Clinical trials: Parkinsonian Syndrome
Dementia With Lewy Bodies, REM Sleep Behavior Disorder
Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD)
This study seeks to evaluate the safety and efficacy of Nelotanserin for the treatment of Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with dementia with Lewy bodies (DLB) or Parkinson's disease dementia…
- Conditions
- Dementia With Lewy Bodies, REM Sleep Behavior Disorder, Parkinson's Disease Dementia
- Trial name
- NCT02708186
- Testing
- Nelotanserin
- Where
- 23 sites in United States
- Volunteers
- 34 people
- Sponsor
- Axovant Sciences Ltd.
Parkinson's Disease, Dysphagia
Novel Management of Airway Protection in Parkinson's Disease: A Clinical Trial
Currently, there are no efficacious behavioral treatment approaches to address uncompensated aspiration, or aspiration without appropriate cough response, in Parkinson's disease (PD).
- Conditions
- Parkinson's Disease, Dysphagia, Dystussia
- Trial name
- NCT02927691
- Testing
- EMST, smTAP
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Teachers College, Columbia University
Idiopathic Parkinson's Disease
Caregivers' and Physicians' Treatment Preference in Parkinson Patients Treated With Neupro® Requiring Caregiver Support
The study objective is to evaluate advantages and disadvantages of Neupro® versus oral anti-Parkinson medication by caregivers and physicians in idiopathic Parkinson's Disease patients requiring caregiver support in nursing home…
- Trial name
- CARE-ACT (NCT01330290)
- Testing
- Neupro®
- Where
- 54 sites in Germany
- Volunteers
- 148 people
- Sponsor
- UCB Pharma
Lewy Body Dementia, Parkinson Disease
Anti-Diabetic Medications to Fight PD and LBD
The purpose of this study is to test the hypothesis that DPP4 inhibitors and SGLT2 inhibitors are well tolerated and have beneficial neurological effects, specifically for Parkinson's disease and Lewy body dementia.
- Trial name
- NCT06263673
- Testing
- Sitagliptin, Dapagliflozin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Parkinson's Disease (PD)
An Open-label Study in Healthy Male Subjects to Assess the Absorption, Distribution, Metabolism and Excretion of [14C]-Labelled BIA 9-1067 and Metabolites
The purpose of this study is to determine the rate and routes of excretion of OPC and the mass balance in urine, faeces and expired air.
- Trial name
- NCT02169427
- Testing
- OPC
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Parkinson Disease
Pramipexole Conversion to Ropinirole Controlled Release (CR)
A conversion study of Mirapex (pramipexole) to Requip (ropinirole) controlled release (CR) in patients with Parkinson's disease to determine the appropriate conversion ratio and side effects related to the drug.
- Trial name
- NCT00275275
- Testing
- Requip PR, Mirapex
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Rajesh Pahwa, MD
Parkinson's Disease
Real-PD Trial: Development of Clinical Prognostic Models for Parkinson's Disease
Background: Long-term management of Parkinson's disease (PD) does not reach its full potential due to lack of knowledge about disease progression.
- Trial name
- NCT02474329
- Testing
- Clinical assessment, Fox Insight self-monitoring android app and falls detector
- Where
- Netherlands
- Volunteers
- 304 people
- Sponsor
- Radboud University Medical Center
Parkinson's Disease
Evaluation of Long-term Effect of Resonator Therapy on Parkinson's Disease (PD)
An extension study for subjects with prior participation in previous resonator studies using low level magnetic fields to treat some of the symptoms of idiopathic Parkinson's Disease.
- Trial name
- NCT00862537
- Testing
- Resonator Device
- Volunteers
- 18 people
- Sponsor
- pico-tesla Magnetic Therapies, LLC
Parkinson Disease
Pivotal Study in Advanced Parkinsons Disease Patients
The general aim of this trial is to determine the efficacy (as measured by the change from baseline to the end of the maintenance phase in the total score for Unified Parkinsons Disease Rating Scale Parts II and III combined)…
- Trial name
- NCT00466167
- Testing
- Pramipexol Extended Release, Pramipexol Immediate Release
- Where
- 76 sites in Austria, Czechia and 12 more
- Volunteers
- 517 people
- Sponsor
- Boehringer Ingelheim
Parkinson Disease
Barre Exercise in Parkinson's
This study asks if a barre exercise program is a feasible and acceptable form of exercise for individuals with Parkinson disease.
