Clinical trials: Parodontitis
Periodontitis
L-PRF Plus Non Surgical Periodontal Treatment
Abstract: Background: Leucocyte and Platelet-Rich Fibrin (L-PRF) has shown to promote regenerative processes, even reporting antibacterial effect.
- Trial name
- NCT04520438
- Testing
- Leukocyte and platelet rich fibrin, Non-Surgical Periodontal treatment
- Where
- Chile
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Bacterial Infections
Effect of Passive Ultrasonic Irrigation on Bacteria That Persist After Root Canal Preparation
This study aims to evaluate the effectiveness of ultrasonic irrigation in improving root canal disinfection after chemomechanical procedures.
- Trial name
- NCT05100433
- Testing
- Ultrasonic irrigation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Root Canal Obturation, Apical Periodontitis
Evaluation of Postoperative Pain and Lesion Healing in Periapical Lesion-Affected Teeth Obturated With Different Root Canal Sealers
The root canal treatment of volunteers with asymptomatic apical periodontitis will be completed using TotalFill BC and AH Plus root canal sealers, and postoperative pain as well as healing will be comparatively evaluated through…
- Trial name
- NCT07307807
- Testing
- AH Plus and PAI 2-3, AH Plus and PAI 4, TotalFill BC Sealer and PAI 2-3
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ankara Yildirim Beyazıt University
Ozone-therapy (O3), Periodontitis
Ozone-therapy in Non-surgical Periodontal Therapy
Non-surgical periodontal therapy is a widely adopted procedure for the treatment of periodontitis, particularly in its moderate to severe stages.
- Conditions
- Ozone-therapy (O3), Periodontitis, Antimicrobial Ozone Therapy
- Trial name
- PD-OZONE (NCT07202312)
- Testing
- Ozone-therapy after non-surgical therapy
- Where
- Italy
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Irreversible Pulpitis, Apical Periodontitis
Success of Pulpotomy in Molars With Pulpitis With Periodontitis Detected Using AI and Those Without Periodontitis
Statement of problem: Although performing full pulpotomy in mature permanent molars with irreversible pulpitis showed success rates comparable to RCT, there is a growing need for further studies in order to determine the…
- Conditions
- Irreversible Pulpitis, Apical Periodontitis, Pulpitis
- Trial name
- NCT06767371
- Testing
- Patients with mature permanent molars diagnosed with severe pulpitis with apical periodontitis to be treated with full pulpotomy., Patients with mature permanent molars diagnosed with moderate pulpitis without apical periodontitis to be treated with full pulpotomy., Teeth with irreversible pulpitis
- Where
- Egypt
- Volunteers
- 57 people
- Sponsor
- Misr International University
Chronic Periodontitis
Dose Parameters for Photodynamic Therapy on Periodontal Disease
Due to the phenomenon of bacterial resistance, photodynamic therapy (PDT) has been studied as an alternative to the use of antibiotics on the periodontal treatment.
- Trial name
- NCT03262077
- Testing
- Methylene Blue, Methylene Blue Oral Product
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Pain and Discomfort During Scaling and Root Planning of Patients With, Periodontitis
Effect of Local Anesthesia in Patients With Marginal Periodontitis Undergoing Scaling and Root Planning
A randomised cross-over study comparing two methods of local anaesthesia for patients diagnosed with periodontitis undergoing scaling and root planning.
- Trial name
- NCT01878864
- Testing
- Bupivacaine lozenge, Lidocaine-adrenalin injection
- Where
- 3 sites in Denmark
- Volunteers
- 12 people
- Sponsor
- Ove Andersen
Halitosis
Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis
The purpose of this study is to determine whether Lactobacillus reuteri-containing lozenges (Prodentis) are effective in treatment of halitosis in patients with chronic periodontitis.
- Trial name
- NCT02789436
- Testing
- L. reuteri Prodentis® lozenges
- Where
- Croatia
- Volunteers
- 30 people
- Sponsor
- University of Zagreb
Chronic Periodontal Disease, Aggressive Periodontitis
Transplantation of Bone Marrow Mesenchymal Stromal Cells for Periodontal Regeneration
The goal of this study is to evaluate the capacity of allogeneic bone marrow mesenchymal stromal cells (MSC) to induce bone regeneration in patients with periodontal disease.
