Clinical trials: Parkinsons Disease (PD)
Parkinson's Disease
Study Assessing Tolerability and Safety and Exploring the Immunogenicity and Therapeutic Activity of AFFITOPE® PD01A in PD-GBA Patients
This is a randomized, placebo-controlled, parallel group, patient-blind, single-center phase I clinical trial of repeated once every 4 weeks administration by subcutaneous injection of AFFITOPE® PD01A, adsorbed to aluminium oxide…
- Trial name
- NCT02758730
- Testing
- AFFITOPE® PD01A + Adjuvant, Adjuvant without active component
- Where
- Germany
- Sponsor
- Affiris AG
Parkinson Disease
Multiple Practice Contexts to Reduce Context-dependent Learning in PD
Context-dependent learning (CDL) is a phenomenon that an individual demonstrates superior motor performance in the environmental context in which a task was originally learned and practiced, while the performance may decrease if…
- Trial name
- NCT03368443
- Testing
- treadmill training and overground gait training
- Where
- Taiwan
- Volunteers
- 58 people
- Sponsor
- National Taiwan University Hospital
Parkinson's Disease
GDNF Gene Therapy for Parkinson's Disease
The objective of this Phase 1b investigation is to evaluate the safety and potential clinical effect of AAV2-GDNF delivered to the putamen in subjects with either a recent or a long-standing diagnosis of PD.
- Trial name
- NCT04167540
- Testing
- AAV2-GDNF
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Brain Neurotherapy Bio, Inc.
Parkinson Disease
Transcranial Direct Current Stimulation and Dual Tasks
The project aims to evaluate the clinical and biological effects on patients with Parkinson's disease of an innovative treatment characterized by the use of transcranial Direct Current Stmulation (tDCs) with Dual Task (DT), i.e.
- Trial name
- Tdcs&DT (NCT05871359)
- Testing
- Transcranial Direct Current Stimulation, Dual task
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Casa di Cura Privata del Policlinico SpA
Parkinson Disease
Donepezil to Treat Dementia in Parkinson's Disease
This study will evaluate the safety and effectiveness of donepezil (Aricept) for treating mild dementia in patients with Parkinson's disease.
- Trial name
- NCT00030979
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease, Healthy
Single-Ascending Dose Study of BIIB054 in Healthy Participants and Early Parkinson's Disease
The primary objective of the study is to evaluate the safety and tolerability of a range of single BIIB054 doses, administered as a single intravenous (IV) infusion, in healthy participants and participants with early Parkinson's…
- Trial name
- NCT02459886
- Testing
- BIIB054
- Where
- 9 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Biogen
Parkinson Disease (PD), Gut Microbiota
Developing Precision Microbiota-Based Cocktail Modification Therapy to Delay the Progression of Parkinson's Disease (PD) - Use Preclinical Human Trials to Confirm the Impact of the Optimal "Probiotic Y7, Tryptophan and Branched-chain Amino Acid" Cocktail Formula on Early Stage PD Patients
Preclinical human trials will be utilized to validate the research direction, followed by clinical trials to assess the impact of a cocktail formula product containing the optimal probiotic Y7 combined metabolites on motor…
- Conditions
- Parkinson Disease (PD), Gut Microbiota, Probiotic
- Trial name
- NCT07619560
- Testing
- Y7
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University
Parkinson Disease
A Study to Evaluate the Efficacy and Safety of Safinamide, as add-on Therapy, in Idiopathic Chinese Parkinson's Disease (PD) Patients With Motor Fluctuations Treated With Stable Doses of Levodopa
This is a Phase III, multicentre, randomised, double-blind, placebo-controlled study to evaluate the effects of 100 mg safinamide, administered orally once daily (OD), in Chinese Parkinson's disease (PD) patients, experiencing…
- Trial name
- NCT03881371
- Testing
- Safinamide
- Where
- 31 sites in China
- Volunteers
- 307 people
- Sponsor
- Zambon SpA
Parkinson Disease (PD), Immersive Virtual Reality
Virtual Reality on Balance of Parkinson's Disease
This study, titled: Effectiveness of immersive virtual reality on balance in people with Parkinson's disease. Is a randomized clinical trial conducted at Zaragoza Parkinson's Association in Spain.
- Conditions
- Parkinson Disease (PD), Immersive Virtual Reality, Physical Therapy
- Trial name
- RVI-PD (NCT07274514)
- Testing
- Immersive Virtual Reality Program, Standard Rehabilitation Program
- Where
- Spain
- Volunteers
- 57 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Parkinson's Disease
Staccato Apomorphine Multi-dose PK and PD in Patients With Parkinson's Disease
This study will be conducted in subjects with established Parkinson's disease in 2 parts. Part A will examine the tolerability, safety, and pharmacokinetics of AZ-009 dose escalation ; and Part B will assess the tolerability…
- Trial name
- NCT04157933
- Testing
- 009-A1, 009-A2, 009-A3
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Alexza Pharmaceuticals, Inc.
