Clinical trials: Parodontitis
Acute Irreversible Pulpitis With Apical Periodontitis
Ketorolac Irrigant on Post Operative Pain
Endodontic post-treatment pain management is one of the most challenging problems in the clinical practice of endodontics. Although this pain is decreased after root canal treatment, there may be residual symptoms due to…
- Trial name
- NCT04319549
- Testing
- Ketorolac Tromethamine irrigant, sodium hypochlorite irrigant
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis Chronic Localized Slight
Locally Delivered Whey Protein Nanoparticles Gel in Stage II Grade B Periodontitis
Aim of the current study is to evaluate radiographic and clinical alterations following topical application of CWP gel and CWP nanoparticles gel in stage II grade B periodontitis patients.
- Trial name
- NCT06401798
- Testing
- CWP gel, NCWP gel
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Periodontal Disease, Periodontitis (Stage 3)
Evaluation of Wnt5a and LRP5 Levels in Serum and Saliva Samples and the Relationship Between Clinical Periodontal Parameters
Objectives: Wnt5a is a secreted Wnt ligand that plays an important role in cellular homeostasis. Wnt interaction with coreceptor low-density lipoprotein receptor-related protein 5 (LRP5) induces the proliferation of osteoblasts…
- Conditions
- Periodontal Disease, Periodontitis (Stage 3), Periodontitis Stage III
- Trial name
- NCT06933784
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ankara University
Cardiovascular Disease in Obstructive Sleep Apnea
Impact of Treatment of Periodontis on Endothelial Function in Patients With Obstructive Sleep Apnea
Evaluation of the add-on effect on endothelial dysfunction of treatment of periodontitis in patients with chronic periodontitis and severe obstructive sleep apnea treated by CPAP.
- Trial name
- EndothSAS (NCT02573116)
- Testing
- scaling and root planing
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Hopital Foch
Periodontitis, Intrabony Periodontal Defect
C-PRF With Minimally Invasive Non-Surgical Periodontal Therapy
This randomized controlled clinical study evaluated whether concentrated platelet-rich fibrin (C-PRF) provides additional clinical and radiographic benefits when used together with minimally invasive non-surgical periodontal…
- Conditions
- Periodontitis, Intrabony Periodontal Defect, Non Surgical Periodontal Treatment
- Trial name
- NCT07696845
- Testing
- Minimally Invasive Non-Surgical Treatment, Concentrated Platelet-Rich Fibrin
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Altinbas University
Pulpitis, Periapical Periodontitis
Comparative Evaluation of Different File Systems in Postoperative Pain
Postoperative pain is a frequent complication associated with root canal treatment. The apical extrusion of irrigant and debris, including bacteria and necrotic tissue, may lead to postoperative pain, periapical inflammation, and…
- Conditions
- Pulpitis, Periapical Periodontitis, Necrotic Pulp
- Trial name
- NCT03708081
- Testing
- ProTaper Next, TF Adaptive
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bulent Ecevit University
Metabolic Syndrome (MetS), Periodontitis
Metabolic Syndrome Associated Diet
The goal of this observational study is to examine the relationship between metabolic syndrome (MetS) and periodontitis, and to evaluate the role of the Dietary Inflammatory Index (DII) in this association.
- Conditions
- Metabolic Syndrome (MetS), Periodontitis, Diet, Food and Nutrition
- Trial name
- NCT07462104
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Periodontitis
Complementary Naturopathic Medicine for Periodontitis
This study aims to assess selected naturopathic medicines for adult periodontitis and to identify variables that influence successful outcomes when traditional and alternative approaches to preventing and treating periodontal…
- Trial name
- NCT00010634
- Testing
- Connective Tissue Nutrient Formula, Adaptogenic herbs, glutamine
- Where
- United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Coronary Heart Disease, Periodontitis
Effect of Non-surgical Periodontal Treatment on Cardiovascular Risk Markers
The research question was to investigate whether non-surgical periodontal therapy could reduce cardiovascular risk markers in Coronary heart disease (CHD) patients.
- Trial name
- NCT04305171
- Testing
- non-surgical periodontal treatment
- Where
- 3 sites in Thailand
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Peri-Implantitis, Type 2 Diabetes Mellitus
Surgical Treatment of Periimplantitis in Patients With Risk Factors
This study evaluates clinical and radiographic parameters among riks factor groups in patients with periimplantitis. This study will also treat and evaluate the patients response before and after surgical treatment.