- Trial name
- BMMSC (NCT05975892)
- Testing
- Transplantation of allogeneic MSCs in periodontal disease
- Where
- Venezuela
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Venezolano de Investigaciones Cientificas
Chronic Periodontitis, End Stage Renal Disease
Novel PAradigm to Improve Inflammatory Burden in ESRD (rePAIR): A Pilot and Feasibility Randomized Controlled Trial
The goal of this project is to assess repeated and ongoing oral care and the way it may affect inflammation and quality of life in hemodialysis patients.
- Trial name
- rePAIR (NCT03241511)
- Testing
- Test
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- UConn Health
Histopathology, Periodontitis
Effects of Smoking on Oral Tissue Samples
Smoking negatively affects the prognosis of periodontal disease by impairing tissue healing. While micronucleus is the most popular parameter for demonstrating DNA damage, inflammatory cell and vascular densities are the most…
- Conditions
- Histopathology, Periodontitis, Smoking, Micronuclei
- Trial name
- NCT05484765
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul Medipol University Hospital
Periodontitis
Complementary Naturopathic Medicine for Periodontitis
This study aims to assess selected naturopathic medicines for adult periodontitis and to identify variables that influence successful outcomes when traditional and alternative approaches to preventing and treating periodontal…
- Trial name
- NCT00010634
- Testing
- Connective Tissue Nutrient Formula, Adaptogenic herbs, glutamine
- Where
- United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Generalized Chronic Periodontitis, Osteoporosis
A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis
Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.
- Trial name
- CTROP (NCT02273128)
- Testing
- CTR Gene
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Periodontitis
Nonsurgical Periodontal Therapy on Banded First Molars
The aim of this study was to evaluate the effect of nonsurgical periodontal therapy on first molars banded for fixed orthodontic treatment.
- Trial name
- NCT03410602
- Testing
- Full-mouth supragingival scaling, Subgingival scaling, Subgingival irrigation
- Volunteers
- 30 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Oral Disease, Cardiovascular Diseases
Oral Health in Adults: Social Gradients and Correlation With Cardiovascular Health
Non-communicable diseases (NCDs) are rising in prevalence because of aging, unhealthy diet and sedentary lifestyle, and common NCDs are caries and periodontitis (here oral diseases) and cardiovascular disease (CVD).
- Conditions
- Oral Disease, Cardiovascular Diseases, Diabetes
- Trial name
- HUSK (NCT05758467)
- Where
- Norway
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Oral Health Centre of Expertise in Western Norway
Periodontitis
Validation of the Clinical and Antimicrobial Effectiveness of a Clorexidine and Sodium DNA Based Mouthwash in Patients With Stage III and IV Periodontitis
Sodium DNA has several properties that may be beneficial in the management of bacterial biofilm in periodontitis. The aim of this RCT study is to clinically evaluate the antimicrobial and oral biofilm control properties of two…
- Trial name
- NCT06028867
- Testing
- Non-surgical periodontal treatment
- Where
- Italy
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Catania
Pulpitis - Irreversible, Pulp Necrosis
Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France
When faced with primary teeth affected by irreversible pulpitis or pulp necrosis, extraction is often the preferred option for practitioners, although validated alternatives exist, notably pulpectomy, which has high success rates…
- Conditions
- Pulpitis - Irreversible, Pulp Necrosis, Apical Periodontitis
- Trial name
- DTNV (NCT07297836)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Periodontitis, Gingivitis
Evaluation of Matrix Metalloproteinase 8 Salivary Test for Diagnosis of Periodontitis
Despite the great progress in understanding the causes of infertility, the reason for the failure of pregnancy has not been discovered among 25% of infertile couples.
- Conditions
- Periodontitis, Gingivitis, Infertility
- Trial name
- NCT03542630
- Testing
- salivary MMP8 test, periodontal examination, blood tests
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Periodontal Diseases, Smoking
Effect of Smoking on Periodontal Therapy in Periodontitis
The present study aimed to assess the effect of smoking on non-surgical periodontal treatment on serum and salivary RANKL, OPG and IL34 levels in periodontitis stage III grade C (P-III-C) patients.
- Trial name
- NCT05262153
- Testing
- Non-surgically performed scaling and root planing
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontitis and Treatment Need
Evaluation of a New Self-reported Tool for Periodontitis Screening
200 patients took part in the questionnaire and were examined using the PSI. Thereafter the participants were divided into two groups, non-periodontitis persons (group 1; PSI 0-2) and periodontitis persons (group 2; PSI 3-4).
- Trial name
- NCT02754401
- Testing
- 16 Items, PSI
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Renatus, Antonio Renatus, Dent., M.Sc
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