Clinical trials: Parodontitis
Apical Periodontitis, Periapical Diseases
Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment
The goal of this randomized controlled clinical trial is to determine whether regenerative endodontic treatment can improve healing outcomes in teeth with apical periodontitis following failed root canal treatment.
- Trial name
- NCT07448571
- Testing
- Non-Surgical Root Canal Retreatment, Regenerative Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Marmara University
Probiotics, Periodontitis
Efficacy of Supplementation With Probiotics as Adjuvant to Mechanical Treatment in Chronic Periodontitis
It aims to demonstrate the superiority of a 6-week supplementation with Lactibiane Buccodental compared to placebo, as adjunctive therapy in chronic periodontitis in patients with generalized chronic periodontitis
- Trial name
- NCT03554187
- Testing
- Ultrasonic periodontal Debridement, with appropriate device, Analyzes of periodontopathogenic bacteria, IL1B test
- Where
- 2 sites in France
- Volunteers
- 51 people
- Sponsor
- PiLeJe
Dental Hygiene, Probiotics, Periodontitis
Probiotic Nanofiber Floss and Subgingival Pathogen Suppression
This randomized, double-blind, crossover clinical trial evaluated the effect of a probiotic-containing nanofiber dental floss on subgingival red complex periopathogens and gingival health in periodontally healthy individuals.
- Conditions
- Dental Hygiene, Probiotics, Periodontitis, Prevention of Dental Caries, Gingivitis and Periodontal Diseases
- Trial name
- NCT07149493
- Testing
- Probiotic nanofiber floss
- Where
- Czechia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Peridontal Disease
Assessment of Pro-Resolution Mediator Levels in Periodontitis Stage III and IV Before and After Periodontal Therapy
This study aims to assess Pro-Resolution Mediator levels during non-surgical periodontal therapy in individuals with Stage III and IV periodontitis, comparing them to healthy subjects.
- Trial name
- NCT06789458
- Testing
- Professional mechanical plaque control
- Where
- 2 sites in Egypt
- Volunteers
- 22 people
- Sponsor
- Cairo University
Periodontitis, Periodontal Intrabony Defects
Impact of Platelet-Rich Fibrin on Periodontal Tissue Regeneration
The purpose of this research is to assess the efficacy of Platelet-Rich Fibrin (PRF) in the regeneration of periodontal tissues in patients suffering from periodontal disease.
- Trial name
- NCT07395726
- Testing
- Open Flap Debridement, Platelet-Rich Fibrin with Open Flap Debridement
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Periodontitis, Dry Eye Disease (DED)
Association Between Periodontitis and Dry Eye Disease: A Cross-Sectional Study
This study is aiming at exploring the association between periodontitis and dry eye disease, which are both chronic inflammatory diseases that might have common pathogenic mechanisms.
- Trial name
- NCT07873697
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sulaimani
Periodontitis Chronic Generalized Severe
Hyaluronic Acid Versus Red Injectable Platelet Rich Fibrin in Treatment of Periodontitis
the aim of this clinical trial is to compare the efficacy of hyaluronic acid (HA) used as an adjunctive to scaling and root planing (SRP) and red injectable platelet rich-fibrin (i-PRF) in the non-surgical treatment of stage III…
- Trial name
- NCT05768243
- Testing
- Hyaluronic acid, red injectable platelet rich fibrin (i-prf)
- Where
- Lebanon
- Volunteers
- 75 people
- Sponsor
- Beirut Arab University
Aggressive Periodontitis, Generalized, Periodontal Health
GCF HIF-1α, VEGF and TNF-α Levels in G-AgP Patients Before and After Periodontal Treatment.
Hypoxia-inducible angiogenic pathway involving hypoxia inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor (VEGF) and tumour necrosis factor- alpha (TNF-α) may regulate the several biological processes related…
- Trial name
- NCT04020315
- Testing
- Non-surgically performed scaling and root planing
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Healthy, Periodontitis
Oral and Gut Microbiota Changes During Long-term Fasting in Humans
The aim of this longitudinal trial is to investigate the effects of a 10±3-day fasting period in 30 subjects. Changes in the oral and gut microbiota, halitosis, as well as inflammatory and antioxidative parameters and biomarkers…
- Trial name
- OralFast (NCT05449249)
- Testing
- Long-term fasting
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Buchinger Wilhelmi Development & Holding GmbH
Periodontitis
Clinical and Biochemical Evaluation of 1% Metformin in Non-surgical Treatment of Periodontitis
The aim of the study to evaluate the clinical and biochemical efficacy of 1% Metformin gel in treatment of periodontitis patients
- Trial name
- NCT06204185
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Apical Periodontitis
To Evaluate Periapical Healing Post Full Pulpotomy in Teeth With and Without Apical Periodontitis
This clinical study aims to evaluate the periapical and clinical healing outcomes of full pulpotomy using MTA in mandibular permanent molars diagnosed with symptomatic irreversible pulpitis.
