Clinical trials: Parodontitis
Chronic Periodontitis
New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin
The aim of the present study is to determine whether the association of Melatonin and Hyaluronic Acid to the antimicrobial TM paste (3% Tetracyclin and 3% Metronidazole) for periodontal maintenance therapy can improve the…
- Trial name
- HAMELDENT (NCT03656484)
- Testing
- Tetracycline-Metronidazole (TM) group, TM-Melatonin-Hyaluronic acid (TM-MHa) group
- Where
- 2 sites in Romania
- Volunteers
- 50 people
- Sponsor
- Concordia Dent Srl
Periodontitis
Changes in Periodontal Pocket Depth After Periodontal Treatment
This study is a prospective, observational clinical research conducted at the Department of Periodontology, Faculty of Dentistry, Necmettin Erbakan University.
- Trial name
- NCT07327658
- Testing
- Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Necmettin Erbakan University
Bone Loss, Periodontitis
Impact of Parathyroid Hormone (PTH) on Osseous Cavity
Parathyroid hormone (PTH) has potent bone-building actions and has been approved for the treatment of osteoporosis as FORTEO by Eli Lilly \& Co.
- Trial name
- NCT00277706
- Testing
- Periodontal surgery, FORTEO, Vitamin D and Calcium
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Periodontitis
Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy
This study aimed to determine the effect of anti-inflammatory nutrition on non-surgical periodontal treatment in individuals with periodontitis by evaluating gingival crevicular fluid (GCF) and serum biomarkers and clinical…
- Trial name
- NCT07287540
- Testing
- non surgical periodontal trearment, anti-inflammatory nutrition education
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Periodontitis
Interleukin-1 Receptor Antagonist Gene Polymorphism and Adverse Pregnancy Outcome in Turkish Women
The investigators hypothesized that the IL-1A (+4895), IL-1B (+3954), and IL-1RN gene polymorphisms may be associated with PLBW.
- Trial name
- IRAGPAAOITW (NCT01812083)
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Intrabony Periodontal Defect
Perforated Collagen Membrane With Nanohydroxyapatite for Intrabony Defects
The ultimate goal of periodontal therapy is the regeneration of periodontal tissues which have been destroyed due to periodontal disease.
- Trial name
- NCT03399279
- Testing
- Open flap debridment, Perforated collagen membrane, Occlusive membrane
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontitis, Infant, Premature
Obstetrics and Periodontal Therapy (OPT) Study
The purpose of this study is to determine if non-surgical periodontal (gum) treatment can reduce the incidence of preterm birth and low birth weight babies in mothers with periodontitis (gum disease).
- Trial name
- OPT (NCT00066131)
- Testing
- Periodontal scaling and root planing, Scaling and root planing
- Where
- United States
- Volunteers
- 823 people
- Sponsor
- University of Minnesota
Chronic Periodontitis
Influence of Mouth Breathing on Periodontal Healing
Studies reveal association between dry conditions and decreased healing in wounds or any treatment. From these studies, it can be hypothesized that healing in mouth breathers after scaling and root planing in terms of bleeding on…
- Trial name
- NCT03169322
- Testing
- SRP
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Gingivitis
Herbal Pralines - Oral Health
This randomized, double-blinded, placebo-controlled two-arm, parallel group clinical trial is designed to evaluate the impact of the consumption of two herbal pralines containing 200 mg nitrate on clinical signs of gingival…
- Trial name
- NCT06090851
- Testing
- herbal nitrate Pralines with nitrate, herbal nitrate Pralines without nitrate
- Where
- 2 sites in Germany
- Volunteers
- 44 people
- Sponsor
- Wuerzburg University Hospital
Periodontitis, Chronic, Chewing Problem
Assessment of Masticatory Performance in Periodontitis
The loss of periodontal attachment contributes to reduced masticatory performance and has a negative impact on general health.This clinical trial aims to assess the status of masticatory performance among patients with stage I…
- Conditions
- Periodontitis, Chronic, Chewing Problem, Inflammation
- Trial name
- NCT06426069
- Testing
- Masticatory efficiency assessment
- Where
- India
- Volunteers
- 555 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Periodontal Diseases
Behavioral Intervention Program Based on Motivational Interview
The best way for dental professionals act using dialogue methods and individual approaches in daily clinical practice to change behavioral is still inconclusive.
