Clinical trials: Parkinsonian Syndrome
Parkinson's Disease
Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Parkinson's Disease
This study is to evaluate the safety and efficacy of Umbilical Cord Derived Mesenchymal Stem Cells transplantation in Parkinson's disease.
- Trial name
- NCT03550183
- Testing
- mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Hebei Newtherapy BIo-Pharma technology Co., Ltd.
Parkinson's Disease
Study of Tai Chi Exercise and Balance in Persons With Parkinson's Disease
Patients practicing Tai Chi will exhibit significant improvements in primary outcome measures of balance, and secondary outcomes of gait, physical performance, Unified Parkinson's Disease Rating Scale, Falls, muscle strength.
- Trial name
- NCT00611481
- Testing
- Tai Chi, Strength training, Low-Impact Exercise Control
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Oregon Research Institute
Parkinson Disease
Fecal MicrobiotaTransplant for the Treatment of Parkinson's Disease
FMT may significantly improve quality of life and Parkinson Disease (PD) symptom severity measurements. We hypothesize that gut microbial dysbiosis is a major contributing factor in Parkinson's disease.
- Trial name
- NCT06647277
- Testing
- Fecal Microbiota Transplant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- ProgenaBiome
Parkinson Disease, Sleep Fragmentation
Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder that leads to both motor and non-motor symptoms. Therapies have been developed that effectively target the motor symptoms.
- Trial name
- NCT04620551
- Testing
- Sub-clinical stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Parkinson Disease, Autonomic Nervous System Diseases
Biomarkers of Risk of Parkinson Disease
This study (https://pdrisk.ninds.nih.gov) will determine if people who have risk factors for Parkinson disease (PD) have biomarkers (objective ways to measure a disease process) that show that the disease process is actually…
- Conditions
- Parkinson Disease, Autonomic Nervous System Diseases, Pure Autonomic Failure
- Trial name
- NCT00775853
- Testing
- 6-[18F]Fluorodopamine, 6-[18F]Fluorodopa, 13N-Ammonia
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Sclerosis, Epilepsy
Psychometric Evaluation in Patients With Brain Damage During Neuroinflammation
The presence of a damage to the central and / or peripheral nervous system resulting from diseases of a different nature (such as, Multiple Sclerosis, Parkinson's disease, dementia, head trauma, stroke, epilepsy or other…
- Conditions
- Multiple Sclerosis, Epilepsy, Parkinson Disease, Dementia
- Trial name
- NCT05450237
- Testing
- Psychometric Evaluations
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Neuromed IRCCS
Parkinson Disease
The Alouette Test in Parkinson Disease
Reading disorders in Parkinson's Disease (PD) are poorly evaluated due to the lack of validated tests to screen for them. They are often attributed to hand tremors associated with the disease.
- Trial name
- REPEAT (NCT03958175)
- Testing
- Alouette test (reading test)
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon
Parkinson Disease
Cortical Electrophysiology of Response Inhibition in Parkinson's Disease
Patients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus…
- Trial name
- NCT06234995
- Testing
- Levodopa, Clinical DBS Setting, DBS Setting Maximizing Prefrontal Activation
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Dementia With Lewy Bodies
Effects of Nucleus Basalis of Meynert Stimulation on Cognitive Disorders in Dementia With Lewy Bodies
Deep brain stimulation has been developed as a substitute for the classical lesioning methods previously used in stereotactic and functional neurosurgery.
- Trial name
- DEMENSTIM (NCT01340001)
- Testing
- Electrical stimulation of the nucleus basalis of Meynert
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Rouen
Parkinsons Disease (PD), Anxiety
TMS in Anxiety-Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's dementia. Anxiety in PD is common, has major effects on quality of life and contributes to increased disability.
