Clinical trials: Parodontitis
Periodontitis, Periodontal Regeneration, Clinical and Radiographic Results, Modified Minimal Invasive Surgery
Endoscope-assisted Flapless Approach Versus Papillary Preservation Technique in Periodontal Regeneration.
The standard of care for regeneration of lost periodontal tissue from disease at contained defect sites non-responding to non-surgical periodontal therapy is periodontal regenerative surgery.
- Conditions
- Periodontitis, Periodontal Regeneration, Clinical and Radiographic Results, Modified Minimal Invasive Surgery, Periodontal Regeneration
- Trial name
- EAFAR (NCT06978036)
- Testing
- Flapless periodontal regeneration with EMD + EASD, Periodontal regeneration with EMD + PPT
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- The University of Hong Kong
Periodontitis, MEDİTERRANEAN DİET
Evaluation of Nutritional Habits, Oral Hygiene, Relationship Between Dental Caries and Periodontal Condition
The purpose of this observational study is to identify the dental and periodontal health issues, oral hygiene practices, and potential relationships between them by assessing the variables that may have an impact on them.The main…
- Trial name
- NCT06129357
- Testing
- 180 individuals who applied to the Periodontology Clinic were included in the study. Individuals were divided into 3 groups as healthy (n=60), gingivitis (n=60) and periodontitis (n=60).
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Necmettin Erbakan University
Periodontitis, Adult
Cleansing Efficacy of Waist-shaped Interdental Brushes.
The aim of the present randomized and single-blinded cross-over study was to compare the cleansing efficacy of waist-shaped interdental brushes with that of cylindric interdental brushes in interproximal sites.
- Trial name
- Waist-shaped (NCT03851757)
- Testing
- waist-shaped interdental brush, cylindric interdental brush
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University Innsbruck
Periodontitis
Disease Perception and Oral Health Impact Profile (OHIP) Before and After Non-surgical Periodontal Treatment
The presence of periodontal diseases in patients has been associated to a worsened quality of life overall. Many different indices have been proposed over time in order to evaluate patient's centred outcomes.
- Trial name
- NCT04683016
- Testing
- Questionnaires
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Siena
Post-operative Pain, Apical Periodontitis
The Effect of Different Irrigation and Disinfection Methods on Post-operative Pain (PP)
Aim: The aim of this study was to examine post-operative pain (PP) severity after conventional irrigation and sonic activation methods, with and without laser disinfection in mandibular molar teeth diagnosed with symptomatic…
- Trial name
- PP (NCT05195021)
- Testing
- EDDY, Diode Laser device, Conventional irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Biruni University
Chronic Periodontitis, Type 2 Diabetes Mellitus
Chronic Periodontitis Microbiota in Type 2 Diabetes Mellitus Patients
This study is a retrospective comparative evaluation of six main periodontal pathogens and total bacterial load in chronic periodontitis patients affected or not by type 2 diabetes mellitus by polymerase chain reaction analysis.
- Trial name
- NCT03786133
- Testing
- Analysis of microbiological tests
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Bologna
Periodontal Diseases
LED Light As An Adjunct Treatment Modality of Periodontal Diseases
By promoting the cellular activities, it has been shown that the low-level laser therapy (LLLT) is able to accelerate the wound healing, reduce gingival inflammation, relief the discomfort, and serve as an adjunct to the…
- Trial name
- NCT03557814
- Testing
- LED appliance during mechanical debridement, LED appliance after mechanical debridement, Mechanical debridement alone
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Periodontitis, Healthy
Effect Of Scaling and Root Planning on ALP in Saliva and GCF In Periodontitis Patients Compared With Healthy Individuals
The goal of this [interventional clinical trial] is to test effect of scaling and root plaining on Alkaline phosphatase in Saliva and Gingival crevicular fluid in periodontitis patients compared with healthy subjects The…
- Trial name
- NCT06048016
- Testing
- Scaling and Root Planning
- Where
- Egypt
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periapical Periodontitis
Single Versus Multiple Visits Endodontic Treatment
Healing rate after single visit or multiple visit endodontic treatment using triple paste intracanal medicament will be assessed both clinically and radio-graphically for follow-up period up to one year
- Trial name
- NCT02947763
- Testing
- mixture of metronidazole, ciprofloxacin, and minocycline
- Volunteers
- 44 people
- Sponsor
- Cairo University
Periapical Periodontitis
Adrenomedullin Upregulation in Apical Periodontitis
The aim of the present study was to investigate the relationship between Apical periodontitis (AP) severity and inflammatory markers (IL-12, TNF-alpha), and Mid-Regional Pro Adrenomedullin (MR-proADM) in patients with AP.