- Conditions
- Peri-Implantitis, Type 2 Diabetes Mellitus, Smoking, Cigarette, Periodontal Diseases
- Trial name
- NCT03814434
- Testing
- Non-Surgical treatment, Surgical Treatment
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Luiz Antonio Pugliesi Alves de Lima
Chronic Periodontitis
Efficacy of a Probiotic Lozenges in Chronic Periodontitis Patients.
Periodontal disease is an infectious disease resulting in inflammation within supporting tissues of the teeth, progressive attachment loss, and bone loss.
- Trial name
- NCT02121665
- Testing
- Probiotic (Inersan)
- Where
- India
- Volunteers
- 42 people
- Sponsor
- CD Pharma India Pvt. Ltd.
Periodontal Diseases, Patient Education
Supporting Oral Self-care of Patients With Periodontitis Through Motivational Interview
The aim of this study was to evaluate the potential additive effect of Motivational Interviewing (MI) on gingival health and self-care.
- Conditions
- Periodontal Diseases, Patient Education, Self-Care
- Trial name
- NCT04023500
- Testing
- Motivational interview vs. prevailing education
- Volunteers
- 28 people
- Sponsor
- University of Turku
Adiposity, Dental Diseases
Oral Health in Bariatric Patients
As few is known about the oral health of bariatric patients, this study aimed to analyze the prevalence and severity of erosive tooth wear, dental caries and periodontal diseases of obese patients who underwent bariatric surgery…
- Conditions
- Adiposity, Dental Diseases, Bariatric Surgery Candidate
- Trial name
- NCT03516201
- Where
- Germany
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Göttingen
Periodontitis, Periodontal Pocket
Treatment of Advanced Periodontitis With a Chitosan Brush and a Chitosan Gel
In the here suggested study, the aim is to test non-surgical treatment of advanced periodontal disease with a chitosan brush with or without chitosan gel in patients with advanced periodontal disease having responded poorly to a…
- Conditions
- Periodontitis, Periodontal Pocket, Periodontal Diseases, Periodontal Inflammation
- Trial name
- Chitosangel (NCT05773911)
- Testing
- 4% chitosan gel (pH 3.48)., Reciprocal Chitosan brush
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Caspar Wohlfahrt
Periodontal Diseases
Locally Delivered Melatonin Gel in Management of Stage II Grade B Periodontitis
Background: Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting tissues, driven by an imbalance between bacterial pathogens and the host immune response.
- Trial name
- NCT07813936
- Testing
- 2% Melatonin gel
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Alexandria University
Periodontitis
Dietary Supplements and Periodontal Wound Healing
Patient with periodontal disease undergoing full mouth disinfection will be given dietary supplements or placebo and reevaluated after 3 months.
- Trial name
- NCT02315222
- Testing
- Regenium, Full Mouth Disinfection
- Where
- 3 sites in Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Milan
Periodontal Inflammation
Role of TLR2 and TLR4 in Stage 2 Periodontitis Patients
In Health, mucosal inflammation is prevented by TLR (Toll like receptors) that interact with Specific MAMP (microbe associated molecular pattern). Currently about 13TLRs have been identified.
- Trial name
- NCT04201912
- Testing
- saliva analysis for Toll like receptor activity
- Where
- United Arab Emirates
- Volunteers
- 60 people
- Sponsor
- Ajman University
Chronic Periodontitis, Preterm Labor
Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients With Chronic Periodontitis
This case control-study measures the levels of Interleukin-17 in gingival crevicular fluid and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic…
- Trial name
- NCT03171675
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Chronic Periodontitis, Diabetes Mellitus
Chemerin and IL-6 Levels in Diabetes and Periodontitis
The aims of the present study were to determine the gingival crevicular fluid (GCF) chemerin and interleukin-6 (IL-6) levels and to analyse the relationship between chemerin and IL-6 in periodontal health and in chronic…
- Trial name
- NCT02596581
- Testing
- non-surgical periodontal treatment
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Chronic Periodontitis
Utilization of a Videoscope in Periodontal Regeneration
Clinical and preclinical studies confirm that regeneration of supporting tissues of teeth lost due to periodontal disease can be achieved using the principles of minimally invasive surgery (MIS).
- Trial name
- NCT05275192
- Testing
- Videoscope-assisted periodontal regeneration minimally invasive surgery, Periodontal regeneration minimally invasive surgery, Guided tissue regeneration surgery
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
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