Clinical trials: Parodontitis
Gingivitis, Periodontitis
Clinical Examination of Metal Free Interdental Brushes
The aim of the study was to evaluate the clinical efficacy (Eastman Interdental Bleeding Index, Quigley and Hein) of a novel metal-free interdentalbrush compared to a classig metal-core interdental brush.
- Trial name
- NCT01593540
- Testing
- metal-free interdental brush, metal-core interdental brush
- Where
- Germany
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Freiburg
Apical Periodontitis
Effects of PDT and Bioceramic Filling on Periapical Healing and Postoperative Pain After Endodontic Retreatment
The purpose is to investigate influence of bioceramic filling of the root canal and photodynamic therapy on periapical healing and development of postoperative pain after endodontic retreatment.
- Trial name
- NCT04072926
- Testing
- BioRoot
- Where
- Croatia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medical Innovation Center Wroclaw
Carotid Artery Calcification, Periodontal Diseases
Assessment of Carotid Artery Calcifications
The aim of the study was to determine retrospectively the presence of carotid artery calcification (CAC) detected on digital panoramic radiographs (DPRs) and correlate the finding of such calcifications with gender, smoking…
- Trial name
- NCT04017078
- Testing
- diagnosis of carotid artery calcification on digital panoramic radiograph
- Where
- Turkey (Türkiye)
- Volunteers
- 1,101 people
- Sponsor
- Baskent University
Periodontitis, Adult
Clinical Study of the Presence of Trichomonas Tenax and Entamoeba Gingivalis in Patients With Periodontitis
The buccal cavity presents microorganismes whose the number and composition vary with oral hygiene and medical context (pathologies and associated drug therapies) of the patient.
- Trial name
- Paro-Proto 2 (NCT03178838)
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Periodontitis, Diabetes
Full-mouth and Partial-mouth Scaling and Root Planing in Type 2 Diabetic Subjects
The aim of this study will be to evaluate: 1- the effect of full-mouth (FM) scaling and root (SRP) planing in 24 hours associated with or without extensive application of chlorhexidine (CLX) on clinical, microbiological, glycemic…
- Trial name
- NCT02062047
- Testing
- FMSRP, Chlorhexidine, PMSRP
- Volunteers
- 60 people
- Sponsor
- University of Guarulhos
Microbial Colonization, Periodontal Diseases
Impact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome
Periodontitis is an inflammatory disease characterized by a dysbiotic microbiome which can lead to bone destruction and tooth loss.
- Conditions
- Microbial Colonization, Periodontal Diseases, Periodontal Inflammation
- Trial name
- NCT04580355
- Testing
- One-Stage Full Mouth Debridement, Amoxicillin 500mg, Metronidazole 400mg
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Campinas, Brazil
Periodontitis
Periodontitis on Gingival Crevicular Fluid Metobolomics
This cross-sectional observational study will compare the gingival crevicular fluid metabolomic profile of 30 adults with periodontitis and 30 periodontally healthy adults.
- Trial name
- NCT07739732
- Testing
- Periodontal probing depth
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Catania
Chronic Periodontitis, Smoking
MTZ Plus AMX in the Treatment of Smokers and Non-smokers
Randomized controlled clinical trials have demonstrated that the use of amoxicillin (AMX) and metronidazole (MTZ) as adjuncts to mechanical therapy improves the clinical and microbiological outcomes of scaling and root planing…
- Trial name
- NCT01837199
- Testing
- Metronidazole plus Amoxicillin
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- University of Guarulhos
End Stage Renal Failure on Dialysis, Periodontitis
Effect of Non-Surgical Periodontal Therapy on Serum Albumin Levels of Patients on Maintenance Hemodialysis Therapy,
Periodontitis is a destructive chronic infection of the gums, ligaments, and bone, predominantly caused by Gram-negative bacteria. Individuals with periodontal disease are at increased risk of systemic diseases.
- Trial name
- NCT01641757
- Testing
- non-surgical periodontal therapy
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- University of the Punjab
Periodontitis
Intra-pocket Application of Tea Tree Oil Gel in the Treatment of Stage-2 Periodontitis
This study aimed to assess clinically and biochemically the effect of intrapocket application of tea tree oil (TTO) gel adjunctive to SRP in the management of stage 2(moderate) periodontitis and to correlate the biochemical…
- Trial name
- NCT04769271
- Testing
- Scaling and Root Planing, Scaling and Root Planing with tea tree oil
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Apical Periodontitis
Therapeutic Irrigation Procedures to Treat Apical Periodontitis
Apical periodontitis is a dental infection which develops around the root of a tooth and affects ~4-6% of the UK population. Current treatment strategies focus solely on removing bacteria from within the root canal space during…
- Trial name
- TIPTAP (NCT03987659)
- Testing
- Irrigation protocols that promote release of dECMs, Conventional Irrigation protocols
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Chronic Periodontitis
Evaluation of Nano-crystalline Hydroxyapatite Silica Gel in Management of Periodontal Intrabony Defects
A clinical and radiographic evaluation of Nano-crystalline hydroxyapatite silica gel in comparison with open flap debridement for management of periodontal intrabony defects.
