Clinical trials: Parodontitis
Periodontitis
Impact of E-Cigarette Smoking on Healing Response to Non-Surgical Periodontal Therapy
the goal of this clinical trial is to compare the effect of vaping vs traditional smoking on non surgical periodontal therapy . the main question it aims to answer is what is the impact of traditional smoking and vaping on…
- Trial name
- NCT07668947
- Testing
- non surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 117 people
- Sponsor
- Ain Shams University
Pulmonary Disease, Chronic Obstructive, Generalized Chronic Periodontitis
The Association of SERPINA1 Gene Disturbance in Patients With Lung and Gum Disorders
Chronic obstructive pulmonary disease and periodontitis are chronic inflammatory diseases. The study aims to determine if the genetic polymorphism of SERPINA1 gene in patients with COPD serve as a risk factor for developing…
- Trial name
- SA1PLG (NCT02498938)
- Testing
- SERPINA1 gene
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Asymptomatic Apical Periodontitis, Root Canal Retreatment
Non-Surgical Single Visit Endodontic Retreatment in Cases With Asymptomatic Apical Periodontitis Using Bioceramic Sealer
The goal of this clinical trial is to learn if using bioceramic sealers in non surgical single visit endodontic retreatment in patients with endodontic treatment failure and asymptomatic apical periodontitis will work in…
- Trial name
- NCT06973135
- Testing
- Bioceramic sealer root canal obturation, resin sealer root canal obturation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Saly Nazeer
Peridontal Disease, Dental Anxiety
The Effect of Hypnosis on Periodontal Treatment
Treatment of periodontal diseases relies on the mechanical removal of microbial dental plaque, calculus, and necrotic cementum from root surfaces in both supra- and subgingival areas to control inflammation in periodontal…
- Trial name
- NCT06808373
- Testing
- hypnosis
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Afyonkarahisar Health Sciences University
Periodontitis
Administration of L. Paracasei 28.4 as an Adjunct to the Treatment of Periodontitis
The aim of this study is to evaluate the effects of probiotic administration of L. paracasei 28.4 as an adjunct to the non-surgical periodontal treatment in patients with periodontitis.
- Trial name
- NCT05107622
- Testing
- FMUD+Probiotic
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Periapical Abscess
Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess
Aim: The aim of this study was to compare the analgesic efficacy of two combinations of opioid and non-opioid analgesics for acute periradicular abscesses.
- Trial name
- NCT02750696
- Testing
- Fixed-dose oral tablet of codeine/ acetaminophen every 4 hours for 3 days, Fixed-dose oral tablet of tramadol/ acetaminophen every 4 hours for 3 days
- Volunteers
- 27 people
- Sponsor
- Federal University of Rio Grande do Sul
Chronic Periodontitis
Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects
The present clinical trial included 20 patients (11 females and 9 males, aged 36 to 56 years) suffering from moderate or advanced chronic periodontitis.
- Trial name
- NCT04643288
- Testing
- open flap debridement, n-HA bone graft
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Weam Ahmed Elbattawy
Periodontitis, Diabetes Mellitus, Type 2
Effect of Periodontal Treatment on Adipokine Levels
The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM).
- Trial name
- NCT06225154
- Testing
- Non-surgical periodontal treatment
- Where
- 2 sites in Finland, Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontitis
Influence of Gum Disease Treatment on Long-term Dental Implant Success
The aim of this study is to evaluate the influence of periodontal care response on long term dental implant success. Investigator's hypothesis is that patients who do not well respond to periodontal care have more chance to…
- Trial name
- NCT03841656
- Testing
- PARORISKIMPLANT
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Periodontitis
Platelet Rich Fibrin With 1% Metformin Gel for Treatment of Intrabony Defects
ABSTRACT: Background: Platelet-rich fibrin (PRF) is a second-generation platelet concentrate which releases various growth factors that promote tissue regeneration.
- Trial name
- NCT02283554
- Testing
- open flap debridement (OFD), Platelet rich fibrin (PRF), Metformin
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Cardiovascular Risk Markers, Chronic Periodontitis
Non-surgical Peridontal Treatment on Cardiovascular Risk Markers
The study evaluates the influence of non-surgical mechanical periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases
- Trial name
- NCT04540328
- Testing
- Non-surgical periodontal treatment
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Periodontitis, Rheumatoid Arthritis
The Effect of Non-Surgical Periodontal Therapy on Rheumatoid Arthritis
Periodontitis is a common chronic inflammatory disease characterised by the destruction of the soft and hard tissues supporting the tooth, including alveolar bone, periodontal ligament and cementum.