- Trial name
- NCT06203990
- Testing
- Barre exercise
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Washington University School of Medicine
Parkinson's Disease
Effects of Cholinergic Augmentation on Measures of Balance and Gait
This study will compare the effects of placebo and donepezil, a drug that helps conserve concentrations of the neurotransmitter, acetylcholine, on measures of balance and gait in subjects with Parkinson's disease (PD).
- Trial name
- NCT02206620
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Oregon Health and Science University
Parkinson's Disease
Neural Signatures of Parkinson's Disease
The purpose of this study is to provide objective measurements of abnormal movements of the body in correlation with neural activity of the brain and track how these change over time.
- Trial name
- BrainRadio (NCT01990313)
- Testing
- Activa PC+S
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Parkinson Disease
Immersive Virtual Reality Bicycling for Persons With Parkinson's Disease
This study has three objectives about persons with Parkinson's Disease during bicycling: 1. Determine the effect of visual feedback and competition during virtual bicycling on neuromuscular and cardiovascular intensity 2.
- Trial name
- NCT05160025
- Testing
- Virtual reality bicycling
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Rutgers, The State University of New Jersey
Parkinson Disease
Special Survey on Parkinson's Disease (PD) Patients Without Concomitant Use of L-Dopa
The survey is conducted to collect safety and effectiveness information in Parkinson's Disease patients treated with Pramipexole without concomitant L-Dopa supplementation in the daily clinical settings in Japan.
- Trial name
- NCT00613301
- Where
- 119 sites in Japan
- Volunteers
- 416 people
- Sponsor
- Boehringer Ingelheim
Parkinson's Disease
Vestibular Stimulation in Parkinson's Disease
The purpose of this study is to determine whether caloric vestibular stimulation improves symptoms of Parkinson's Disease.
- Trial name
- NCT02703844
- Testing
- Caloric Vestibular Stimulation
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- University of Kent
Cough, Parkinson's Disease
Respiratory Kinematics of Cough in Healthy Older Adults and Parkinson's Disease
The purpose of this research study is to test cough function in individuals with Parkinson's disease and healthy older adults. Cough is a complex, defensive function which involves movement of the chest and lungs.
- Trial name
- NCT02183519
- Testing
- Capsaicin, Voluntary cough test
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson Disease
Evaluation of a Millimeter Wave Emission Bracelet for Improving Parkinson's Disease Symptoms
Idiopathic Parkinson's disease is a common neurodegenerative disease, with a prevalence of around 2% in people over 65 years of age in France.
- Trial name
- BOMP (NCT04648150)
- Testing
- Evaluation of a millimeter wave emission bracelet for improving Parkinson's disease symptoms
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Dementia, Dementia, Vascular
Palliative Care for Persons With Late-stage Alzheimer's and Related Dementias and Their Caregivers
Millions of Americans have late-stage Alzheimer's and related dementias (ADRD), causing suffering due to loss of awareness of self and family, progressive dependency, physical and neuropsychiatric symptoms, and physical…
- Conditions
- Dementia, Dementia, Vascular, Dementia With Lewy Bodies, Dementia Frontal
- Trial name
- ADRD-PC (NCT04948866)
- Testing
- ADRD-PC Program
- Where
- 5 sites in United States
- Volunteers
- 884 people
- Sponsor
- University of North Carolina, Chapel Hill
Parkinson's Disease
The Effects of Dual Task Training in Individuals With Parkinson's Disease
The primary aim of the proposed project is to characterize dual tasking (DT) deficits to improve motor, cognitive, and quality of life outcomes in individuals with Parkinson's disease (PD).
- Trial name
- NCT02538029
- Testing
- Dual Task Group, Single Task Group
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Parkinson Disease, Mindfulness
Moving Mindfully for Freezing of Gait
The investigators will conduct an randomized controlled trial (RCT) among people with Parkinson disease (PD) and freezing of gait (FOG) to evaluate the feasibility of a mindfulness intervention compared to a educational program…
- Trial name
- MM-RCT (NCT05923229)
- Testing
- Mindfulness Based Walking Therapy (MBWT), Freezing of Gait (FOG) Education
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Washington University School of Medicine