- Trial name
- NCT02507596
- Testing
- Nano-crystalline hydroxyapatite silica gel, open flap debridement
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis
Prevalence of Porphyromonas Gingivalis Fimbrial Subunit Genotype in Smokers and Nonsmokers After Periodontal Therapy
The aims of the present study will be identify 5 types of fimbrial subunit genotype strains in smokers and nonsmokers with periodontitis, before and after periodontal therapy.
- Trial name
- NCT02879903
- Testing
- Periodontal treatment, Microbiological collect, Questionnaire
- Volunteers
- 32 people
- Sponsor
- Universidade Federal Fluminense
Apical Periodontitis, Apical Periodontal Cyst
Endodontic Microsurgery With the Use of L-PRF Block
This study evaluates the effect of leucocyte and platelet rich fibrin Block (L-PRF Block) during endodontic microsurgery (EMS) on patient's post-operative comfort and periapical bone healing in large peri-apical lesions.
- Trial name
- NCT05379010
- Testing
- Endodontic Microsurgery
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dental Caries (Diagnosis), Dental Plaque (Diagnosis)
Assessment of Dental Pathologies Using Digital Tools
Digital technology is playing an increasingly important role in dentistry, because of its ability to support the practitioner and increase work efficiency.
- Conditions
- Dental Caries (Diagnosis), Dental Plaque (Diagnosis), Periodontitis
- Trial name
- RESTODATA-NUM (NCT07205588)
- Where
- 22 sites in France, Reunion
- Volunteers
- 350 people
- Sponsor
- Recherche Clinique en Odontologie (ReCOL)
Periodontitis
Lactobacillus Reuteri for Non-surgical Periodontal Treatment of Chronic Periodontitis With Type 2 Diabetes Patients
This study aims to investigate the clinical and microbiological efficacy of Lactobacillus reuteri as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis with type 2 diabetes.
- Trial name
- NCT05275803
- Testing
- Probiotics, Control
- Volunteers
- 48 people
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Periodontitis, Diabetes
Gingival Crevicular IL-34 and CSF-1 Levels in Patients With Periodontitis and Uncontrolled Type 2 Diabetes
Type 2 diabetes mellitus is a metabolic disorder. There is a bidirectional association between periodontal disease and DM. Currently there is no data relationship between CSF-1 and IL-34, periodontal disease and diabetes.The aim…
- Trial name
- NCT04891627
- Testing
- Gingival crevicular fluid
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Uşak University
Chronic Apical Periodontitis
Evaluation of Post-Operative Pain Following the Use of Nano-Calcium Hydroxide
The goal of this clinical trial is to evaluate the effect of different intracanal medicaments-conventional calcium hydroxide (CH) and nano-sized calcium hydroxide (NCH)-on the intensity of postoperative pain following root canal…
- Trial name
- NCT07057336
- Testing
- Conventional Calcium Hydroxide (CH), Nanocalcium Hydroxide (NCH)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Cukurova University
Gingivitis, Periodontal Diseases
Changes in Oral Health in Tobacco Cigarettes Smokers After Switching to Combustion-Free Nicotine Delivery Systems
Although the well-known detrimental effects of conventional cigarette smoking on oral health, there are still lack of evidences about the impact of less harmful alternatives (such as electronic cigarettes or heat not burn…
- Trial name
- SMILE (NCT04649645)
- Testing
- TOBACCO CIGARETTES, COMBUSTION-FREE NICOTINE DELIVERY SYSTEMS (C-F NDS), NOT SMOKING
- Where
- Italy
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Eclat Srl.
Healing Surgical Wounds, Periodontitis
Modified Vertical Internal Mattress Suture Versus Simple Loop Interrupted Suture.
Aim of study was clinical comparative evaluation of using modified vertical internal mattress suturing technique and simple loop interrupted suturing technique in the outcome of modified Widman flap surgery for the management of…
- Trial name
- NCT03556163
- Testing
- Modified vertical internal mattress sutures + MWF surgery., Simple loop interrupted sutures + MWF surgery.
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
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