Clinical trials: Parkinsonism
Parkinson Disease
Effects of Amazonian Dance on Motor and Non-motor Symptoms of People With Parkinson's: Study Protocol
This randomized controlled trial aims to evaluate the effects of a 12-week Amazonian dance program on cognitive and motor symptoms in people with Parkinson's disease (PD), comparing outcomes between participants in the…
- Trial name
- NCT06967493
- Testing
- Amazonian Dance, Nordic Walking
- Where
- 2 sites in Brazil
- Volunteers
- 80 people
- Sponsor
- Federal University of Rio Grande do Sul
Parkinson's Disease
Efficacy Study of Amantadine to Treat Gait Dysfunction and Freezing in Parkinson's Disease
The purpose of this study is to explore the efficacy of the drug Amantadine for the treatment of freezing of gait in patients with Parkinson's Disease.
- Trial name
- NCT01652534
- Testing
- Amantadine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Parkinson Disease
Effects of Routine Physical Therapy With and Without Proprioceptive Neuromuscular Facilitation on Balance, Gait and Function in Patients With Parkinson's Disease
Objective of this study is to compare the effectiveness of routine physical therapy with and without Proprioceptive Neuromuscular Facilitation on Balance, gait and function in patients with Parkinson's disease.
- Trial name
- NCT05154552
- Testing
- Proprioceptive Neuromuscular Facilitation, Routine physical therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 38 people
- Sponsor
- University of Lahore
Parkinson Disease
Multisensory Training in PD
People with Parkinson's disease (PD) were characterized by many motor symptoms, including rigidity, postural instability, bradykinesia, and resting tremor. These motor symptoms might cause gait dysfunction.
- Trial name
- NCT05027555
- Testing
- Multisensory training, Conventional training
- Volunteers
- 40 people
- Sponsor
- National Yang Ming Chiao Tung University
Parkinson Disease, Mood
The Benefits of Nature for Mood and Cognition in Persons With and Without Parkinson's Disease
This online study aims to explore the benefits of nature for mood and cognition in persons with and without Parkinson's disease.
- Conditions
- Parkinson Disease, Mood, Cognition
- Trial name
- NCT06483126
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Parkinson's Disease
A Study to Compare Pharmacokinetics and Pharmacodynamics of IPX066 to Standard Carbidopa-Levodopa
This study evaluated the pharmacokinetics, motor effects, and assessed the safety of IPX066 compared with an immediate-release cabridopa-levodopa formulation in subjects with advanced Parkinson's disease.
- Trial name
- NCT00869791
- Testing
- IPX066, IR CD-LD
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Impax Laboratories, LLC
Parkinson Disease
Noise-augmented Automatic Speech Recognition for Speech Treatment in Parkinson's Disease
The goal of this clinical trial is to learn whether noise-augmented feedback using automatic speech recognition improves intelligibility and social participation in individuals with Parkinson's disease.
- Trial name
- NCT06540989
- Testing
- Immediate treatment, Deferred treatment
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Teachers College, Columbia University
Parkinson Disease, Huntington Disease
A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions
Measurement of metabotropic glutamate receptor type 5 (mGluR5) binding capacity in the brain, may be a valuable tool in the early detection, understanding, or evaluation of Parkinson disease (PD), Huntington disease (HD), Fragile…
- Conditions
- Parkinson Disease, Huntington Disease, Autistic Spectrum Disorders, Fragile X Syndrome
- Trial name
- FPEB (NCT00870974)
- Testing
- [18F]FPEB
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Parkinson's Disease
Retinal Function in Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by muscle rigidity, tremor, a slowing of physical movement (bradykinesia) and, in extreme cases, a loss of physical movement.
- Trial name
- NCT01010074
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Parkinson's Disease
Study of NP002 in Subjects With Idiopathic Parkinson's Disease to Treat Dyskinesias Due to Levodopa Therapy
The study is designed to answer the question: will nicotine at doses that do not cause serious side effects, show feasibility in treatment of levodopa-induced dyskinesia in patients with Parkinson's disease?
- Trial name
- NCT00957918
- Testing
- nicotine
- Where
- 12 sites in United States
- Volunteers
- 65 people
- Sponsor
- Neuraltus Pharmaceuticals, Inc.
Parkinson Disease
Effect of Oral Enteral Nutrition Feeding in Parkinson Disease
The goal of this or clinical trial is to explore Intermittent Oro-esophageal Tube Feeding vs. Nasogastric Tube Feeding on nutritional status, dysphagia, and activities of daily living in patients with Parkinson's disease.
