Clinical trials: Parodontitis
Periodontitis
The Use of Adhesion Molecule Loaded Hydrogel With Minimally Invasive Surgical Technique in Treatment of Periodontal Intrabony Defect
Primary aim of the study is to evaluate efficacy of RGD adhesion molecule loaded hydrogel with minimally invasive surgical technique in treatment of periodontal intrabony defect at baseline and 6months.
- Trial name
- NCT05653245
- Testing
- RGD Peptide
- Where
- 2 sites in Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Minia University
Periodontitis
Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization
The purpose of this study is to determine the size of the benefit of an adjunctive empiric antibiotic therapy compared to standard mechanical debridement and oral hygiene instructions in a representative sample of German…
- Trial name
- ABPARO-Studie (NCT00707369)
- Testing
- Amoxicillin and Metronidazole
- Where
- 8 sites in Germany
- Volunteers
- 540 people
- Sponsor
- University Hospital Muenster
Periodontitis, Hypertension
Study of the Effects of Intensive Treatment of Periodontitis on Blood Pressure Control
Hypertensive patients with chronic periodontitis will be randomized to either intensive treatment or supragingival hygienic treatment and the effects on blood pressure will be identified.
- Trial name
- PerioBP (NCT02131922)
- Testing
- Intensive Treatment, Dental Hygienization Treatment, Chlorhexidine (Intensive Treatment)
- Where
- 2 sites in Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
Periodontitis
Effect of Periodontitis Treatment on Quality of Life and Experiences of Fear, Anxiety and Pain
There are different protocols to treat gum diseases. One relevant differential aspect is related to time. There are protocols that usually takes one to two months to be completed while other are completed within 24 hours.
- Trial name
- NCT02409966
- Testing
- Quadrant-wise scaling, Full-mouth 24-hour scaling
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Taubate
Periodontitis, Smoking
Interaction Between Smoking, GCF Periostin, IL17A, IL17E and Non-surgical Periodontal Therapy
It was aimed to evaluate the changes in the levels of Periostin, IL-17A and IL-17E cytokines in the gingival crevicular fluid (GCF) of periodontitis patients which non-surgical (Phase I) periodontal treatment applied to and their…
- Trial name
- NCT06326073
- Testing
- Non Surgical Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Chronic Periodontitis
Different Surgical Modalities in the Treatment of Periodontitis
The purpose of the present study is to determine: 1) the efficacy of 2 periodontal surgical procedures, the conservative simplified papilla preservation technique and the more resective open flap debridement with osseous…
- Trial name
- NCT01642641
- Testing
- Non-surgical Subgingival Debridement (SD), Simplified Papilla Preservation Flap, Resective Periodontal Flap with Osseous Recontouring (RPFO)
- Where
- 3 sites in United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Periodontal Pocket
Quantitation of Bacteria Associated With Severe Periodontitis by Real -Time PCR Following Application of Diode Laser
1. Primary objective To measure the gingival crevicular levels of A.actinomycetemcomitans and P.gingivalis after intra-pocket application of diode laser in severe periodontitis (stage 3 grade C) patients. 2.
- Trial name
- NCT05222737
- Testing
- medency diode laser, spirazole forte
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Periodontitis
Effects of Periodontal Therapy on Markers of Acute Phase Response, Oxidative Stress
This study began enrollment in 2003 with final report completed in October of 2015. This submission is being provided to acquire an NCT number.
- Trial name
- BCU2 (NCT03375372)
- Testing
- Scaling and Root Planing (S&RP)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Root Canal Obturation, Apical Periodontitis
Evaluation of Postoperative Pain and Lesion Healing in Periapical Lesion-Affected Teeth Obturated With Different Root Canal Sealers
The root canal treatment of volunteers with asymptomatic apical periodontitis will be completed using TotalFill BC and AH Plus root canal sealers, and postoperative pain as well as healing will be comparatively evaluated through…
- Trial name
- NCT07307807
- Testing
- AH Plus and PAI 2-3, AH Plus and PAI 4, TotalFill BC Sealer and PAI 2-3
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ankara Yildirim Beyazıt University
Periodontitis, Tongue Coating
Effect of Periodontal Treatment on Tongue Coating and Smell Function
This study aims to investigate the effect of periodontal treatment on olfactory function in patients with periodontitis by comparing pre- and post-treatment periodontal indices, Winkel tongue coating scores, and Sniffin' Sticks…
- Conditions
- Periodontitis, Tongue Coating, Olfactory Dysfunction
- Trial name
- EPTOS (NCT07326319)
- Testing
- Non-Surgical Periodontal Treatment (Scaling and Root Planing
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Batman University
Periodontitis, Gingivitis
Evaluation of Salivary Biomarker Levels in Individuals With Different Periodontal Conditions
In order to determine the pathogenesis of chronic inflammatory diseases, the levels of various cytokines are examined in tissues and fluids taken from the body.