Parkinson's Disease
Subthalamic Deep Brain Stimulation (DBS) in Parkinson's Disease
The purpose of this study is to examine the brain changes in people with Parkinson's Disease (PD) after they get deep brain stimulation (DBS) surgery, compared with people who do not have Parkinson's Disease.
- Trial name
- NCT02012647
- Testing
- Transcranial Magnetic Stimulation (TMS), Motor Physiology Testing
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson Disease
Non Motor Symptoms in Glucocerebrosidase-related Parkinson's Disease
The goal of this observational study is to describe non motor symptoms in a prospective study of patients with Parkinson's disease associated to glucocerebrosidase (GBA-PD) mutations.
- Trial name
- PROGENS-PD (NCT06451419)
- Testing
- Tests on non motor symptoms
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Juan Pablo Romero. MD, PhD
Parkinson Disease, Neurologic Manifestations
A Feasibility Study on the Safety and Preliminary Efficacy of Bilateral Subthalamotomy Using MRgFUS for Treatment of PD
The objective of this study is to test the safety and preliminary efficacy of staged bilateral subthalamotomy performed using the ExAblate Transcranial System for the treatment of Parkinson's disease (PD) motor features
- Trial name
- NCT03964272
- Testing
- Exablate Bilateral Subthalamotomy
- Where
- Spain
- Volunteers
- 6 people
- Sponsor
- InSightec
Parkinson Disease, PD
Genetic Characterization of Parkinson's Disease
This study will explore the risks and causes of Parkinson's disease, a chronic progressive nervous system disorder. Patients typically have tremors, muscle weakness and a shuffling gait.
- Conditions
- Parkinson Disease, PD, Movement Disorder, Healthy Volunteer
- Trial name
- NCT00105131
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease (PD)
An Observational Study of Subcutaneous Infusion of ABBV-951 to Assess Change in Disease Activity and Adverse Events In Adult Japanese Participants With Advanced Parkinson's Disease
Parkinson's disease (PD) is a neurological condition, which affects the brain. Some symptoms of PD are tremors, stiffness, and slowness of movement.
- Trial name
- NCT05916157
- Where
- 17 sites in Japan
- Volunteers
- 250 people
- Sponsor
- AbbVie
Parkinson Disease
Deep Brain Stimulation on Dual-task Gait Performance in PD
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Motor symptoms include rigidity, bradykinesia, tremor, and postural instability, these motor symptoms can cause gait…
- Trial name
- NCT05314322
- Testing
- Deep brain stimulation with high frequency, Deep brain stimulation with low frequency
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- National Yang Ming Chiao Tung University
Geriatric, Parkinsons Disease (PD)
Collection of Digital Parameters From Parts of the Neurological Examination Using an Eye Tracker
The neurological examination (NE) is a cornerstone of clinical neurology, with ocular motor assessment being a key component. Technology offers an opportunity to augment and standardize parts of the NE.
- Conditions
- Geriatric, Parkinsons Disease (PD), Progressive Supranuclear Palsy(PSP), Neurological Diseases or Conditions
- Trial name
- NEX-Eye (NCT07141719)
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- University of Kiel
Parkinson's Disease and Parkinsonism, Dysphagia
Clinical Efficacy and Mechanism of tDCS for Dysphagia in PD
This study aims to verify transcranial direct current stimulation(tDCS) efficacy for Parkinson's disease (PD)-related dysphagia and its mechanism.
- Trial name
- NCT07153692
- Testing
- tDCS, Conventional Dysphagia Treatment
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Wang Ping
Parkinson's Disease
A Longitudinal Study in Parkinson's Disease (PD) Patients
This is a longitudinal study in patients with Parkinson's Disease (PD) carriers of a genetic mutation - substitution of gly with ser in position 2019 (G2019S) in the leucine-rich repeat kinase 2 (LRRK2) gene.
- Trial name
- NCT01730599
- Testing
- neurological exam
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinson Disease, Fatigue
Can a Flavonoid-rich Pure Cocoa Reduce Fatigue in People With Parkinson's (PD)
This study determines to evaluate the effectiveness of the daily consumption of flavonoid-rich cocoa in the treatment of fatigue in Parkinson's patients.
- Trial name
- NCT03288155
- Testing
- Cocoa
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Oxford Brookes University