- Trial name
- NCT06303947
- Testing
- Intermittent Oro-esophageal Tube, Nasogastric tube, Comprehensive rehabilitation training
- Volunteers
- 80 people
- Sponsor
- Muhammad
Parkinsonism
The Effect of Spinal Cord Stimulation on Orthostatic Hypotension in Parkinsonism and Its Related Mechanisms
Parkinson's disease (PDS) is a syndrome characterized by tremor, bradykinesia, rigidity, and postural disturbances. Causes include Parkinson's disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and…
- Trial name
- NCT07322458
- Testing
- Epidural spinal cord stimulation, Transcutaneous spinal cord stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Parkinson Disease
A Phase 1b Study of the NLRP3 Inhibitor VENT-02 in Patients With Mild to Moderate Parkinson's Disease
This trial is a randomized, double-blind, placebo-controlled Phase 1b study evaluating the safety/tolerability, PK, and pharmacodynamics of VENT 02, administered orally at 1 dose level twice daily (BID) over 28 days in patients…
- Trial name
- NCT06822517
- Testing
- VENT-02
- Where
- 23 sites in United States
- Volunteers
- 29 people
- Sponsor
- Ventus Therapeutics U.S., Inc.
Parkinson Disease, Fluctuating Mood Symptoms
Validation of the Neuropsychiatric Fluctuations Scale (EFN-VALID))
Neuropsychiatric fluctuations (NF) are among the most disabling non motor fluctuations in Parkinson disease (PD). The investigators developed the NF-scale for acute assessment of non-motor neuropsychiatric fluctuations between…
- Trial name
- EFN-VALID (NCT04455074)
- Testing
- FN scale auto-questionnaire
- Where
- 6 sites in France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Grenoble
Alzheimer Disease, Dementia With Lewy Bodies
Neurological Soft Signs in Neurodegenerative Dementias
The goal of this observational study is to investigate the prevalence of Neurological Soft Signs (NSS) in various categories of dementia patients compared to matched controls.
- Conditions
- Alzheimer Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Corticobasal Degeneration
- Trial name
- DemeNSS (NCT06354933)
- Testing
- Neurological Soft Signs
- Where
- Italy
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Idiopathic Parkinson Disease, Parkinsonian Syndrome
Multicenter Study of Blood Biomarkers of Mitochondrial and Peroxisomal Metabolism to Differentiate Idiopathic Parkinson's Disease From Related Conditions
With the aging of the population due to an increase in longevity, the number of people with Parkinson's disease is increasing (166,712 in France, as of December 31, 2015) and the number of patients with motor or…
- Trial name
- BiomarPark (NCT05110547)
- Testing
- blood collection
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Injury Brain, Eye Abnormalities
Reading Problems Associated With Central Nervous System (CNS) Pathologies.
This project aims to analyse eye movements, their alterations and influence in reading performance in patients with acquired CNS diseases and compare them with people of the same age, without neurological or ocular pathology and…
- Conditions
- Injury Brain, Eye Abnormalities, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT04937725
- Testing
- eye tracking
- Where
- Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Dementia With Lewy Body Disease
Post-marketing Surveillance of Donepezil Hydrochloride - Investigation of Long Term Safety and Efficacy of Aricept as Well as Its Proper Use Information in Patients With Dementia With Lewy Bodies (DLB).
To investigate long term safety (especially about Parkinsonism) and efficacy of donepezil hydrochloride in clinical practice as well as its proper use information in participants with DLB.
- Trial name
- NCT02448784
- Testing
- Donepezil Hydrochloride
- Where
- Japan
- Volunteers
- 591 people
- Sponsor
- Eisai Co., Ltd.
Alzheimer Disease, Parkinson Disease
Evaluation of [18F]MNI-1126 as an Imaging Marker for Synaptic Density Loss
The primary objective of this protocol is to examine [18F]MNI-1126 as a tool to assess synaptic density loss.
- Conditions
- Alzheimer Disease, Parkinson Disease, Healthy Volunteers
- Trial name
- NCT03587649
- Testing
- [18F]MNI-1126
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Invicro
Alzheimer's Disease, Dementia
Diagnosis and Natural History Study of Patients With Neurological Conditions
The purpose of this study is to improve understanding of neurological conditions. Patients participating in this study will continue receiving medical care, routine laboratory tests, and diagnostics tests (X-rays, CT-scans, and…
- Conditions
- Alzheimer's Disease, Dementia, Movement Disorder, Multiple System Atrophy
- Trial name
- NCT00001549
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)