's Disease (PD)
The relationship between WM lesions (WM) and Postural Instability Gait Disorders (PIGD-PD)in Parkinson's disease patients is largely unknown.
- Trial name
- NCT01039831
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinson's Disease (PD), Essential Tremor
LIFUS For Neurological Disorders
Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation.
- Conditions
- Parkinson's Disease (PD), Essential Tremor, Orthostatic Tremor, Dystonia
- Trial name
- NCT07417280
- Testing
- LIFUS
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Parkinson, Cerebellar Tumor
Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity
Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify and track during disease progression. This study propose to explore the rhythmicity of distal muscle contractions in the upper limb to…
- Conditions
- Parkinson, Cerebellar Tumor, Rest Tremor, Diagnoses Disease
- Trial name
- TREMORHYTHM (NCT05998486)
- Testing
- EMG in wrist flexor-pronators and extensor-supinators
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Henri Mondor University Hospital
Parkinson's Disease (PD), Tremor
Cerebellar Transcranial Alternating Current Stimulation (tACS) to Modulate Parkinson's Disease Tremor
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by different motor symptoms, including tremor, which is particularly difficult to manage.
- Trial name
- tACS_PD_TR (NCT06993571)
- Testing
- Active-tACS, Unlocked-tACS
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Parkinson's Disease
Phase I Deep Brain Stimulation (DBS) vs. Best Medical Therapy (BMT) Trial
The goals of this study are to determine if simultaneous bilateral subthalamic nucleus stimulation or simultaneous bilateral globus pallidus stimulation is more effective in reducing symptoms of Parkinson's disease, and if deep…
- Trial name
- NCT00056563
- Testing
- Bilateral Deep Brain Stimulation, best medical therapy
- Where
- 14 sites in United States
- Volunteers
- 255 people
- Sponsor
- US Department of Veterans Affairs
Parkinson Disease, Essential Tremor
The Effects of Vibrotactile Stimulation in Patients With Movement Disorders
Vibration applied to the skin has been anecdotally reported to potentially improve motor control in patients with movement disorders including Parkinson's disease, however few devices have been studied formally.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT05106816
- Testing
- skin surface vibration
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Florida
Parkinson Disease
Using Low Intensity Focused Ultrasound to Modulate Deep Brain Areas for Tremor Control in Parkinson's Disease Patients.
Researchers have found that a treatment called Magnetic Resonance guided Focused Ultrasound (MRgFUS) can effectively reduce tremors in patients with essential tremor (ET) and Parkinson's disease (PD).
- Trial name
- NCT06259708
- Testing
- Low intensity focused ultrasound
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Essential Tremor, Movement Disorders, Essential Tremor
Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's Disease
Background and Rationale Essential tremor (ET) affects over 6 million Americans and approximately 5% of adults over age 60. Patients with ET have a 10-20 times higher risk of developing Parkinson's disease (PD) compared to…
- Conditions
- Essential Tremor, Movement Disorders, Essential Tremor, Essential Tremor-plus
- Trial name
- Syn-T (NCT07428447)
- Where
- 11 sites in United States
- Volunteers
- 300 people
- Sponsor
- CND Life Sciences
Parkinson's Disease, Essential Tremor
Sensory Gating Measured With Microelectrode Recording (MER) During Deep Brain Stimulation (DBS) Surgery
Deep brain stimulation (DBS) is an FDA approved, and widely used method for treating the motor symptoms of Parkinson's disease (PD), Essential Tremor (ET), Dystonia and Obsessive Compulsive disorder (OCD).
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia, Obsessive Compulsive Disorder
- Trial name
- NCT02320266
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parkinson's Disease
Automated Telehealth Diagnostics for Remote Parkinson Monitoring
The objective is to clinically assess the Kinesia HomeView system for automated and remote monitoring of Parkinson's disease (PD) motor symptoms.
- Trial name
- PDRemote (NCT02152319)
- Testing
- KHV reporting, Standard care
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Movement Disorders (Incl Parkinsonism), Stroke
Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control
In this study the investigators aim to enroll patients scheduled to undergo deep brain stimulation (DBS) implantation for movement disorders for intra-operative testing.
- Conditions
- Movement Disorders (Incl Parkinsonism), Stroke, Traumatic Brain Injury, Brain Diseases
- Trial name
- NCT07056361
- Testing
- Direct cortical stimulation and deep brain stimulation of motor thalamus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Jorge Gonzalez-Martinez
Parkinson Disease, Epilepsy
Neurofeedback Using Implanted Deep Brain Stimulation Electrodes
Deep brain stimulation (DBS) has become a gold-standard symptomatic treatment option for Parkinson's disease (PD) and is also explored for a variety of other neurological disorders.
- Conditions
- Parkinson Disease, Epilepsy, Essential Tremor
- Trial name
- NCT05101161
- Testing
- Neurofeedback
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- ETH Zurich
Parkinson Disease, Dystonia
In Vivo Measurement of the Accuracy of the "Neurolocate" Module of the Neurosurgical Robot "Neuromate" in Its Application to Deep Brain Stimulation
The purpose of this study is to evaluate the accuracy of the Neurolocate recording system of the neurosurgical robot Neuromate, marketed by Renishaw, in order to optimize surgical procedures, costs and patient comfort.
- Conditions
- Parkinson Disease, Dystonia, Tremor
- Trial name
- NEUROLOCATE (NCT04712552)
- Testing
- deep brain stimulation
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Parkinson Disease (PD), Tremor
A Study Comparing Propranolol and Amantadine for Reducing Tremors in People With Parkinson's Disease
Parkinson's disease is a common brain disorder in older adults that causes tremors (shaking), stiffness, and problems with movement.
- Trial name
- NCT07113015
- Testing
- propranolol, Amantadine
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Multan Medical And Dental College
Dystonia, Parkinson Disease
Impact of a Standardized Music Therapy Protocol on the Quality of Life of Patients With Abnormal Movements Treated With Continuous Electrical Neuromodulation
The study of the impact of music on emotional, motor and cognitive aspects remains recent. Music therapy has experienced a major boom over the last half century thanks to neuroradiological techniques for investigating the brain…
- Conditions
- Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- Music-QOL (NCT05214313)
- Testing
- Music Therapy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Parkinson's Disease (PD), Essential Tremor
Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients
This study will examine how two important brain circuits - one involving the subthalamic nucleus (STN) and one involving the ventral intermediate nucleus of the thalamus (VIM) - contribute to learning and producing speech…
- Trial name
- NCT07455760
- Testing
- Phoneme sequence learning, Cessation and re-enabling of stimulation of the STN, Cessation and re-enabling of stimulation of the VIM thalamic nucleus
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Boston University Charles River Campus