- Trial name
- NCT07179835
- Testing
- Full pulpotomy in adults ≥18 years with restorable mandibular first or second molars diagnosed with irreversible pulpitis, with or without apical periodontitis.
- Where
- India
- Volunteers
- 128 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Stage II Grade B Periodontitis
Clinical & Biochemical Evaluation of Antioxidant Vs. Chlorhexidine as an Adjunctive to Non-Surgical Treatment of Stage II-grade B Periodontitis
This randomized clinical trial aims to evaluate and compare the clinical and biochemical effects of an antioxidant agent and chlorhexidine when used as adjuncts to non-surgical periodontal therapy in patients with Stage II Grade…
- Trial name
- NCT07801417
- Testing
- Perioscience Gel, High Cure Chlorhexidine Gel, High Cure Chlorhexidine Gel + Perioscience Gel
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Al-Azhar University
Periodontal Diseases, Obesity
Evaluation of Periodontal Diseases and Obesity in Women
The aim of this study was to evaluate the effect of obesity and exercise on periodontal and biochemical parameters [serum, saliva and gingival crevicular fluid (GCF) adipokines (interleukin-1β, tumor necrosis factor-α, leptin…
- Trial name
- NCT03442920
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Periodontitis, Gingivitis
Evaluation of Mandibular Bone Microstructure Changes After Periodontal Treatment (M-BONE Study)
This prospective study evaluates how non-surgical treatment for gum disease affects the bone of the mandible. Gum disease (periodontitis) can lead to changes in the bone supporting the teeth, but these changes are not always easy…
- Trial name
- NCT07488403
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Periodontitis
Connection Between Periodontitis and Exudative Age-related Macular Degeneration
Aqueous flare is increased in different kind of inflammations of eye. This is caused by disruption of blood-aqueous-barrier. The investigators assume that low grade systemic inflammation, such as periodontitis, increase aqueous…
- Trial name
- FLAREPARO (NCT03958461)
- Testing
- Anti-infective treatment of periodontal pockets
- Where
- Finland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Diabetes Mellitus Type 2 With Periodontal Disease
Diabetes Mellitus and Periodontitis and Vitamin D Supplementation
This study investigates the clinical and biochemical results of vitamin D supplementation in addition to non-surgical periodontal treatment in individuals with Type II diabetes mellitus and periodontitis.
- Trial name
- NCT06077708
- Testing
- Vitamin D3K2, Saline Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Chronic Apical Periodontitis, Necrosis of Pulp
Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth
This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in…
- Conditions
- Chronic Apical Periodontitis, Necrosis of Pulp, Acute Apical Periodontitis of Pulpal Origin, Periapical Abscess
- Trial name
- NCT07192289
- Testing
- Using advanced platelet-rich fibrin (A-PRF+) or injectable platelet-rich fibrin (i-PRF) in regenerative endodontic treatment in mature permanent teeth.
- Where
- Vietnam
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Chronic Periodontitis
Prevalence of Porphyromonas Gingivalis Fimbrial Subunit Genotype in Smokers and Nonsmokers After Periodontal Therapy
The aims of the present study will be identify 5 types of fimbrial subunit genotype strains in smokers and nonsmokers with periodontitis, before and after periodontal therapy.
- Trial name
- NCT02879903
- Testing
- Periodontal treatment, Microbiological collect, Questionnaire
- Volunteers
- 32 people
- Sponsor
- Universidade Federal Fluminense
Periodontal Diseases, Diabetes Mellitus
Anti Oxidant Enzymes and Total Antioxidant Levels in Diabetes Mellitus Type II Patients and Healthy Individuals With Periodontitis
To evaluate the role of antioxidants - superoxide dismutase, catalase, glutathione and total anti oxidant levels in the serum of chronic periodontitis patients and chronic periodontitis with DM Type II patients, then to compare…
- Conditions
- Periodontal Diseases, Diabetes Mellitus, Enzyme Disorder
- Trial name
- NCT04180332
- Testing
- Blood sample
- Where
- India
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ajman University
Irreversible Pulpitis, Apical Periodontitis
Evaluation of iRoot SP as Root Canal Sealer: A Clinical Study
The purpose of this study was to evaluate the clinical and radiological outcomes of iRoot SP as a root canal sealer in comparison with AH Plus sealer within 1-year follow up.Patients needing root canal treatment were enrolled and…
- Trial name
- NCT02981693
- Testing
- Root canal sealer
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- Hui Chen
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