Clinical trials: Parkinsons Disease (PD), open to volunteers
Parkinson Disease, Older People
Tele-Rehabilitation Intervention in Community-Based Healthcare for Patients With Parkinson's Disease (DHEAL-COM-PD)
The study aims to measure the improvement in functional capacity in a group of elderly people suffering from early-stage Parkinson's disease (Hoehn \& Yahr scale 1-3), following a telerehabilitation intervention integrated with…
- Trial name
- DHEAL-COM-PD (NCT06984393)
- Testing
- home tele-rehabilitation, Usual care
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Parkinson Disease(PD)
Adaptive DBS for PD
The goal of this clinical trial is to evaluate the efficacy and safety of an adaptive deep brain stimulation (aDBS) system for managing Parkinson's disease symptoms.
- Trial name
- SMART-DBS (NCT07635823)
- Testing
- adaptive deep brain stimulation, conventional deep brain stimulation
- Where
- 9 sites in China
- Volunteers
- 60 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Parkinson's Disease (PD)
A Phase 2 Study to Assess the Effects of SUL-238 on High Energy Phosphates With ³¹P-MRS in Patients With Early, Untreated Parkinson's Disease
The main goal of the study is to investigate how well the new drug SUL-238 works in Parkinson's Disease (PD). This is done by means of an MRS scan. An MRS scan is similar to a regular MRI scan.
- Trial name
- SHEPHERD (NCT07322887)
- Testing
- SUL-238 (1500 mg t.i.d.) film-coated tablets, SUL-238 (500 mg t.i.d.) film-coated tablets
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- GEN İlaç ve Sağlık Ürünleri A.Ş.
Tauopathies
Study of Biodistribution, Metabolism, Excretion and Brain Uptake 18F-JSS20-183A
The current protocol is to determine the biodistribution, metabolism, excretion and brain uptake of 18F-JSS20-183A. The goal of this radiotracer is to quantify 4Repeat Tau (4Rtau) protein that is abnormally deposited in the brain…
- Trial name
- NCT06932809
- Testing
- 18F-JSS20-183A PET, Brain MRI, Amyloid PET
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Pennsylvania
PD - Parkinson's Disease
Freezing of Gait - Clinical Outcomes Assessment
To develop a reliable and accurate clinician-reported outcome (ClinRO) measure (against a new and precise definition) and patient reported outcome (PRO) for use by clinicians and researchers to quantify the severity of Freezing…
- Trial name
- FOG-COA (NCT06519279)
- Testing
- Opals, Axivity
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Amyotrophic Lateral Sclerosis (ALS), Parkinson Disease (PD)
Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers
This is a Phase 1/2 study to evaluate the safety and tolerability of 18F-OP-801 in subjects with ALS, AD, MS, PD and age-matched HVs.
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Parkinson Disease (PD), Alzheimer Disease (AD), Multiple Sclerosis (MS)
- Trial name
- NCT05395624
- Testing
- 18F-OP-801
- Where
- 3 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Ashvattha Therapeutics, Inc.
Parkinson's Disease, Non-motor Symptoms
International Validation of Two Non-motor Scales in PD (NFS and SPARK)
The goal of this project is to develop the international validation of two new rating scales, the Neuropsychiatric Fluctuations Scale (NFS) and the Shame in PARKinson's disease (SPARK) Scale, in order to improve the understanding…
- Trial name
- NCT04366804
- Where
- 8 sites in France, Germany and 5 more
- Volunteers
- 300 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Freezing of Gait, Parkinson Disease
Percept Transitions in FOG and PD
The purpose of this research is to examine the possible causes and signs of freezing of gait (FOG) secondary to Parkinson's disease (PD).
- Trial name
- NCT06848205
- Testing
- OFF Parkinson's Medication(s), OFF Deep Brain Stimulation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Parkinson's Disease (PD)
Immediate Effects of External Trigeminal Nerve Stimulation on Motor Dysfunction in Parkinson's Disease
Parkinson's disease (PD), the most common movement disorder, is characterized by motor symptoms including tremor, rigidity, bradykinesia, and postural instability.
- Trial name
- NCT07656129
- Testing
- external Trigeminal Nerve Stimulation, eTNS
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhengli Di
Parkinson Disease (PD)
Different Frequency Temporal Interference Stimulation on Bilateral Subthalamic Nucleus for Parkinson's Disease
This clinical trial will evaluate the efficacy of accelerated Temporal Interference Stimulation (TIS) as a therapeutic intervention for individuals diagnosed with Parkinson's disease.
