Clinical trials: Parodontitis
Periodontitis, Coronary Heart Disease
Periodontitis and Coronary Heart Disease
"Atherosclerosis is an inflammatory disease". The hypothesis of an infectious burden as trigger or initiator of the inflammatory process in atherosclerosis has been extensively discussed in the past years.
- Trial name
- NCT01045070
- Where
- Germany
- Volunteers
- 960 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Periapical Lesion Healing, Apical Periodontitis
The Effect of Different Intracanal Medicaments on Periapical Lesion Healing
This study is planned to evaluate the effects of two different intracanal medicaments-calcium hydroxide and diclofenac sodium-on periapical healing following endodontic retreatment.
- Trial name
- NCT07237620
- Testing
- Diclofenac sodium
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Antibiotic Resistance, Antibiotic Use
Antibiotics, Antibiotic Resistance, and Prescribing Practices Among Periodontists: Cross Sectional KAP Study
Antibiotic resistance is a global health threats that require attention from all healthcare providers. In Periodontology, antibiotic is prescribed in many clinical situations.
- Conditions
- Antibiotic Resistance, Antibiotic Use, Periodontitis
- Trial name
- NCT06371560
- Testing
- Questionnaire
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis, Diabetes Mellitus, Type 2
White Blood Cell Signaling and Defense Mechanisms in Patients With Diabetes Mellitus Type 2 and Periodontitis
White blood cell membrane and surface structures are affected by the metabolic disorders and complications found in diabetes mellitus.
- Trial name
- DMS (NCT01848379)
- Testing
- ADT+FD, FD
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Zentrum fuer Zahn-, Mund- und Kieferheilkunde
Vitamin D Deficiency, Periodontitis
25-Hydroxyvitamin D Levels in Patients With Periodontitis (Stage III)
Periodontitis; is an inflammatory disease of tissues characterized by bone destruction around the teeth. Vitamin D plays an important role in several inflammatory diseases by promoting the expression of inflammatory cytokines…
- Trial name
- NCT05343273
- Testing
- taking a blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Oral Squamous Cell Carcinoma (OSCC), Periodontal Disease
Discovery and Validation of Biomarkers for Periodontitis, Dental Caries and Oral Squamous Cell Carcinoma
The goal of this observational study is to develop better ways to detect and predict major oral diseases, including oral cancer, gum disease, and tooth decay.
- Conditions
- Oral Squamous Cell Carcinoma (OSCC), Periodontal Disease, Dental Caries
- Trial name
- NCT07745803
- Testing
- Step 1 and 2 periodontal therapy according to the EFP clinical practice guidelines, Dental filling with or without root canal treatment, Oral cancer surgical resection including extension, dissection and reconstruction with adjunctive radiation, chemotherapy and/or biological treatments per international guidelines,
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Periodontitis, Smoking Cessation
Effect of Nicotine Gingival Fibroblast Intoxication on the Response of Periodontal Treatment
Impact of nicotine gingival intoxication on the clinical outcomes after periodontitis non surgical treatment
- Conditions
- Periodontitis, Smoking Cessation, Tobacco Dependence
- Trial name
- ENIPT's (NCT07491627)
- Testing
- periodontal non-surgical treatment
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- University of Liege
Serum HbA1c and Vitamin D, Vitamin B12 Values in Periodontal Diseases
Vitamin D, HbA1c and Vitamin B12 Levels in Patients
Abstract Aim: to compare the serum vitamin D, HbA1c and vitamin B12 levels in patients with gingivitis and four different periodontitis stages diagnosed according to the 2017 Periodontal Disease Classification.
- Trial name
- NCT05745779
- Testing
- HbA1c, Vitamin D, Vitamin B12
- Where
- Turkey (Türkiye)
- Volunteers
- 606 people
- Sponsor
- Hacettepe University
Periodontitis
Emdogain Minimally Invasive Surgical Technique
The aim of this controlled study is to assess the clinical outcomes and patient reported outcomes of using minimally invasive surgical procedure with Straumann Emdogain as an adjunct (test treatment) or without Straumann Emdogain…
- Trial name
- NCT02551770
- Testing
- Scaling and root planing, Scaling and root planing without Emdogain, Emdogain application
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Institut Straumann AG
Periodontitis (Stage 3)
A Clinical Trial Comparing 2x/Day for 30-minutes Use of the Emanate Perio PODS Post-SRP to a Control Group Post-SRP.