- Trial name
- NCT05297747
- Testing
- Apical periodontitis, Chronic periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Periapical Lesions, Chronic Apical Periodontitis of Pulpal Origin
Outcome of Bone Window Approach in Endodontic Microsurgery Using Novel Piezoelectric Device
The Bone window technique provides excellent access to the surgical site while preserving cortical bone in cases of tooth with large periapical lesion and an intact cortical plate.
- Trial name
- NCT06587048
- Testing
- periapical surgery
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Periodontal Inflammation
Hyaluronic Acid and Albumin-PRF in Non-Surgical Periodontal Therapy
Periodontitis is a chronic inflammatory disease that leads to the destruction of the supporting tissues of the teeth. Non-surgical periodontal treatment is the first-line approach for the management of periodontitis; however, the…
- Trial name
- NCT07415148
- Testing
- Non-Surgical Periodontal Treatment, Albumin Platelet-Rich Fibrin (Alb-PRF), Hyaluronic Acid Gel
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Inonu University
Severe Periodontitis
The Efficacy of Systemic Valacyclovir (Valtrex) on Periodontitis
The experiment outlined in this proposal is designed to test the hypothesis that herpesvirus suppression by the systemic anti-herpesvirus valacyclovir (Valtrex) can significantly help to arrest the progressive course of severe…
- Trial name
- NCT05712343
- Testing
- Valacyclovir group, Control group
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Periodontitis, Diabetes
Effect of Non Surgical Treatment of Periodontitis on Diabetes Control
The aim of this study is to investigate the effects of non-surgical periodontal treatment on the metabolic control of type2 diabetes patients.
- Trial name
- PARODIA1 (NCT02745015)
- Testing
- non-surgical periodontal treatment
- Where
- Cameroon
- Volunteers
- 45 people
- Sponsor
- Yaounde Central Hospital
Peri-implantitis, Periodontitis
Transcriptome, Proteome and Microbiome Profile in Periodontal and Peri-implant Diseases
1. To investigate the transcriptomic profile of periodontitis and peri-implantitis. Patients with defined periodontitis, at two non-adjacent teeth and peri-implantitis at ≥ one implant in function of ≥ one year, will be included…
- Trial name
- NCT06262035
- Testing
- Periodontitis and Peri-implantitis
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Periodontitis, Probiotics
Clinical and Microbiological Aspects of Probiotics in Non-surgical Periodontal Therapy.
The goal of this randomized clinical trial is to test the effect orally administration of Probiotics based on Lactobacillus rhamnosus LR04 and Lactobacillus plantarum LP14 as adjuvant in people suffering from periodontitis stage…
- Conditions
- Periodontitis, Probiotics, Non Surgical Periodontal Therapy
- Trial name
- NCT06063226
- Testing
- Experimental, Negative control, Positive control
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- G. d'Annunzio University
Cone Beam Computed Tomography, Periodontitis
Evaluation of the Effects of Smoking on Trabecular Bone Microarchitecture Using CBCT in Periodontal Disease
The purpose of this cross-sectional study is to evaluate the morphometric properties of trabecular bone quality using Cone-beam computed tomography in periodontal disease at different stages, comparing smokers and non-smokers.
- Conditions
- Cone Beam Computed Tomography, Periodontitis, Diagnosis of Bone Quality, Diagnosis, Oral
- Trial name
- NCT06676358
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Okan University
Metabolic Syndrome (MetS), Periodontitis
Metabolic Syndrome-Associated Periodontal Inflammatory Surface Area
This study aims to examine the potential of metabolic syndrome (MetS), a systemic, inflammatory disease, to influence the relationship between periodontal inflammatory surface area (PISA) and diabetes and obesity parameters.
- Trial name
- NCT07354815
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Periodontitis
Timing of Periodontal Re-evaluation After Non-surgical Periodontal Therapy
Literature on non surgical periodontal therapy (NSPT) shows lack of clarity in reporting information on re-evaluation timing and clinical response.
- Trial name
- NCT04826926
- Testing
- Procedure/Surgery: Non Surgical Periodontal Therapy
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Apical Periodontitis
Clinical and Radiographic Success of Regeneration Using Injectable Platelet Rich Fibrin
Study aimed at assessing the clinical and radiographic success of pulp regeneration using injectable platelet-rich fibrin in mature permanent molars with apical periodontitis versus root canal treatment using Gutta Percha (GP)…
- Trial name
- NCT06086249
- Testing
- Regeneration using Injectable platelet-rich fibrin, Root canal treatment
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
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