- Trial name
- NCT06999330
- Testing
- Theta burst stimulation active coil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- HealthPartners Institute
Idiopathic Parkinson's Disease
Stalevo in Early Wearing-Off Patients
The purpose of this study is to demonstrate in patients with Parkinson's disease that, when compared to levodopa/carbidopa, Stalevo will delay the time from initiation of study drug to the time an increase in antiparkinsonian…
- Trial name
- SEWOP (NCT00125567)
- Testing
- Stalevo (levodopa/carbidopa/entacapone), Levodopa/carbidopa
- Where
- 19 sites in Denmark, Finland and 4 more
- Volunteers
- 223 people
- Sponsor
- Orion Corporation, Orion Pharma
Alzheimer Disease, Amyotrophic Lateral Sclerosis
The Ontario Neurodegenerative Disease Research Initiative
The Ontario Neurodegenerative Disease Research Initiative (ONDRI) is a province-wide collaboration studying dementia and how to improve the diagnosis and treatment of neurodegenerative diseases including: Alzheimer's disease (AD)…
- Conditions
- Alzheimer Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Parkinson Disease
- Trial name
- ONDRI (NCT04104373)
- Testing
- Observational Cohort
- Where
- 12 sites in Canada
- Volunteers
- 522 people
- Sponsor
- Ontario Neurodegeneration Disease Research Initiative
Parkinson Disease
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for Parkinson's Disease
This trial will study the safety and efficacy of intranasal instillation of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of Parkinson's Disease
- Trial name
- NCT05152394
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Parkinson's Disease (PD)
Automated Image-Guided Programming of Deep Brain Stimulation (DBS) for Parkinson's Disease
The goal of this clinical trial is to evaluate an automated deep brain stimulation (DBS) algorithm developed by Boston Scientific called Illumina 3D for motor symptoms in Parkinson's disease (PD).
- Trial name
- NCT07215481
- Testing
- Standard of Care Deep Brain Stimulation, Illumina 3D Deep Brain Stimulation, Illumina 3D Deep Brain Stimulation Reduced Amplitude
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Parkinson's Disease
Evaluation of the Long-term Safety, Tolerability, and Efficacy of Perampanel (E2007) as an Adjunctive Therapy in Levodopa Treated Parkinson's Disease Subjects With Motor Fluctuations
This is a multicentre, open-label extension study to evaluate the long-term safety, tolerability, and efficacy of Perampanel (E2007) as an adjunctive therapy in levodopa treated PD subjects with motor fluctuations.
- Trial name
- NCT00505622
- Testing
- Perampanel
- Where
- France
- Volunteers
- 328 people
- Sponsor
- Eisai Limited
Psychological
Testing the Feasibility of an Online Guided-writing Intervention Designed for Informal Caregivers of People With Parkinson's Disease
When informal caregivers of people with Parkinson's disease treat themselves harshly, they can experience psychological distress.
- Trial name
- NCT07804953
- Testing
- An online guided-writing intervention that uses guidance based on self-compassion principles
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- University of Reading
Parkinson Disease, Mild Cognitive Impairment
Randomized Clinical Trial of Donepezil for the Treatment of Mild Cognitive Impairment in Parkinson's Disease
Phase II, multi-centric, randomized, double-blinded, placebo-controlled, parallel design clinical trial to evaluate the safety, tolerability and efficacy of Donepezil in patients with Mild Cognitive Impairment in Parkinson's…
- Trial name
- NCT05709301
- Testing
- Donepezil Hydrochloride
- Volunteers
- 120 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
PARKINSON DISEASE (Disorder), Deep Brain Stimulation
Anesthesia and Postoperative Delirium in Parkinson DBS
Parkinson's disease (PD) is the second most common neurodegenerative disorder, with a rising incidence due to global aging. Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is a core therapeutic modality for motor…
- Conditions
- PARKINSON DISEASE (Disorder), Deep Brain Stimulation, Postoperative Delirium
- Trial name
- POD-DBS-PD (NCT07792265)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Tiantan Hospital
Major Depressive Disorder (MDD), Schizophenia Disorder
Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders
This is a prospective observational study to identify sociodemographic factors that predict mental health outcomes in the European population and provide evidence linking common, modifiable sociodemographic risk factors for…
- Conditions
- Major Depressive Disorder (MDD), Schizophenia Disorder, Bipolar 1 Disorder, Alzheimer Disease
- Trial name
- Synapsing-SD (NCT07239843)
- Where
- Spain
- Volunteers
- 1,310 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Parkinson Disease, Parkinsonian Syndrome
A Study of the Sense of Smell in Relatives of Parkinson's Disease Patients
In this study, individuals complete and return a mail survey, specifically a 40 item scratch and sniff smell test.
- Trial name
- NCT00096876
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
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