- Trial name
- NCT06245265
- Testing
- ELISA (Enzyme-Linked ImmunoSorbent Assay)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Biruni University
Inflammation, Periodontitis
Specialized Pro-resolving Mediators (SPM) as Biomarkers of Periodontal Inflammation
Periodontal diseases are a public health burden in all countries. Hence, Periodontitis is the sixth-most prevalent disease in the world, the most common bone diseases in human and the primary cause for tooth loss in adults…
- Trial name
- NCT05706675
- Testing
- Non surgical periodontal therapy
- Where
- United Arab Emirates
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Systemic Sclerosis, Periodontitis
Periodontal Health Status in Patients with Systemic Sclerosis
The aim of the research will be to evaluate the effects of NSPT on clinical periodontal parameters, level of antioxidants in unstimulated saliva and the levels of biomarkers (VEGF, TGF-β, IL-17) in the GCF in SSc patients in…
- Trial name
- NCT05215431
- Testing
- periodontal examination's, determination of salivary antioxidants and cytokine levels (VEGF, TGF-β, Il-17) in gingival crevicular fluid, Non-surgical therapy of periodontitis, Activity of antioxidants in unstimulated saliva (GPX, SOD, UA), Total cytokine levels (VEGF, TGF-β, Il-17) in gingival crevicular fluid
- Where
- Serbia
- Volunteers
- 60 people
- Sponsor
- University of Belgrade
Myocardial Infarction, Chronic Periodontitis
The Effect of Periodontal Therapy in Chronic Periodontitis Patients With and Without Acute Myocardial Infarction
The aim of this study was to evaluate the effects of periodontal treatment on gingival crevicular fluid (GCF) levels of Neopterin(N) and vascular cell adhesion molecule (VCAM-1) in chronic periodontitis(CP) patients with acute…
- Trial name
- NCT03005886
- Testing
- Periodontal examination, GCF sampling, phase I therapy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Apical Periodontitis
N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis
A randomized controlled trial comparing the postoperative pain intensity, periapical biomarkers level, and periapical healing in patients with necrotic mature teeth and apical periodontitis treated with N-acetylcysteine (NAC), as…
- Trial name
- NAC (NCT07262554)
- Testing
- Calcium hydroxide (Ca(OH)₂), N-Acetylcysteine (NAC)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Periodontitis
The Efficacy of Scaling and Root Planing on Endothelin-1 Level
Periodontitis is a chronic inflammatory disease resulting from bacterial invasion. Endothelin (ET-1) is a potent vasoconstrictor critical in the pathophysiology of periodontal diseases.
- Trial name
- clinical (NCT06784869)
- Testing
- Scaling and root surface debritment
- Volunteers
- 24 people
- Sponsor
- University of Baghdad
Periodontitis
SRP, Systemic Inflammation and Serum Bone Resorption Markers Premenopausal Women With Periodontitis and Low BMD
To assess the impact of scaling and root planing on systemic inflammation and serum bone resorption markers in pre-menopausal women with periodontitis
- Trial name
- NCT04259242
- Testing
- SRP
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Adult
Garlic Product Impact on Periodontitis (GPIP)
This is a randomized, controlled, examiner-blind, 2-treatment parallel group study. The study will be conducted at the Hebrew University, Hadassah, Israel.
- Trial name
- NCT03492723
- Testing
- Aged Garlic Extract
- Where
- 2 sites in Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Chronic Periodontitis
Effect of Nonsurgical Periodontal Therapy Verses Oral Hygiene Instructions on Patients With Chronic Periodontitis
Periodontitis, a bacterial dental biofilm based infectious disease, is a chronic inflammatory disease of the periodontium which results in irreversible destruction of supporting structures of the teeth such as periodontal…
- Trial name
- NCT02208739
- Testing
- Nonsurgical periodontal therapy, Oral hygiene instructions
- Where
- Malaysia
- Volunteers
- 56 people
- Sponsor
- University of Malaya
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