- Conditions
- Periodontitis, Periodontal Diseases, Motivational Interviewing
- Trial name
- NCT05948722
- Testing
- Motivational Interview Group (MIG), Conventional treatment group (CTG)
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- Universidade Federal de Santa Maria
Chronic Periodontitis
Combined Use of Er:YAG and Nd:YAG Laser
The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planning with hand instruments in nonsurgical treatment of chronic periodontitis.
- Trial name
- NCT02851823
- Testing
- Periodontal curettes, Er-YAG+Nd-YAG lasers
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Symptomatic Apical Periodontitis, Postoperative Pain
Photobiomodulation After Nonsurgical Root Canal Treatment
This randomized, double-blind controlled clinical trial will evaluate whether adjunctive photobiomodulation improves recovery after nonsurgical root canal treatment in adults with teeth diagnosed with symptomatic apical…
- Conditions
- Symptomatic Apical Periodontitis, Postoperative Pain, Mechanical Allodynia
- Trial name
- NCT07886723
- Testing
- Adjunctive Photobiomodulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Generalized Aggressive Periodontitis
Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families.
Generalized aggressive periodontitis (GAP) is an inflammatory disease that causes the severe and rapid destruction of periodontal tissue.
- Trial name
- NCT03642353
- Testing
- Triclosan
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Periodontitis
Adjunctive Laser for Periodontal Intrabony Defects
Participants with periodontitis and presence of bilateral intrabony defect will be randomised to have one side of the mouth undergo root surface debridement using hand instruments and ultrasonic scaler alone, while the…
- Trial name
- NCT04847830
- Testing
- Er:YAG laser (Waterlase), root surface dbridement
- Volunteers
- 28 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Periodontal Disease, Melatonin
Adjunctive Topical Melatonin Gel in Non-Surgical Periodontal Therapy for Periodontitis
The goal of this clinical trial is to evaluate the clinical effectiveness of adjunctive topical melatonin gel when used with non-surgical periodontal therapy (NSPT) in adult patients with periodontitis.
- Trial name
- NCT07605767
- Testing
- Topical 5% Melatonin Gel
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Liaquat College of Medicine and Dentistry
Pulpitis - Irreversible
The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo
Aim. To compare the outcome of preoperative administration of single-dose ketorolac, non-steroidal anti-inflammatory drug and placebo on postoperative pain in teeth with irreversible pulpitis and apical periodontitis.
- Trial name
- PreOp (NCT03116672)
- Testing
- one dose ketorolac 10 mg, One dose Diclofenac
- Where
- Mexico
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Periodontitis, Adult
Evaluation of Multiple Subgingival Irrigations.
The study will be conducted at the Department of Periodontology, Cliniques universitaires Saint Luc. Patients diagnosed with Generalized Chronic Periodontitis (GChP) based on the current classification of the American Academy of…
- Trial name
- POLYVIDONE (NCT03432975)
- Testing
- Povidone-Iodine 10%, Saline Solution
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Periapical Periodontitis, Periapical Abscess
A Retrospective Cohort Study on the Non-Surgical Treatment of Periapical Inflammatory Lesions With Vitapex Paste
Background: Periapical inflammation is a common clinical condition, classified into periapical periodontitis, periapical granuloma, and periapical cyst.
- Conditions
- Periapical Periodontitis, Periapical Abscess, Periapical Radiolucency
- Trial name
- NCT07907367
- Testing
- Vitapex Paste
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Affiliated Hospital of Jinggangshan University
Periodontitis, Periodontal Diseases
Efficacy of Periodontal Risk Communication in Patients With and Without History of Tooth Loss
SCIENTIFIC BACKGROUND The periodontal risk assessment method proposed by the University of Ferrara (namely, the PerioRisk; Trombelli et al.
- Conditions
- Periodontitis, Periodontal Diseases, Communication
- Trial name
- PERIORISK (NCT05078411)
- Testing
- Test treatment, Control treatment
- Where
- 2 sites in Italy
- Volunteers
- 87 people
- Sponsor
- Università degli Studi di Ferrara
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