- Trial name
- NCT07721688
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ke Dong, MD
Parkinson Disease
Chinese PD-SNCA Registry
The purpose of the Chinese PD-SNCA Registry(CPD-SNCAR) is to develop a database of patients of Parkinson's disease with a-synuclein (SNCA) gene variants in mainland China.
- Trial name
- NCT03523052
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Xiangya Hospital of Central South University
Acoustic Stimulation, Parkinson Disease
Effects and Mechanisms of RAS Training on Upper-limb Movements in PD Patients
Introduction Bradykinesia (i.e., slow movements) is one of the most prominent symptoms of Parkinson's disease (PD) and has a negative impact on quality of life.
- Conditions
- Acoustic Stimulation, Parkinson Disease, Electroencephalography
- Trial name
- NCT05782322
- Testing
- Upper-limb training involving RAS, Upper-limb training without the aid of RAS
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Essential Tremor, Parkinson's Disease (PD)
Attention and Eye Movement in Parkinson's Disease
The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and non-PD movement…
- Conditions
- Essential Tremor, Parkinson's Disease (PD), Dystonias
- Trial name
- NCT06899022
- Testing
- Normal therapeutic DBS, Reduced current DBS, Reduced frequency DBS
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Parkinsons Disease (PD), Constipation - Functional
Nutritional Intervention for Constipation Symptoms in Patients With Parkinson's Disease
The goal of this clinical trial is to evaluate whether a dietitian-guided nutritional intervention can improve constipation symptoms in people with Parkinson's disease (PD).
- Trial name
- NUTRI-GUT-PD (NCT07213856)
- Testing
- Dietitian-Guided Nutritional Intervention
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Parkinson Disease, Prodromal Stage
Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity
α-Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are the second most common neurodegenerative diseases.
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia Diseases
- Trial name
- ALPHA-FIT (NCT07324330)
- Testing
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
- Where
- Germany
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Parkinson's Disease (PD), Parkinson Disease (PD)
Effects of Transcutaneous Cervical Vagus Nerve Stimulation on Non-motor Symptoms in Parkinson's Disease
The goal of this clinical trial is to learn if home-based transcutaneous cervical vagus nerve stimulation (tcVNS) can improve symptoms in adults with Parkinson's disease.
- Trial name
- tcVNS-PD (NCT07839481)
- Testing
- transcutaneous vagus nerve stimulation
- Volunteers
- 15 people
- Sponsor
- Kyoungwon Baik
Parkinson's Disease (PD)
A Phase Ib Trial of Combined Febuxostat and Inosine Therapy in Patients With Parkinson's Disease
This study will test the safety of twice-daily oral dosing of combined febuxostat and inosine in 24 patients with Parkinson's disease.
- Trial name
- iFRESH-PD (NCT07170475)
- Testing
- Febuxostat, Inosine
- Where
- Japan
- Volunteers
- 24 people
- Sponsor
- Fujita Health University
Parkinson Disease
Black and African Americans Connections to Parkinson's Disease (BLAAC PD)
BLAAC PD is a research study to understand what Parkinson's disease looks like for Black and African American communities. BLAAC PD is happening at research centers around the United States.
- Trial name
- BLAAC PD (NCT06719583)
- Where
- 12 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Parkinson Disease (PD)
Sensor-Based Optimization of Therapy for Parkinson's Disease Patients With Motor Fluctuations
Although numerous tools have been developed in recent years with the enhancement of new technologies precision and the reduction of their size, still few medical devices are used in clinical routine in Parkinson's Disease.
- Trial name
- SO-TOP (NCT07074119)
- Testing
- wearable-based adjustment therapy
- Where
- France
- Volunteers
- 218 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson's Disease (PD)
Clinical Study of Chemogenetic Gene Therapy With AAV for Parkinson's Disease Using Stereotactic Surgery in the Subthalamic Nucleus
The investigators propose a gene therapy strategy for Parkinson's disease - a chemogenetic inhibition technique to intervene in the abnormal activity of the subthalamic nucleus in Parkinson's patients.
- Trial name
- CGTPD (NCT07533591)
- Testing
- gene therapy
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine