Clinical trials: Parodontitis
Apical Periodontitis
Outcome of Regenerative Endodontic Procedure and Root Canal Treatment for the Management of Apical Periodontitis
Background Root canal therapy is the primary treatment of choice for necrotic mature teeth with periapical lesions (PRLs), which does not restore the tooth's vitality.
- Trial name
- NCT06179433
- Testing
- Root canal treatment, Regenerative endodontic procedure
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Diabetes Mellitus, Chronic Periodontitis
Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus
A study on the effect of locally delivered aloe vera gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis patients with controlled type II diabetes mellitus.The evaluation of Plaque Index…
- Trial name
- NCT02437747
- Testing
- SRP + Aloe, SRP
- Volunteers
- 15 people
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Apical Periodontitis, Periapical Lesion
Evaluation of Different Root Canal Obturation Techniques
The aim of this clinical study is to evaluate the effect of root canal filling, which is the last stage of root canal treatment (RCT), on the post-operative pain level on single rooted permanent teeth with wide lesions with…
- Trial name
- NCT07106307
- Testing
- Bioceramic Sealer, Warm Vertical Compaction, Epoxy Resin-Based Sealer
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Medipol University
Periodontal Diseases, Periodontitis
Observational Prospective Study on Resective and Regenerative Periodontal Therapy: Short & Longterm Follow-up
Periodontitis is a common inflammatory disease affecting approximately 40% of the Belgian population. The goal of this observational study is to learn about the treatment outcomes of surgical periodontal therapy in adults with…
- Trial name
- UZFLAPSTUD (NCT07283393)
- Testing
- Periodontal charting, peri-apical radiograph and low-dose small-field cone beam CT
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Ghent
Periodontitis
Effect of Spirulina on Periodontitis
The purpose of this study is to assess the clinical and immunological effect of spirulina in treatment of stage II periodontitis.
- Trial name
- NCT06016933
- Testing
- spirulina gel, SRP of all teeth
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Periodontal Diseases
Impact of Full Mouth Erythritol Powder Air Polishing on Systemic Inflammatory Response
Periodontitis (PD) is an inflammatory condition that affects 20%-50% of the total global population, with severe disease occurring in 9.8% of individuals.
- Trial name
- NCT05812391
- Testing
- test, conventional
- Where
- Iraq
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Root Canal Treatment, Intracanal Medicament
The Success of Root Canal Treatments Performed Using Two Different Intracanal Medicaments
Previously untreated, asymptomatic, single-rooted maxillary anterior teeth with periapical lesions <5 mm, no fractures, resorption, calcification, or recent antibiotic use will performed two-visit root canal treatment.
- Conditions
- Root Canal Treatment, Intracanal Medicament, Post Operative Pain, Apical Periodontitis
- Trial name
- NCT07210177
- Testing
- Bio-C Temp Intracanal Medication, Metapaste Intracanal Medication
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ege University
Stage III Periodontitis
Evaluation of Serum TRACP-5b, BALP, and 25-Hydroxyvitamin D3 Levels in Stage III Periodontitis Patients
Periodontitis is a chronic inflammatory disease characterized by the progressive destruction of the supporting tissues of the teeth.
- Trial name
- TRACP-BALP-D3 (NCT07438977)
- Testing
- Non-Surgical Periodontal Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Ataturk University
Apical Periodontitis
Accuracy of PoCT to ELISA by Detecting Human IL-6 in Teeth with Apical Periodontitis
To compare the diagnostic agreement of human IL-6 chairside PoCT to ELISA in apical periodontitis undergoing endodontic therapy which could be clinically helpful to monitor the healing of periapical tissues enabling the clinician…
- Trial name
- PoCT ELISA (NCT06701266)
- Testing
- Point of Care Test
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- Manipal University College Malaysia
Apical Periodontitis, Oxidative Stress
Examination of the Effect of Nd:YAG Laser on Oxidative Stress and Matrix Metalloproteinase-9 in Teeth With Apical Periodontitis
The objective of this clinical investigation is to examine the impact of Nd:YAG laser therapy on oxidative stress and matrix metalloproteinase-9 (MMP-9) levels in teeth afflicted with apical periodontitis.