- Conditions
- Periodontitis, Gingivitis, Periodontal Health
- Trial name
- NCT06558136
- Testing
- Saliva obtaining
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Periodontal Disease, Periodontitis
Effect of Nano-Hyaluronic Acid in Intrabony Defects Treated With Minimally Invasive Non-Surgical Technique
This randomized controlled clinical trial aims to evaluate the effectiveness of using nano-hyaluronic acid (nano-HyA) gel alongside a minimally invasive non-surgical technique (MINST) to treat deep intrabony defects in patients…
- Trial name
- NCT07595757
- Testing
- Minimally invasive non-surgical technique (MINST), nano-hyaluronic acid
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Cairo University
Cryotherapy
Effect of Cryotherapy on Post-endodontic Pain
The goal of this clinical trial is to compare Cryotherapy with occlusal reduction in the reduction of post-endodontic pain in molars with symptomatic apical periodontitis.
- Trial name
- NCT05722704
- Testing
- Cryotherapy, Occlusal reduction
- Where
- United Arab Emirates
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Periodontitis, Periodontal Intrabony Defects
Impact of Platelet-Rich Fibrin on Periodontal Tissue Regeneration
The purpose of this research is to assess the efficacy of Platelet-Rich Fibrin (PRF) in the regeneration of periodontal tissues in patients suffering from periodontal disease.
- Trial name
- NCT07395726
- Testing
- Open Flap Debridement, Platelet-Rich Fibrin with Open Flap Debridement
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Chronic Periapical Periodontitis, Alveolar Ridge Preservation
Rotary Versus Manual Degranulation in Alveolar Ridge Preservation
After a tooth is taken out, the empty socket needs to heal. Sometimes unhealthy soft tissue (called granulation tissue) is left behind and can slow down healing. This study compares two ways to clean the socket: 1.
- Trial name
- NCT07607314
- Testing
- Rotary Degranulation, Manual Curettage
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
L-PRF, Photodynamic Therapy
The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis
Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria.
- Conditions
- L-PRF, Photodynamic Therapy, Aggressive Periodontitis
- Trial name
- NCT05043935
- Testing
- L-PRF with antimicrobial photodynamic therapy, antimicrobial photodynamic therapy without L-PRF
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Periodontal Diseases, Periodontitis
Assessment of Tooth Mobility After Non-surgical Periodontal Treatment Followed by Tooth Splinting
This clinical study aims to investigate changes in tooth mobility after non-surgical periodontal treatment in anterior teeth with mobility.
- Trial name
- NCT06929676
- Testing
- Periodontal Treatment, assessment of tooth mobility before and after periodontal treatment, Evaluation of Clinical Parameters
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Campinas, Brazil
Periodontitis
GCF PLAP-1, Sclerostin and TNF-α Levels in Periodontitis
Periodontal ligament-associated protein-1 (PLAP-1) and sclerostin play an important role in the suppression of bone formation. Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine involved in periodontal…
- Trial name
- NCT05656989
- Testing
- Periodontal clinical measurements and GCF sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Periodontitis, Periodontal Diseases
Microbial Associations in Periodontal Health and Disease
The purpose of this study is to determine the clinical and microbiological effects of systemically administered metronidazole alone or in combination with professional plaque removal on periodontally diseased patients.
- Trial name
- NCT00066001
- Testing
- metronidazole
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- The Forsyth Institute
Apical Periodontitis
Effect of Various Sealers on Healing of Teeth With Apical Periodontitis
This study will compare the effect of three different sealers on healing of teeth with apical periodontitis after primary root canal treatment.
- Trial name
- NCT03397875
- Testing
- Zinc oxide based sealer, Epoxy resin based sealer, Bioactive silicone based sealer
- Where
- India
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
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