The goal of this clinical trial is to compare safety and to see if individuals with generalized stage III periodontitis that are given a periodontal hydrogel dressing on a wound healing after plaque and tartar have been removed…
- Trial name
- NCT06914596
- Testing
- Emanate Perio PODS
- Where
- 9 sites in United States
- Volunteers
- 72 people
- Sponsor
- McGuire Institute
Symptomatic Apical Periodontitis
Postoperative Pain and Substance P Levels After Bioceramic vs Calcium Hydroxide Intracanal Medicaments in Symptomatic Apical Periodontitis
Clinical Evaluation of the Postoperative Pain and Substance P levels Following the use of Bioceramic verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular molars with Symptomatic Apical Periodontitis
- Trial name
- (BCvsCaOH) (NCT07585721)
- Testing
- Calcium Hydroxide (Ca(OH)2), Bioceramic Intracanal Medicament
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Periodontitis, Gingivitis
Effect of a Liquid Toothpaste on Periodontal Disease
The aim of the present clinical study is to evaluate the efficacy and safety of the novel toothpaste in patients diagnosed with gingivitis and/or periodontitis.
- Trial name
- NCT03117153
- Testing
- DA-5502 liquid toothpaste
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Dong-A Pharmaceutical
Periodontitis
Evaluation of Photodynamic Treatment FOTOSAN® Efficacy in Periodontology
Periodontitis are infectious and inflammatory diseases of gum and tooth supporting tissues leading to tooth loss and oral disability.
- Trial name
- NCT02030470
- Testing
- Fotosan®630. LED lamp. Toluidinblue. Photoactivated disinfection
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Strasbourg, France
Periodontitis Stage II, Periodontitis Stage III
Development and Validation of the Periodontal Map Derived From IOS and CBCT Registration for Diagnosis and Treatment Planning in Moderate-to-severe Periodontitis
This prospective diagnostic study aims to validate the clinical utility of a "Periodontal Panoramic Map" generated by the PerioAI V2.0 system, an artificial intelligence-based platform that integrates intraoral scans and…
- Conditions
- Periodontitis Stage II, Periodontitis Stage III, Periodontitis Stage IV
- Trial name
- NCT07505251
- Testing
- Perio AI V2.0 System
- Volunteers
- 80 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Periodontal Diseases, Periodontal Pocket
Effectiveness of SRP+ Lipo-curcumin Gel for the Treatment of Stage III Periodontitis.
The aim of the present study is to clinically and radiographically compare the effectivness of Scaling and Root Plannig (SRP) in association with lipo-curcumin gel (LC) respect SRP+ lipo-gel (L), SRP+ discharged (D) gel and SRP…
- Conditions
- Periodontal Diseases, Periodontal Pocket, Periodontal Attachment Loss
- Trial name
- NCT06624241
- Testing
- Lipo-Curcumin gel + SRP, Lipo gel + SRP, Discharged Gel + SRP
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Periodontitis, Diabetes Mellitus
Endocan Biomarker Level in Gingival Crevicular Fluid in Periodontitis Patients With Type 2 Diabetes Mellitus
Aim of the current study was to evaluate Endocan biomarker level in gingival crevicular fluid of patients with stage 1 or 2 (mild to moderate) periodontitis with controlled type 2 diabetes mellitus (DM) and compare it to that in…
- Trial name
- NCT05667051
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Alexandria University
Irreversible Pulpitis
Comparison of Antimicrobial Action of Sodium Hypochlorite and Polyhexamethylene Biguanide as Root Canal Irrigants
The aim of this randomized clinical trial is to compare the antibacterial effects of sodium hypochlorite (NaOCl) and Polyhexamethylene biguanide during root canal treatment .
- Trial name
- NCT05306431
- Testing
- Polyhexamethylene biguanide, Sodium Hypochlorite
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
Necrotic Teeth With Chronic Apical Periodontitis
Regenerative Endodontics in Mature Necrotic Teeth
The goal of this clinical trial is to learn if nanochitosan can achieve regeneration in mature necrotic teeth. It will also provide data about the healing potential \& postoperative pain after using different irrigation…
- Trial name
- NCT07584928
- Testing
- Intervention 1: 1% nanochitosan, Intervention 2: 1% nanochitosan & 17% EDTA
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Periapical Periodontitis
Healing of Apical periodontitis-the Effect of Diabetes Mellitus and Tobacco Smoking
Apical periodontitis is an inflammatory process located around the apex of the root. It is mainly caused by a microbial infection of the pulp space.
- Trial name
- NCT04812171
- Testing
- non-surgical endodontic treatment
- Where
- Croatia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Romana Peršić Bukmir
Aggressive Periodontitis
Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis
The adjunctive use of systemically administered antibiotics has been shown to provide a better clinical outcome, particularly in terms of probing depth (PD) reduction and attachment-level gain than SRP in subjects with Aggressive…
- Trial name
- NCT02125812
- Testing
- scaling and systemic moxifloxacin, scaling and root planing
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Facultad Nacional de Salud Publica
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