- Trial name
- NCT07243353
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Kırıkkale University
Periodontal Diseases, Gingival Diseases
Asprosin and Total Antioxidant/Oxidant Status in Diabetes and Periodontal Disease
The goal of this observational study is to learn about how different periodontal health status affects the levels of asprosin (a hormone) and total oxidant/antioxidant status in the gingival crevicular fluid and blood serum of…
- Conditions
- Periodontal Diseases, Gingival Diseases, Type 2 Diabetes
- Trial name
- NCT07691060
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Chronic Periodontitis
Effect of Omega 3 on Periodontitis in Postmenopausal Women
The study was aimed to investigating changes in periodontal parameters and superoxide dismutase activity after root surface debridement with and without Omega 3 fatty acids (ω-3 FAs) supplementation in postmenopausal women.
- Trial name
- NCT02764879
- Testing
- Omega 3 fatty acids, scaling and root planing
- Volunteers
- 50 people
- Sponsor
- October 6 University
Rheumatoid Arthritis, Periodontitis
Prolactin Hormone in Rheumatoid Arthritis Patients With Periodontitis
In this study we will assess the presence of prolactin hormone in the gingival crevicular fluid , and synovial fluid of patient with rheumatoid arthritis and periodontitis
- Trial name
- NCT04279691
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Periapical Periodontitis, Irrigation Activation
Effects of Different Irrigation Activation Techniques on the Healing of Large Periapical Lesions
The primary goal of endodontic treatment is to treat the infection by optimally cleaning the root canal system and precentig reinfection.
- Conditions
- Periapical Periodontitis, Irrigation Activation, Lasers
- Trial name
- NCT06991803
- Testing
- root canal treatment and irrigation activation
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Recep Tayyip Erdogan University
Dental Implant Failure Nos, Periapical Granuloma
Periapical Lesions and Immediate Implants
The aim of this case-control study is to evaluate the success and survival rates of dental implants immediately placed into extraction sites in the presence of periapical pathology.
- Conditions
- Dental Implant Failure Nos, Periapical Granuloma, Osseointegration Failure of Dental Implant
- Trial name
- NCT06521203
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Periodontitis, Metabolic Syndrome
Periodontitis Provokes Retinal Neurodegenerative Effects of Metabolic Syndrome: A Cross-Sectional Study
This cross-sectional study aimed to investigate the retino-choroidal degenerative effects of periodontitis, metabolic syndrome (Mets), and the combination of these diseases using optical coherence tomography (OCT) measurements.
- Conditions
- Periodontitis, Metabolic Syndrome, Neurodegeneration, Oxidative Stress
- Trial name
- NCT06638580
- Testing
- Clinical Periodontal Measurements (plaque index, gingival index, bleeding index, clinical attachment level), Optical Coherence Tomographic Measurements, Serum IL1-β, TNF-α, IL-10, TAS, TOS, OSİ levels
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Periodontitis
Effect of Smoking on Salivary and Serum Metabolomic Profiles in Periodontitis
This observational study investigated the effect of smoking on salivary and serum metabolomic profiles in individuals with and without periodontitis.
- Trial name
- PERIO-META (NCT07897162)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ankara University
Tooth Discoloration, Periodontal Diseases
Evaluating the Efficacy of a Gum Health Formulation on Teeth Whitening in Patients With Gingivitis and Periodontitis
The purpose of this study is to evaluate the efficacy of a novel gum health formulation, when used in an intra-oral device or on a toothbrush, for teeth whitening and clinical improvements in periodontal diseases.
- Trial name
- NCT02906982
- Testing
- Gum health formulation in intra-oral device, Gum health formulation on toothbrush
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Glo Science, Inc.
Symptomatic Periapical Periodontitis
Effect of Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain
The aim of this prospective, randomized, placebo controlled study is to evaluate the effect of amoxicillin/clavulanic acid combination on post-operative pain and swelling in adult patient with symptomatic apical periodontitis.
- Trial name
- NCT03007342
- Testing
- Amoxicillin/Clavulanate Potassium 875 mg-125 mg oral tablet
- Volunteers
- 78 people
- Sponsor
- Cairo University
Periodontitis, Oxidative Stress
Gingival TrxR1 Expression in Periodontal Health and Periodontitis
This study aims to investigate the role of the thioredoxin system in the development and progression of periodontitis. Researchers will examine the levels of specific antioxidant markers, such as thioredoxin reductase 1 (TrxR1)…
- Trial name
- NCT07598942
- Testing
- Gingival Tissue Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
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